Amino acid dipepetide frequency for Dickeya phage Ninurta

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.21AlaAla: 11.21 ± 1.523
0.664AlaCys: 0.664 ± 0.21
5.979AlaAsp: 5.979 ± 1.011
5.48AlaGlu: 5.48 ± 0.718
2.74AlaPhe: 2.74 ± 0.504
6.809AlaGly: 6.809 ± 0.768
1.91AlaHis: 1.91 ± 0.404
4.816AlaIle: 4.816 ± 0.702
7.141AlaLys: 7.141 ± 0.641
6.892AlaLeu: 6.892 ± 0.797
3.072AlaMet: 3.072 ± 0.617
4.982AlaAsn: 4.982 ± 0.728
3.321AlaPro: 3.321 ± 0.421
4.069AlaGln: 4.069 ± 0.713
4.069AlaArg: 4.069 ± 0.54
4.484AlaSer: 4.484 ± 0.649
4.318AlaThr: 4.318 ± 0.683
5.729AlaVal: 5.729 ± 0.844
1.329AlaTrp: 1.329 ± 0.486
2.574AlaTyr: 2.574 ± 0.658
0.0AlaXaa: 0.0 ± 0.0
Cys
0.664CysAla: 0.664 ± 0.222
0.083CysCys: 0.083 ± 0.085
0.747CysAsp: 0.747 ± 0.364
0.415CysGlu: 0.415 ± 0.159
0.664CysPhe: 0.664 ± 0.258
0.415CysGly: 0.415 ± 0.234
0.249CysHis: 0.249 ± 0.175
0.498CysIle: 0.498 ± 0.242
0.498CysLys: 0.498 ± 0.251
0.415CysLeu: 0.415 ± 0.174
0.0CysMet: 0.0 ± 0.0
0.332CysAsn: 0.332 ± 0.225
0.249CysPro: 0.249 ± 0.142
0.415CysGln: 0.415 ± 0.219
0.332CysArg: 0.332 ± 0.212
0.415CysSer: 0.415 ± 0.22
0.332CysThr: 0.332 ± 0.176
0.747CysVal: 0.747 ± 0.288
0.249CysTrp: 0.249 ± 0.16
0.332CysTyr: 0.332 ± 0.237
0.0CysXaa: 0.0 ± 0.0
Asp
5.729AspAla: 5.729 ± 0.834
0.664AspCys: 0.664 ± 0.304
4.235AspAsp: 4.235 ± 0.974
5.397AspGlu: 5.397 ± 0.785
2.823AspPhe: 2.823 ± 0.43
6.892AspGly: 6.892 ± 0.636
0.996AspHis: 0.996 ± 0.312
2.906AspIle: 2.906 ± 0.404
3.654AspLys: 3.654 ± 0.637
4.235AspLeu: 4.235 ± 0.504
1.91AspMet: 1.91 ± 0.242
3.321AspAsn: 3.321 ± 0.448
3.238AspPro: 3.238 ± 0.642
1.993AspGln: 1.993 ± 0.436
2.906AspArg: 2.906 ± 0.495
3.404AspSer: 3.404 ± 0.475
3.571AspThr: 3.571 ± 0.458
4.152AspVal: 4.152 ± 0.508
0.913AspTrp: 0.913 ± 0.403
2.076AspTyr: 2.076 ± 0.405
0.0AspXaa: 0.0 ± 0.0
Glu
6.726GluAla: 6.726 ± 0.831
0.581GluCys: 0.581 ± 0.262
3.571GluAsp: 3.571 ± 0.611
2.574GluGlu: 2.574 ± 0.59
3.238GluPhe: 3.238 ± 0.503
4.816GluGly: 4.816 ± 0.768
1.827GluHis: 1.827 ± 0.491
2.159GluIle: 2.159 ± 0.611
2.325GluLys: 2.325 ± 0.59
6.311GluLeu: 6.311 ± 1.019
2.242GluMet: 2.242 ± 0.4
4.069GluAsn: 4.069 ± 0.701
1.495GluPro: 1.495 ± 0.341
3.404GluGln: 3.404 ± 0.439
3.488GluArg: 3.488 ± 0.519
3.82GluSer: 3.82 ± 0.813
4.318GluThr: 4.318 ± 0.535
4.401GluVal: 4.401 ± 0.655
1.079GluTrp: 1.079 ± 0.319
3.072GluTyr: 3.072 ± 0.538
0.0GluXaa: 0.0 ± 0.0
Phe
2.657PheAla: 2.657 ± 0.456
0.415PheCys: 0.415 ± 0.212
2.159PheAsp: 2.159 ± 0.49
1.744PheGlu: 1.744 ± 0.391
0.996PhePhe: 0.996 ± 0.284
3.155PheGly: 3.155 ± 0.557
0.83PheHis: 0.83 ± 0.31
1.495PheIle: 1.495 ± 0.404
2.74PheLys: 2.74 ± 0.634
3.404PheLeu: 3.404 ± 0.567
1.744PheMet: 1.744 ± 0.266
2.325PheAsn: 2.325 ± 0.507
1.163PhePro: 1.163 ± 0.321
1.329PheGln: 1.329 ± 0.346
1.827PheArg: 1.827 ± 0.343
2.823PheSer: 2.823 ± 0.53
2.823PheThr: 2.823 ± 0.434
2.491PheVal: 2.491 ± 0.501
0.415PheTrp: 0.415 ± 0.177
0.83PheTyr: 0.83 ± 0.226
0.0PheXaa: 0.0 ± 0.0
Gly
6.643GlyAla: 6.643 ± 0.667
0.747GlyCys: 0.747 ± 0.301
5.896GlyAsp: 5.896 ± 0.757
5.563GlyGlu: 5.563 ± 0.683
2.74GlyPhe: 2.74 ± 0.36
5.065GlyGly: 5.065 ± 0.542
1.246GlyHis: 1.246 ± 0.396
3.903GlyIle: 3.903 ± 0.717
5.314GlyLys: 5.314 ± 0.919
5.896GlyLeu: 5.896 ± 0.876
2.076GlyMet: 2.076 ± 0.451
3.321GlyAsn: 3.321 ± 0.467
0.996GlyPro: 0.996 ± 0.293
2.159GlyGln: 2.159 ± 0.405
4.401GlyArg: 4.401 ± 0.507
4.733GlySer: 4.733 ± 0.534
5.065GlyThr: 5.065 ± 0.727
5.397GlyVal: 5.397 ± 0.628
1.329GlyTrp: 1.329 ± 0.381
3.155GlyTyr: 3.155 ± 0.468
0.0GlyXaa: 0.0 ± 0.0
His
1.246HisAla: 1.246 ± 0.28
0.415HisCys: 0.415 ± 0.185
0.996HisAsp: 0.996 ± 0.268
1.329HisGlu: 1.329 ± 0.245
1.163HisPhe: 1.163 ± 0.299
1.495HisGly: 1.495 ± 0.333
0.249HisHis: 0.249 ± 0.13
1.246HisIle: 1.246 ± 0.354
0.913HisLys: 0.913 ± 0.289
1.329HisLeu: 1.329 ± 0.373
0.996HisMet: 0.996 ± 0.334
0.83HisAsn: 0.83 ± 0.344
0.581HisPro: 0.581 ± 0.22
0.581HisGln: 0.581 ± 0.207
0.83HisArg: 0.83 ± 0.265
1.246HisSer: 1.246 ± 0.324
1.329HisThr: 1.329 ± 0.402
0.913HisVal: 0.913 ± 0.266
0.332HisTrp: 0.332 ± 0.171
0.747HisTyr: 0.747 ± 0.309
0.0HisXaa: 0.0 ± 0.0
Ile
4.401IleAla: 4.401 ± 0.583
0.249IleCys: 0.249 ± 0.18
3.321IleAsp: 3.321 ± 0.489
3.072IleGlu: 3.072 ± 0.633
1.079IlePhe: 1.079 ± 0.306
3.82IleGly: 3.82 ± 0.42
1.495IleHis: 1.495 ± 0.42
2.989IleIle: 2.989 ± 0.58
3.238IleLys: 3.238 ± 0.596
3.571IleLeu: 3.571 ± 0.504
1.079IleMet: 1.079 ± 0.261
2.574IleAsn: 2.574 ± 0.446
1.993IlePro: 1.993 ± 0.413
2.159IleGln: 2.159 ± 0.405
3.82IleArg: 3.82 ± 0.48
2.989IleSer: 2.989 ± 0.539
3.238IleThr: 3.238 ± 0.555
3.155IleVal: 3.155 ± 0.704
0.498IleTrp: 0.498 ± 0.227
1.329IleTyr: 1.329 ± 0.384
0.0IleXaa: 0.0 ± 0.0
Lys
7.722LysAla: 7.722 ± 0.948
0.415LysCys: 0.415 ± 0.208
3.737LysAsp: 3.737 ± 0.507
5.314LysGlu: 5.314 ± 0.732
1.661LysPhe: 1.661 ± 0.368
4.401LysGly: 4.401 ± 0.644
1.578LysHis: 1.578 ± 0.541
2.242LysIle: 2.242 ± 0.454
3.82LysLys: 3.82 ± 0.798
5.397LysLeu: 5.397 ± 0.778
1.495LysMet: 1.495 ± 0.292
2.242LysAsn: 2.242 ± 0.371
2.989LysPro: 2.989 ± 0.75
2.906LysGln: 2.906 ± 0.666
3.903LysArg: 3.903 ± 0.749
3.571LysSer: 3.571 ± 0.542
4.235LysThr: 4.235 ± 0.926
5.148LysVal: 5.148 ± 0.682
0.498LysTrp: 0.498 ± 0.204
2.076LysTyr: 2.076 ± 0.367
0.0LysXaa: 0.0 ± 0.0
Leu
6.394LeuAla: 6.394 ± 0.94
0.249LeuCys: 0.249 ± 0.161
5.065LeuAsp: 5.065 ± 0.704
5.397LeuGlu: 5.397 ± 0.796
2.657LeuPhe: 2.657 ± 0.415
4.899LeuGly: 4.899 ± 0.854
1.246LeuHis: 1.246 ± 0.306
4.235LeuIle: 4.235 ± 0.596
7.722LeuLys: 7.722 ± 0.792
4.318LeuLeu: 4.318 ± 0.645
1.993LeuMet: 1.993 ± 0.429
4.152LeuAsn: 4.152 ± 0.633
2.906LeuPro: 2.906 ± 0.397
3.654LeuGln: 3.654 ± 0.533
4.65LeuArg: 4.65 ± 0.442
5.065LeuSer: 5.065 ± 0.508
4.484LeuThr: 4.484 ± 0.523
5.813LeuVal: 5.813 ± 0.608
1.495LeuTrp: 1.495 ± 0.343
2.491LeuTyr: 2.491 ± 0.49
0.0LeuXaa: 0.0 ± 0.0
Met
2.823MetAla: 2.823 ± 0.429
0.083MetCys: 0.083 ± 0.08
1.661MetAsp: 1.661 ± 0.442
1.578MetGlu: 1.578 ± 0.362
1.329MetPhe: 1.329 ± 0.409
1.661MetGly: 1.661 ± 0.339
0.166MetHis: 0.166 ± 0.112
1.079MetIle: 1.079 ± 0.27
1.329MetLys: 1.329 ± 0.347
2.989MetLeu: 2.989 ± 0.42
0.747MetMet: 0.747 ± 0.251
1.163MetAsn: 1.163 ± 0.279
1.163MetPro: 1.163 ± 0.289
2.408MetGln: 2.408 ± 0.543
2.076MetArg: 2.076 ± 0.34
1.993MetSer: 1.993 ± 0.312
1.578MetThr: 1.578 ± 0.416
1.91MetVal: 1.91 ± 0.464
0.332MetTrp: 0.332 ± 0.147
0.498MetTyr: 0.498 ± 0.208
0.0MetXaa: 0.0 ± 0.0
Asn
4.069AsnAla: 4.069 ± 0.494
0.415AsnCys: 0.415 ± 0.246
2.906AsnAsp: 2.906 ± 0.51
3.321AsnGlu: 3.321 ± 0.574
2.325AsnPhe: 2.325 ± 0.379
5.065AsnGly: 5.065 ± 0.803
0.664AsnHis: 0.664 ± 0.305
2.325AsnIle: 2.325 ± 0.344
2.076AsnLys: 2.076 ± 0.57
3.404AsnLeu: 3.404 ± 0.629
1.578AsnMet: 1.578 ± 0.508
2.076AsnAsn: 2.076 ± 0.723
2.325AsnPro: 2.325 ± 0.42
2.74AsnGln: 2.74 ± 0.517
2.076AsnArg: 2.076 ± 0.556
2.159AsnSer: 2.159 ± 0.573
2.574AsnThr: 2.574 ± 0.473
2.74AsnVal: 2.74 ± 0.573
0.83AsnTrp: 0.83 ± 0.235
1.91AsnTyr: 1.91 ± 0.418
0.0AsnXaa: 0.0 ± 0.0
Pro
3.571ProAla: 3.571 ± 0.491
0.166ProCys: 0.166 ± 0.122
2.491ProAsp: 2.491 ± 0.348
3.155ProGlu: 3.155 ± 0.577
1.827ProPhe: 1.827 ± 0.343
0.913ProGly: 0.913 ± 0.382
0.747ProHis: 0.747 ± 0.267
1.578ProIle: 1.578 ± 0.335
2.325ProLys: 2.325 ± 0.416
2.325ProLeu: 2.325 ± 0.41
1.079ProMet: 1.079 ± 0.256
2.076ProAsn: 2.076 ± 0.508
0.581ProPro: 0.581 ± 0.241
1.246ProGln: 1.246 ± 0.303
1.661ProArg: 1.661 ± 0.428
2.657ProSer: 2.657 ± 0.382
1.91ProThr: 1.91 ± 0.321
2.574ProVal: 2.574 ± 0.448
0.913ProTrp: 0.913 ± 0.286
1.163ProTyr: 1.163 ± 0.417
0.0ProXaa: 0.0 ± 0.0
Gln
4.733GlnAla: 4.733 ± 0.781
0.498GlnCys: 0.498 ± 0.213
2.906GlnAsp: 2.906 ± 0.642
2.823GlnGlu: 2.823 ± 0.468
1.91GlnPhe: 1.91 ± 0.395
2.906GlnGly: 2.906 ± 0.494
0.249GlnHis: 0.249 ± 0.135
1.91GlnIle: 1.91 ± 0.316
3.072GlnLys: 3.072 ± 0.586
3.737GlnLeu: 3.737 ± 0.684
1.495GlnMet: 1.495 ± 0.284
1.079GlnAsn: 1.079 ± 0.25
1.329GlnPro: 1.329 ± 0.319
2.989GlnGln: 2.989 ± 0.651
2.408GlnArg: 2.408 ± 0.611
2.076GlnSer: 2.076 ± 0.323
2.491GlnThr: 2.491 ± 0.575
3.072GlnVal: 3.072 ± 0.667
0.913GlnTrp: 0.913 ± 0.334
1.412GlnTyr: 1.412 ± 0.38
0.0GlnXaa: 0.0 ± 0.0
Arg
4.235ArgAla: 4.235 ± 0.666
0.581ArgCys: 0.581 ± 0.283
3.488ArgAsp: 3.488 ± 0.554
3.072ArgGlu: 3.072 ± 0.498
2.076ArgPhe: 2.076 ± 0.368
4.235ArgGly: 4.235 ± 0.597
0.83ArgHis: 0.83 ± 0.357
3.072ArgIle: 3.072 ± 0.48
3.737ArgLys: 3.737 ± 0.644
4.982ArgLeu: 4.982 ± 0.615
1.079ArgMet: 1.079 ± 0.243
2.076ArgAsn: 2.076 ± 0.499
1.329ArgPro: 1.329 ± 0.35
2.657ArgGln: 2.657 ± 0.678
2.159ArgArg: 2.159 ± 0.374
3.488ArgSer: 3.488 ± 0.557
3.404ArgThr: 3.404 ± 0.622
3.986ArgVal: 3.986 ± 0.516
0.747ArgTrp: 0.747 ± 0.261
1.661ArgTyr: 1.661 ± 0.317
0.0ArgXaa: 0.0 ± 0.0
Ser
3.986SerAla: 3.986 ± 0.71
0.498SerCys: 0.498 ± 0.228
5.314SerAsp: 5.314 ± 0.624
4.152SerGlu: 4.152 ± 0.937
2.574SerPhe: 2.574 ± 0.463
4.733SerGly: 4.733 ± 0.695
1.329SerHis: 1.329 ± 0.292
3.654SerIle: 3.654 ± 0.536
4.318SerLys: 4.318 ± 0.801
4.816SerLeu: 4.816 ± 0.729
1.163SerMet: 1.163 ± 0.314
3.155SerAsn: 3.155 ± 0.458
2.491SerPro: 2.491 ± 0.403
1.578SerGln: 1.578 ± 0.487
3.072SerArg: 3.072 ± 0.603
3.155SerSer: 3.155 ± 0.675
2.574SerThr: 2.574 ± 0.504
3.238SerVal: 3.238 ± 0.468
0.498SerTrp: 0.498 ± 0.17
3.321SerTyr: 3.321 ± 0.583
0.0SerXaa: 0.0 ± 0.0
Thr
4.401ThrAla: 4.401 ± 0.718
0.498ThrCys: 0.498 ± 0.213
3.903ThrAsp: 3.903 ± 0.572
3.571ThrGlu: 3.571 ± 0.646
1.993ThrPhe: 1.993 ± 0.413
4.899ThrGly: 4.899 ± 0.757
0.996ThrHis: 0.996 ± 0.253
3.654ThrIle: 3.654 ± 0.654
3.82ThrLys: 3.82 ± 0.472
5.148ThrLeu: 5.148 ± 0.708
1.993ThrMet: 1.993 ± 0.391
2.242ThrAsn: 2.242 ± 0.311
2.325ThrPro: 2.325 ± 0.467
2.408ThrGln: 2.408 ± 0.618
1.661ThrArg: 1.661 ± 0.329
4.733ThrSer: 4.733 ± 1.137
3.404ThrThr: 3.404 ± 0.688
4.65ThrVal: 4.65 ± 0.845
0.664ThrTrp: 0.664 ± 0.202
2.076ThrTyr: 2.076 ± 0.35
0.0ThrXaa: 0.0 ± 0.0
Val
6.809ValAla: 6.809 ± 0.72
0.332ValCys: 0.332 ± 0.153
3.488ValAsp: 3.488 ± 0.697
4.235ValGlu: 4.235 ± 0.691
2.574ValPhe: 2.574 ± 0.639
5.148ValGly: 5.148 ± 0.565
1.661ValHis: 1.661 ± 0.52
3.986ValIle: 3.986 ± 0.595
4.982ValLys: 4.982 ± 0.665
5.065ValLeu: 5.065 ± 0.577
1.744ValMet: 1.744 ± 0.358
3.155ValAsn: 3.155 ± 0.594
2.657ValPro: 2.657 ± 0.377
2.491ValGln: 2.491 ± 0.42
4.567ValArg: 4.567 ± 0.638
4.235ValSer: 4.235 ± 0.6
4.567ValThr: 4.567 ± 0.701
4.982ValVal: 4.982 ± 0.849
0.747ValTrp: 0.747 ± 0.231
1.661ValTyr: 1.661 ± 0.339
0.0ValXaa: 0.0 ± 0.0
Trp
0.913TrpAla: 0.913 ± 0.266
0.166TrpCys: 0.166 ± 0.102
0.498TrpAsp: 0.498 ± 0.207
1.079TrpGlu: 1.079 ± 0.357
0.332TrpPhe: 0.332 ± 0.194
1.412TrpGly: 1.412 ± 0.288
0.166TrpHis: 0.166 ± 0.151
0.747TrpIle: 0.747 ± 0.281
1.163TrpLys: 1.163 ± 0.368
1.412TrpLeu: 1.412 ± 0.335
0.249TrpMet: 0.249 ± 0.116
0.996TrpAsn: 0.996 ± 0.331
0.249TrpPro: 0.249 ± 0.162
0.83TrpGln: 0.83 ± 0.277
0.664TrpArg: 0.664 ± 0.263
0.913TrpSer: 0.913 ± 0.326
0.996TrpThr: 0.996 ± 0.186
1.163TrpVal: 1.163 ± 0.482
0.083TrpTrp: 0.083 ± 0.08
0.498TrpTyr: 0.498 ± 0.285
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.657TyrAla: 2.657 ± 0.404
0.332TyrCys: 0.332 ± 0.17
2.657TyrAsp: 2.657 ± 0.513
2.242TyrGlu: 2.242 ± 0.462
0.664TyrPhe: 0.664 ± 0.249
2.906TyrGly: 2.906 ± 0.425
0.332TyrHis: 0.332 ± 0.115
1.578TyrIle: 1.578 ± 0.355
1.246TyrLys: 1.246 ± 0.4
3.238TyrLeu: 3.238 ± 0.453
0.747TyrMet: 0.747 ± 0.245
1.412TyrAsn: 1.412 ± 0.364
1.578TyrPro: 1.578 ± 0.388
1.993TyrGln: 1.993 ± 0.556
2.325TyrArg: 2.325 ± 0.442
1.661TyrSer: 1.661 ± 0.332
1.827TyrThr: 1.827 ± 0.381
2.823TyrVal: 2.823 ± 0.38
0.664TyrTrp: 0.664 ± 0.232
0.581TyrTyr: 0.581 ± 0.269
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 46 proteins (12044 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski