Amino acid dipepetide frequency for WU polyomavirus (WUPyV)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.962AlaAla: 8.962 ± 3.743
1.054AlaCys: 1.054 ± 0.854
3.69AlaAsp: 3.69 ± 1.39
3.163AlaGlu: 3.163 ± 0.654
0.527AlaPhe: 0.527 ± 0.374
5.799AlaGly: 5.799 ± 2.442
0.0AlaHis: 0.0 ± 0.0
2.636AlaIle: 2.636 ± 0.711
4.217AlaLys: 4.217 ± 0.485
8.434AlaLeu: 8.434 ± 2.471
0.527AlaMet: 0.527 ± 0.356
0.527AlaAsn: 0.527 ± 0.427
4.217AlaPro: 4.217 ± 1.442
0.527AlaGln: 0.527 ± 0.427
1.054AlaArg: 1.054 ± 0.448
5.271AlaSer: 5.271 ± 2.262
10.016AlaThr: 10.016 ± 2.887
6.326AlaVal: 6.326 ± 2.095
0.527AlaTrp: 0.527 ± 0.374
1.581AlaTyr: 1.581 ± 0.486
0.0AlaXaa: 0.0 ± 0.0
Cys
0.527CysAla: 0.527 ± 0.427
0.527CysCys: 0.527 ± 0.488
0.527CysAsp: 0.527 ± 0.427
1.054CysGlu: 1.054 ± 0.747
1.054CysPhe: 1.054 ± 0.976
0.527CysGly: 0.527 ± 0.374
0.0CysHis: 0.0 ± 0.0
1.054CysIle: 1.054 ± 0.747
2.109CysLys: 2.109 ± 1.216
1.054CysLeu: 1.054 ± 0.58
0.0CysMet: 0.0 ± 0.0
3.163CysAsn: 3.163 ± 1.774
0.0CysPro: 0.0 ± 0.0
0.527CysGln: 0.527 ± 0.374
1.054CysArg: 1.054 ± 0.448
0.527CysSer: 0.527 ± 0.374
2.109CysThr: 2.109 ± 0.831
1.054CysVal: 1.054 ± 0.611
1.054CysTrp: 1.054 ± 0.611
2.109CysTyr: 2.109 ± 1.439
0.0CysXaa: 0.0 ± 0.0
Asp
3.69AspAla: 3.69 ± 0.846
0.0AspCys: 0.0 ± 0.0
1.581AspAsp: 1.581 ± 0.706
2.636AspGlu: 2.636 ± 1.102
1.054AspPhe: 1.054 ± 0.747
2.636AspGly: 2.636 ± 1.17
0.0AspHis: 0.0 ± 0.0
3.69AspIle: 3.69 ± 1.485
4.744AspLys: 4.744 ± 2.66
3.69AspLeu: 3.69 ± 0.505
2.109AspMet: 2.109 ± 0.801
2.109AspAsn: 2.109 ± 1.037
2.109AspPro: 2.109 ± 0.462
1.054AspGln: 1.054 ± 0.747
1.054AspArg: 1.054 ± 0.422
1.054AspSer: 1.054 ± 0.747
0.527AspThr: 0.527 ± 0.427
4.744AspVal: 4.744 ± 0.738
3.163AspTrp: 3.163 ± 1.129
1.054AspTyr: 1.054 ± 0.747
0.0AspXaa: 0.0 ± 0.0
Glu
3.69GluAla: 3.69 ± 0.988
3.163GluCys: 3.163 ± 1.535
3.69GluAsp: 3.69 ± 2.288
10.543GluGlu: 10.543 ± 2.683
3.69GluPhe: 3.69 ± 1.787
2.636GluGly: 2.636 ± 1.186
0.527GluHis: 0.527 ± 0.374
1.581GluIle: 1.581 ± 0.886
4.744GluLys: 4.744 ± 2.083
11.07GluLeu: 11.07 ± 1.095
0.527GluMet: 0.527 ± 0.374
2.109GluAsn: 2.109 ± 1.037
0.527GluPro: 0.527 ± 0.374
1.581GluGln: 1.581 ± 0.486
0.0GluArg: 0.0 ± 0.0
2.636GluSer: 2.636 ± 0.716
5.271GluThr: 5.271 ± 1.132
2.636GluVal: 2.636 ± 1.11
0.527GluTrp: 0.527 ± 0.488
3.163GluTyr: 3.163 ± 1.129
0.0GluXaa: 0.0 ± 0.0
Phe
1.581PheAla: 1.581 ± 1.121
1.054PheCys: 1.054 ± 0.747
0.0PheAsp: 0.0 ± 0.0
2.636PheGlu: 2.636 ± 1.476
1.054PhePhe: 1.054 ± 0.58
1.054PheGly: 1.054 ± 0.58
2.109PheHis: 2.109 ± 1.216
1.581PheIle: 1.581 ± 0.486
2.636PheLys: 2.636 ± 1.39
1.581PheLeu: 1.581 ± 1.04
0.0PheMet: 0.0 ± 0.0
4.217PheAsn: 4.217 ± 1.829
1.581PhePro: 1.581 ± 0.887
0.0PheGln: 0.0 ± 0.0
3.163PheArg: 3.163 ± 0.675
1.581PheSer: 1.581 ± 0.706
1.581PheThr: 1.581 ± 1.121
3.69PheVal: 3.69 ± 0.846
0.527PheTrp: 0.527 ± 0.427
1.581PheTyr: 1.581 ± 1.464
0.0PheXaa: 0.0 ± 0.0
Gly
3.163GlyAla: 3.163 ± 1.746
0.527GlyCys: 0.527 ± 0.374
2.636GlyAsp: 2.636 ± 0.793
4.217GlyGlu: 4.217 ± 1.003
3.163GlyPhe: 3.163 ± 1.539
10.016GlyGly: 10.016 ± 2.573
0.0GlyHis: 0.0 ± 0.0
7.38GlyIle: 7.38 ± 2.262
1.581GlyLys: 1.581 ± 1.121
8.962GlyLeu: 8.962 ± 1.54
2.109GlyMet: 2.109 ± 0.557
3.69GlyAsn: 3.69 ± 1.358
2.636GlyPro: 2.636 ± 1.605
3.69GlyGln: 3.69 ± 1.233
5.799GlyArg: 5.799 ± 2.986
1.581GlySer: 1.581 ± 0.764
3.69GlyThr: 3.69 ± 1.233
7.907GlyVal: 7.907 ± 1.515
0.0GlyTrp: 0.0 ± 0.0
1.054GlyTyr: 1.054 ± 0.422
0.0GlyXaa: 0.0 ± 0.0
His
0.527HisAla: 0.527 ± 0.428
0.0HisCys: 0.0 ± 0.0
0.0HisAsp: 0.0 ± 0.0
0.0HisGlu: 0.0 ± 0.0
0.527HisPhe: 0.527 ± 0.427
0.0HisGly: 0.0 ± 0.0
0.0HisHis: 0.0 ± 0.0
0.0HisIle: 0.0 ± 0.0
2.636HisLys: 2.636 ± 0.793
2.636HisLeu: 2.636 ± 0.299
0.527HisMet: 0.527 ± 0.374
1.054HisAsn: 1.054 ± 0.747
2.109HisPro: 2.109 ± 0.766
1.581HisGln: 1.581 ± 0.887
1.581HisArg: 1.581 ± 0.486
2.636HisSer: 2.636 ± 1.17
1.054HisThr: 1.054 ± 0.448
0.527HisVal: 0.527 ± 0.427
0.0HisTrp: 0.0 ± 0.0
1.581HisTyr: 1.581 ± 0.785
0.0HisXaa: 0.0 ± 0.0
Ile
5.799IleAla: 5.799 ± 2.76
0.527IleCys: 0.527 ± 0.488
2.109IleAsp: 2.109 ± 1.494
1.054IleGlu: 1.054 ± 0.58
1.581IlePhe: 1.581 ± 1.04
2.636IleGly: 2.636 ± 0.745
1.054IleHis: 1.054 ± 0.422
1.054IleIle: 1.054 ± 0.573
2.109IleLys: 2.109 ± 0.483
5.799IleLeu: 5.799 ± 0.582
0.0IleMet: 0.0 ± 0.0
1.581IleAsn: 1.581 ± 0.706
5.799IlePro: 5.799 ± 1.274
1.054IleGln: 1.054 ± 0.422
0.0IleArg: 0.0 ± 0.0
6.853IleSer: 6.853 ± 2.681
0.527IleThr: 0.527 ± 0.427
2.109IleVal: 2.109 ± 0.483
2.109IleTrp: 2.109 ± 0.462
0.527IleTyr: 0.527 ± 0.428
0.0IleXaa: 0.0 ± 0.0
Lys
3.163LysAla: 3.163 ± 1.032
2.109LysCys: 2.109 ± 1.216
1.581LysAsp: 1.581 ± 0.887
4.744LysGlu: 4.744 ± 2.779
0.527LysPhe: 0.527 ± 0.374
5.271LysGly: 5.271 ± 2.204
1.054LysHis: 1.054 ± 0.747
3.163LysIle: 3.163 ± 0.916
5.799LysLys: 5.799 ± 2.228
4.217LysLeu: 4.217 ± 1.285
1.581LysMet: 1.581 ± 0.887
1.581LysAsn: 1.581 ± 0.706
4.217LysPro: 4.217 ± 1.683
1.581LysGln: 1.581 ± 0.894
5.799LysArg: 5.799 ± 1.386
3.163LysSer: 3.163 ± 0.972
6.326LysThr: 6.326 ± 0.497
4.217LysVal: 4.217 ± 0.738
0.0LysTrp: 0.0 ± 0.0
3.69LysTyr: 3.69 ± 1.552
0.0LysXaa: 0.0 ± 0.0
Leu
5.799LeuAla: 5.799 ± 1.789
2.636LeuCys: 2.636 ± 1.123
5.799LeuAsp: 5.799 ± 2.533
5.271LeuGlu: 5.271 ± 1.356
2.109LeuPhe: 2.109 ± 1.037
7.38LeuGly: 7.38 ± 0.624
4.217LeuHis: 4.217 ± 1.728
1.054LeuIle: 1.054 ± 0.448
4.217LeuLys: 4.217 ± 1.939
11.07LeuLeu: 11.07 ± 2.145
3.163LeuMet: 3.163 ± 1.774
7.907LeuAsn: 7.907 ± 1.973
7.38LeuPro: 7.38 ± 1.87
7.907LeuGln: 7.907 ± 1.828
1.054LeuArg: 1.054 ± 0.747
8.962LeuSer: 8.962 ± 0.596
4.217LeuThr: 4.217 ± 1.041
3.69LeuVal: 3.69 ± 0.81
0.0LeuTrp: 0.0 ± 0.0
6.853LeuTyr: 6.853 ± 1.548
0.0LeuXaa: 0.0 ± 0.0
Met
2.109MetAla: 2.109 ± 0.462
0.527MetCys: 0.527 ± 0.374
1.581MetAsp: 1.581 ± 0.887
1.054MetGlu: 1.054 ± 0.448
0.0MetPhe: 0.0 ± 0.0
0.527MetGly: 0.527 ± 0.428
0.0MetHis: 0.0 ± 0.0
0.0MetIle: 0.0 ± 0.0
1.054MetLys: 1.054 ± 0.611
1.054MetLeu: 1.054 ± 0.448
0.0MetMet: 0.0 ± 0.0
1.054MetAsn: 1.054 ± 0.747
1.581MetPro: 1.581 ± 0.486
2.109MetGln: 2.109 ± 1.221
1.054MetArg: 1.054 ± 0.611
1.054MetSer: 1.054 ± 0.747
2.109MetThr: 2.109 ± 0.801
1.054MetVal: 1.054 ± 0.448
0.527MetTrp: 0.527 ± 0.488
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
6.326AsnAla: 6.326 ± 1.046
1.054AsnCys: 1.054 ± 0.58
1.054AsnAsp: 1.054 ± 0.448
5.271AsnGlu: 5.271 ± 2.506
4.217AsnPhe: 4.217 ± 0.834
3.69AsnGly: 3.69 ± 0.587
0.0AsnHis: 0.0 ± 0.0
2.636AsnIle: 2.636 ± 1.355
2.109AsnLys: 2.109 ± 0.897
4.744AsnLeu: 4.744 ± 0.738
0.527AsnMet: 0.527 ± 0.374
1.581AsnAsn: 1.581 ± 0.706
1.581AsnPro: 1.581 ± 0.823
0.527AsnGln: 0.527 ± 0.427
4.744AsnArg: 4.744 ± 1.542
4.217AsnSer: 4.217 ± 0.806
2.109AsnThr: 2.109 ± 0.462
2.636AsnVal: 2.636 ± 1.122
0.527AsnTrp: 0.527 ± 0.374
0.0AsnTyr: 0.0 ± 0.0
0.0AsnXaa: 0.0 ± 0.0
Pro
4.217ProAla: 4.217 ± 1.312
0.527ProCys: 0.527 ± 0.374
4.744ProAsp: 4.744 ± 0.765
3.69ProGlu: 3.69 ± 1.824
1.054ProPhe: 1.054 ± 0.747
5.271ProGly: 5.271 ± 1.263
2.109ProHis: 2.109 ± 1.039
2.109ProIle: 2.109 ± 0.462
3.69ProLys: 3.69 ± 1.734
4.217ProLeu: 4.217 ± 1.806
0.527ProMet: 0.527 ± 0.488
0.527ProAsn: 0.527 ± 0.427
4.217ProPro: 4.217 ± 1.119
1.581ProGln: 1.581 ± 0.349
3.163ProArg: 3.163 ± 0.675
3.69ProSer: 3.69 ± 1.393
4.744ProThr: 4.744 ± 1.284
4.217ProVal: 4.217 ± 1.464
0.0ProTrp: 0.0 ± 0.0
1.054ProTyr: 1.054 ± 0.498
0.0ProXaa: 0.0 ± 0.0
Gln
3.69GlnAla: 3.69 ± 0.824
0.527GlnCys: 0.527 ± 0.374
1.581GlnAsp: 1.581 ± 0.486
1.054GlnGlu: 1.054 ± 0.611
1.054GlnPhe: 1.054 ± 0.747
4.217GlnGly: 4.217 ± 1.668
0.0GlnHis: 0.0 ± 0.0
2.109GlnIle: 2.109 ± 0.483
2.636GlnLys: 2.636 ± 0.546
4.217GlnLeu: 4.217 ± 1.603
0.527GlnMet: 0.527 ± 0.374
1.054GlnAsn: 1.054 ± 0.72
2.109GlnPro: 2.109 ± 1.039
1.581GlnGln: 1.581 ± 0.486
3.69GlnArg: 3.69 ± 2.143
1.581GlnSer: 1.581 ± 0.349
0.0GlnThr: 0.0 ± 0.0
4.744GlnVal: 4.744 ± 1.849
1.054GlnTrp: 1.054 ± 0.72
0.527GlnTyr: 0.527 ± 0.427
0.0GlnXaa: 0.0 ± 0.0
Arg
2.636ArgAla: 2.636 ± 1.444
1.054ArgCys: 1.054 ± 0.611
3.163ArgAsp: 3.163 ± 0.972
2.636ArgGlu: 2.636 ± 0.546
1.581ArgPhe: 1.581 ± 0.706
2.109ArgGly: 2.109 ± 1.439
2.109ArgHis: 2.109 ± 1.216
1.054ArgIle: 1.054 ± 0.72
3.69ArgLys: 3.69 ± 1.488
5.799ArgLeu: 5.799 ± 1.414
2.109ArgMet: 2.109 ± 0.821
3.163ArgAsn: 3.163 ± 0.675
1.054ArgPro: 1.054 ± 0.422
1.581ArgGln: 1.581 ± 0.785
5.799ArgArg: 5.799 ± 2.253
2.636ArgSer: 2.636 ± 0.745
5.271ArgThr: 5.271 ± 1.363
4.744ArgVal: 4.744 ± 1.281
0.0ArgTrp: 0.0 ± 0.0
1.581ArgTyr: 1.581 ± 0.706
0.0ArgXaa: 0.0 ± 0.0
Ser
2.636SerAla: 2.636 ± 0.793
0.0SerCys: 0.0 ± 0.0
4.217SerAsp: 4.217 ± 1.641
4.744SerGlu: 4.744 ± 1.608
2.636SerPhe: 2.636 ± 0.299
4.217SerGly: 4.217 ± 0.795
1.581SerHis: 1.581 ± 0.785
2.636SerIle: 2.636 ± 0.774
6.326SerLys: 6.326 ± 2.014
5.799SerLeu: 5.799 ± 0.283
1.054SerMet: 1.054 ± 0.72
3.69SerAsn: 3.69 ± 0.587
2.109SerPro: 2.109 ± 0.656
6.853SerGln: 6.853 ± 0.832
4.744SerArg: 4.744 ± 0.738
3.69SerSer: 3.69 ± 1.378
4.217SerThr: 4.217 ± 1.291
1.054SerVal: 1.054 ± 0.422
0.527SerTrp: 0.527 ± 0.427
2.109SerTyr: 2.109 ± 0.483
0.0SerXaa: 0.0 ± 0.0
Thr
5.799ThrAla: 5.799 ± 1.522
1.581ThrCys: 1.581 ± 0.591
0.527ThrAsp: 0.527 ± 0.374
4.217ThrGlu: 4.217 ± 1.806
0.527ThrPhe: 0.527 ± 0.488
6.326ThrGly: 6.326 ± 2.938
1.581ThrHis: 1.581 ± 0.486
4.217ThrIle: 4.217 ± 0.924
3.69ThrLys: 3.69 ± 0.777
4.744ThrLeu: 4.744 ± 1.166
1.581ThrMet: 1.581 ± 0.591
1.581ThrAsn: 1.581 ± 0.792
6.853ThrPro: 6.853 ± 1.383
3.163ThrGln: 3.163 ± 1.705
3.163ThrArg: 3.163 ± 0.264
2.636ThrSer: 2.636 ± 1.444
4.744ThrThr: 4.744 ± 1.254
8.962ThrVal: 8.962 ± 1.355
0.0ThrTrp: 0.0 ± 0.0
1.581ThrTyr: 1.581 ± 0.486
0.0ThrXaa: 0.0 ± 0.0
Val
3.163ValAla: 3.163 ± 0.879
1.054ValCys: 1.054 ± 0.448
2.109ValAsp: 2.109 ± 0.462
5.271ValGlu: 5.271 ± 0.952
5.271ValPhe: 5.271 ± 0.52
4.217ValGly: 4.217 ± 1.49
2.636ValHis: 2.636 ± 0.445
2.109ValIle: 2.109 ± 1.037
2.109ValLys: 2.109 ± 1.037
5.799ValLeu: 5.799 ± 1.541
0.527ValMet: 0.527 ± 0.628
4.744ValAsn: 4.744 ± 0.683
4.744ValPro: 4.744 ± 1.05
1.054ValGln: 1.054 ± 0.498
4.217ValArg: 4.217 ± 2.21
6.853ValSer: 6.853 ± 0.808
6.326ValThr: 6.326 ± 1.82
3.163ValVal: 3.163 ± 0.495
1.054ValTrp: 1.054 ± 0.611
3.69ValTyr: 3.69 ± 0.469
0.0ValXaa: 0.0 ± 0.0
Trp
0.527TrpAla: 0.527 ± 0.427
0.527TrpCys: 0.527 ± 0.374
1.054TrpAsp: 1.054 ± 0.611
1.054TrpGlu: 1.054 ± 0.448
0.527TrpPhe: 0.527 ± 0.488
1.054TrpGly: 1.054 ± 0.611
0.0TrpHis: 0.0 ± 0.0
2.636TrpIle: 2.636 ± 1.408
1.581TrpLys: 1.581 ± 0.887
0.0TrpLeu: 0.0 ± 0.0
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
0.0TrpArg: 0.0 ± 0.0
2.109TrpSer: 2.109 ± 0.801
1.054TrpThr: 1.054 ± 0.72
2.109TrpVal: 2.109 ± 0.462
0.527TrpTrp: 0.527 ± 0.374
0.527TrpTyr: 0.527 ± 0.374
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.054TyrAla: 1.054 ± 0.72
1.581TyrCys: 1.581 ± 1.04
1.054TyrAsp: 1.054 ± 0.72
0.0TyrGlu: 0.0 ± 0.0
1.054TyrPhe: 1.054 ± 0.854
4.217TyrGly: 4.217 ± 0.834
0.0TyrHis: 0.0 ± 0.0
1.581TyrIle: 1.581 ± 0.591
2.109TyrLys: 2.109 ± 0.831
5.799TyrLeu: 5.799 ± 3.31
0.527TyrMet: 0.527 ± 0.374
4.217TyrAsn: 4.217 ± 2.171
0.527TyrPro: 0.527 ± 0.428
0.0TyrGln: 0.0 ± 0.0
2.636TyrArg: 2.636 ± 1.44
2.109TyrSer: 2.109 ± 1.191
1.581TyrThr: 1.581 ± 0.823
1.054TyrVal: 1.054 ± 0.72
3.163TyrTrp: 3.163 ± 1.437
2.109TyrTyr: 2.109 ± 0.553
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5 proteins (1898 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski