Amino acid dipepetide frequency for Staphylococcus virus 3a

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.678AlaAla: 2.678 ± 0.692
0.362AlaCys: 0.362 ± 0.154
3.04AlaAsp: 3.04 ± 0.529
4.27AlaGlu: 4.27 ± 0.545
1.809AlaPhe: 1.809 ± 0.271
3.329AlaGly: 3.329 ± 0.688
0.941AlaHis: 0.941 ± 0.239
4.559AlaIle: 4.559 ± 0.658
6.803AlaLys: 6.803 ± 0.981
5.428AlaLeu: 5.428 ± 1.001
1.158AlaMet: 1.158 ± 0.296
4.125AlaAsn: 4.125 ± 0.724
1.375AlaPro: 1.375 ± 0.33
1.737AlaGln: 1.737 ± 0.358
2.605AlaArg: 2.605 ± 0.333
4.993AlaSer: 4.993 ± 0.866
3.836AlaThr: 3.836 ± 0.505
2.75AlaVal: 2.75 ± 0.512
1.23AlaTrp: 1.23 ± 0.347
2.605AlaTyr: 2.605 ± 0.498
0.0AlaXaa: 0.0 ± 0.0
Cys
0.217CysAla: 0.217 ± 0.119
0.145CysCys: 0.145 ± 0.138
0.145CysAsp: 0.145 ± 0.115
0.362CysGlu: 0.362 ± 0.185
0.434CysPhe: 0.434 ± 0.209
0.289CysGly: 0.289 ± 0.128
0.145CysHis: 0.145 ± 0.109
0.579CysIle: 0.579 ± 0.208
0.796CysLys: 0.796 ± 0.265
0.579CysLeu: 0.579 ± 0.216
0.145CysMet: 0.145 ± 0.105
0.145CysAsn: 0.145 ± 0.12
0.072CysPro: 0.072 ± 0.066
0.145CysGln: 0.145 ± 0.106
0.434CysArg: 0.434 ± 0.193
0.145CysSer: 0.145 ± 0.094
0.289CysThr: 0.289 ± 0.139
0.145CysVal: 0.145 ± 0.125
0.0CysTrp: 0.0 ± 0.0
0.217CysTyr: 0.217 ± 0.139
0.0CysXaa: 0.0 ± 0.0
Asp
3.112AspAla: 3.112 ± 0.572
0.289AspCys: 0.289 ± 0.166
3.908AspAsp: 3.908 ± 0.664
4.559AspGlu: 4.559 ± 0.675
3.691AspPhe: 3.691 ± 0.536
3.836AspGly: 3.836 ± 0.667
1.013AspHis: 1.013 ± 0.305
5.355AspIle: 5.355 ± 0.553
6.803AspLys: 6.803 ± 0.589
6.369AspLeu: 6.369 ± 0.652
2.099AspMet: 2.099 ± 0.43
2.822AspAsn: 2.822 ± 0.453
1.086AspPro: 1.086 ± 0.341
1.303AspGln: 1.303 ± 0.275
2.026AspArg: 2.026 ± 0.376
3.474AspSer: 3.474 ± 0.518
3.546AspThr: 3.546 ± 0.566
3.763AspVal: 3.763 ± 0.462
0.796AspTrp: 0.796 ± 0.225
3.184AspTyr: 3.184 ± 0.574
0.0AspXaa: 0.0 ± 0.0
Glu
4.632GluAla: 4.632 ± 0.53
0.579GluCys: 0.579 ± 0.18
4.776GluAsp: 4.776 ± 0.678
7.526GluGlu: 7.526 ± 0.97
2.895GluPhe: 2.895 ± 0.424
3.763GluGly: 3.763 ± 0.564
0.868GluHis: 0.868 ± 0.27
5.283GluIle: 5.283 ± 0.81
8.178GluLys: 8.178 ± 0.959
7.237GluLeu: 7.237 ± 0.873
2.171GluMet: 2.171 ± 0.438
4.632GluAsn: 4.632 ± 0.577
1.447GluPro: 1.447 ± 0.332
2.967GluGln: 2.967 ± 0.562
3.401GluArg: 3.401 ± 0.599
3.618GluSer: 3.618 ± 0.495
3.98GluThr: 3.98 ± 0.558
4.053GluVal: 4.053 ± 0.477
0.941GluTrp: 0.941 ± 0.202
2.75GluTyr: 2.75 ± 0.672
0.0GluXaa: 0.0 ± 0.0
Phe
2.099PheAla: 2.099 ± 0.411
0.579PheCys: 0.579 ± 0.199
3.546PheAsp: 3.546 ± 0.43
3.401PheGlu: 3.401 ± 0.552
1.23PhePhe: 1.23 ± 0.294
3.474PheGly: 3.474 ± 0.482
0.362PheHis: 0.362 ± 0.151
3.546PheIle: 3.546 ± 0.595
4.125PheLys: 4.125 ± 0.556
2.822PheLeu: 2.822 ± 0.454
1.23PheMet: 1.23 ± 0.214
3.691PheAsn: 3.691 ± 0.502
0.796PhePro: 0.796 ± 0.262
1.23PheGln: 1.23 ± 0.331
0.941PheArg: 0.941 ± 0.237
2.243PheSer: 2.243 ± 0.396
1.737PheThr: 1.737 ± 0.371
1.954PheVal: 1.954 ± 0.41
0.289PheTrp: 0.289 ± 0.12
1.809PheTyr: 1.809 ± 0.355
0.0PheXaa: 0.0 ± 0.0
Gly
3.98GlyAla: 3.98 ± 0.822
0.145GlyCys: 0.145 ± 0.09
3.908GlyAsp: 3.908 ± 0.47
3.618GlyGlu: 3.618 ± 0.428
2.243GlyPhe: 2.243 ± 0.391
4.993GlyGly: 4.993 ± 0.877
1.303GlyHis: 1.303 ± 0.38
3.691GlyIle: 3.691 ± 0.538
6.151GlyLys: 6.151 ± 0.728
5.79GlyLeu: 5.79 ± 0.873
1.23GlyMet: 1.23 ± 0.326
2.895GlyAsn: 2.895 ± 0.553
0.941GlyPro: 0.941 ± 0.209
1.664GlyGln: 1.664 ± 0.408
2.316GlyArg: 2.316 ± 0.459
3.763GlySer: 3.763 ± 0.578
3.763GlyThr: 3.763 ± 0.545
4.776GlyVal: 4.776 ± 0.643
0.868GlyTrp: 0.868 ± 0.256
2.678GlyTyr: 2.678 ± 0.598
0.0GlyXaa: 0.0 ± 0.0
His
0.941HisAla: 0.941 ± 0.341
0.072HisCys: 0.072 ± 0.066
0.796HisAsp: 0.796 ± 0.307
1.23HisGlu: 1.23 ± 0.269
1.158HisPhe: 1.158 ± 0.382
1.375HisGly: 1.375 ± 0.336
0.434HisHis: 0.434 ± 0.164
1.23HisIle: 1.23 ± 0.296
1.086HisLys: 1.086 ± 0.248
1.664HisLeu: 1.664 ± 0.303
0.217HisMet: 0.217 ± 0.133
0.941HisAsn: 0.941 ± 0.261
0.868HisPro: 0.868 ± 0.179
0.724HisGln: 0.724 ± 0.257
0.724HisArg: 0.724 ± 0.252
1.158HisSer: 1.158 ± 0.228
1.013HisThr: 1.013 ± 0.233
0.651HisVal: 0.651 ± 0.285
0.362HisTrp: 0.362 ± 0.158
0.868HisTyr: 0.868 ± 0.248
0.0HisXaa: 0.0 ± 0.0
Ile
4.415IleAla: 4.415 ± 0.635
0.579IleCys: 0.579 ± 0.301
5.355IleAsp: 5.355 ± 0.795
5.428IleGlu: 5.428 ± 0.699
2.75IlePhe: 2.75 ± 0.523
3.546IleGly: 3.546 ± 0.512
1.809IleHis: 1.809 ± 0.388
4.342IleIle: 4.342 ± 0.773
7.816IleLys: 7.816 ± 0.818
4.776IleLeu: 4.776 ± 0.753
1.592IleMet: 1.592 ± 0.357
5.066IleAsn: 5.066 ± 0.555
2.316IlePro: 2.316 ± 0.357
1.664IleGln: 1.664 ± 0.48
3.401IleArg: 3.401 ± 0.403
5.066IleSer: 5.066 ± 0.473
4.415IleThr: 4.415 ± 0.564
3.474IleVal: 3.474 ± 0.536
0.651IleTrp: 0.651 ± 0.223
2.533IleTyr: 2.533 ± 0.521
0.0IleXaa: 0.0 ± 0.0
Lys
7.599LysAla: 7.599 ± 1.225
0.145LysCys: 0.145 ± 0.098
5.428LysAsp: 5.428 ± 0.706
8.467LysGlu: 8.467 ± 0.934
2.171LysPhe: 2.171 ± 0.421
4.921LysGly: 4.921 ± 0.875
1.882LysHis: 1.882 ± 0.335
6.658LysIle: 6.658 ± 0.777
7.382LysLys: 7.382 ± 0.995
9.263LysLeu: 9.263 ± 0.932
2.605LysMet: 2.605 ± 0.344
5.79LysAsn: 5.79 ± 0.848
2.461LysPro: 2.461 ± 0.459
4.921LysGln: 4.921 ± 0.418
3.329LysArg: 3.329 ± 0.556
6.224LysSer: 6.224 ± 1.238
4.776LysThr: 4.776 ± 0.564
5.428LysVal: 5.428 ± 0.716
1.882LysTrp: 1.882 ± 0.36
5.211LysTyr: 5.211 ± 0.595
0.0LysXaa: 0.0 ± 0.0
Leu
4.921LeuAla: 4.921 ± 0.711
0.434LeuCys: 0.434 ± 0.186
5.717LeuAsp: 5.717 ± 0.872
6.658LeuGlu: 6.658 ± 0.674
3.184LeuPhe: 3.184 ± 0.4
4.559LeuGly: 4.559 ± 0.924
1.23LeuHis: 1.23 ± 0.457
5.862LeuIle: 5.862 ± 0.832
9.191LeuLys: 9.191 ± 1.16
7.02LeuLeu: 7.02 ± 1.096
2.316LeuMet: 2.316 ± 0.403
5.862LeuAsn: 5.862 ± 0.566
3.401LeuPro: 3.401 ± 0.579
2.75LeuGln: 2.75 ± 0.604
3.401LeuArg: 3.401 ± 0.447
5.79LeuSer: 5.79 ± 0.697
5.5LeuThr: 5.5 ± 0.743
3.98LeuVal: 3.98 ± 0.558
0.434LeuTrp: 0.434 ± 0.185
3.763LeuTyr: 3.763 ± 0.721
0.0LeuXaa: 0.0 ± 0.0
Met
1.23MetAla: 1.23 ± 0.306
0.145MetCys: 0.145 ± 0.106
0.941MetAsp: 0.941 ± 0.296
1.52MetGlu: 1.52 ± 0.431
0.796MetPhe: 0.796 ± 0.232
1.664MetGly: 1.664 ± 0.432
0.362MetHis: 0.362 ± 0.176
1.23MetIle: 1.23 ± 0.206
2.605MetLys: 2.605 ± 0.536
2.026MetLeu: 2.026 ± 0.439
0.289MetMet: 0.289 ± 0.133
1.375MetAsn: 1.375 ± 0.291
1.013MetPro: 1.013 ± 0.236
1.809MetGln: 1.809 ± 0.509
0.868MetArg: 0.868 ± 0.239
2.388MetSer: 2.388 ± 0.48
2.822MetThr: 2.822 ± 0.4
1.013MetVal: 1.013 ± 0.216
0.217MetTrp: 0.217 ± 0.123
0.868MetTyr: 0.868 ± 0.243
0.0MetXaa: 0.0 ± 0.0
Asn
3.908AsnAla: 3.908 ± 0.466
0.289AsnCys: 0.289 ± 0.141
4.342AsnAsp: 4.342 ± 0.527
4.27AsnGlu: 4.27 ± 0.611
2.026AsnPhe: 2.026 ± 0.361
4.27AsnGly: 4.27 ± 0.507
1.086AsnHis: 1.086 ± 0.31
4.27AsnIle: 4.27 ± 0.504
6.513AsnLys: 6.513 ± 0.674
4.993AsnLeu: 4.993 ± 0.559
0.724AsnMet: 0.724 ± 0.206
3.763AsnAsn: 3.763 ± 0.639
2.171AsnPro: 2.171 ± 0.322
2.388AsnGln: 2.388 ± 0.471
2.75AsnArg: 2.75 ± 0.411
3.98AsnSer: 3.98 ± 0.708
3.618AsnThr: 3.618 ± 0.401
3.184AsnVal: 3.184 ± 0.528
1.086AsnTrp: 1.086 ± 0.33
2.316AsnTyr: 2.316 ± 0.479
0.0AsnXaa: 0.0 ± 0.0
Pro
1.086ProAla: 1.086 ± 0.259
0.217ProCys: 0.217 ± 0.125
1.375ProAsp: 1.375 ± 0.325
2.171ProGlu: 2.171 ± 0.432
1.737ProPhe: 1.737 ± 0.48
1.664ProGly: 1.664 ± 0.304
0.289ProHis: 0.289 ± 0.149
2.099ProIle: 2.099 ± 0.398
2.026ProLys: 2.026 ± 0.444
2.388ProLeu: 2.388 ± 0.468
0.796ProMet: 0.796 ± 0.248
1.809ProAsn: 1.809 ± 0.354
0.796ProPro: 0.796 ± 0.257
1.375ProGln: 1.375 ± 0.277
1.375ProArg: 1.375 ± 0.352
2.243ProSer: 2.243 ± 0.307
1.664ProThr: 1.664 ± 0.366
1.303ProVal: 1.303 ± 0.326
0.362ProTrp: 0.362 ± 0.136
1.013ProTyr: 1.013 ± 0.283
0.0ProXaa: 0.0 ± 0.0
Gln
2.533GlnAla: 2.533 ± 0.365
0.289GlnCys: 0.289 ± 0.154
2.026GlnAsp: 2.026 ± 0.351
2.605GlnGlu: 2.605 ± 0.433
1.664GlnPhe: 1.664 ± 0.294
2.316GlnGly: 2.316 ± 0.485
0.651GlnHis: 0.651 ± 0.166
2.75GlnIle: 2.75 ± 0.629
3.04GlnLys: 3.04 ± 0.462
3.329GlnLeu: 3.329 ± 0.529
1.013GlnMet: 1.013 ± 0.312
1.664GlnAsn: 1.664 ± 0.362
1.158GlnPro: 1.158 ± 0.24
1.013GlnGln: 1.013 ± 0.328
2.026GlnArg: 2.026 ± 0.368
2.243GlnSer: 2.243 ± 0.348
1.303GlnThr: 1.303 ± 0.337
2.026GlnVal: 2.026 ± 0.38
0.362GlnTrp: 0.362 ± 0.176
1.52GlnTyr: 1.52 ± 0.367
0.0GlnXaa: 0.0 ± 0.0
Arg
2.461ArgAla: 2.461 ± 0.471
0.0ArgCys: 0.0 ± 0.0
3.184ArgAsp: 3.184 ± 0.372
2.388ArgGlu: 2.388 ± 0.481
2.171ArgPhe: 2.171 ± 0.38
2.099ArgGly: 2.099 ± 0.415
0.796ArgHis: 0.796 ± 0.262
3.257ArgIle: 3.257 ± 0.432
3.836ArgLys: 3.836 ± 0.45
3.618ArgLeu: 3.618 ± 0.604
1.013ArgMet: 1.013 ± 0.248
2.316ArgAsn: 2.316 ± 0.43
0.724ArgPro: 0.724 ± 0.313
1.23ArgGln: 1.23 ± 0.277
1.52ArgArg: 1.52 ± 0.403
2.171ArgSer: 2.171 ± 0.428
2.243ArgThr: 2.243 ± 0.46
2.099ArgVal: 2.099 ± 0.369
0.289ArgTrp: 0.289 ± 0.15
2.171ArgTyr: 2.171 ± 0.585
0.0ArgXaa: 0.0 ± 0.0
Ser
3.836SerAla: 3.836 ± 0.715
0.289SerCys: 0.289 ± 0.149
4.704SerAsp: 4.704 ± 0.604
4.632SerGlu: 4.632 ± 0.598
2.75SerPhe: 2.75 ± 0.441
4.632SerGly: 4.632 ± 0.693
1.158SerHis: 1.158 ± 0.277
4.053SerIle: 4.053 ± 0.568
6.586SerLys: 6.586 ± 1.189
4.921SerLeu: 4.921 ± 0.512
2.243SerMet: 2.243 ± 0.378
4.559SerAsn: 4.559 ± 0.647
1.737SerPro: 1.737 ± 0.421
2.388SerGln: 2.388 ± 0.442
2.243SerArg: 2.243 ± 0.356
4.415SerSer: 4.415 ± 0.661
3.112SerThr: 3.112 ± 0.533
4.27SerVal: 4.27 ± 0.56
1.013SerTrp: 1.013 ± 0.242
2.243SerTyr: 2.243 ± 0.409
0.0SerXaa: 0.0 ± 0.0
Thr
3.474ThrAla: 3.474 ± 0.607
0.217ThrCys: 0.217 ± 0.133
3.257ThrAsp: 3.257 ± 0.556
3.546ThrGlu: 3.546 ± 0.489
2.822ThrPhe: 2.822 ± 0.395
4.125ThrGly: 4.125 ± 0.483
1.23ThrHis: 1.23 ± 0.267
4.342ThrIle: 4.342 ± 0.475
5.066ThrLys: 5.066 ± 0.647
4.125ThrLeu: 4.125 ± 0.555
1.013ThrMet: 1.013 ± 0.27
3.401ThrAsn: 3.401 ± 0.425
2.678ThrPro: 2.678 ± 0.442
1.592ThrGln: 1.592 ± 0.365
1.809ThrArg: 1.809 ± 0.33
3.474ThrSer: 3.474 ± 0.494
2.822ThrThr: 2.822 ± 0.546
4.125ThrVal: 4.125 ± 0.477
0.651ThrTrp: 0.651 ± 0.267
2.388ThrTyr: 2.388 ± 0.436
0.0ThrXaa: 0.0 ± 0.0
Val
3.184ValAla: 3.184 ± 0.532
0.217ValCys: 0.217 ± 0.107
3.618ValAsp: 3.618 ± 0.531
4.776ValGlu: 4.776 ± 0.612
2.533ValPhe: 2.533 ± 0.45
3.184ValGly: 3.184 ± 0.576
0.868ValHis: 0.868 ± 0.247
4.197ValIle: 4.197 ± 0.494
4.487ValLys: 4.487 ± 0.763
4.487ValLeu: 4.487 ± 0.491
1.664ValMet: 1.664 ± 0.278
3.618ValAsn: 3.618 ± 0.513
1.52ValPro: 1.52 ± 0.351
2.099ValGln: 2.099 ± 0.41
2.243ValArg: 2.243 ± 0.361
4.125ValSer: 4.125 ± 0.582
2.822ValThr: 2.822 ± 0.485
3.257ValVal: 3.257 ± 0.465
0.507ValTrp: 0.507 ± 0.177
2.316ValTyr: 2.316 ± 0.524
0.0ValXaa: 0.0 ± 0.0
Trp
0.724TrpAla: 0.724 ± 0.214
0.0TrpCys: 0.0 ± 0.0
0.362TrpAsp: 0.362 ± 0.189
0.941TrpGlu: 0.941 ± 0.318
1.303TrpPhe: 1.303 ± 0.32
0.434TrpGly: 0.434 ± 0.163
0.072TrpHis: 0.072 ± 0.082
0.868TrpIle: 0.868 ± 0.265
0.724TrpLys: 0.724 ± 0.251
1.158TrpLeu: 1.158 ± 0.232
0.362TrpMet: 0.362 ± 0.215
1.013TrpAsn: 1.013 ± 0.254
0.362TrpPro: 0.362 ± 0.245
0.651TrpGln: 0.651 ± 0.175
0.434TrpArg: 0.434 ± 0.196
1.23TrpSer: 1.23 ± 0.386
0.579TrpThr: 0.579 ± 0.18
0.724TrpVal: 0.724 ± 0.282
0.145TrpTrp: 0.145 ± 0.12
0.651TrpTyr: 0.651 ± 0.274
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.605TyrAla: 2.605 ± 0.322
0.434TyrCys: 0.434 ± 0.175
2.605TyrAsp: 2.605 ± 0.618
3.329TyrGlu: 3.329 ± 0.541
1.737TyrPhe: 1.737 ± 0.396
2.243TyrGly: 2.243 ± 0.527
1.013TyrHis: 1.013 ± 0.262
2.822TyrIle: 2.822 ± 0.542
3.329TyrLys: 3.329 ± 0.462
3.98TyrLeu: 3.98 ± 0.65
1.23TyrMet: 1.23 ± 0.271
2.461TyrAsn: 2.461 ± 0.644
0.868TyrPro: 0.868 ± 0.266
1.882TyrGln: 1.882 ± 0.331
1.737TyrArg: 1.737 ± 0.484
3.04TyrSer: 3.04 ± 0.392
2.316TyrThr: 2.316 ± 0.511
2.75TyrVal: 2.75 ± 0.464
0.651TyrTrp: 0.651 ± 0.184
1.882TyrTyr: 1.882 ± 0.523
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 67 proteins (13819 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski