Amino acid dipepetide frequency for Mouse mammary tumor virus (strain C3H) (MMTV)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.461AlaAla: 5.461 ± 0.561
2.137AlaCys: 2.137 ± 0.402
1.899AlaAsp: 1.899 ± 0.573
4.986AlaGlu: 4.986 ± 0.859
1.899AlaPhe: 1.899 ± 0.504
4.511AlaGly: 4.511 ± 0.692
1.899AlaHis: 1.899 ± 0.272
3.324AlaIle: 3.324 ± 0.563
2.374AlaLys: 2.374 ± 0.804
5.698AlaLeu: 5.698 ± 2.281
1.425AlaMet: 1.425 ± 0.524
2.374AlaAsn: 2.374 ± 0.721
3.324AlaPro: 3.324 ± 0.274
1.899AlaGln: 1.899 ± 0.813
3.799AlaArg: 3.799 ± 0.598
2.612AlaSer: 2.612 ± 0.64
3.561AlaThr: 3.561 ± 0.612
4.748AlaVal: 4.748 ± 0.787
1.662AlaTrp: 1.662 ± 0.428
3.324AlaTyr: 3.324 ± 0.41
0.0AlaXaa: 0.0 ± 0.0
Cys
0.237CysAla: 0.237 ± 0.254
0.237CysCys: 0.237 ± 0.262
0.0CysAsp: 0.0 ± 0.0
0.0CysGlu: 0.0 ± 0.0
1.425CysPhe: 1.425 ± 0.313
1.187CysGly: 1.187 ± 0.341
0.237CysHis: 0.237 ± 0.254
0.712CysIle: 0.712 ± 0.292
2.849CysLys: 2.849 ± 0.715
1.662CysLeu: 1.662 ± 0.361
0.237CysMet: 0.237 ± 0.262
0.0CysAsn: 0.0 ± 0.0
1.662CysPro: 1.662 ± 0.474
1.187CysGln: 1.187 ± 0.13
0.237CysArg: 0.237 ± 0.254
0.237CysSer: 0.237 ± 0.254
0.237CysThr: 0.237 ± 0.165
0.712CysVal: 0.712 ± 0.464
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
1.662AspAla: 1.662 ± 0.153
1.187AspCys: 1.187 ± 0.341
6.41AspAsp: 6.41 ± 1.663
2.612AspGlu: 2.612 ± 0.271
1.662AspPhe: 1.662 ± 0.885
1.899AspGly: 1.899 ± 0.267
0.712AspHis: 0.712 ± 0.262
2.374AspIle: 2.374 ± 0.178
5.698AspLys: 5.698 ± 0.761
8.547AspLeu: 8.547 ± 0.651
2.137AspMet: 2.137 ± 0.366
1.187AspAsn: 1.187 ± 0.542
1.425AspPro: 1.425 ± 0.509
2.374AspGln: 2.374 ± 0.724
0.95AspArg: 0.95 ± 0.515
4.748AspSer: 4.748 ± 0.937
2.849AspThr: 2.849 ± 0.425
2.374AspVal: 2.374 ± 0.374
4.036AspTrp: 4.036 ± 0.842
2.374AspTyr: 2.374 ± 0.539
0.0AspXaa: 0.0 ± 0.0
Glu
4.274GluAla: 4.274 ± 0.215
0.95GluCys: 0.95 ± 0.359
2.612GluAsp: 2.612 ± 0.843
9.972GluGlu: 9.972 ± 2.342
1.187GluPhe: 1.187 ± 0.341
4.036GluGly: 4.036 ± 0.828
2.612GluHis: 2.612 ± 0.706
4.986GluIle: 4.986 ± 0.896
8.31GluLys: 8.31 ± 1.321
3.799GluLeu: 3.799 ± 0.516
2.137GluMet: 2.137 ± 1.019
3.086GluAsn: 3.086 ± 0.714
2.137GluPro: 2.137 ± 0.343
2.374GluGln: 2.374 ± 0.287
3.086GluArg: 3.086 ± 0.559
4.748GluSer: 4.748 ± 0.231
2.612GluThr: 2.612 ± 0.736
2.849GluVal: 2.849 ± 0.517
0.237GluTrp: 0.237 ± 0.165
0.95GluTyr: 0.95 ± 0.255
0.0GluXaa: 0.0 ± 0.0
Phe
2.137PheAla: 2.137 ± 0.454
0.475PheCys: 0.475 ± 0.241
1.187PheAsp: 1.187 ± 0.13
0.95PheGlu: 0.95 ± 0.477
0.237PhePhe: 0.237 ± 0.165
0.95PheGly: 0.95 ± 0.258
1.187PheHis: 1.187 ± 0.48
1.899PheIle: 1.899 ± 0.587
0.475PheLys: 0.475 ± 0.238
4.036PheLeu: 4.036 ± 0.325
0.712PheMet: 0.712 ± 0.262
0.712PheAsn: 0.712 ± 0.321
3.086PhePro: 3.086 ± 0.213
1.899PheGln: 1.899 ± 0.681
0.95PheArg: 0.95 ± 0.814
2.612PheSer: 2.612 ± 0.999
3.324PheThr: 3.324 ± 0.548
3.324PheVal: 3.324 ± 0.095
0.712PheTrp: 0.712 ± 0.579
0.95PheTyr: 0.95 ± 0.255
0.0PheXaa: 0.0 ± 0.0
Gly
2.374GlyAla: 2.374 ± 0.442
0.237GlyCys: 0.237 ± 0.254
3.561GlyAsp: 3.561 ± 0.507
3.799GlyGlu: 3.799 ± 0.499
2.137GlyPhe: 2.137 ± 0.263
4.036GlyGly: 4.036 ± 0.632
1.899GlyHis: 1.899 ± 0.773
1.899GlyIle: 1.899 ± 0.535
4.986GlyLys: 4.986 ± 0.614
10.446GlyLeu: 10.446 ± 1.378
1.899GlyMet: 1.899 ± 0.501
3.086GlyAsn: 3.086 ± 0.864
2.849GlyPro: 2.849 ± 0.408
3.799GlyGln: 3.799 ± 0.875
4.036GlyArg: 4.036 ± 1.024
5.935GlySer: 5.935 ± 0.627
6.173GlyThr: 6.173 ± 1.449
4.274GlyVal: 4.274 ± 0.526
0.712GlyTrp: 0.712 ± 0.464
1.187GlyTyr: 1.187 ± 0.297
0.0GlyXaa: 0.0 ± 0.0
His
0.95HisAla: 0.95 ± 0.454
0.237HisCys: 0.237 ± 0.254
1.662HisAsp: 1.662 ± 0.351
0.712HisGlu: 0.712 ± 0.234
0.95HisPhe: 0.95 ± 0.319
1.187HisGly: 1.187 ± 0.13
0.475HisHis: 0.475 ± 0.331
3.324HisIle: 3.324 ± 0.413
1.662HisLys: 1.662 ± 0.351
2.137HisLeu: 2.137 ± 0.967
0.237HisMet: 0.237 ± 0.165
0.0HisAsn: 0.0 ± 0.0
1.187HisPro: 1.187 ± 0.365
2.137HisGln: 2.137 ± 0.402
0.95HisArg: 0.95 ± 0.505
0.0HisSer: 0.0 ± 0.0
0.95HisThr: 0.95 ± 0.319
2.849HisVal: 2.849 ± 0.774
1.425HisTrp: 1.425 ± 0.363
1.187HisTyr: 1.187 ± 0.297
0.0HisXaa: 0.0 ± 0.0
Ile
1.899IleAla: 1.899 ± 0.437
0.475IleCys: 0.475 ± 0.508
2.137IleAsp: 2.137 ± 0.479
2.374IleGlu: 2.374 ± 0.903
2.374IlePhe: 2.374 ± 1.101
2.137IleGly: 2.137 ± 0.707
2.374IleHis: 2.374 ± 0.939
4.274IleIle: 4.274 ± 1.219
6.41IleLys: 6.41 ± 0.856
5.223IleLeu: 5.223 ± 0.322
0.475IleMet: 0.475 ± 0.196
0.475IleAsn: 0.475 ± 0.238
2.374IlePro: 2.374 ± 0.377
1.899IleGln: 1.899 ± 0.694
3.324IleArg: 3.324 ± 0.35
3.799IleSer: 3.799 ± 0.838
1.187IleThr: 1.187 ± 0.602
3.086IleVal: 3.086 ± 0.898
1.187IleTrp: 1.187 ± 0.13
1.662IleTyr: 1.662 ± 0.457
0.0IleXaa: 0.0 ± 0.0
Lys
3.324LysAla: 3.324 ± 0.413
0.0LysCys: 0.0 ± 0.0
7.123LysAsp: 7.123 ± 0.673
7.835LysGlu: 7.835 ± 1.194
1.187LysPhe: 1.187 ± 0.341
9.497LysGly: 9.497 ± 1.407
0.237LysHis: 0.237 ± 0.165
2.374LysIle: 2.374 ± 0.444
7.597LysLys: 7.597 ± 1.354
6.173LysLeu: 6.173 ± 0.903
0.0LysMet: 0.0 ± 0.0
2.374LysAsn: 2.374 ± 0.547
2.849LysPro: 2.849 ± 0.151
4.036LysGln: 4.036 ± 0.747
7.123LysArg: 7.123 ± 0.888
4.986LysSer: 4.986 ± 0.45
6.648LysThr: 6.648 ± 0.976
4.986LysVal: 4.986 ± 0.857
0.475LysTrp: 0.475 ± 0.241
3.086LysTyr: 3.086 ± 0.767
0.0LysXaa: 0.0 ± 0.0
Leu
7.123LeuAla: 7.123 ± 0.475
2.612LeuCys: 2.612 ± 0.594
4.036LeuAsp: 4.036 ± 0.787
5.698LeuGlu: 5.698 ± 0.624
2.849LeuPhe: 2.849 ± 0.555
5.935LeuGly: 5.935 ± 1.543
2.137LeuHis: 2.137 ± 0.263
6.173LeuIle: 6.173 ± 0.673
6.173LeuLys: 6.173 ± 0.616
10.684LeuLeu: 10.684 ± 1.393
1.187LeuMet: 1.187 ± 0.226
4.511LeuAsn: 4.511 ± 0.684
9.497LeuPro: 9.497 ± 1.063
7.597LeuGln: 7.597 ± 1.832
3.799LeuArg: 3.799 ± 0.55
8.784LeuSer: 8.784 ± 1.373
6.173LeuThr: 6.173 ± 0.378
4.274LeuVal: 4.274 ± 0.787
2.137LeuTrp: 2.137 ± 0.263
0.475LeuTyr: 0.475 ± 0.241
0.0LeuXaa: 0.0 ± 0.0
Met
1.899MetAla: 1.899 ± 0.575
0.0MetCys: 0.0 ± 0.0
0.712MetAsp: 0.712 ± 0.496
0.0MetGlu: 0.0 ± 0.0
0.0MetPhe: 0.0 ± 0.0
2.849MetGly: 2.849 ± 0.715
0.475MetHis: 0.475 ± 0.241
0.95MetIle: 0.95 ± 0.477
1.662MetLys: 1.662 ± 0.351
1.899MetLeu: 1.899 ± 0.782
0.475MetMet: 0.475 ± 0.196
0.237MetAsn: 0.237 ± 0.254
1.187MetPro: 1.187 ± 0.347
0.95MetGln: 0.95 ± 0.235
1.662MetArg: 1.662 ± 0.428
0.95MetSer: 0.95 ± 0.814
0.712MetThr: 0.712 ± 0.292
1.662MetVal: 1.662 ± 0.189
0.475MetTrp: 0.475 ± 0.238
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
4.274AsnAla: 4.274 ± 0.382
0.475AsnCys: 0.475 ± 0.238
1.425AsnAsp: 1.425 ± 0.313
2.137AsnGlu: 2.137 ± 0.366
0.237AsnPhe: 0.237 ± 0.165
1.662AsnGly: 1.662 ± 0.427
0.475AsnHis: 0.475 ± 0.238
0.95AsnIle: 0.95 ± 0.454
1.187AsnLys: 1.187 ± 0.48
3.561AsnLeu: 3.561 ± 0.488
0.475AsnMet: 0.475 ± 0.238
1.425AsnAsn: 1.425 ± 0.491
2.849AsnPro: 2.849 ± 0.43
0.712AsnGln: 0.712 ± 0.322
0.475AsnArg: 0.475 ± 0.371
4.036AsnSer: 4.036 ± 0.965
1.187AsnThr: 1.187 ± 0.542
0.712AsnVal: 0.712 ± 0.761
0.95AsnTrp: 0.95 ± 0.29
1.187AsnTyr: 1.187 ± 0.495
0.0AsnXaa: 0.0 ± 0.0
Pro
1.662ProAla: 1.662 ± 0.189
0.237ProCys: 0.237 ± 0.254
1.899ProAsp: 1.899 ± 0.66
3.324ProGlu: 3.324 ± 0.901
2.137ProPhe: 2.137 ± 0.685
4.511ProGly: 4.511 ± 0.421
1.662ProHis: 1.662 ± 0.586
4.511ProIle: 4.511 ± 1.014
2.612ProLys: 2.612 ± 0.738
6.648ProLeu: 6.648 ± 1.053
1.425ProMet: 1.425 ± 0.363
1.425ProAsn: 1.425 ± 0.456
6.173ProPro: 6.173 ± 1.241
1.899ProGln: 1.899 ± 0.694
3.799ProArg: 3.799 ± 0.26
4.511ProSer: 4.511 ± 0.579
4.274ProThr: 4.274 ± 1.218
5.223ProVal: 5.223 ± 0.747
1.662ProTrp: 1.662 ± 0.153
4.036ProTyr: 4.036 ± 0.236
0.0ProXaa: 0.0 ± 0.0
Gln
2.849GlnAla: 2.849 ± 0.62
0.237GlnCys: 0.237 ± 0.254
4.036GlnAsp: 4.036 ± 0.583
3.086GlnGlu: 3.086 ± 0.5
1.899GlnPhe: 1.899 ± 0.51
5.223GlnGly: 5.223 ± 0.82
1.187GlnHis: 1.187 ± 0.42
1.899GlnIle: 1.899 ± 0.272
5.935GlnLys: 5.935 ± 1.277
3.799GlnLeu: 3.799 ± 0.996
0.237GlnMet: 0.237 ± 0.165
0.95GlnAsn: 0.95 ± 0.661
1.425GlnPro: 1.425 ± 0.496
1.187GlnGln: 1.187 ± 0.543
2.612GlnArg: 2.612 ± 0.271
3.324GlnSer: 3.324 ± 0.541
3.324GlnThr: 3.324 ± 0.857
1.899GlnVal: 1.899 ± 0.838
1.187GlnTrp: 1.187 ± 0.341
0.237GlnTyr: 0.237 ± 0.254
0.0GlnXaa: 0.0 ± 0.0
Arg
4.274ArgAla: 4.274 ± 1.003
0.95ArgCys: 0.95 ± 0.235
2.374ArgAsp: 2.374 ± 0.432
3.799ArgGlu: 3.799 ± 0.559
1.899ArgPhe: 1.899 ± 0.567
5.223ArgGly: 5.223 ± 0.858
0.712ArgHis: 0.712 ± 0.496
0.95ArgIle: 0.95 ± 0.258
6.41ArgLys: 6.41 ± 1.315
4.274ArgLeu: 4.274 ± 0.463
1.425ArgMet: 1.425 ± 0.724
0.712ArgAsn: 0.712 ± 0.579
3.086ArgPro: 3.086 ± 0.383
0.475ArgGln: 0.475 ± 0.241
2.849ArgArg: 2.849 ± 1.156
2.612ArgSer: 2.612 ± 0.896
2.849ArgThr: 2.849 ± 0.62
2.137ArgVal: 2.137 ± 0.406
1.662ArgTrp: 1.662 ± 0.574
0.712ArgTyr: 0.712 ± 0.579
0.0ArgXaa: 0.0 ± 0.0
Ser
6.648SerAla: 6.648 ± 0.552
1.187SerCys: 1.187 ± 0.414
5.461SerAsp: 5.461 ± 0.791
4.986SerGlu: 4.986 ± 0.816
2.137SerPhe: 2.137 ± 1.241
3.324SerGly: 3.324 ± 0.87
1.187SerHis: 1.187 ± 0.586
1.899SerIle: 1.899 ± 0.542
5.698SerLys: 5.698 ± 1.391
5.223SerLeu: 5.223 ± 0.516
0.475SerMet: 0.475 ± 0.305
1.187SerAsn: 1.187 ± 0.586
8.31SerPro: 8.31 ± 0.621
4.274SerGln: 4.274 ± 0.778
2.374SerArg: 2.374 ± 0.287
5.698SerSer: 5.698 ± 0.8
3.086SerThr: 3.086 ± 0.713
2.849SerVal: 2.849 ± 0.423
0.712SerTrp: 0.712 ± 0.322
2.374SerTyr: 2.374 ± 0.624
0.0SerXaa: 0.0 ± 0.0
Thr
5.461ThrAla: 5.461 ± 1.063
0.475ThrCys: 0.475 ± 0.196
3.561ThrAsp: 3.561 ± 0.226
4.748ThrGlu: 4.748 ± 0.931
4.274ThrPhe: 4.274 ± 0.612
6.173ThrGly: 6.173 ± 0.689
0.712ThrHis: 0.712 ± 0.496
0.95ThrIle: 0.95 ± 0.309
1.662ThrLys: 1.662 ± 0.601
6.173ThrLeu: 6.173 ± 0.523
2.137ThrMet: 2.137 ± 0.397
2.612ThrAsn: 2.612 ± 0.812
5.698ThrPro: 5.698 ± 1.077
1.425ThrGln: 1.425 ± 0.315
1.662ThrArg: 1.662 ± 0.281
2.612ThrSer: 2.612 ± 0.885
2.374ThrThr: 2.374 ± 0.178
2.849ThrVal: 2.849 ± 0.423
0.237ThrTrp: 0.237 ± 0.254
2.612ThrTyr: 2.612 ± 0.449
0.0ThrXaa: 0.0 ± 0.0
Val
3.086ValAla: 3.086 ± 0.729
0.712ValCys: 0.712 ± 0.262
4.036ValAsp: 4.036 ± 0.713
0.712ValGlu: 0.712 ± 0.464
1.899ValPhe: 1.899 ± 0.272
1.899ValGly: 1.899 ± 0.471
1.899ValHis: 1.899 ± 0.477
2.849ValIle: 2.849 ± 0.84
6.648ValLys: 6.648 ± 0.875
8.072ValLeu: 8.072 ± 0.665
0.95ValMet: 0.95 ± 0.255
1.899ValAsn: 1.899 ± 0.694
1.899ValPro: 1.899 ± 0.66
3.561ValGln: 3.561 ± 0.694
2.612ValArg: 2.612 ± 0.36
5.461ValSer: 5.461 ± 0.384
4.036ValThr: 4.036 ± 0.441
2.849ValVal: 2.849 ± 0.551
0.95ValTrp: 0.95 ± 0.255
0.712ValTyr: 0.712 ± 0.262
0.0ValXaa: 0.0 ± 0.0
Trp
0.237TrpAla: 0.237 ± 0.254
0.237TrpCys: 0.237 ± 0.262
1.187TrpAsp: 1.187 ± 0.347
2.612TrpGlu: 2.612 ± 0.714
1.187TrpPhe: 1.187 ± 0.414
1.425TrpGly: 1.425 ± 0.315
0.712TrpHis: 0.712 ± 0.262
0.475TrpIle: 0.475 ± 0.331
2.612TrpLys: 2.612 ± 0.806
2.374TrpLeu: 2.374 ± 0.377
0.0TrpMet: 0.0 ± 0.0
1.187TrpAsn: 1.187 ± 0.13
1.425TrpPro: 1.425 ± 0.584
1.425TrpGln: 1.425 ± 0.315
1.662TrpArg: 1.662 ± 0.49
0.237TrpSer: 0.237 ± 0.165
0.237TrpThr: 0.237 ± 0.254
1.187TrpVal: 1.187 ± 0.264
0.237TrpTrp: 0.237 ± 0.262
0.237TrpTyr: 0.237 ± 0.254
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.086TyrAla: 3.086 ± 0.44
0.0TyrCys: 0.0 ± 0.0
1.899TyrAsp: 1.899 ± 0.272
2.612TyrGlu: 2.612 ± 0.706
0.237TyrPhe: 0.237 ± 0.254
1.662TyrGly: 1.662 ± 0.572
1.425TyrHis: 1.425 ± 0.524
2.374TyrIle: 2.374 ± 0.725
0.95TyrLys: 0.95 ± 0.498
1.662TyrLeu: 1.662 ± 0.654
0.475TyrMet: 0.475 ± 0.331
0.95TyrAsn: 0.95 ± 0.505
1.187TyrPro: 1.187 ± 0.414
1.425TyrGln: 1.425 ± 0.471
1.425TyrArg: 1.425 ± 0.813
1.187TyrSer: 1.187 ± 0.297
2.612TyrThr: 2.612 ± 0.483
1.899TyrVal: 1.899 ± 0.339
0.237TyrTrp: 0.237 ± 0.254
0.475TyrTyr: 0.475 ± 0.241
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5 proteins (4213 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski