Amino acid dipepetide frequency for Pelargonium line pattern virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.556AlaAla: 5.556 ± 1.558
1.852AlaCys: 1.852 ± 0.545
1.852AlaAsp: 1.852 ± 0.885
1.235AlaGlu: 1.235 ± 0.425
3.704AlaPhe: 3.704 ± 1.482
5.556AlaGly: 5.556 ± 3.818
3.086AlaHis: 3.086 ± 0.85
5.556AlaIle: 5.556 ± 0.908
6.79AlaLys: 6.79 ± 2.055
5.556AlaLeu: 5.556 ± 2.223
1.235AlaMet: 1.235 ± 0.615
5.556AlaAsn: 5.556 ± 1.982
0.617AlaPro: 0.617 ± 0.33
1.235AlaGln: 1.235 ± 0.425
5.556AlaArg: 5.556 ± 1.558
5.556AlaSer: 5.556 ± 1.118
4.321AlaThr: 4.321 ± 1.145
6.173AlaVal: 6.173 ± 1.562
2.469AlaTrp: 2.469 ± 1.23
2.469AlaTyr: 2.469 ± 1.42
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
0.0CysAsp: 0.0 ± 0.0
0.617CysGlu: 0.617 ± 0.33
0.617CysPhe: 0.617 ± 0.33
1.852CysGly: 1.852 ± 0.545
0.0CysHis: 0.0 ± 0.0
3.704CysIle: 3.704 ± 1.709
0.0CysLys: 0.0 ± 0.0
4.938CysLeu: 4.938 ± 1.448
0.0CysMet: 0.0 ± 0.0
1.235CysAsn: 1.235 ± 0.615
0.617CysPro: 0.617 ± 0.33
1.852CysGln: 1.852 ± 0.741
1.235CysArg: 1.235 ± 0.425
1.235CysSer: 1.235 ± 1.153
3.086CysThr: 3.086 ± 2.095
0.617CysVal: 0.617 ± 0.33
2.469CysTrp: 2.469 ± 1.23
0.617CysTyr: 0.617 ± 0.33
0.0CysXaa: 0.0 ± 0.0
Asp
4.321AspAla: 4.321 ± 1.266
3.086AspCys: 3.086 ± 0.914
1.235AspAsp: 1.235 ± 0.425
3.704AspGlu: 3.704 ± 1.845
1.852AspPhe: 1.852 ± 0.702
3.086AspGly: 3.086 ± 1.781
0.0AspHis: 0.0 ± 0.0
1.235AspIle: 1.235 ± 0.808
6.79AspLys: 6.79 ± 1.744
0.617AspLeu: 0.617 ± 0.804
0.617AspMet: 0.617 ± 0.33
0.617AspAsn: 0.617 ± 0.531
1.852AspPro: 1.852 ± 0.903
1.235AspGln: 1.235 ± 0.661
1.852AspArg: 1.852 ± 0.741
6.173AspSer: 6.173 ± 1.681
1.235AspThr: 1.235 ± 0.661
1.235AspVal: 1.235 ± 0.808
0.0AspTrp: 0.0 ± 0.0
1.852AspTyr: 1.852 ± 0.741
0.0AspXaa: 0.0 ± 0.0
Glu
4.938GluAla: 4.938 ± 1.052
0.617GluCys: 0.617 ± 0.531
1.852GluAsp: 1.852 ± 0.741
6.173GluGlu: 6.173 ± 1.884
3.704GluPhe: 3.704 ± 1.281
5.556GluGly: 5.556 ± 0.885
3.704GluHis: 3.704 ± 1.066
0.617GluIle: 0.617 ± 0.33
3.086GluLys: 3.086 ± 1.243
8.642GluLeu: 8.642 ± 1.985
0.617GluMet: 0.617 ± 0.33
1.852GluAsn: 1.852 ± 0.741
2.469GluPro: 2.469 ± 1.42
2.469GluGln: 2.469 ± 0.871
3.086GluArg: 3.086 ± 0.653
3.704GluSer: 3.704 ± 0.691
2.469GluThr: 2.469 ± 2.124
4.938GluVal: 4.938 ± 2.053
1.852GluTrp: 1.852 ± 0.909
1.852GluTyr: 1.852 ± 1.229
0.0GluXaa: 0.0 ± 0.0
Phe
2.469PheAla: 2.469 ± 1.23
2.469PheCys: 2.469 ± 0.795
2.469PheAsp: 2.469 ± 0.969
6.79PheGlu: 6.79 ± 2.052
1.235PhePhe: 1.235 ± 0.86
3.704PheGly: 3.704 ± 1.482
0.617PheHis: 0.617 ± 0.33
0.617PheIle: 0.617 ± 0.73
1.235PheLys: 1.235 ± 0.425
1.852PheLeu: 1.852 ± 0.702
0.617PheMet: 0.617 ± 0.72
1.852PheAsn: 1.852 ± 0.545
0.617PhePro: 0.617 ± 0.531
1.852PheGln: 1.852 ± 0.545
0.617PheArg: 0.617 ± 0.33
4.321PheSer: 4.321 ± 1.733
2.469PheThr: 2.469 ± 0.969
4.938PheVal: 4.938 ± 1.846
0.0PheTrp: 0.0 ± 0.0
1.852PheTyr: 1.852 ± 0.991
0.0PheXaa: 0.0 ± 0.0
Gly
3.704GlyAla: 3.704 ± 1.634
3.086GlyCys: 3.086 ± 1.724
3.086GlyAsp: 3.086 ± 1.089
6.79GlyGlu: 6.79 ± 0.701
1.852GlyPhe: 1.852 ± 0.909
4.321GlyGly: 4.321 ± 2.863
1.235GlyHis: 1.235 ± 0.661
1.852GlyIle: 1.852 ± 0.545
2.469GlyLys: 2.469 ± 1.149
10.494GlyLeu: 10.494 ± 2.882
1.852GlyMet: 1.852 ± 1.936
4.321GlyAsn: 4.321 ± 1.588
2.469GlyPro: 2.469 ± 0.497
1.852GlyGln: 1.852 ± 1.504
4.321GlyArg: 4.321 ± 0.674
3.704GlySer: 3.704 ± 1.634
1.235GlyThr: 1.235 ± 1.05
6.173GlyVal: 6.173 ± 2.123
1.852GlyTrp: 1.852 ± 0.959
2.469GlyTyr: 2.469 ± 0.854
0.0GlyXaa: 0.0 ± 0.0
His
1.235HisAla: 1.235 ± 0.615
0.0HisCys: 0.0 ± 0.0
0.0HisAsp: 0.0 ± 0.0
0.617HisGlu: 0.617 ± 0.531
0.617HisPhe: 0.617 ± 0.33
1.852HisGly: 1.852 ± 0.944
1.235HisHis: 1.235 ± 0.425
0.0HisIle: 0.0 ± 0.0
2.469HisLys: 2.469 ± 0.871
1.852HisLeu: 1.852 ± 1.023
0.0HisMet: 0.0 ± 0.0
0.617HisAsn: 0.617 ± 0.33
1.235HisPro: 1.235 ± 0.705
0.617HisGln: 0.617 ± 0.33
0.617HisArg: 0.617 ± 0.33
5.556HisSer: 5.556 ± 1.375
0.0HisThr: 0.0 ± 0.0
1.235HisVal: 1.235 ± 0.425
0.0HisTrp: 0.0 ± 0.0
1.235HisTyr: 1.235 ± 0.615
0.0HisXaa: 0.0 ± 0.0
Ile
4.321IleAla: 4.321 ± 0.979
0.617IleCys: 0.617 ± 0.33
0.0IleAsp: 0.0 ± 0.0
2.469IleGlu: 2.469 ± 0.85
3.086IlePhe: 3.086 ± 0.666
4.938IleGly: 4.938 ± 1.034
0.0IleHis: 0.0 ± 0.0
0.617IleIle: 0.617 ± 0.33
2.469IleLys: 2.469 ± 1.026
1.852IleLeu: 1.852 ± 0.892
1.235IleMet: 1.235 ± 0.917
0.617IleAsn: 0.617 ± 0.531
3.086IlePro: 3.086 ± 1.243
3.086IleGln: 3.086 ± 1.085
2.469IleArg: 2.469 ± 1.032
5.556IleSer: 5.556 ± 2.661
3.704IleThr: 3.704 ± 1.155
4.938IleVal: 4.938 ± 1.297
0.0IleTrp: 0.0 ± 0.0
3.086IleTyr: 3.086 ± 1.243
0.0IleXaa: 0.0 ± 0.0
Lys
5.556LysAla: 5.556 ± 1.112
4.321LysCys: 4.321 ± 1.119
3.086LysAsp: 3.086 ± 1.069
4.938LysGlu: 4.938 ± 1.346
3.086LysPhe: 3.086 ± 0.809
2.469LysGly: 2.469 ± 1.306
0.0LysHis: 0.0 ± 0.0
4.321LysIle: 4.321 ± 0.815
5.556LysLys: 5.556 ± 2.223
9.259LysLeu: 9.259 ± 2.183
2.469LysMet: 2.469 ± 0.929
3.086LysAsn: 3.086 ± 1.229
5.556LysPro: 5.556 ± 1.823
0.617LysGln: 0.617 ± 0.531
4.938LysArg: 4.938 ± 1.65
4.938LysSer: 4.938 ± 1.201
1.852LysThr: 1.852 ± 0.741
4.321LysVal: 4.321 ± 1.011
1.235LysTrp: 1.235 ± 0.705
4.321LysTyr: 4.321 ± 0.979
0.617LysXaa: 0.617 ± 0.33
Leu
9.877LeuAla: 9.877 ± 2.2
1.235LeuCys: 1.235 ± 0.86
3.086LeuAsp: 3.086 ± 1.058
3.704LeuGlu: 3.704 ± 0.605
3.704LeuPhe: 3.704 ± 0.691
6.79LeuGly: 6.79 ± 1.269
1.235LeuHis: 1.235 ± 0.86
4.938LeuIle: 4.938 ± 1.222
5.556LeuLys: 5.556 ± 0.953
7.407LeuLeu: 7.407 ± 1.381
2.469LeuMet: 2.469 ± 0.813
3.086LeuAsn: 3.086 ± 1.837
4.321LeuPro: 4.321 ± 1.073
2.469LeuGln: 2.469 ± 0.497
4.321LeuArg: 4.321 ± 0.677
6.79LeuSer: 6.79 ± 3.223
7.407LeuThr: 7.407 ± 1.121
8.642LeuVal: 8.642 ± 2.497
1.852LeuTrp: 1.852 ± 0.824
0.617LeuTyr: 0.617 ± 0.33
0.0LeuXaa: 0.0 ± 0.0
Met
3.704MetAla: 3.704 ± 1.035
0.0MetCys: 0.0 ± 0.0
1.235MetAsp: 1.235 ± 0.808
1.852MetGlu: 1.852 ± 0.824
0.617MetPhe: 0.617 ± 0.33
1.852MetGly: 1.852 ± 0.903
0.0MetHis: 0.0 ± 0.0
0.0MetIle: 0.0 ± 0.0
2.469MetLys: 2.469 ± 0.869
0.617MetLeu: 0.617 ± 1.003
0.0MetMet: 0.0 ± 0.0
0.617MetAsn: 0.617 ± 0.531
0.617MetPro: 0.617 ± 1.003
0.0MetGln: 0.0 ± 0.0
0.0MetArg: 0.0 ± 0.0
1.852MetSer: 1.852 ± 0.991
0.617MetThr: 0.617 ± 1.003
0.0MetVal: 0.0 ± 0.0
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
3.086AsnAla: 3.086 ± 0.714
1.235AsnCys: 1.235 ± 0.898
4.938AsnAsp: 4.938 ± 1.709
1.235AsnGlu: 1.235 ± 0.615
2.469AsnPhe: 2.469 ± 1.575
1.852AsnGly: 1.852 ± 0.824
0.617AsnHis: 0.617 ± 0.531
0.617AsnIle: 0.617 ± 0.33
3.086AsnLys: 3.086 ± 1.754
6.173AsnLeu: 6.173 ± 1.547
0.0AsnMet: 0.0 ± 0.0
1.235AsnAsn: 1.235 ± 0.661
2.469AsnPro: 2.469 ± 1.42
1.235AsnGln: 1.235 ± 0.661
1.235AsnArg: 1.235 ± 0.898
2.469AsnSer: 2.469 ± 0.869
1.852AsnThr: 1.852 ± 1.875
1.235AsnVal: 1.235 ± 0.425
0.0AsnTrp: 0.0 ± 0.0
1.235AsnTyr: 1.235 ± 0.615
0.0AsnXaa: 0.0 ± 0.0
Pro
1.235ProAla: 1.235 ± 0.425
1.852ProCys: 1.852 ± 0.741
3.086ProAsp: 3.086 ± 0.653
3.086ProGlu: 3.086 ± 0.653
1.235ProPhe: 1.235 ± 0.661
1.852ProGly: 1.852 ± 0.903
0.617ProHis: 0.617 ± 0.73
1.852ProIle: 1.852 ± 0.991
2.469ProLys: 2.469 ± 1.42
3.086ProLeu: 3.086 ± 0.703
0.0ProMet: 0.0 ± 0.0
1.852ProAsn: 1.852 ± 0.892
1.852ProPro: 1.852 ± 1.593
1.852ProGln: 1.852 ± 0.702
5.556ProArg: 5.556 ± 1.81
2.469ProSer: 2.469 ± 0.869
3.704ProThr: 3.704 ± 1.155
3.086ProVal: 3.086 ± 1.089
1.235ProTrp: 1.235 ± 0.615
0.617ProTyr: 0.617 ± 0.33
0.0ProXaa: 0.0 ± 0.0
Gln
1.852GlnAla: 1.852 ± 0.536
0.617GlnCys: 0.617 ± 0.33
0.0GlnAsp: 0.0 ± 0.0
3.086GlnGlu: 3.086 ± 0.653
0.617GlnPhe: 0.617 ± 0.33
1.852GlnGly: 1.852 ± 1.396
1.235GlnHis: 1.235 ± 0.661
1.235GlnIle: 1.235 ± 0.661
2.469GlnLys: 2.469 ± 0.795
4.321GlnLeu: 4.321 ± 0.673
0.617GlnMet: 0.617 ± 0.33
0.0GlnAsn: 0.0 ± 0.0
2.469GlnPro: 2.469 ± 1.23
1.852GlnGln: 1.852 ± 0.741
0.0GlnArg: 0.0 ± 0.0
1.852GlnSer: 1.852 ± 1.251
1.852GlnThr: 1.852 ± 0.944
0.617GlnVal: 0.617 ± 0.531
0.617GlnTrp: 0.617 ± 0.531
0.0GlnTyr: 0.0 ± 0.0
0.0GlnXaa: 0.0 ± 0.0
Arg
6.173ArgAla: 6.173 ± 0.647
0.617ArgCys: 0.617 ± 1.003
2.469ArgAsp: 2.469 ± 1.189
2.469ArgGlu: 2.469 ± 0.871
2.469ArgPhe: 2.469 ± 0.795
5.556ArgGly: 5.556 ± 0.839
1.235ArgHis: 1.235 ± 0.661
3.704ArgIle: 3.704 ± 1.071
2.469ArgLys: 2.469 ± 1.032
4.321ArgLeu: 4.321 ± 1.786
0.617ArgMet: 0.617 ± 0.33
3.086ArgAsn: 3.086 ± 1.321
3.086ArgPro: 3.086 ± 1.321
0.617ArgGln: 0.617 ± 1.003
9.259ArgArg: 9.259 ± 1.77
3.704ArgSer: 3.704 ± 1.006
1.235ArgThr: 1.235 ± 0.425
8.025ArgVal: 8.025 ± 2.188
1.235ArgTrp: 1.235 ± 0.661
2.469ArgTyr: 2.469 ± 0.795
0.0ArgXaa: 0.0 ± 0.0
Ser
5.556SerAla: 5.556 ± 0.969
1.235SerCys: 1.235 ± 0.615
6.79SerAsp: 6.79 ± 1.653
3.086SerGlu: 3.086 ± 2.384
1.852SerPhe: 1.852 ± 0.545
4.938SerGly: 4.938 ± 1.493
0.617SerHis: 0.617 ± 0.531
4.938SerIle: 4.938 ± 1.446
11.111SerLys: 11.111 ± 2.581
3.704SerLeu: 3.704 ± 1.03
0.617SerMet: 0.617 ± 0.531
1.852SerAsn: 1.852 ± 1.061
4.321SerPro: 4.321 ± 1.717
1.852SerGln: 1.852 ± 1.504
5.556SerArg: 5.556 ± 2.531
8.025SerSer: 8.025 ± 6.613
5.556SerThr: 5.556 ± 2.318
4.938SerVal: 4.938 ± 2.388
1.235SerTrp: 1.235 ± 0.898
3.704SerTyr: 3.704 ± 1.998
0.0SerXaa: 0.0 ± 0.0
Thr
2.469ThrAla: 2.469 ± 2.306
1.235ThrCys: 1.235 ± 0.661
1.852ThrAsp: 1.852 ± 1.593
1.852ThrGlu: 1.852 ± 0.741
4.321ThrPhe: 4.321 ± 1.145
0.617ThrGly: 0.617 ± 0.33
0.617ThrHis: 0.617 ± 0.531
6.79ThrIle: 6.79 ± 0.701
4.321ThrLys: 4.321 ± 1.045
2.469ThrLeu: 2.469 ± 1.264
0.0ThrMet: 0.0 ± 0.0
1.852ThrAsn: 1.852 ± 2.095
2.469ThrPro: 2.469 ± 0.869
1.235ThrGln: 1.235 ± 0.615
7.407ThrArg: 7.407 ± 1.715
4.321ThrSer: 4.321 ± 3.412
3.086ThrThr: 3.086 ± 1.094
3.704ThrVal: 3.704 ± 1.237
0.0ThrTrp: 0.0 ± 0.0
0.617ThrTyr: 0.617 ± 0.531
0.0ThrXaa: 0.0 ± 0.0
Val
5.556ValAla: 5.556 ± 2.081
0.617ValCys: 0.617 ± 0.73
5.556ValAsp: 5.556 ± 1.112
7.407ValGlu: 7.407 ± 1.544
2.469ValPhe: 2.469 ± 0.497
6.173ValGly: 6.173 ± 2.569
3.704ValHis: 3.704 ± 0.962
2.469ValIle: 2.469 ± 0.85
7.407ValLys: 7.407 ± 1.59
5.556ValLeu: 5.556 ± 2.279
1.852ValMet: 1.852 ± 0.741
2.469ValAsn: 2.469 ± 1.321
0.617ValPro: 0.617 ± 0.531
0.617ValGln: 0.617 ± 0.33
3.704ValArg: 3.704 ± 1.091
5.556ValSer: 5.556 ± 1.341
3.086ValThr: 3.086 ± 0.85
6.173ValVal: 6.173 ± 1.784
0.617ValTrp: 0.617 ± 1.003
1.852ValTyr: 1.852 ± 0.545
0.0ValXaa: 0.0 ± 0.0
Trp
1.852TrpAla: 1.852 ± 0.536
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
0.617TrpGlu: 0.617 ± 0.33
1.235TrpPhe: 1.235 ± 0.615
1.852TrpGly: 1.852 ± 0.545
1.235TrpHis: 1.235 ± 0.615
2.469TrpIle: 2.469 ± 0.869
0.617TrpLys: 0.617 ± 0.33
1.235TrpLeu: 1.235 ± 0.898
0.0TrpMet: 0.0 ± 0.0
0.617TrpAsn: 0.617 ± 0.73
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
1.852TrpArg: 1.852 ± 0.741
0.617TrpSer: 0.617 ± 0.73
1.852TrpThr: 1.852 ± 1.875
1.235TrpVal: 1.235 ± 0.661
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.469TyrAla: 2.469 ± 0.497
0.0TyrCys: 0.0 ± 0.0
0.0TyrAsp: 0.0 ± 0.0
2.469TyrGlu: 2.469 ± 0.795
1.852TyrPhe: 1.852 ± 0.892
2.469TyrGly: 2.469 ± 0.497
0.0TyrHis: 0.0 ± 0.0
0.617TyrIle: 0.617 ± 0.531
3.704TyrLys: 3.704 ± 0.907
5.556TyrLeu: 5.556 ± 1.112
0.617TyrMet: 0.617 ± 0.531
1.852TyrAsn: 1.852 ± 0.545
1.852TyrPro: 1.852 ± 1.214
0.617TyrGln: 0.617 ± 0.33
1.235TyrArg: 1.235 ± 0.661
3.086TyrSer: 3.086 ± 1.534
0.617TyrThr: 0.617 ± 0.33
1.235TyrVal: 1.235 ± 0.425
0.617TyrTrp: 0.617 ± 0.33
1.852TyrTyr: 1.852 ± 0.741
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.617XaaGly: 0.617 ± 0.33
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6 proteins (1621 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski