Amino acid dipepetide frequency for Sewage-associated gemycircularvirus 4

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.614AlaAla: 3.614 ± 2.879
0.0AlaCys: 0.0 ± 0.0
0.0AlaAsp: 0.0 ± 0.0
3.614AlaGlu: 3.614 ± 0.48
3.614AlaPhe: 3.614 ± 0.48
0.0AlaGly: 0.0 ± 0.0
3.614AlaHis: 3.614 ± 0.48
0.0AlaIle: 0.0 ± 0.0
2.41AlaLys: 2.41 ± 1.171
1.205AlaLeu: 1.205 ± 0.96
0.0AlaMet: 0.0 ± 0.0
6.024AlaAsn: 6.024 ± 1.511
4.819AlaPro: 4.819 ± 2.342
1.205AlaGln: 1.205 ± 0.922
8.434AlaArg: 8.434 ± 0.731
8.434AlaSer: 8.434 ± 3.753
3.614AlaThr: 3.614 ± 2.879
1.205AlaVal: 1.205 ± 0.922
0.0AlaTrp: 0.0 ± 0.0
2.41AlaTyr: 2.41 ± 0.915
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
2.41CysAsp: 2.41 ± 1.171
0.0CysGlu: 0.0 ± 0.0
3.614CysPhe: 3.614 ± 0.48
3.614CysGly: 3.614 ± 0.48
1.205CysHis: 1.205 ± 0.922
0.0CysIle: 0.0 ± 0.0
0.0CysLys: 0.0 ± 0.0
1.205CysLeu: 1.205 ± 0.922
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
2.41CysArg: 2.41 ± 1.171
0.0CysSer: 0.0 ± 0.0
0.0CysThr: 0.0 ± 0.0
1.205CysVal: 1.205 ± 0.922
0.0CysTrp: 0.0 ± 0.0
1.205CysTyr: 1.205 ± 0.96
0.0CysXaa: 0.0 ± 0.0
Asp
3.614AspAla: 3.614 ± 0.48
0.0AspCys: 0.0 ± 0.0
8.434AspAsp: 8.434 ± 2.3
2.41AspGlu: 2.41 ± 1.171
2.41AspPhe: 2.41 ± 1.919
8.434AspGly: 8.434 ± 2.253
2.41AspHis: 2.41 ± 1.171
3.614AspIle: 3.614 ± 1.633
3.614AspLys: 3.614 ± 1.593
2.41AspLeu: 2.41 ± 1.171
1.205AspMet: 1.205 ± 0.96
1.205AspAsn: 1.205 ± 0.96
7.229AspPro: 7.229 ± 1.682
0.0AspGln: 0.0 ± 0.0
6.024AspArg: 6.024 ± 1.864
3.614AspSer: 3.614 ± 2.879
4.819AspThr: 4.819 ± 0.965
6.024AspVal: 6.024 ± 1.511
3.614AspTrp: 3.614 ± 0.48
6.024AspTyr: 6.024 ± 2.639
0.0AspXaa: 0.0 ± 0.0
Glu
0.0GluAla: 0.0 ± 0.0
0.0GluCys: 0.0 ± 0.0
3.614GluAsp: 3.614 ± 0.48
0.0GluGlu: 0.0 ± 0.0
2.41GluPhe: 2.41 ± 1.844
6.024GluGly: 6.024 ± 1.511
1.205GluHis: 1.205 ± 0.922
3.614GluIle: 3.614 ± 0.48
2.41GluLys: 2.41 ± 1.171
2.41GluLeu: 2.41 ± 1.171
2.41GluMet: 2.41 ± 1.171
3.614GluAsn: 3.614 ± 1.593
0.0GluPro: 0.0 ± 0.0
3.614GluGln: 3.614 ± 0.48
12.048GluArg: 12.048 ± 5.855
6.024GluSer: 6.024 ± 1.864
0.0GluThr: 0.0 ± 0.0
3.614GluVal: 3.614 ± 1.593
1.205GluTrp: 1.205 ± 0.922
2.41GluTyr: 2.41 ± 1.171
0.0GluXaa: 0.0 ± 0.0
Phe
1.205PheAla: 1.205 ± 0.922
0.0PheCys: 0.0 ± 0.0
8.434PheAsp: 8.434 ± 3.76
1.205PheGlu: 1.205 ± 0.922
0.0PhePhe: 0.0 ± 0.0
3.614PheGly: 3.614 ± 0.48
0.0PheHis: 0.0 ± 0.0
2.41PheIle: 2.41 ± 1.171
2.41PheLys: 2.41 ± 1.919
4.819PheLeu: 4.819 ± 0.679
0.0PheMet: 0.0 ± 0.0
2.41PheAsn: 2.41 ± 1.844
2.41PhePro: 2.41 ± 1.171
3.614PheGln: 3.614 ± 0.48
6.024PheArg: 6.024 ± 1.864
4.819PheSer: 4.819 ± 2.518
1.205PheThr: 1.205 ± 0.96
1.205PheVal: 1.205 ± 0.922
2.41PheTrp: 2.41 ± 0.915
1.205PheTyr: 1.205 ± 0.96
0.0PheXaa: 0.0 ± 0.0
Gly
7.229GlyAla: 7.229 ± 1.682
0.0GlyCys: 0.0 ± 0.0
9.639GlyAsp: 9.639 ± 1.912
6.024GlyGlu: 6.024 ± 2.639
4.819GlyPhe: 4.819 ± 2.324
3.614GlyGly: 3.614 ± 1.593
0.0GlyHis: 0.0 ± 0.0
0.0GlyIle: 0.0 ± 0.0
6.024GlyLys: 6.024 ± 1.547
0.0GlyLeu: 0.0 ± 0.0
0.0GlyMet: 0.0 ± 0.0
7.229GlyAsn: 7.229 ± 2.804
3.614GlyPro: 3.614 ± 1.593
1.205GlyGln: 1.205 ± 0.96
4.819GlyArg: 4.819 ± 0.965
2.41GlySer: 2.41 ± 1.919
1.205GlyThr: 1.205 ± 0.96
7.229GlyVal: 7.229 ± 1.108
1.205GlyTrp: 1.205 ± 0.922
0.0GlyTyr: 0.0 ± 0.0
0.0GlyXaa: 0.0 ± 0.0
His
1.205HisAla: 1.205 ± 0.922
0.0HisCys: 0.0 ± 0.0
0.0HisAsp: 0.0 ± 0.0
3.614HisGlu: 3.614 ± 0.48
0.0HisPhe: 0.0 ± 0.0
2.41HisGly: 2.41 ± 1.171
0.0HisHis: 0.0 ± 0.0
2.41HisIle: 2.41 ± 1.171
0.0HisLys: 0.0 ± 0.0
1.205HisLeu: 1.205 ± 0.922
2.41HisMet: 2.41 ± 1.171
0.0HisAsn: 0.0 ± 0.0
2.41HisPro: 2.41 ± 1.919
2.41HisGln: 2.41 ± 1.171
1.205HisArg: 1.205 ± 0.96
2.41HisSer: 2.41 ± 0.915
3.614HisThr: 3.614 ± 0.48
0.0HisVal: 0.0 ± 0.0
0.0HisTrp: 0.0 ± 0.0
2.41HisTyr: 2.41 ± 1.171
0.0HisXaa: 0.0 ± 0.0
Ile
4.819IleAla: 4.819 ± 0.965
3.614IleCys: 3.614 ± 1.593
1.205IleAsp: 1.205 ± 0.96
1.205IleGlu: 1.205 ± 0.922
0.0IlePhe: 0.0 ± 0.0
4.819IleGly: 4.819 ± 2.342
1.205IleHis: 1.205 ± 0.96
3.614IleIle: 3.614 ± 1.593
3.614IleLys: 3.614 ± 1.593
4.819IleLeu: 4.819 ± 0.679
2.41IleMet: 2.41 ± 0.915
3.614IleAsn: 3.614 ± 0.48
3.614IlePro: 3.614 ± 0.48
2.41IleGln: 2.41 ± 0.915
0.0IleArg: 0.0 ± 0.0
2.41IleSer: 2.41 ± 1.919
3.614IleThr: 3.614 ± 1.593
2.41IleVal: 2.41 ± 1.171
0.0IleTrp: 0.0 ± 0.0
0.0IleTyr: 0.0 ± 0.0
0.0IleXaa: 0.0 ± 0.0
Lys
2.41LysAla: 2.41 ± 1.171
0.0LysCys: 0.0 ± 0.0
9.639LysAsp: 9.639 ± 4.684
1.205LysGlu: 1.205 ± 0.922
0.0LysPhe: 0.0 ± 0.0
3.614LysGly: 3.614 ± 1.567
0.0LysHis: 0.0 ± 0.0
2.41LysIle: 2.41 ± 1.919
4.819LysLys: 4.819 ± 2.518
1.205LysLeu: 1.205 ± 0.96
0.0LysMet: 0.0 ± 0.0
0.0LysAsn: 0.0 ± 0.0
2.41LysPro: 2.41 ± 0.915
1.205LysGln: 1.205 ± 0.96
2.41LysArg: 2.41 ± 0.915
3.614LysSer: 3.614 ± 1.593
2.41LysThr: 2.41 ± 0.915
1.205LysVal: 1.205 ± 0.96
3.614LysTrp: 3.614 ± 1.593
3.614LysTyr: 3.614 ± 1.567
0.0LysXaa: 0.0 ± 0.0
Leu
2.41LeuAla: 2.41 ± 1.171
2.41LeuCys: 2.41 ± 1.171
2.41LeuAsp: 2.41 ± 0.915
7.229LeuGlu: 7.229 ± 3.513
4.819LeuPhe: 4.819 ± 0.679
6.024LeuGly: 6.024 ± 1.547
0.0LeuHis: 0.0 ± 0.0
2.41LeuIle: 2.41 ± 0.915
3.614LeuLys: 3.614 ± 1.593
8.434LeuLeu: 8.434 ± 2.66
0.0LeuMet: 0.0 ± 0.0
4.819LeuAsn: 4.819 ± 2.324
0.0LeuPro: 0.0 ± 0.0
3.614LeuGln: 3.614 ± 1.567
0.0LeuArg: 0.0 ± 0.0
6.024LeuSer: 6.024 ± 2.639
1.205LeuThr: 1.205 ± 0.96
0.0LeuVal: 0.0 ± 0.0
2.41LeuTrp: 2.41 ± 1.919
1.205LeuTyr: 1.205 ± 0.922
0.0LeuXaa: 0.0 ± 0.0
Met
2.41MetAla: 2.41 ± 1.919
1.205MetCys: 1.205 ± 0.922
1.205MetAsp: 1.205 ± 0.922
2.41MetGlu: 2.41 ± 1.171
1.205MetPhe: 1.205 ± 0.96
0.0MetGly: 0.0 ± 0.0
0.0MetHis: 0.0 ± 0.0
0.0MetIle: 0.0 ± 0.0
0.0MetLys: 0.0 ± 0.0
0.0MetLeu: 0.0 ± 0.0
0.0MetMet: 0.0 ± 0.0
1.205MetAsn: 1.205 ± 0.96
2.41MetPro: 2.41 ± 1.171
0.0MetGln: 0.0 ± 0.0
0.0MetArg: 0.0 ± 0.0
0.0MetSer: 0.0 ± 0.0
0.0MetThr: 0.0 ± 0.0
1.205MetVal: 1.205 ± 0.96
0.0MetTrp: 0.0 ± 0.0
2.41MetTyr: 2.41 ± 1.171
0.0MetXaa: 0.0 ± 0.0
Asn
2.41AsnAla: 2.41 ± 1.919
1.205AsnCys: 1.205 ± 0.922
0.0AsnAsp: 0.0 ± 0.0
1.205AsnGlu: 1.205 ± 0.922
2.41AsnPhe: 2.41 ± 0.915
2.41AsnGly: 2.41 ± 1.171
1.205AsnHis: 1.205 ± 0.96
6.024AsnIle: 6.024 ± 1.511
0.0AsnLys: 0.0 ± 0.0
3.614AsnLeu: 3.614 ± 1.593
1.205AsnMet: 1.205 ± 0.922
3.614AsnAsn: 3.614 ± 2.879
3.614AsnPro: 3.614 ± 1.633
0.0AsnGln: 0.0 ± 0.0
3.614AsnArg: 3.614 ± 0.48
3.614AsnSer: 3.614 ± 0.48
2.41AsnThr: 2.41 ± 1.171
3.614AsnVal: 3.614 ± 2.879
0.0AsnTrp: 0.0 ± 0.0
2.41AsnTyr: 2.41 ± 1.919
0.0AsnXaa: 0.0 ± 0.0
Pro
1.205ProAla: 1.205 ± 0.96
0.0ProCys: 0.0 ± 0.0
3.614ProAsp: 3.614 ± 0.48
9.639ProGlu: 9.639 ± 4.684
0.0ProPhe: 0.0 ± 0.0
1.205ProGly: 1.205 ± 0.96
0.0ProHis: 0.0 ± 0.0
3.614ProIle: 3.614 ± 1.593
3.614ProLys: 3.614 ± 0.48
1.205ProLeu: 1.205 ± 0.96
2.41ProMet: 2.41 ± 1.919
2.41ProAsn: 2.41 ± 0.915
4.819ProPro: 4.819 ± 2.342
2.41ProGln: 2.41 ± 1.171
7.229ProArg: 7.229 ± 0.96
9.639ProSer: 9.639 ± 0.286
2.41ProThr: 2.41 ± 0.915
1.205ProVal: 1.205 ± 0.96
0.0ProTrp: 0.0 ± 0.0
3.614ProTyr: 3.614 ± 0.48
0.0ProXaa: 0.0 ± 0.0
Gln
4.819GlnAla: 4.819 ± 2.342
1.205GlnCys: 1.205 ± 0.96
7.229GlnAsp: 7.229 ± 0.96
0.0GlnGlu: 0.0 ± 0.0
1.205GlnPhe: 1.205 ± 0.922
2.41GlnGly: 2.41 ± 0.915
0.0GlnHis: 0.0 ± 0.0
1.205GlnIle: 1.205 ± 0.96
2.41GlnLys: 2.41 ± 0.915
4.819GlnLeu: 4.819 ± 0.679
0.0GlnMet: 0.0 ± 0.0
0.0GlnAsn: 0.0 ± 0.0
0.0GlnPro: 0.0 ± 0.0
2.41GlnGln: 2.41 ± 1.171
2.41GlnArg: 2.41 ± 1.171
0.0GlnSer: 0.0 ± 0.0
0.0GlnThr: 0.0 ± 0.0
3.614GlnVal: 3.614 ± 0.48
0.0GlnTrp: 0.0 ± 0.0
1.205GlnTyr: 1.205 ± 0.96
0.0GlnXaa: 0.0 ± 0.0
Arg
4.819ArgAla: 4.819 ± 2.342
0.0ArgCys: 0.0 ± 0.0
3.614ArgAsp: 3.614 ± 2.879
3.614ArgGlu: 3.614 ± 0.48
6.024ArgPhe: 6.024 ± 1.511
9.639ArgGly: 9.639 ± 1.931
2.41ArgHis: 2.41 ± 1.171
7.229ArgIle: 7.229 ± 0.96
3.614ArgLys: 3.614 ± 1.633
2.41ArgLeu: 2.41 ± 1.171
0.0ArgMet: 0.0 ± 1.016
1.205ArgAsn: 1.205 ± 0.96
6.024ArgPro: 6.024 ± 1.864
3.614ArgGln: 3.614 ± 0.48
12.048ArgArg: 12.048 ± 6.62
6.024ArgSer: 6.024 ± 0.479
7.229ArgThr: 7.229 ± 3.185
3.614ArgVal: 3.614 ± 1.633
3.614ArgTrp: 3.614 ± 0.48
8.434ArgTyr: 8.434 ± 1.185
0.0ArgXaa: 0.0 ± 0.0
Ser
2.41SerAla: 2.41 ± 1.919
3.614SerCys: 3.614 ± 0.48
3.614SerAsp: 3.614 ± 1.633
3.614SerGlu: 3.614 ± 0.48
3.614SerPhe: 3.614 ± 2.879
0.0SerGly: 0.0 ± 0.0
1.205SerHis: 1.205 ± 0.96
0.0SerIle: 0.0 ± 0.0
1.205SerLys: 1.205 ± 0.96
7.229SerLeu: 7.229 ± 3.185
2.41SerMet: 2.41 ± 0.754
3.614SerAsn: 3.614 ± 0.48
3.614SerPro: 3.614 ± 0.48
1.205SerGln: 1.205 ± 0.96
12.048SerArg: 12.048 ± 1.033
4.819SerSer: 4.819 ± 2.518
8.434SerThr: 8.434 ± 6.718
4.819SerVal: 4.819 ± 2.342
1.205SerTrp: 1.205 ± 0.96
2.41SerTyr: 2.41 ± 0.915
0.0SerXaa: 0.0 ± 0.0
Thr
1.205ThrAla: 1.205 ± 0.96
0.0ThrCys: 0.0 ± 0.0
2.41ThrAsp: 2.41 ± 0.915
2.41ThrGlu: 2.41 ± 1.919
7.229ThrPhe: 7.229 ± 0.96
3.614ThrGly: 3.614 ± 1.633
0.0ThrHis: 0.0 ± 0.0
4.819ThrIle: 4.819 ± 2.324
1.205ThrLys: 1.205 ± 0.96
2.41ThrLeu: 2.41 ± 0.915
0.0ThrMet: 0.0 ± 0.0
0.0ThrAsn: 0.0 ± 0.0
6.024ThrPro: 6.024 ± 1.864
3.614ThrGln: 3.614 ± 0.48
3.614ThrArg: 3.614 ± 2.879
0.0ThrSer: 0.0 ± 0.0
1.205ThrThr: 1.205 ± 0.96
6.024ThrVal: 6.024 ± 1.864
0.0ThrTrp: 0.0 ± 0.0
3.614ThrTyr: 3.614 ± 0.48
0.0ThrXaa: 0.0 ± 0.0
Val
3.614ValAla: 3.614 ± 2.879
1.205ValCys: 1.205 ± 0.96
2.41ValAsp: 2.41 ± 0.915
0.0ValGlu: 0.0 ± 0.0
1.205ValPhe: 1.205 ± 0.922
1.205ValGly: 1.205 ± 0.96
4.819ValHis: 4.819 ± 2.342
2.41ValIle: 2.41 ± 1.844
3.614ValLys: 3.614 ± 1.567
1.205ValLeu: 1.205 ± 0.922
0.0ValMet: 0.0 ± 0.0
2.41ValAsn: 2.41 ± 1.919
1.205ValPro: 1.205 ± 0.96
2.41ValGln: 2.41 ± 1.171
7.229ValArg: 7.229 ± 0.96
4.819ValSer: 4.819 ± 2.342
3.614ValThr: 3.614 ± 0.48
4.819ValVal: 4.819 ± 0.965
0.0ValTrp: 0.0 ± 0.0
4.819ValTyr: 4.819 ± 0.965
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.0TrpCys: 0.0 ± 0.0
1.205TrpAsp: 1.205 ± 0.96
1.205TrpGlu: 1.205 ± 0.96
0.0TrpPhe: 0.0 ± 0.0
2.41TrpGly: 2.41 ± 0.915
6.024TrpHis: 6.024 ± 0.479
0.0TrpIle: 0.0 ± 0.0
0.0TrpLys: 0.0 ± 0.0
7.229TrpLeu: 7.229 ± 3.185
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
0.0TrpArg: 0.0 ± 0.0
1.205TrpSer: 1.205 ± 0.96
1.205TrpThr: 1.205 ± 0.96
0.0TrpVal: 0.0 ± 0.0
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
4.819TyrAla: 4.819 ± 0.679
2.41TyrCys: 2.41 ± 1.171
6.024TyrAsp: 6.024 ± 1.864
6.024TyrGlu: 6.024 ± 2.639
4.819TyrPhe: 4.819 ± 0.679
1.205TyrGly: 1.205 ± 0.922
2.41TyrHis: 2.41 ± 1.171
3.614TyrIle: 3.614 ± 0.48
1.205TyrLys: 1.205 ± 0.922
1.205TyrLeu: 1.205 ± 0.96
0.0TyrMet: 0.0 ± 0.0
1.205TyrAsn: 1.205 ± 0.96
6.024TyrPro: 6.024 ± 1.511
0.0TyrGln: 0.0 ± 0.0
4.819TyrArg: 4.819 ± 2.518
1.205TyrSer: 1.205 ± 0.96
1.205TyrThr: 1.205 ± 0.96
0.0TyrVal: 0.0 ± 0.0
1.205TyrTrp: 1.205 ± 0.96
3.614TyrTyr: 3.614 ± 0.48
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3 proteins (831 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski