Amino acid dipepetide frequency for Parapedobacter luteus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.992AlaAla: 7.992 ± 0.094
0.782AlaCys: 0.782 ± 0.023
5.225AlaAsp: 5.225 ± 0.067
5.046AlaGlu: 5.046 ± 0.07
3.913AlaPhe: 3.913 ± 0.059
6.503AlaGly: 6.503 ± 0.083
1.676AlaHis: 1.676 ± 0.035
5.721AlaIle: 5.721 ± 0.069
4.075AlaLys: 4.075 ± 0.063
8.396AlaLeu: 8.396 ± 0.09
2.036AlaMet: 2.036 ± 0.042
3.843AlaAsn: 3.843 ± 0.056
2.759AlaPro: 2.759 ± 0.046
3.28AlaGln: 3.28 ± 0.054
3.778AlaArg: 3.778 ± 0.056
4.949AlaSer: 4.949 ± 0.065
4.574AlaThr: 4.574 ± 0.061
6.002AlaVal: 6.002 ± 0.069
1.109AlaTrp: 1.109 ± 0.031
3.442AlaTyr: 3.442 ± 0.052
0.0AlaXaa: 0.0 ± 0.0
Cys
0.549CysAla: 0.549 ± 0.02
0.152CysCys: 0.152 ± 0.011
0.393CysAsp: 0.393 ± 0.017
0.362CysGlu: 0.362 ± 0.016
0.377CysPhe: 0.377 ± 0.018
0.639CysGly: 0.639 ± 0.025
0.194CysHis: 0.194 ± 0.011
0.551CysIle: 0.551 ± 0.018
0.306CysLys: 0.306 ± 0.015
0.757CysLeu: 0.757 ± 0.027
0.195CysMet: 0.195 ± 0.012
0.29CysAsn: 0.29 ± 0.016
0.299CysPro: 0.299 ± 0.015
0.245CysGln: 0.245 ± 0.014
0.409CysArg: 0.409 ± 0.017
0.464CysSer: 0.464 ± 0.018
0.44CysThr: 0.44 ± 0.018
0.465CysVal: 0.465 ± 0.018
0.093CysTrp: 0.093 ± 0.008
0.314CysTyr: 0.314 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
4.532AspAla: 4.532 ± 0.061
0.34AspCys: 0.34 ± 0.015
2.95AspAsp: 2.95 ± 0.049
3.831AspGlu: 3.831 ± 0.052
2.965AspPhe: 2.965 ± 0.05
4.755AspGly: 4.755 ± 0.072
1.141AspHis: 1.141 ± 0.031
3.919AspIle: 3.919 ± 0.052
2.76AspLys: 2.76 ± 0.052
4.777AspLeu: 4.777 ± 0.06
1.236AspMet: 1.236 ± 0.027
2.58AspAsn: 2.58 ± 0.045
2.231AspPro: 2.231 ± 0.045
1.69AspGln: 1.69 ± 0.034
3.06AspArg: 3.06 ± 0.047
2.936AspSer: 2.936 ± 0.051
2.934AspThr: 2.934 ± 0.052
3.81AspVal: 3.81 ± 0.054
0.897AspTrp: 0.897 ± 0.024
2.557AspTyr: 2.557 ± 0.042
0.0AspXaa: 0.0 ± 0.0
Glu
5.29GluAla: 5.29 ± 0.074
0.306GluCys: 0.306 ± 0.014
2.767GluAsp: 2.767 ± 0.045
3.724GluGlu: 3.724 ± 0.058
2.028GluPhe: 2.028 ± 0.036
3.689GluGly: 3.689 ± 0.051
1.306GluHis: 1.306 ± 0.034
3.794GluIle: 3.794 ± 0.057
3.48GluLys: 3.48 ± 0.057
5.749GluLeu: 5.749 ± 0.066
1.354GluMet: 1.354 ± 0.027
2.831GluAsn: 2.831 ± 0.045
1.932GluPro: 1.932 ± 0.039
2.727GluGln: 2.727 ± 0.045
3.705GluArg: 3.705 ± 0.06
2.857GluSer: 2.857 ± 0.049
3.054GluThr: 3.054 ± 0.044
4.031GluVal: 4.031 ± 0.055
0.753GluTrp: 0.753 ± 0.022
2.022GluTyr: 2.022 ± 0.036
0.0GluXaa: 0.0 ± 0.0
Phe
3.666PheAla: 3.666 ± 0.06
0.404PheCys: 0.404 ± 0.017
2.958PheAsp: 2.958 ± 0.044
2.616PheGlu: 2.616 ± 0.047
2.429PhePhe: 2.429 ± 0.05
3.662PheGly: 3.662 ± 0.051
0.95PheHis: 0.95 ± 0.027
2.923PheIle: 2.923 ± 0.049
2.116PheLys: 2.116 ± 0.044
4.098PheLeu: 4.098 ± 0.063
1.083PheMet: 1.083 ± 0.027
2.405PheAsn: 2.405 ± 0.044
1.803PhePro: 1.803 ± 0.032
1.431PheGln: 1.431 ± 0.032
2.357PheArg: 2.357 ± 0.043
3.352PheSer: 3.352 ± 0.05
2.712PheThr: 2.712 ± 0.053
3.06PheVal: 3.06 ± 0.045
0.577PheTrp: 0.577 ± 0.022
1.872PheTyr: 1.872 ± 0.037
0.0PheXaa: 0.0 ± 0.0
Gly
5.408GlyAla: 5.408 ± 0.074
0.61GlyCys: 0.61 ± 0.022
3.885GlyAsp: 3.885 ± 0.062
3.854GlyGlu: 3.854 ± 0.048
3.547GlyPhe: 3.547 ± 0.05
5.496GlyGly: 5.496 ± 0.078
1.511GlyHis: 1.511 ± 0.033
5.484GlyIle: 5.484 ± 0.064
4.326GlyLys: 4.326 ± 0.058
6.912GlyLeu: 6.912 ± 0.079
1.925GlyMet: 1.925 ± 0.036
3.629GlyAsn: 3.629 ± 0.066
1.909GlyPro: 1.909 ± 0.041
2.767GlyGln: 2.767 ± 0.044
3.835GlyArg: 3.835 ± 0.052
4.356GlySer: 4.356 ± 0.062
4.438GlyThr: 4.438 ± 0.069
5.055GlyVal: 5.055 ± 0.065
1.112GlyTrp: 1.112 ± 0.027
3.481GlyTyr: 3.481 ± 0.054
0.0GlyXaa: 0.0 ± 0.0
His
1.743HisAla: 1.743 ± 0.038
0.215HisCys: 0.215 ± 0.012
1.089HisAsp: 1.089 ± 0.027
1.227HisGlu: 1.227 ± 0.032
1.177HisPhe: 1.177 ± 0.031
1.564HisGly: 1.564 ± 0.033
0.67HisHis: 0.67 ± 0.022
1.541HisIle: 1.541 ± 0.035
0.799HisLys: 0.799 ± 0.025
2.029HisLeu: 2.029 ± 0.039
0.421HisMet: 0.421 ± 0.016
0.907HisAsn: 0.907 ± 0.024
1.246HisPro: 1.246 ± 0.031
0.895HisGln: 0.895 ± 0.023
1.334HisArg: 1.334 ± 0.029
1.096HisSer: 1.096 ± 0.027
1.212HisThr: 1.212 ± 0.031
1.417HisVal: 1.417 ± 0.033
0.339HisTrp: 0.339 ± 0.017
1.022HisTyr: 1.022 ± 0.03
0.0HisXaa: 0.0 ± 0.0
Ile
6.209IleAla: 6.209 ± 0.062
0.578IleCys: 0.578 ± 0.019
4.005IleAsp: 4.005 ± 0.056
3.616IleGlu: 3.616 ± 0.053
2.511IlePhe: 2.511 ± 0.05
5.007IleGly: 5.007 ± 0.06
1.421IleHis: 1.421 ± 0.034
4.016IleIle: 4.016 ± 0.066
3.287IleLys: 3.287 ± 0.052
5.268IleLeu: 5.268 ± 0.064
1.192IleMet: 1.192 ± 0.029
3.356IleAsn: 3.356 ± 0.054
3.126IlePro: 3.126 ± 0.048
2.272IleGln: 2.272 ± 0.04
3.729IleArg: 3.729 ± 0.057
4.175IleSer: 4.175 ± 0.061
3.907IleThr: 3.907 ± 0.052
4.096IleVal: 4.096 ± 0.06
0.694IleTrp: 0.694 ± 0.025
2.279IleTyr: 2.279 ± 0.045
0.0IleXaa: 0.0 ± 0.0
Lys
4.415LysAla: 4.415 ± 0.064
0.233LysCys: 0.233 ± 0.012
2.784LysAsp: 2.784 ± 0.048
3.24LysGlu: 3.24 ± 0.059
1.654LysPhe: 1.654 ± 0.034
3.545LysGly: 3.545 ± 0.053
1.185LysHis: 1.185 ± 0.027
3.062LysIle: 3.062 ± 0.056
3.131LysLys: 3.131 ± 0.058
4.712LysLeu: 4.712 ± 0.066
1.168LysMet: 1.168 ± 0.034
2.419LysAsn: 2.419 ± 0.045
2.251LysPro: 2.251 ± 0.051
2.257LysGln: 2.257 ± 0.044
2.992LysArg: 2.992 ± 0.042
2.717LysSer: 2.717 ± 0.048
3.082LysThr: 3.082 ± 0.047
3.165LysVal: 3.165 ± 0.047
0.627LysTrp: 0.627 ± 0.022
1.855LysTyr: 1.855 ± 0.036
0.0LysXaa: 0.0 ± 0.0
Leu
8.595LeuAla: 8.595 ± 0.091
0.805LeuCys: 0.805 ± 0.026
5.298LeuAsp: 5.298 ± 0.062
5.049LeuGlu: 5.049 ± 0.068
4.687LeuPhe: 4.687 ± 0.076
6.396LeuGly: 6.396 ± 0.071
2.128LeuHis: 2.128 ± 0.044
5.763LeuIle: 5.763 ± 0.081
5.095LeuLys: 5.095 ± 0.065
10.139LeuLeu: 10.139 ± 0.11
2.19LeuMet: 2.19 ± 0.043
4.597LeuAsn: 4.597 ± 0.07
4.508LeuPro: 4.508 ± 0.059
3.657LeuGln: 3.657 ± 0.044
5.041LeuArg: 5.041 ± 0.068
6.509LeuSer: 6.509 ± 0.076
5.408LeuThr: 5.408 ± 0.066
6.151LeuVal: 6.151 ± 0.068
1.089LeuTrp: 1.089 ± 0.031
3.467LeuTyr: 3.467 ± 0.05
0.0LeuXaa: 0.0 ± 0.0
Met
2.175MetAla: 2.175 ± 0.034
0.133MetCys: 0.133 ± 0.01
1.315MetAsp: 1.315 ± 0.028
1.493MetGlu: 1.493 ± 0.034
0.72MetPhe: 0.72 ± 0.024
1.648MetGly: 1.648 ± 0.039
0.445MetHis: 0.445 ± 0.016
1.169MetIle: 1.169 ± 0.03
1.465MetLys: 1.465 ± 0.029
2.244MetLeu: 2.244 ± 0.042
0.609MetMet: 0.609 ± 0.02
1.11MetAsn: 1.11 ± 0.028
1.101MetPro: 1.101 ± 0.028
0.953MetGln: 0.953 ± 0.02
1.259MetArg: 1.259 ± 0.029
1.193MetSer: 1.193 ± 0.033
1.184MetThr: 1.184 ± 0.025
1.552MetVal: 1.552 ± 0.034
0.213MetTrp: 0.213 ± 0.013
0.642MetTyr: 0.642 ± 0.021
0.0MetXaa: 0.0 ± 0.0
Asn
3.774AsnAla: 3.774 ± 0.051
0.26AsnCys: 0.26 ± 0.014
2.424AsnAsp: 2.424 ± 0.048
2.726AsnGlu: 2.726 ± 0.046
2.117AsnPhe: 2.117 ± 0.042
3.638AsnGly: 3.638 ± 0.061
1.04AsnHis: 1.04 ± 0.026
3.156AsnIle: 3.156 ± 0.052
2.219AsnLys: 2.219 ± 0.04
4.14AsnLeu: 4.14 ± 0.061
1.017AsnMet: 1.017 ± 0.024
2.417AsnAsn: 2.417 ± 0.055
2.687AsnPro: 2.687 ± 0.047
1.766AsnGln: 1.766 ± 0.036
2.862AsnArg: 2.862 ± 0.052
2.514AsnSer: 2.514 ± 0.046
2.89AsnThr: 2.89 ± 0.052
3.03AsnVal: 3.03 ± 0.056
0.671AsnTrp: 0.671 ± 0.02
2.004AsnTyr: 2.004 ± 0.046
0.0AsnXaa: 0.0 ± 0.0
Pro
3.635ProAla: 3.635 ± 0.056
0.242ProCys: 0.242 ± 0.012
2.994ProAsp: 2.994 ± 0.046
3.025ProGlu: 3.025 ± 0.049
1.988ProPhe: 1.988 ± 0.034
3.079ProGly: 3.079 ± 0.05
0.904ProHis: 0.904 ± 0.023
2.558ProIle: 2.558 ± 0.042
1.735ProLys: 1.735 ± 0.037
3.894ProLeu: 3.894 ± 0.055
0.904ProMet: 0.904 ± 0.024
1.944ProAsn: 1.944 ± 0.034
1.364ProPro: 1.364 ± 0.038
1.581ProGln: 1.581 ± 0.035
1.582ProArg: 1.582 ± 0.032
2.362ProSer: 2.362 ± 0.04
2.148ProThr: 2.148 ± 0.039
3.188ProVal: 3.188 ± 0.048
0.486ProTrp: 0.486 ± 0.022
1.74ProTyr: 1.74 ± 0.04
0.0ProXaa: 0.0 ± 0.0
Gln
3.306GlnAla: 3.306 ± 0.05
0.197GlnCys: 0.197 ± 0.012
1.698GlnAsp: 1.698 ± 0.038
2.16GlnGlu: 2.16 ± 0.038
1.629GlnPhe: 1.629 ± 0.035
2.463GlnGly: 2.463 ± 0.04
1.129GlnHis: 1.129 ± 0.031
2.098GlnIle: 2.098 ± 0.039
1.734GlnLys: 1.734 ± 0.04
4.497GlnLeu: 4.497 ± 0.058
0.786GlnMet: 0.786 ± 0.023
1.535GlnAsn: 1.535 ± 0.037
1.715GlnPro: 1.715 ± 0.035
2.423GlnGln: 2.423 ± 0.047
2.469GlnArg: 2.469 ± 0.045
2.041GlnSer: 2.041 ± 0.039
2.106GlnThr: 2.106 ± 0.037
2.515GlnVal: 2.515 ± 0.04
0.554GlnTrp: 0.554 ± 0.019
1.645GlnTyr: 1.645 ± 0.038
0.0GlnXaa: 0.0 ± 0.0
Arg
3.722ArgAla: 3.722 ± 0.058
0.318ArgCys: 0.318 ± 0.016
2.692ArgAsp: 2.692 ± 0.039
3.117ArgGlu: 3.117 ± 0.045
2.881ArgPhe: 2.881 ± 0.045
3.169ArgGly: 3.169 ± 0.048
1.253ArgHis: 1.253 ± 0.034
3.987ArgIle: 3.987 ± 0.053
3.062ArgLys: 3.062 ± 0.055
5.521ArgLeu: 5.521 ± 0.055
1.464ArgMet: 1.464 ± 0.034
2.63ArgAsn: 2.63 ± 0.045
2.038ArgPro: 2.038 ± 0.038
2.4ArgGln: 2.4 ± 0.04
2.948ArgArg: 2.948 ± 0.055
2.838ArgSer: 2.838 ± 0.051
2.709ArgThr: 2.709 ± 0.046
3.282ArgVal: 3.282 ± 0.054
0.872ArgTrp: 0.872 ± 0.023
2.711ArgTyr: 2.711 ± 0.049
0.0ArgXaa: 0.0 ± 0.0
Ser
4.969SerAla: 4.969 ± 0.065
0.515SerCys: 0.515 ± 0.019
3.037SerAsp: 3.037 ± 0.05
2.951SerGlu: 2.951 ± 0.047
3.057SerPhe: 3.057 ± 0.046
5.007SerGly: 5.007 ± 0.073
1.155SerHis: 1.155 ± 0.031
3.854SerIle: 3.854 ± 0.054
2.623SerLys: 2.623 ± 0.04
5.968SerLeu: 5.968 ± 0.065
1.278SerMet: 1.278 ± 0.027
2.629SerAsn: 2.629 ± 0.05
2.518SerPro: 2.518 ± 0.039
1.905SerGln: 1.905 ± 0.035
3.072SerArg: 3.072 ± 0.046
3.558SerSer: 3.558 ± 0.068
3.258SerThr: 3.258 ± 0.051
4.093SerVal: 4.093 ± 0.06
0.791SerTrp: 0.791 ± 0.022
2.52SerTyr: 2.52 ± 0.045
0.0SerXaa: 0.0 ± 0.0
Thr
5.108ThrAla: 5.108 ± 0.071
0.348ThrCys: 0.348 ± 0.016
3.299ThrAsp: 3.299 ± 0.047
2.858ThrGlu: 2.858 ± 0.049
2.681ThrPhe: 2.681 ± 0.047
4.675ThrGly: 4.675 ± 0.066
1.162ThrHis: 1.162 ± 0.026
3.793ThrIle: 3.793 ± 0.052
2.461ThrLys: 2.461 ± 0.043
5.532ThrLeu: 5.532 ± 0.075
1.074ThrMet: 1.074 ± 0.025
2.407ThrAsn: 2.407 ± 0.053
2.749ThrPro: 2.749 ± 0.048
1.846ThrGln: 1.846 ± 0.039
2.385ThrArg: 2.385 ± 0.037
3.117ThrSer: 3.117 ± 0.05
3.195ThrThr: 3.195 ± 0.054
4.255ThrVal: 4.255 ± 0.068
0.731ThrTrp: 0.731 ± 0.025
2.436ThrTyr: 2.436 ± 0.044
0.0ThrXaa: 0.0 ± 0.0
Val
5.816ValAla: 5.816 ± 0.08
0.611ValCys: 0.611 ± 0.022
4.013ValAsp: 4.013 ± 0.057
3.586ValGlu: 3.586 ± 0.059
3.394ValPhe: 3.394 ± 0.052
4.541ValGly: 4.541 ± 0.059
1.291ValHis: 1.291 ± 0.028
4.331ValIle: 4.331 ± 0.057
3.314ValLys: 3.314 ± 0.046
6.566ValLeu: 6.566 ± 0.071
1.503ValMet: 1.503 ± 0.032
3.203ValAsn: 3.203 ± 0.047
2.848ValPro: 2.848 ± 0.038
2.234ValGln: 2.234 ± 0.035
3.307ValArg: 3.307 ± 0.047
4.645ValSer: 4.645 ± 0.063
3.784ValThr: 3.784 ± 0.076
5.176ValVal: 5.176 ± 0.068
0.819ValTrp: 0.819 ± 0.027
2.623ValTyr: 2.623 ± 0.045
0.0ValXaa: 0.0 ± 0.0
Trp
0.942TrpAla: 0.942 ± 0.028
0.125TrpCys: 0.125 ± 0.009
0.703TrpAsp: 0.703 ± 0.024
0.773TrpGlu: 0.773 ± 0.024
0.594TrpPhe: 0.594 ± 0.024
1.03TrpGly: 1.03 ± 0.03
0.312TrpHis: 0.312 ± 0.015
0.743TrpIle: 0.743 ± 0.025
0.728TrpLys: 0.728 ± 0.023
1.425TrpLeu: 1.425 ± 0.034
0.411TrpMet: 0.411 ± 0.016
0.626TrpAsn: 0.626 ± 0.023
0.43TrpPro: 0.43 ± 0.02
0.639TrpGln: 0.639 ± 0.021
0.744TrpArg: 0.744 ± 0.023
0.719TrpSer: 0.719 ± 0.024
0.623TrpThr: 0.623 ± 0.026
0.863TrpVal: 0.863 ± 0.032
0.253TrpTrp: 0.253 ± 0.015
0.536TrpTyr: 0.536 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.254TyrAla: 3.254 ± 0.047
0.322TyrCys: 0.322 ± 0.013
2.371TyrAsp: 2.371 ± 0.046
2.142TyrGlu: 2.142 ± 0.038
2.125TyrPhe: 2.125 ± 0.043
3.037TyrGly: 3.037 ± 0.049
1.071TyrHis: 1.071 ± 0.026
2.282TyrIle: 2.282 ± 0.039
1.778TyrLys: 1.778 ± 0.033
3.949TyrLeu: 3.949 ± 0.052
0.774TyrMet: 0.774 ± 0.024
1.995TyrAsn: 1.995 ± 0.043
1.839TyrPro: 1.839 ± 0.038
1.734TyrGln: 1.734 ± 0.04
2.747TyrArg: 2.747 ± 0.048
2.36TyrSer: 2.36 ± 0.041
2.45TyrThr: 2.45 ± 0.053
2.399TyrVal: 2.399 ± 0.04
0.539TyrTrp: 0.539 ± 0.021
1.831TyrTyr: 1.831 ± 0.042
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4124 proteins (1476030 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski