Amino acid dipepetide frequency for Acetobacter sp. KACC 21233

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
15.467AlaAla: 15.467 ± 0.186
1.504AlaCys: 1.504 ± 0.047
6.342AlaAsp: 6.342 ± 0.083
6.551AlaGlu: 6.551 ± 0.112
3.826AlaPhe: 3.826 ± 0.065
10.483AlaGly: 10.483 ± 0.144
2.749AlaHis: 2.749 ± 0.056
5.165AlaIle: 5.165 ± 0.084
2.643AlaLys: 2.643 ± 0.068
13.815AlaLeu: 13.815 ± 0.165
3.316AlaMet: 3.316 ± 0.058
2.552AlaAsn: 2.552 ± 0.061
6.174AlaPro: 6.174 ± 0.101
5.506AlaGln: 5.506 ± 0.109
8.979AlaArg: 8.979 ± 0.124
6.565AlaSer: 6.565 ± 0.094
6.718AlaThr: 6.718 ± 0.108
8.242AlaVal: 8.242 ± 0.109
1.64AlaTrp: 1.64 ± 0.048
2.437AlaTyr: 2.437 ± 0.057
0.0AlaXaa: 0.0 ± 0.0
Cys
1.299CysAla: 1.299 ± 0.04
0.183CysCys: 0.183 ± 0.014
0.529CysAsp: 0.529 ± 0.025
0.388CysGlu: 0.388 ± 0.021
0.367CysPhe: 0.367 ± 0.021
1.141CysGly: 1.141 ± 0.04
0.3CysHis: 0.3 ± 0.02
0.493CysIle: 0.493 ± 0.023
0.18CysLys: 0.18 ± 0.014
1.214CysLeu: 1.214 ± 0.039
0.242CysMet: 0.242 ± 0.018
0.253CysAsn: 0.253 ± 0.019
0.614CysPro: 0.614 ± 0.033
0.344CysGln: 0.344 ± 0.019
0.696CysArg: 0.696 ± 0.027
0.527CysSer: 0.527 ± 0.026
0.597CysThr: 0.597 ± 0.029
0.89CysVal: 0.89 ± 0.032
0.142CysTrp: 0.142 ± 0.013
0.227CysTyr: 0.227 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
6.139AspAla: 6.139 ± 0.1
0.513AspCys: 0.513 ± 0.026
2.743AspAsp: 2.743 ± 0.067
2.736AspGlu: 2.736 ± 0.064
1.88AspPhe: 1.88 ± 0.045
4.615AspGly: 4.615 ± 0.074
1.251AspHis: 1.251 ± 0.041
3.26AspIle: 3.26 ± 0.061
1.532AspLys: 1.532 ± 0.04
5.395AspLeu: 5.395 ± 0.081
1.682AspMet: 1.682 ± 0.041
1.417AspAsn: 1.417 ± 0.042
3.113AspPro: 3.113 ± 0.059
1.792AspGln: 1.792 ± 0.049
3.494AspArg: 3.494 ± 0.06
2.731AspSer: 2.731 ± 0.057
3.419AspThr: 3.419 ± 0.07
4.17AspVal: 4.17 ± 0.072
0.936AspTrp: 0.936 ± 0.039
1.37AspTyr: 1.37 ± 0.04
0.0AspXaa: 0.0 ± 0.0
Glu
6.635GluAla: 6.635 ± 0.121
0.372GluCys: 0.372 ± 0.02
2.705GluAsp: 2.705 ± 0.072
3.023GluGlu: 3.023 ± 0.068
1.399GluPhe: 1.399 ± 0.043
3.939GluGly: 3.939 ± 0.069
1.389GluHis: 1.389 ± 0.043
2.6GluIle: 2.6 ± 0.066
2.063GluLys: 2.063 ± 0.061
4.356GluLeu: 4.356 ± 0.075
1.145GluMet: 1.145 ± 0.038
1.601GluAsn: 1.601 ± 0.049
1.959GluPro: 1.959 ± 0.053
2.517GluGln: 2.517 ± 0.064
3.988GluArg: 3.988 ± 0.084
2.263GluSer: 2.263 ± 0.053
3.3GluThr: 3.3 ± 0.068
3.067GluVal: 3.067 ± 0.059
0.609GluTrp: 0.609 ± 0.027
0.923GluTyr: 0.923 ± 0.033
0.0GluXaa: 0.0 ± 0.0
Phe
3.567PheAla: 3.567 ± 0.053
0.471PheCys: 0.471 ± 0.025
2.096PheAsp: 2.096 ± 0.055
1.709PheGlu: 1.709 ± 0.05
1.281PhePhe: 1.281 ± 0.048
3.167PheGly: 3.167 ± 0.072
0.814PheHis: 0.814 ± 0.031
1.464PheIle: 1.464 ± 0.041
0.748PheLys: 0.748 ± 0.033
3.416PheLeu: 3.416 ± 0.069
0.928PheMet: 0.928 ± 0.03
0.998PheAsn: 0.998 ± 0.042
1.604PhePro: 1.604 ± 0.042
1.09PheGln: 1.09 ± 0.033
2.201PheArg: 2.201 ± 0.051
2.491PheSer: 2.491 ± 0.056
1.974PheThr: 1.974 ± 0.049
2.661PheVal: 2.661 ± 0.058
0.5PheTrp: 0.5 ± 0.029
0.894PheTyr: 0.894 ± 0.036
0.0PheXaa: 0.0 ± 0.0
Gly
8.528GlyAla: 8.528 ± 0.13
0.962GlyCys: 0.962 ± 0.033
3.666GlyAsp: 3.666 ± 0.072
3.675GlyGlu: 3.675 ± 0.072
3.176GlyPhe: 3.176 ± 0.059
7.259GlyGly: 7.259 ± 0.138
2.199GlyHis: 2.199 ± 0.047
3.977GlyIle: 3.977 ± 0.068
2.717GlyLys: 2.717 ± 0.07
9.451GlyLeu: 9.451 ± 0.121
2.571GlyMet: 2.571 ± 0.06
2.116GlyAsn: 2.116 ± 0.055
3.528GlyPro: 3.528 ± 0.065
3.85GlyGln: 3.85 ± 0.072
5.971GlyArg: 5.971 ± 0.083
4.569GlySer: 4.569 ± 0.08
4.837GlyThr: 4.837 ± 0.091
6.41GlyVal: 6.41 ± 0.096
1.426GlyTrp: 1.426 ± 0.047
2.181GlyTyr: 2.181 ± 0.049
0.0GlyXaa: 0.0 ± 0.0
His
2.998HisAla: 2.998 ± 0.06
0.267HisCys: 0.267 ± 0.018
1.591HisAsp: 1.591 ± 0.046
1.119HisGlu: 1.119 ± 0.036
0.903HisPhe: 0.903 ± 0.035
2.18HisGly: 2.18 ± 0.057
0.749HisHis: 0.749 ± 0.029
1.17HisIle: 1.17 ± 0.04
0.617HisLys: 0.617 ± 0.029
2.282HisLeu: 2.282 ± 0.057
0.571HisMet: 0.571 ± 0.026
0.675HisAsn: 0.675 ± 0.028
1.513HisPro: 1.513 ± 0.05
0.742HisGln: 0.742 ± 0.028
1.418HisArg: 1.418 ± 0.039
1.234HisSer: 1.234 ± 0.038
1.387HisThr: 1.387 ± 0.044
1.844HisVal: 1.844 ± 0.055
0.405HisTrp: 0.405 ± 0.023
0.676HisTyr: 0.676 ± 0.029
0.0HisXaa: 0.0 ± 0.0
Ile
5.858IleAla: 5.858 ± 0.087
0.497IleCys: 0.497 ± 0.026
2.586IleAsp: 2.586 ± 0.057
2.472IleGlu: 2.472 ± 0.063
1.468IlePhe: 1.468 ± 0.046
3.955IleGly: 3.955 ± 0.078
0.923IleHis: 0.923 ± 0.031
2.174IleIle: 2.174 ± 0.059
1.182IleLys: 1.182 ± 0.037
4.402IleLeu: 4.402 ± 0.074
1.125IleMet: 1.125 ± 0.034
1.399IleAsn: 1.399 ± 0.049
2.46IlePro: 2.46 ± 0.06
1.388IleGln: 1.388 ± 0.039
3.217IleArg: 3.217 ± 0.072
2.879IleSer: 2.879 ± 0.069
3.075IleThr: 3.075 ± 0.067
3.572IleVal: 3.572 ± 0.065
0.534IleTrp: 0.534 ± 0.023
0.918IleTyr: 0.918 ± 0.037
0.0IleXaa: 0.0 ± 0.0
Lys
3.631LysAla: 3.631 ± 0.083
0.147LysCys: 0.147 ± 0.012
1.517LysAsp: 1.517 ± 0.046
1.302LysGlu: 1.302 ± 0.05
0.645LysPhe: 0.645 ± 0.028
2.37LysGly: 2.37 ± 0.054
0.552LysHis: 0.552 ± 0.028
1.423LysIle: 1.423 ± 0.051
1.162LysLys: 1.162 ± 0.049
2.653LysLeu: 2.653 ± 0.073
0.611LysMet: 0.611 ± 0.026
0.894LysAsn: 0.894 ± 0.037
1.687LysPro: 1.687 ± 0.046
1.039LysGln: 1.039 ± 0.037
1.767LysArg: 1.767 ± 0.046
1.452LysSer: 1.452 ± 0.045
1.796LysThr: 1.796 ± 0.048
2.017LysVal: 2.017 ± 0.053
0.317LysTrp: 0.317 ± 0.022
0.534LysTyr: 0.534 ± 0.025
0.0LysXaa: 0.0 ± 0.0
Leu
13.68LeuAla: 13.68 ± 0.175
1.357LeuCys: 1.357 ± 0.041
6.041LeuAsp: 6.041 ± 0.102
5.226LeuGlu: 5.226 ± 0.09
3.619LeuPhe: 3.619 ± 0.078
8.029LeuGly: 8.029 ± 0.122
2.661LeuHis: 2.661 ± 0.057
4.001LeuIle: 4.001 ± 0.076
3.024LeuLys: 3.024 ± 0.061
10.782LeuLeu: 10.782 ± 0.162
2.301LeuMet: 2.301 ± 0.058
2.763LeuAsn: 2.763 ± 0.057
6.974LeuPro: 6.974 ± 0.12
3.337LeuGln: 3.337 ± 0.07
7.739LeuArg: 7.739 ± 0.118
7.112LeuSer: 7.112 ± 0.103
5.963LeuThr: 5.963 ± 0.092
7.584LeuVal: 7.584 ± 0.101
1.356LeuTrp: 1.356 ± 0.044
2.165LeuTyr: 2.165 ± 0.055
0.0LeuXaa: 0.0 ± 0.0
Met
3.335MetAla: 3.335 ± 0.062
0.156MetCys: 0.156 ± 0.014
1.304MetAsp: 1.304 ± 0.041
1.172MetGlu: 1.172 ± 0.037
0.641MetPhe: 0.641 ± 0.028
1.956MetGly: 1.956 ± 0.055
0.534MetHis: 0.534 ± 0.026
1.069MetIle: 1.069 ± 0.039
0.771MetLys: 0.771 ± 0.029
2.685MetLeu: 2.685 ± 0.061
0.567MetMet: 0.567 ± 0.024
0.699MetAsn: 0.699 ± 0.029
1.618MetPro: 1.618 ± 0.046
1.042MetGln: 1.042 ± 0.035
1.748MetArg: 1.748 ± 0.044
1.601MetSer: 1.601 ± 0.042
1.991MetThr: 1.991 ± 0.047
1.737MetVal: 1.737 ± 0.042
0.169MetTrp: 0.169 ± 0.013
0.294MetTyr: 0.294 ± 0.017
0.0MetXaa: 0.0 ± 0.0
Asn
3.172AsnAla: 3.172 ± 0.063
0.263AsnCys: 0.263 ± 0.017
1.283AsnAsp: 1.283 ± 0.041
1.031AsnGlu: 1.031 ± 0.038
0.906AsnPhe: 0.906 ± 0.037
2.429AsnGly: 2.429 ± 0.064
0.549AsnHis: 0.549 ± 0.03
1.483AsnIle: 1.483 ± 0.053
0.644AsnLys: 0.644 ± 0.03
2.445AsnLeu: 2.445 ± 0.061
0.62AsnMet: 0.62 ± 0.024
0.735AsnAsn: 0.735 ± 0.036
1.82AsnPro: 1.82 ± 0.047
0.863AsnGln: 0.863 ± 0.033
1.794AsnArg: 1.794 ± 0.04
1.359AsnSer: 1.359 ± 0.049
1.792AsnThr: 1.792 ± 0.051
1.837AsnVal: 1.837 ± 0.053
0.427AsnTrp: 0.427 ± 0.022
0.679AsnTyr: 0.679 ± 0.034
0.0AsnXaa: 0.0 ± 0.0
Pro
7.112ProAla: 7.112 ± 0.117
0.434ProCys: 0.434 ± 0.024
4.016ProAsp: 4.016 ± 0.072
3.604ProGlu: 3.604 ± 0.068
1.948ProPhe: 1.948 ± 0.048
4.505ProGly: 4.505 ± 0.076
1.44ProHis: 1.44 ± 0.042
1.842ProIle: 1.842 ± 0.051
1.215ProLys: 1.215 ± 0.04
5.441ProLeu: 5.441 ± 0.087
1.246ProMet: 1.246 ± 0.04
1.137ProAsn: 1.137 ± 0.041
3.388ProPro: 3.388 ± 0.112
2.47ProGln: 2.47 ± 0.058
2.98ProArg: 2.98 ± 0.068
3.078ProSer: 3.078 ± 0.059
3.108ProThr: 3.108 ± 0.075
4.877ProVal: 4.877 ± 0.087
0.805ProTrp: 0.805 ± 0.032
1.25ProTyr: 1.25 ± 0.038
0.0ProXaa: 0.0 ± 0.0
Gln
6.093GlnAla: 6.093 ± 0.109
0.315GlnCys: 0.315 ± 0.017
2.39GlnAsp: 2.39 ± 0.05
1.951GlnGlu: 1.951 ± 0.051
1.145GlnPhe: 1.145 ± 0.039
2.964GlnGly: 2.964 ± 0.055
0.975GlnHis: 0.975 ± 0.036
1.967GlnIle: 1.967 ± 0.052
1.374GlnLys: 1.374 ± 0.042
3.103GlnLeu: 3.103 ± 0.065
0.978GlnMet: 0.978 ± 0.03
1.125GlnAsn: 1.125 ± 0.034
2.316GlnPro: 2.316 ± 0.057
1.806GlnGln: 1.806 ± 0.057
2.547GlnArg: 2.547 ± 0.053
2.161GlnSer: 2.161 ± 0.053
2.61GlnThr: 2.61 ± 0.057
2.683GlnVal: 2.683 ± 0.056
0.497GlnTrp: 0.497 ± 0.025
0.828GlnTyr: 0.828 ± 0.034
0.0GlnXaa: 0.0 ± 0.0
Arg
7.361ArgAla: 7.361 ± 0.11
0.601ArgCys: 0.601 ± 0.025
3.732ArgAsp: 3.732 ± 0.074
3.443ArgGlu: 3.443 ± 0.068
2.595ArgPhe: 2.595 ± 0.053
4.47ArgGly: 4.47 ± 0.091
1.98ArgHis: 1.98 ± 0.051
3.605ArgIle: 3.605 ± 0.067
2.307ArgLys: 2.307 ± 0.05
8.304ArgLeu: 8.304 ± 0.132
1.792ArgMet: 1.792 ± 0.045
1.968ArgAsn: 1.968 ± 0.045
3.585ArgPro: 3.585 ± 0.064
3.348ArgGln: 3.348 ± 0.072
5.326ArgArg: 5.326 ± 0.111
3.556ArgSer: 3.556 ± 0.063
3.694ArgThr: 3.694 ± 0.072
4.823ArgVal: 4.823 ± 0.073
1.049ArgTrp: 1.049 ± 0.039
1.816ArgTyr: 1.816 ± 0.05
0.0ArgXaa: 0.0 ± 0.0
Ser
6.357SerAla: 6.357 ± 0.095
0.617SerCys: 0.617 ± 0.028
2.778SerAsp: 2.778 ± 0.06
2.329SerGlu: 2.329 ± 0.049
2.306SerPhe: 2.306 ± 0.051
5.587SerGly: 5.587 ± 0.106
1.292SerHis: 1.292 ± 0.041
2.853SerIle: 2.853 ± 0.059
1.34SerLys: 1.34 ± 0.042
6.377SerLeu: 6.377 ± 0.076
1.443SerMet: 1.443 ± 0.041
1.425SerAsn: 1.425 ± 0.054
3.222SerPro: 3.222 ± 0.071
1.904SerGln: 1.904 ± 0.052
3.747SerArg: 3.747 ± 0.07
3.609SerSer: 3.609 ± 0.099
3.464SerThr: 3.464 ± 0.079
4.474SerVal: 4.474 ± 0.074
0.794SerTrp: 0.794 ± 0.029
1.497SerTyr: 1.497 ± 0.051
0.0SerXaa: 0.0 ± 0.0
Thr
6.83ThrAla: 6.83 ± 0.099
0.575ThrCys: 0.575 ± 0.021
2.988ThrAsp: 2.988 ± 0.064
2.556ThrGlu: 2.556 ± 0.053
1.913ThrPhe: 1.913 ± 0.049
5.386ThrGly: 5.386 ± 0.086
1.508ThrHis: 1.508 ± 0.044
2.729ThrIle: 2.729 ± 0.068
1.177ThrLys: 1.177 ± 0.044
7.518ThrLeu: 7.518 ± 0.115
1.195ThrMet: 1.195 ± 0.035
1.42ThrAsn: 1.42 ± 0.05
4.385ThrPro: 4.385 ± 0.084
2.391ThrGln: 2.391 ± 0.058
3.738ThrArg: 3.738 ± 0.074
3.317ThrSer: 3.317 ± 0.077
3.651ThrThr: 3.651 ± 0.089
4.548ThrVal: 4.548 ± 0.071
0.771ThrTrp: 0.771 ± 0.034
1.247ThrTyr: 1.247 ± 0.045
0.0ThrXaa: 0.0 ± 0.0
Val
8.858ValAla: 8.858 ± 0.124
0.914ValCys: 0.914 ± 0.038
3.712ValAsp: 3.712 ± 0.06
3.92ValGlu: 3.92 ± 0.08
2.75ValPhe: 2.75 ± 0.057
5.462ValGly: 5.462 ± 0.081
1.511ValHis: 1.511 ± 0.045
3.395ValIle: 3.395 ± 0.067
1.702ValLys: 1.702 ± 0.049
8.246ValLeu: 8.246 ± 0.111
1.949ValMet: 1.949 ± 0.051
1.79ValAsn: 1.79 ± 0.053
4.121ValPro: 4.121 ± 0.079
2.741ValGln: 2.741 ± 0.068
5.082ValArg: 5.082 ± 0.073
4.858ValSer: 4.858 ± 0.076
4.439ValThr: 4.439 ± 0.071
6.033ValVal: 6.033 ± 0.103
1.056ValTrp: 1.056 ± 0.038
1.442ValTyr: 1.442 ± 0.045
0.0ValXaa: 0.0 ± 0.0
Trp
1.196TrpAla: 1.196 ± 0.038
0.213TrpCys: 0.213 ± 0.017
0.658TrpAsp: 0.658 ± 0.029
0.517TrpGlu: 0.517 ± 0.026
0.512TrpPhe: 0.512 ± 0.027
0.989TrpGly: 0.989 ± 0.036
0.427TrpHis: 0.427 ± 0.023
0.526TrpIle: 0.526 ± 0.023
0.5TrpLys: 0.5 ± 0.023
1.73TrpLeu: 1.73 ± 0.047
0.338TrpMet: 0.338 ± 0.022
0.464TrpAsn: 0.464 ± 0.028
0.751TrpPro: 0.751 ± 0.034
0.814TrpGln: 0.814 ± 0.03
1.272TrpArg: 1.272 ± 0.038
0.832TrpSer: 0.832 ± 0.032
0.727TrpThr: 0.727 ± 0.028
0.916TrpVal: 0.916 ± 0.036
0.215TrpTrp: 0.215 ± 0.017
0.342TrpTyr: 0.342 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.559TyrAla: 2.559 ± 0.06
0.268TyrCys: 0.268 ± 0.018
1.514TyrAsp: 1.514 ± 0.044
1.127TyrGlu: 1.127 ± 0.034
0.793TyrPhe: 0.793 ± 0.03
2.183TyrGly: 2.183 ± 0.06
0.542TyrHis: 0.542 ± 0.029
0.886TyrIle: 0.886 ± 0.034
0.618TyrLys: 0.618 ± 0.029
2.103TyrLeu: 2.103 ± 0.053
0.471TyrMet: 0.471 ± 0.025
0.697TyrAsn: 0.697 ± 0.036
1.062TyrPro: 1.062 ± 0.038
0.844TyrGln: 0.844 ± 0.031
1.652TyrArg: 1.652 ± 0.046
1.219TyrSer: 1.219 ± 0.045
1.299TyrThr: 1.299 ± 0.043
1.595TyrVal: 1.595 ± 0.044
0.29TyrTrp: 0.29 ± 0.017
0.666TyrTyr: 0.666 ± 0.031
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2638 proteins (885515 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski