Amino acid dipepetide frequency for Mycobacterium virus PMC

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
15.192AlaAla: 15.192 ± 2.25
0.957AlaCys: 0.957 ± 0.241
6.865AlaAsp: 6.865 ± 0.71
7.652AlaGlu: 7.652 ± 0.749
2.701AlaPhe: 2.701 ± 0.516
9.847AlaGly: 9.847 ± 1.4
2.194AlaHis: 2.194 ± 0.378
3.826AlaIle: 3.826 ± 0.585
4.22AlaLys: 4.22 ± 0.45
7.878AlaLeu: 7.878 ± 0.696
2.87AlaMet: 2.87 ± 0.404
2.757AlaAsn: 2.757 ± 0.442
4.895AlaPro: 4.895 ± 0.516
3.376AlaGln: 3.376 ± 0.429
8.046AlaArg: 8.046 ± 0.933
5.233AlaSer: 5.233 ± 0.645
6.358AlaThr: 6.358 ± 0.602
7.259AlaVal: 7.259 ± 0.635
2.813AlaTrp: 2.813 ± 0.404
2.194AlaTyr: 2.194 ± 0.333
0.0AlaXaa: 0.0 ± 0.0
Cys
1.069CysAla: 1.069 ± 0.271
0.113CysCys: 0.113 ± 0.082
1.069CysAsp: 1.069 ± 0.306
0.9CysGlu: 0.9 ± 0.247
0.169CysPhe: 0.169 ± 0.097
1.576CysGly: 1.576 ± 0.357
0.281CysHis: 0.281 ± 0.13
0.056CysIle: 0.056 ± 0.06
0.506CysLys: 0.506 ± 0.193
0.675CysLeu: 0.675 ± 0.203
0.225CysMet: 0.225 ± 0.117
0.506CysAsn: 0.506 ± 0.185
1.35CysPro: 1.35 ± 0.37
0.394CysGln: 0.394 ± 0.152
0.731CysArg: 0.731 ± 0.222
0.9CysSer: 0.9 ± 0.281
0.844CysThr: 0.844 ± 0.23
0.731CysVal: 0.731 ± 0.182
0.338CysTrp: 0.338 ± 0.144
0.225CysTyr: 0.225 ± 0.118
0.0CysXaa: 0.0 ± 0.0
Asp
6.246AspAla: 6.246 ± 0.581
0.844AspCys: 0.844 ± 0.201
4.108AspAsp: 4.108 ± 0.473
3.432AspGlu: 3.432 ± 0.421
1.576AspPhe: 1.576 ± 0.251
6.021AspGly: 6.021 ± 0.608
1.463AspHis: 1.463 ± 0.266
2.42AspIle: 2.42 ± 0.379
1.632AspLys: 1.632 ± 0.282
5.852AspLeu: 5.852 ± 0.527
1.125AspMet: 1.125 ± 0.252
1.801AspAsn: 1.801 ± 0.398
5.12AspPro: 5.12 ± 0.55
2.363AspGln: 2.363 ± 0.339
5.008AspArg: 5.008 ± 0.663
3.264AspSer: 3.264 ± 0.546
4.614AspThr: 4.614 ± 0.518
4.558AspVal: 4.558 ± 0.612
1.576AspTrp: 1.576 ± 0.292
1.969AspTyr: 1.969 ± 0.333
0.0AspXaa: 0.0 ± 0.0
Glu
6.358GluAla: 6.358 ± 0.767
0.957GluCys: 0.957 ± 0.228
2.982GluAsp: 2.982 ± 0.402
2.757GluGlu: 2.757 ± 0.505
2.194GluPhe: 2.194 ± 0.341
3.32GluGly: 3.32 ± 0.395
1.519GluHis: 1.519 ± 0.363
2.532GluIle: 2.532 ± 0.439
2.026GluLys: 2.026 ± 0.335
5.852GluLeu: 5.852 ± 0.641
1.294GluMet: 1.294 ± 0.244
2.026GluAsn: 2.026 ± 0.299
3.207GluPro: 3.207 ± 0.454
2.588GluGln: 2.588 ± 0.372
5.345GluArg: 5.345 ± 0.698
3.207GluSer: 3.207 ± 0.527
4.614GluThr: 4.614 ± 0.601
3.826GluVal: 3.826 ± 0.565
1.407GluTrp: 1.407 ± 0.286
1.857GluTyr: 1.857 ± 0.377
0.0GluXaa: 0.0 ± 0.0
Phe
3.038PheAla: 3.038 ± 0.446
0.338PheCys: 0.338 ± 0.155
2.082PheAsp: 2.082 ± 0.458
2.026PheGlu: 2.026 ± 0.358
0.9PhePhe: 0.9 ± 0.279
2.701PheGly: 2.701 ± 0.636
0.394PheHis: 0.394 ± 0.136
1.407PheIle: 1.407 ± 0.338
1.013PheLys: 1.013 ± 0.253
1.576PheLeu: 1.576 ± 0.264
0.563PheMet: 0.563 ± 0.202
1.238PheAsn: 1.238 ± 0.332
1.632PhePro: 1.632 ± 0.317
1.069PheGln: 1.069 ± 0.357
1.632PheArg: 1.632 ± 0.249
1.688PheSer: 1.688 ± 0.289
2.251PheThr: 2.251 ± 0.343
2.082PheVal: 2.082 ± 0.331
0.788PheTrp: 0.788 ± 0.171
0.844PheTyr: 0.844 ± 0.256
0.0PheXaa: 0.0 ± 0.0
Gly
8.947GlyAla: 8.947 ± 1.256
1.125GlyCys: 1.125 ± 0.261
5.739GlyAsp: 5.739 ± 0.593
3.883GlyGlu: 3.883 ± 0.494
2.701GlyPhe: 2.701 ± 0.505
10.41GlyGly: 10.41 ± 2.131
1.969GlyHis: 1.969 ± 0.314
3.826GlyIle: 3.826 ± 0.55
2.476GlyLys: 2.476 ± 0.372
5.852GlyLeu: 5.852 ± 0.529
2.363GlyMet: 2.363 ± 0.445
3.545GlyAsn: 3.545 ± 0.44
4.164GlyPro: 4.164 ± 0.46
2.138GlyGln: 2.138 ± 0.594
4.558GlyArg: 4.558 ± 0.607
5.908GlySer: 5.908 ± 0.893
6.246GlyThr: 6.246 ± 0.794
6.527GlyVal: 6.527 ± 0.487
2.532GlyTrp: 2.532 ± 0.39
2.138GlyTyr: 2.138 ± 0.439
0.0GlyXaa: 0.0 ± 0.0
His
2.082HisAla: 2.082 ± 0.402
0.45HisCys: 0.45 ± 0.158
0.957HisAsp: 0.957 ± 0.23
1.294HisGlu: 1.294 ± 0.308
0.338HisPhe: 0.338 ± 0.148
2.026HisGly: 2.026 ± 0.339
1.125HisHis: 1.125 ± 0.281
1.463HisIle: 1.463 ± 0.304
0.9HisLys: 0.9 ± 0.219
1.744HisLeu: 1.744 ± 0.292
0.619HisMet: 0.619 ± 0.138
0.9HisAsn: 0.9 ± 0.205
1.463HisPro: 1.463 ± 0.217
0.844HisGln: 0.844 ± 0.293
2.026HisArg: 2.026 ± 0.356
0.788HisSer: 0.788 ± 0.209
1.463HisThr: 1.463 ± 0.397
1.294HisVal: 1.294 ± 0.307
0.619HisTrp: 0.619 ± 0.207
0.844HisTyr: 0.844 ± 0.219
0.0HisXaa: 0.0 ± 0.0
Ile
5.233IleAla: 5.233 ± 0.614
0.563IleCys: 0.563 ± 0.169
3.714IleAsp: 3.714 ± 0.468
3.601IleGlu: 3.601 ± 0.397
0.788IlePhe: 0.788 ± 0.232
3.714IleGly: 3.714 ± 0.404
1.632IleHis: 1.632 ± 0.366
1.294IleIle: 1.294 ± 0.256
1.182IleLys: 1.182 ± 0.256
2.251IleLeu: 2.251 ± 0.363
0.394IleMet: 0.394 ± 0.16
1.969IleAsn: 1.969 ± 0.327
2.307IlePro: 2.307 ± 0.301
1.294IleGln: 1.294 ± 0.225
2.532IleArg: 2.532 ± 0.323
2.138IleSer: 2.138 ± 0.39
3.489IleThr: 3.489 ± 0.392
2.813IleVal: 2.813 ± 0.377
0.957IleTrp: 0.957 ± 0.233
1.069IleTyr: 1.069 ± 0.247
0.0IleXaa: 0.0 ± 0.0
Lys
3.545LysAla: 3.545 ± 0.52
0.394LysCys: 0.394 ± 0.141
1.463LysAsp: 1.463 ± 0.285
1.407LysGlu: 1.407 ± 0.294
1.238LysPhe: 1.238 ± 0.197
2.476LysGly: 2.476 ± 0.349
1.125LysHis: 1.125 ± 0.247
0.788LysIle: 0.788 ± 0.255
1.238LysLys: 1.238 ± 0.38
2.87LysLeu: 2.87 ± 0.541
0.675LysMet: 0.675 ± 0.208
0.844LysAsn: 0.844 ± 0.233
2.532LysPro: 2.532 ± 0.39
1.801LysGln: 1.801 ± 0.275
2.363LysArg: 2.363 ± 0.371
1.801LysSer: 1.801 ± 0.292
1.913LysThr: 1.913 ± 0.333
2.251LysVal: 2.251 ± 0.379
0.844LysTrp: 0.844 ± 0.248
0.957LysTyr: 0.957 ± 0.246
0.0LysXaa: 0.0 ± 0.0
Leu
8.046LeuAla: 8.046 ± 0.875
0.9LeuCys: 0.9 ± 0.227
5.345LeuAsp: 5.345 ± 0.663
3.826LeuGlu: 3.826 ± 0.433
2.476LeuPhe: 2.476 ± 0.33
5.008LeuGly: 5.008 ± 0.571
1.463LeuHis: 1.463 ± 0.348
2.87LeuIle: 2.87 ± 0.429
2.138LeuLys: 2.138 ± 0.347
4.783LeuLeu: 4.783 ± 0.482
1.463LeuMet: 1.463 ± 0.324
2.532LeuAsn: 2.532 ± 0.371
5.571LeuPro: 5.571 ± 0.689
2.87LeuGln: 2.87 ± 0.442
4.952LeuArg: 4.952 ± 0.625
4.783LeuSer: 4.783 ± 0.543
5.852LeuThr: 5.852 ± 0.537
5.289LeuVal: 5.289 ± 0.588
1.407LeuTrp: 1.407 ± 0.264
2.138LeuTyr: 2.138 ± 0.348
0.0LeuXaa: 0.0 ± 0.0
Met
1.857MetAla: 1.857 ± 0.29
0.169MetCys: 0.169 ± 0.094
1.182MetAsp: 1.182 ± 0.244
1.013MetGlu: 1.013 ± 0.168
0.506MetPhe: 0.506 ± 0.144
1.969MetGly: 1.969 ± 0.319
0.225MetHis: 0.225 ± 0.112
0.844MetIle: 0.844 ± 0.234
0.619MetLys: 0.619 ± 0.207
1.913MetLeu: 1.913 ± 0.284
0.394MetMet: 0.394 ± 0.181
0.9MetAsn: 0.9 ± 0.203
1.182MetPro: 1.182 ± 0.289
0.45MetGln: 0.45 ± 0.17
1.519MetArg: 1.519 ± 0.317
2.926MetSer: 2.926 ± 0.522
1.744MetThr: 1.744 ± 0.269
1.35MetVal: 1.35 ± 0.319
0.394MetTrp: 0.394 ± 0.139
0.281MetTyr: 0.281 ± 0.121
0.0MetXaa: 0.0 ± 0.0
Asn
3.601AsnAla: 3.601 ± 0.395
0.338AsnCys: 0.338 ± 0.125
1.969AsnAsp: 1.969 ± 0.317
1.969AsnGlu: 1.969 ± 0.381
0.844AsnPhe: 0.844 ± 0.31
4.22AsnGly: 4.22 ± 0.639
1.013AsnHis: 1.013 ± 0.23
1.576AsnIle: 1.576 ± 0.422
1.013AsnLys: 1.013 ± 0.249
2.588AsnLeu: 2.588 ± 0.47
0.506AsnMet: 0.506 ± 0.144
1.576AsnAsn: 1.576 ± 0.407
2.588AsnPro: 2.588 ± 0.387
1.35AsnGln: 1.35 ± 0.356
2.194AsnArg: 2.194 ± 0.403
1.407AsnSer: 1.407 ± 0.299
2.251AsnThr: 2.251 ± 0.335
1.744AsnVal: 1.744 ± 0.281
0.788AsnTrp: 0.788 ± 0.173
0.619AsnTyr: 0.619 ± 0.173
0.0AsnXaa: 0.0 ± 0.0
Pro
5.627ProAla: 5.627 ± 0.663
0.731ProCys: 0.731 ± 0.225
4.839ProAsp: 4.839 ± 0.521
4.783ProGlu: 4.783 ± 0.524
1.857ProPhe: 1.857 ± 0.361
6.19ProGly: 6.19 ± 0.756
1.294ProHis: 1.294 ± 0.273
2.082ProIle: 2.082 ± 0.308
2.251ProLys: 2.251 ± 0.349
4.558ProLeu: 4.558 ± 0.591
1.35ProMet: 1.35 ± 0.383
2.194ProAsn: 2.194 ± 0.385
4.389ProPro: 4.389 ± 0.532
2.082ProGln: 2.082 ± 0.311
3.038ProArg: 3.038 ± 0.452
3.151ProSer: 3.151 ± 0.473
3.207ProThr: 3.207 ± 0.506
4.614ProVal: 4.614 ± 0.508
1.407ProTrp: 1.407 ± 0.275
1.407ProTyr: 1.407 ± 0.275
0.0ProXaa: 0.0 ± 0.0
Gln
4.276GlnAla: 4.276 ± 0.578
0.225GlnCys: 0.225 ± 0.113
1.407GlnAsp: 1.407 ± 0.242
1.913GlnGlu: 1.913 ± 0.328
1.182GlnPhe: 1.182 ± 0.249
2.307GlnGly: 2.307 ± 0.407
0.9GlnHis: 0.9 ± 0.229
1.913GlnIle: 1.913 ± 0.377
1.35GlnLys: 1.35 ± 0.237
2.757GlnLeu: 2.757 ± 0.399
0.731GlnMet: 0.731 ± 0.193
0.675GlnAsn: 0.675 ± 0.221
2.532GlnPro: 2.532 ± 0.379
1.182GlnGln: 1.182 ± 0.317
2.813GlnArg: 2.813 ± 0.369
2.701GlnSer: 2.701 ± 0.335
1.688GlnThr: 1.688 ± 0.297
2.42GlnVal: 2.42 ± 0.396
0.788GlnTrp: 0.788 ± 0.206
0.957GlnTyr: 0.957 ± 0.255
0.0GlnXaa: 0.0 ± 0.0
Arg
7.427ArgAla: 7.427 ± 0.808
1.294ArgCys: 1.294 ± 0.366
4.445ArgAsp: 4.445 ± 0.601
5.064ArgGlu: 5.064 ± 0.708
1.857ArgPhe: 1.857 ± 0.349
3.714ArgGly: 3.714 ± 0.473
1.407ArgHis: 1.407 ± 0.292
4.333ArgIle: 4.333 ± 0.508
2.082ArgLys: 2.082 ± 0.354
5.12ArgLeu: 5.12 ± 0.709
2.194ArgMet: 2.194 ± 0.331
2.476ArgAsn: 2.476 ± 0.437
3.376ArgPro: 3.376 ± 0.459
2.363ArgGln: 2.363 ± 0.348
5.345ArgArg: 5.345 ± 0.833
4.051ArgSer: 4.051 ± 0.495
3.489ArgThr: 3.489 ± 0.489
5.008ArgVal: 5.008 ± 0.617
2.251ArgTrp: 2.251 ± 0.37
1.857ArgTyr: 1.857 ± 0.315
0.0ArgXaa: 0.0 ± 0.0
Ser
6.077SerAla: 6.077 ± 1.045
0.45SerCys: 0.45 ± 0.163
3.883SerAsp: 3.883 ± 0.49
3.264SerGlu: 3.264 ± 0.393
2.138SerPhe: 2.138 ± 0.53
6.021SerGly: 6.021 ± 0.939
1.069SerHis: 1.069 ± 0.225
3.038SerIle: 3.038 ± 0.454
2.194SerLys: 2.194 ± 0.36
3.714SerLeu: 3.714 ± 0.475
1.238SerMet: 1.238 ± 0.228
2.307SerAsn: 2.307 ± 0.539
3.264SerPro: 3.264 ± 0.383
1.519SerGln: 1.519 ± 0.236
4.164SerArg: 4.164 ± 0.461
3.826SerSer: 3.826 ± 0.786
3.095SerThr: 3.095 ± 0.407
4.501SerVal: 4.501 ± 0.492
1.182SerTrp: 1.182 ± 0.288
1.35SerTyr: 1.35 ± 0.266
0.0SerXaa: 0.0 ± 0.0
Thr
6.415ThrAla: 6.415 ± 0.645
1.069ThrCys: 1.069 ± 0.31
4.108ThrAsp: 4.108 ± 0.546
3.264ThrGlu: 3.264 ± 0.385
1.857ThrPhe: 1.857 ± 0.392
6.583ThrGly: 6.583 ± 0.606
1.913ThrHis: 1.913 ± 0.345
3.489ThrIle: 3.489 ± 0.486
2.251ThrLys: 2.251 ± 0.358
4.389ThrLeu: 4.389 ± 0.565
1.182ThrMet: 1.182 ± 0.288
2.082ThrAsn: 2.082 ± 0.375
4.614ThrPro: 4.614 ± 0.587
1.801ThrGln: 1.801 ± 0.344
4.108ThrArg: 4.108 ± 0.52
3.77ThrSer: 3.77 ± 0.4
4.783ThrThr: 4.783 ± 0.598
5.739ThrVal: 5.739 ± 0.597
1.125ThrTrp: 1.125 ± 0.311
1.744ThrTyr: 1.744 ± 0.266
0.0ThrXaa: 0.0 ± 0.0
Val
7.315ValAla: 7.315 ± 0.595
1.182ValCys: 1.182 ± 0.26
5.345ValAsp: 5.345 ± 0.647
4.839ValGlu: 4.839 ± 0.749
2.588ValPhe: 2.588 ± 0.418
5.852ValGly: 5.852 ± 0.747
1.069ValHis: 1.069 ± 0.243
2.645ValIle: 2.645 ± 0.376
1.913ValLys: 1.913 ± 0.363
5.345ValLeu: 5.345 ± 0.586
1.013ValMet: 1.013 ± 0.23
2.645ValAsn: 2.645 ± 0.398
4.276ValPro: 4.276 ± 0.439
3.207ValGln: 3.207 ± 0.353
4.558ValArg: 4.558 ± 0.662
4.22ValSer: 4.22 ± 0.567
5.12ValThr: 5.12 ± 0.534
6.021ValVal: 6.021 ± 0.708
1.576ValTrp: 1.576 ± 0.341
1.407ValTyr: 1.407 ± 0.298
0.0ValXaa: 0.0 ± 0.0
Trp
2.251TrpAla: 2.251 ± 0.326
0.281TrpCys: 0.281 ± 0.133
1.688TrpAsp: 1.688 ± 0.341
1.407TrpGlu: 1.407 ± 0.333
0.619TrpPhe: 0.619 ± 0.179
0.957TrpGly: 0.957 ± 0.245
0.788TrpHis: 0.788 ± 0.241
1.35TrpIle: 1.35 ± 0.249
0.9TrpLys: 0.9 ± 0.204
1.969TrpLeu: 1.969 ± 0.367
1.013TrpMet: 1.013 ± 0.247
0.563TrpAsn: 0.563 ± 0.224
1.238TrpPro: 1.238 ± 0.271
1.013TrpGln: 1.013 ± 0.247
2.194TrpArg: 2.194 ± 0.41
1.576TrpSer: 1.576 ± 0.309
1.407TrpThr: 1.407 ± 0.246
1.744TrpVal: 1.744 ± 0.439
0.844TrpTrp: 0.844 ± 0.217
0.563TrpTyr: 0.563 ± 0.198
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.532TyrAla: 2.532 ± 0.352
0.281TyrCys: 0.281 ± 0.122
1.801TyrAsp: 1.801 ± 0.398
1.576TyrGlu: 1.576 ± 0.285
0.731TyrPhe: 0.731 ± 0.208
2.138TyrGly: 2.138 ± 0.357
0.394TyrHis: 0.394 ± 0.147
1.182TyrIle: 1.182 ± 0.247
0.619TyrLys: 0.619 ± 0.19
2.082TyrLeu: 2.082 ± 0.272
0.169TyrMet: 0.169 ± 0.099
0.619TyrAsn: 0.619 ± 0.175
1.35TyrPro: 1.35 ± 0.227
1.013TyrGln: 1.013 ± 0.23
2.026TyrArg: 2.026 ± 0.375
0.957TyrSer: 0.957 ± 0.219
1.857TyrThr: 1.857 ± 0.341
2.363TyrVal: 2.363 ± 0.315
0.731TyrTrp: 0.731 ± 0.179
0.619TyrTyr: 0.619 ± 0.185
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 104 proteins (17773 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski