Amino acid dipepetide frequency for Bacillus saganii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.234AlaAla: 7.234 ± 0.119	0.626AlaCys: 0.626 ± 0.024	3.679AlaAsp: 3.679 ± 0.057	5.445AlaGlu: 5.445 ± 0.082	3.259AlaPhe: 3.259 ± 0.058	6.108AlaGly: 6.108 ± 0.079	1.277AlaHis: 1.277 ± 0.035	6.024AlaIle: 6.024 ± 0.085	4.901AlaLys: 4.901 ± 0.079	7.153AlaLeu: 7.153 ± 0.086	2.128AlaMet: 2.128 ± 0.045	2.772AlaAsn: 2.772 ± 0.055	2.193AlaPro: 2.193 ± 0.049	2.263AlaGln: 2.263 ± 0.044	2.935AlaArg: 2.935 ± 0.062	4.49AlaSer: 4.49 ± 0.074	3.227AlaThr: 3.227 ± 0.058	5.851AlaVal: 5.851 ± 0.076	0.569AlaTrp: 0.569 ± 0.019	2.219AlaTyr: 2.219 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	0.47CysAla: 0.47 ± 0.021	0.112CysCys: 0.112 ± 0.011	0.406CysAsp: 0.406 ± 0.019	0.456CysGlu: 0.456 ± 0.02	0.321CysPhe: 0.321 ± 0.017	0.695CysGly: 0.695 ± 0.027	0.186CysHis: 0.186 ± 0.014	0.527CysIle: 0.527 ± 0.021	0.392CysLys: 0.392 ± 0.017	0.683CysLeu: 0.683 ± 0.025	0.177CysMet: 0.177 ± 0.013	0.3CysAsn: 0.3 ± 0.017	0.369CysPro: 0.369 ± 0.018	0.223CysGln: 0.223 ± 0.015	0.312CysArg: 0.312 ± 0.017	0.526CysSer: 0.526 ± 0.019	0.394CysThr: 0.394 ± 0.021	0.399CysVal: 0.399 ± 0.019	0.071CysTrp: 0.071 ± 0.008	0.265CysTyr: 0.265 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	3.287AspAla: 3.287 ± 0.06	0.372AspCys: 0.372 ± 0.019	2.274AspAsp: 2.274 ± 0.049	4.159AspGlu: 4.159 ± 0.071	2.459AspPhe: 2.459 ± 0.045	3.294AspGly: 3.294 ± 0.069	1.002AspHis: 1.002 ± 0.028	4.309AspIle: 4.309 ± 0.061	3.216AspLys: 3.216 ± 0.059	4.9AspLeu: 4.9 ± 0.068	1.35AspMet: 1.35 ± 0.034	1.933AspAsn: 1.933 ± 0.047	1.903AspPro: 1.903 ± 0.042	1.788AspGln: 1.788 ± 0.044	2.291AspArg: 2.291 ± 0.046	2.769AspSer: 2.769 ± 0.054	2.426AspThr: 2.426 ± 0.045	3.409AspVal: 3.409 ± 0.055	0.58AspTrp: 0.58 ± 0.023	1.993AspTyr: 1.993 ± 0.043	0.0AspXaa: 0.0 ± 0.0
Glu	5.768GluAla: 5.768 ± 0.082	0.393GluCys: 0.393 ± 0.02	3.637GluAsp: 3.637 ± 0.06	6.875GluGlu: 6.875 ± 0.1	2.696GluPhe: 2.696 ± 0.047	4.373GluGly: 4.373 ± 0.063	1.441GluHis: 1.441 ± 0.032	5.952GluIle: 5.952 ± 0.081	6.63GluLys: 6.63 ± 0.079	7.104GluLeu: 7.104 ± 0.087	2.308GluMet: 2.308 ± 0.049	3.74GluAsn: 3.74 ± 0.066	1.986GluPro: 1.986 ± 0.05	3.314GluGln: 3.314 ± 0.059	3.526GluArg: 3.526 ± 0.065	3.742GluSer: 3.742 ± 0.063	3.927GluThr: 3.927 ± 0.061	4.873GluVal: 4.873 ± 0.071	0.773GluTrp: 0.773 ± 0.027	2.278GluTyr: 2.278 ± 0.049	0.0GluXaa: 0.0 ± 0.0
Phe	3.088PheAla: 3.088 ± 0.057	0.385PheCys: 0.385 ± 0.019	2.254PheAsp: 2.254 ± 0.051	2.849PheGlu: 2.849 ± 0.049	2.285PhePhe: 2.285 ± 0.05	3.268PheGly: 3.268 ± 0.06	0.988PheHis: 0.988 ± 0.033	3.832PheIle: 3.832 ± 0.073	2.405PheLys: 2.405 ± 0.045	4.617PheLeu: 4.617 ± 0.074	1.151PheMet: 1.151 ± 0.034	1.848PheAsn: 1.848 ± 0.039	1.698PhePro: 1.698 ± 0.037	1.603PheGln: 1.603 ± 0.033	1.651PheArg: 1.651 ± 0.041	3.337PheSer: 3.337 ± 0.059	2.526PheThr: 2.526 ± 0.052	2.914PheVal: 2.914 ± 0.051	0.471PheTrp: 0.471 ± 0.022	1.62PheTyr: 1.62 ± 0.037	0.0PheXaa: 0.0 ± 0.0
Gly	4.942GlyAla: 4.942 ± 0.081	0.621GlyCys: 0.621 ± 0.027	3.231GlyAsp: 3.231 ± 0.058	4.542GlyGlu: 4.542 ± 0.065	3.464GlyPhe: 3.464 ± 0.072	5.036GlyGly: 5.036 ± 0.088	1.393GlyHis: 1.393 ± 0.039	6.218GlyIle: 6.218 ± 0.09	5.266GlyLys: 5.266 ± 0.069	6.721GlyLeu: 6.721 ± 0.084	2.142GlyMet: 2.142 ± 0.044	2.94GlyAsn: 2.94 ± 0.053	1.81GlyPro: 1.81 ± 0.046	2.297GlyGln: 2.297 ± 0.052	2.969GlyArg: 2.969 ± 0.059	4.309GlySer: 4.309 ± 0.063	4.164GlyThr: 4.164 ± 0.064	4.89GlyVal: 4.89 ± 0.073	0.778GlyTrp: 0.778 ± 0.027	2.802GlyTyr: 2.802 ± 0.052	0.0GlyXaa: 0.0 ± 0.0
His	1.256HisAla: 1.256 ± 0.035	0.208HisCys: 0.208 ± 0.012	0.944HisAsp: 0.944 ± 0.027	1.325HisGlu: 1.325 ± 0.033	1.101HisPhe: 1.101 ± 0.034	1.393HisGly: 1.393 ± 0.036	0.565HisHis: 0.565 ± 0.024	1.475HisIle: 1.475 ± 0.036	1.045HisLys: 1.045 ± 0.028	2.007HisLeu: 2.007 ± 0.047	0.505HisMet: 0.505 ± 0.023	0.824HisAsn: 0.824 ± 0.026	1.125HisPro: 1.125 ± 0.033	0.757HisGln: 0.757 ± 0.027	0.872HisArg: 0.872 ± 0.03	1.327HisSer: 1.327 ± 0.035	1.016HisThr: 1.016 ± 0.03	1.293HisVal: 1.293 ± 0.031	0.195HisTrp: 0.195 ± 0.013	0.771HisTyr: 0.771 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	6.173IleAla: 6.173 ± 0.079	0.669IleCys: 0.669 ± 0.027	4.144IleAsp: 4.144 ± 0.06	5.69IleGlu: 5.69 ± 0.079	3.214IlePhe: 3.214 ± 0.062	5.945IleGly: 5.945 ± 0.092	1.642IleHis: 1.642 ± 0.035	6.037IleIle: 6.037 ± 0.086	4.842IleLys: 4.842 ± 0.07	7.198IleLeu: 7.198 ± 0.093	1.918IleMet: 1.918 ± 0.047	3.451IleAsn: 3.451 ± 0.062	3.472IlePro: 3.472 ± 0.062	2.862IleGln: 2.862 ± 0.048	3.236IleArg: 3.236 ± 0.053	5.588IleSer: 5.588 ± 0.085	4.619IleThr: 4.619 ± 0.063	5.33IleVal: 5.33 ± 0.067	0.582IleTrp: 0.582 ± 0.022	2.4IleTyr: 2.4 ± 0.05	0.0IleXaa: 0.0 ± 0.0
Lys	4.982LysAla: 4.982 ± 0.071	0.336LysCys: 0.336 ± 0.019	3.696LysAsp: 3.696 ± 0.067	6.613LysGlu: 6.613 ± 0.078	1.984LysPhe: 1.984 ± 0.048	4.695LysGly: 4.695 ± 0.069	1.335LysHis: 1.335 ± 0.036	4.983LysIle: 4.983 ± 0.071	5.719LysLys: 5.719 ± 0.078	5.978LysLeu: 5.978 ± 0.083	2.258LysMet: 2.258 ± 0.041	3.387LysAsn: 3.387 ± 0.057	2.326LysPro: 2.326 ± 0.053	3.007LysGln: 3.007 ± 0.054	3.35LysArg: 3.35 ± 0.054	3.61LysSer: 3.61 ± 0.057	3.727LysThr: 3.727 ± 0.058	4.571LysVal: 4.571 ± 0.07	0.756LysTrp: 0.756 ± 0.03	2.115LysTyr: 2.115 ± 0.047	0.0LysXaa: 0.0 ± 0.0
Leu	7.572LeuAla: 7.572 ± 0.086	0.653LeuCys: 0.653 ± 0.024	4.769LeuAsp: 4.769 ± 0.071	6.8LeuGlu: 6.8 ± 0.086	4.669LeuPhe: 4.669 ± 0.084	6.519LeuGly: 6.519 ± 0.083	1.905LeuHis: 1.905 ± 0.044	7.22LeuIle: 7.22 ± 0.1	6.777LeuLys: 6.777 ± 0.086	10.024LeuLeu: 10.024 ± 0.145	2.414LeuMet: 2.414 ± 0.051	4.224LeuAsn: 4.224 ± 0.059	3.961LeuPro: 3.961 ± 0.052	3.54LeuGln: 3.54 ± 0.062	3.746LeuArg: 3.746 ± 0.057	6.823LeuSer: 6.823 ± 0.082	5.355LeuThr: 5.355 ± 0.08	5.926LeuVal: 5.926 ± 0.085	0.762LeuTrp: 0.762 ± 0.025	2.987LeuTyr: 2.987 ± 0.059	0.0LeuXaa: 0.0 ± 0.0
Met	2.25MetAla: 2.25 ± 0.046	0.152MetCys: 0.152 ± 0.011	1.531MetAsp: 1.531 ± 0.036	2.098MetGlu: 2.098 ± 0.051	1.068MetPhe: 1.068 ± 0.03	1.82MetGly: 1.82 ± 0.039	0.425MetHis: 0.425 ± 0.018	2.032MetIle: 2.032 ± 0.045	2.427MetLys: 2.427 ± 0.046	2.546MetLeu: 2.546 ± 0.049	0.788MetMet: 0.788 ± 0.026	1.487MetAsn: 1.487 ± 0.04	1.034MetPro: 1.034 ± 0.035	0.864MetGln: 0.864 ± 0.03	1.063MetArg: 1.063 ± 0.025	1.638MetSer: 1.638 ± 0.036	1.531MetThr: 1.531 ± 0.036	1.825MetVal: 1.825 ± 0.045	0.174MetTrp: 0.174 ± 0.013	0.679MetTyr: 0.679 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	2.959AsnAla: 2.959 ± 0.063	0.316AsnCys: 0.316 ± 0.018	2.119AsnAsp: 2.119 ± 0.053	3.476AsnGlu: 3.476 ± 0.062	1.674AsnPhe: 1.674 ± 0.047	3.444AsnGly: 3.444 ± 0.066	0.967AsnHis: 0.967 ± 0.03	3.465AsnIle: 3.465 ± 0.055	2.928AsnLys: 2.928 ± 0.055	3.841AsnLeu: 3.841 ± 0.061	1.153AsnMet: 1.153 ± 0.035	2.029AsnAsn: 2.029 ± 0.055	2.318AsnPro: 2.318 ± 0.046	1.777AsnGln: 1.777 ± 0.048	2.123AsnArg: 2.123 ± 0.036	2.695AsnSer: 2.695 ± 0.053	2.156AsnThr: 2.156 ± 0.044	2.89AsnVal: 2.89 ± 0.054	0.491AsnTrp: 0.491 ± 0.02	1.39AsnTyr: 1.39 ± 0.039	0.0AsnXaa: 0.0 ± 0.0
Pro	2.779ProAla: 2.779 ± 0.057	0.214ProCys: 0.214 ± 0.013	2.078ProAsp: 2.078 ± 0.05	3.148ProGlu: 3.148 ± 0.063	2.007ProPhe: 2.007 ± 0.045	2.694ProGly: 2.694 ± 0.062	0.762ProHis: 0.762 ± 0.028	2.787ProIle: 2.787 ± 0.046	2.167ProLys: 2.167 ± 0.048	3.484ProLeu: 3.484 ± 0.062	0.788ProMet: 0.788 ± 0.03	1.63ProAsn: 1.63 ± 0.035	1.076ProPro: 1.076 ± 0.031	1.181ProGln: 1.181 ± 0.035	1.229ProArg: 1.229 ± 0.033	2.347ProSer: 2.347 ± 0.046	1.716ProThr: 1.716 ± 0.042	3.052ProVal: 3.052 ± 0.049	0.357ProTrp: 0.357 ± 0.017	1.38ProTyr: 1.38 ± 0.043	0.0ProXaa: 0.0 ± 0.0
Gln	2.801GlnAla: 2.801 ± 0.059	0.215GlnCys: 0.215 ± 0.014	1.624GlnAsp: 1.624 ± 0.045	2.91GlnGlu: 2.91 ± 0.059	1.555GlnPhe: 1.555 ± 0.043	2.221GlnGly: 2.221 ± 0.046	0.757GlnHis: 0.757 ± 0.025	2.503GlnIle: 2.503 ± 0.047	2.683GlnLys: 2.683 ± 0.054	3.741GlnLeu: 3.741 ± 0.066	1.135GlnMet: 1.135 ± 0.034	1.674GlnAsn: 1.674 ± 0.041	1.328GlnPro: 1.328 ± 0.045	1.722GlnGln: 1.722 ± 0.06	1.46GlnArg: 1.46 ± 0.036	2.097GlnSer: 2.097 ± 0.039	1.931GlnThr: 1.931 ± 0.044	2.353GlnVal: 2.353 ± 0.048	0.378GlnTrp: 0.378 ± 0.015	1.24GlnTyr: 1.24 ± 0.04	0.0GlnXaa: 0.0 ± 0.0
Arg	2.586ArgAla: 2.586 ± 0.055	0.276ArgCys: 0.276 ± 0.017	2.151ArgAsp: 2.151 ± 0.046	3.447ArgGlu: 3.447 ± 0.068	1.974ArgPhe: 1.974 ± 0.046	2.474ArgGly: 2.474 ± 0.053	0.837ArgHis: 0.837 ± 0.026	3.288ArgIle: 3.288 ± 0.06	3.256ArgLys: 3.256 ± 0.052	4.168ArgLeu: 4.168 ± 0.068	1.321ArgMet: 1.321 ± 0.03	2.105ArgAsn: 2.105 ± 0.039	1.385ArgPro: 1.385 ± 0.036	1.591ArgGln: 1.591 ± 0.039	1.932ArgArg: 1.932 ± 0.047	2.376ArgSer: 2.376 ± 0.053	2.158ArgThr: 2.158 ± 0.045	2.709ArgVal: 2.709 ± 0.051	0.408ArgTrp: 0.408 ± 0.021	1.547ArgTyr: 1.547 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	4.324SerAla: 4.324 ± 0.066	0.462SerCys: 0.462 ± 0.023	2.952SerAsp: 2.952 ± 0.056	4.222SerGlu: 4.222 ± 0.059	3.324SerPhe: 3.324 ± 0.056	4.729SerGly: 4.729 ± 0.067	1.27SerHis: 1.27 ± 0.034	5.242SerIle: 5.242 ± 0.066	4.0SerLys: 4.0 ± 0.061	6.362SerLeu: 6.362 ± 0.082	1.765SerMet: 1.765 ± 0.043	2.571SerAsn: 2.571 ± 0.051	2.273SerPro: 2.273 ± 0.04	2.073SerGln: 2.073 ± 0.045	2.632SerArg: 2.632 ± 0.049	4.241SerSer: 4.241 ± 0.071	2.9SerThr: 2.9 ± 0.06	4.398SerVal: 4.398 ± 0.061	0.584SerTrp: 0.584 ± 0.025	2.176SerTyr: 2.176 ± 0.051	0.0SerXaa: 0.0 ± 0.0
Thr	4.394ThrAla: 4.394 ± 0.075	0.343ThrCys: 0.343 ± 0.016	2.667ThrAsp: 2.667 ± 0.055	3.663ThrGlu: 3.663 ± 0.058	2.411ThrPhe: 2.411 ± 0.045	4.465ThrGly: 4.465 ± 0.059	0.972ThrHis: 0.972 ± 0.029	4.284ThrIle: 4.284 ± 0.068	3.14ThrLys: 3.14 ± 0.051	5.005ThrLeu: 5.005 ± 0.072	1.256ThrMet: 1.256 ± 0.035	2.208ThrAsn: 2.208 ± 0.043	2.208ThrPro: 2.208 ± 0.043	1.382ThrGln: 1.382 ± 0.039	1.938ThrArg: 1.938 ± 0.043	3.127ThrSer: 3.127 ± 0.056	2.556ThrThr: 2.556 ± 0.059	4.332ThrVal: 4.332 ± 0.068	0.473ThrTrp: 0.473 ± 0.022	1.695ThrTyr: 1.695 ± 0.047	0.0ThrXaa: 0.0 ± 0.0
Val	4.855ValAla: 4.855 ± 0.073	0.562ValCys: 0.562 ± 0.023	3.333ValAsp: 3.333 ± 0.056	4.658ValGlu: 4.658 ± 0.066	3.082ValPhe: 3.082 ± 0.054	4.253ValGly: 4.253 ± 0.077	1.306ValHis: 1.306 ± 0.041	5.718ValIle: 5.718 ± 0.077	4.723ValLys: 4.723 ± 0.073	6.769ValLeu: 6.769 ± 0.086	1.793ValMet: 1.793 ± 0.04	3.138ValAsn: 3.138 ± 0.061	2.789ValPro: 2.789 ± 0.051	2.342ValGln: 2.342 ± 0.05	2.702ValArg: 2.702 ± 0.05	4.737ValSer: 4.737 ± 0.072	4.044ValThr: 4.044 ± 0.069	4.583ValVal: 4.583 ± 0.081	0.579ValTrp: 0.579 ± 0.026	2.262ValTyr: 2.262 ± 0.046	0.0ValXaa: 0.0 ± 0.0
Trp	0.588TrpAla: 0.588 ± 0.029	0.071TrpCys: 0.071 ± 0.009	0.514TrpAsp: 0.514 ± 0.023	0.615TrpGlu: 0.615 ± 0.025	0.501TrpPhe: 0.501 ± 0.021	0.673TrpGly: 0.673 ± 0.026	0.201TrpHis: 0.201 ± 0.015	0.729TrpIle: 0.729 ± 0.027	0.743TrpLys: 0.743 ± 0.028	1.069TrpLeu: 1.069 ± 0.038	0.289TrpMet: 0.289 ± 0.015	0.499TrpAsn: 0.499 ± 0.025	0.246TrpPro: 0.246 ± 0.014	0.345TrpGln: 0.345 ± 0.017	0.379TrpArg: 0.379 ± 0.019	0.529TrpSer: 0.529 ± 0.018	0.437TrpThr: 0.437 ± 0.019	0.617TrpVal: 0.617 ± 0.025	0.119TrpTrp: 0.119 ± 0.011	0.283TrpTyr: 0.283 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.048TyrAla: 2.048 ± 0.046	0.297TyrCys: 0.297 ± 0.015	1.709TyrAsp: 1.709 ± 0.044	2.345TyrGlu: 2.345 ± 0.05	1.741TyrPhe: 1.741 ± 0.051	2.435TyrGly: 2.435 ± 0.046	0.772TyrHis: 0.772 ± 0.024	2.391TyrIle: 2.391 ± 0.039	2.172TyrLys: 2.172 ± 0.048	3.278TyrLeu: 3.278 ± 0.057	0.792TyrMet: 0.792 ± 0.027	1.452TyrAsn: 1.452 ± 0.043	1.377TyrPro: 1.377 ± 0.036	1.397TyrGln: 1.397 ± 0.038	1.645TyrArg: 1.645 ± 0.041	2.192TyrSer: 2.192 ± 0.042	1.705TyrThr: 1.705 ± 0.044	2.01TyrVal: 2.01 ± 0.043	0.345TyrTrp: 0.345 ± 0.016	1.27TyrTyr: 1.27 ± 0.039	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3964 proteins (1141555 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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