Amino acid dipepetide frequency for Candidatus Scalindua japonica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.164AlaAla: 4.164 ± 0.08	0.839AlaCys: 0.839 ± 0.028	3.351AlaAsp: 3.351 ± 0.058	4.367AlaGlu: 4.367 ± 0.068	2.796AlaPhe: 2.796 ± 0.05	4.809AlaGly: 4.809 ± 0.073	1.216AlaHis: 1.216 ± 0.034	5.38AlaIle: 5.38 ± 0.094	4.192AlaLys: 4.192 ± 0.062	5.949AlaLeu: 5.949 ± 0.087	1.599AlaMet: 1.599 ± 0.037	2.59AlaAsn: 2.59 ± 0.045	1.683AlaPro: 1.683 ± 0.036	1.736AlaGln: 1.736 ± 0.037	2.916AlaArg: 2.916 ± 0.046	3.725AlaSer: 3.725 ± 0.057	2.962AlaThr: 2.962 ± 0.058	4.408AlaVal: 4.408 ± 0.066	0.547AlaTrp: 0.547 ± 0.023	2.128AlaTyr: 2.128 ± 0.04	0.0AlaXaa: 0.0 ± 0.0
Cys	0.686CysAla: 0.686 ± 0.028	0.204CysCys: 0.204 ± 0.013	0.706CysAsp: 0.706 ± 0.025	0.732CysGlu: 0.732 ± 0.027	0.617CysPhe: 0.617 ± 0.024	1.084CysGly: 1.084 ± 0.035	0.53CysHis: 0.53 ± 0.04	0.872CysIle: 0.872 ± 0.025	0.81CysLys: 0.81 ± 0.025	1.118CysLeu: 1.118 ± 0.029	0.292CysMet: 0.292 ± 0.015	0.643CysAsn: 0.643 ± 0.022	0.583CysPro: 0.583 ± 0.029	0.356CysGln: 0.356 ± 0.018	0.577CysArg: 0.577 ± 0.025	0.901CysSer: 0.901 ± 0.03	0.585CysThr: 0.585 ± 0.022	0.79CysVal: 0.79 ± 0.029	0.104CysTrp: 0.104 ± 0.01	0.457CysTyr: 0.457 ± 0.022	0.0CysXaa: 0.0 ± 0.0
Asp	3.49AspAla: 3.49 ± 0.054	0.729AspCys: 0.729 ± 0.029	3.103AspAsp: 3.103 ± 0.058	4.138AspGlu: 4.138 ± 0.059	2.662AspPhe: 2.662 ± 0.05	3.948AspGly: 3.948 ± 0.089	1.006AspHis: 1.006 ± 0.027	5.423AspIle: 5.423 ± 0.069	4.456AspLys: 4.456 ± 0.065	5.248AspLeu: 5.248 ± 0.076	1.311AspMet: 1.311 ± 0.036	2.922AspAsn: 2.922 ± 0.057	2.18AspPro: 2.18 ± 0.046	1.419AspGln: 1.419 ± 0.03	2.427AspArg: 2.427 ± 0.041	3.4AspSer: 3.4 ± 0.057	2.953AspThr: 2.953 ± 0.05	3.809AspVal: 3.809 ± 0.064	0.725AspTrp: 0.725 ± 0.028	2.346AspTyr: 2.346 ± 0.049	0.0AspXaa: 0.0 ± 0.0
Glu	4.332GluAla: 4.332 ± 0.064	0.752GluCys: 0.752 ± 0.03	3.712GluAsp: 3.712 ± 0.057	5.833GluGlu: 5.833 ± 0.08	2.722GluPhe: 2.722 ± 0.042	4.06GluGly: 4.06 ± 0.064	1.42GluHis: 1.42 ± 0.037	6.282GluIle: 6.282 ± 0.078	6.818GluLys: 6.818 ± 0.087	6.531GluLeu: 6.531 ± 0.087	1.953GluMet: 1.953 ± 0.039	3.762GluAsn: 3.762 ± 0.065	1.76GluPro: 1.76 ± 0.042	2.235GluGln: 2.235 ± 0.049	3.551GluArg: 3.551 ± 0.07	3.992GluSer: 3.992 ± 0.062	3.746GluThr: 3.746 ± 0.06	4.468GluVal: 4.468 ± 0.066	0.8GluTrp: 0.8 ± 0.033	2.537GluTyr: 2.537 ± 0.048	0.0GluXaa: 0.0 ± 0.0
Phe	2.601PheAla: 2.601 ± 0.053	0.632PheCys: 0.632 ± 0.025	2.799PheAsp: 2.799 ± 0.056	2.727PheGlu: 2.727 ± 0.049	2.186PhePhe: 2.186 ± 0.051	3.179PheGly: 3.179 ± 0.054	0.905PheHis: 0.905 ± 0.027	3.247PheIle: 3.247 ± 0.06	2.984PheLys: 2.984 ± 0.052	3.969PheLeu: 3.969 ± 0.076	0.998PheMet: 0.998 ± 0.032	2.207PheAsn: 2.207 ± 0.044	1.586PhePro: 1.586 ± 0.038	1.153PheGln: 1.153 ± 0.03	1.763PheArg: 1.763 ± 0.036	3.294PheSer: 3.294 ± 0.058	2.316PheThr: 2.316 ± 0.045	2.872PheVal: 2.872 ± 0.053	0.476PheTrp: 0.476 ± 0.019	1.557PheTyr: 1.557 ± 0.037	0.0PheXaa: 0.0 ± 0.0
Gly	4.119GlyAla: 4.119 ± 0.062	1.006GlyCys: 1.006 ± 0.031	3.613GlyAsp: 3.613 ± 0.077	4.213GlyGlu: 4.213 ± 0.056	3.211GlyPhe: 3.211 ± 0.056	4.742GlyGly: 4.742 ± 0.099	1.449GlyHis: 1.449 ± 0.036	5.936GlyIle: 5.936 ± 0.074	5.544GlyLys: 5.544 ± 0.077	6.063GlyLeu: 6.063 ± 0.073	1.869GlyMet: 1.869 ± 0.042	3.348GlyAsn: 3.348 ± 0.065	1.776GlyPro: 1.776 ± 0.049	1.907GlyGln: 1.907 ± 0.042	3.184GlyArg: 3.184 ± 0.06	4.364GlySer: 4.364 ± 0.078	3.813GlyThr: 3.813 ± 0.07	4.773GlyVal: 4.773 ± 0.074	0.78GlyTrp: 0.78 ± 0.022	2.618GlyTyr: 2.618 ± 0.052	0.0GlyXaa: 0.0 ± 0.0
His	1.21HisAla: 1.21 ± 0.033	0.32HisCys: 0.32 ± 0.015	1.047HisAsp: 1.047 ± 0.031	1.254HisGlu: 1.254 ± 0.031	0.925HisPhe: 0.925 ± 0.028	1.485HisGly: 1.485 ± 0.04	0.548HisHis: 0.548 ± 0.023	1.638HisIle: 1.638 ± 0.035	1.364HisLys: 1.364 ± 0.035	1.872HisLeu: 1.872 ± 0.042	0.47HisMet: 0.47 ± 0.017	1.013HisAsn: 1.013 ± 0.031	0.991HisPro: 0.991 ± 0.03	0.628HisGln: 0.628 ± 0.018	0.86HisArg: 0.86 ± 0.027	1.293HisSer: 1.293 ± 0.03	0.999HisThr: 0.999 ± 0.03	1.264HisVal: 1.264 ± 0.039	0.226HisTrp: 0.226 ± 0.013	0.797HisTyr: 0.797 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	5.387IleAla: 5.387 ± 0.079	1.085IleCys: 1.085 ± 0.028	5.222IleAsp: 5.222 ± 0.069	6.055IleGlu: 6.055 ± 0.076	3.295IlePhe: 3.295 ± 0.057	5.347IleGly: 5.347 ± 0.081	1.579IleHis: 1.579 ± 0.029	6.505IleIle: 6.505 ± 0.09	6.436IleLys: 6.436 ± 0.081	6.701IleLeu: 6.701 ± 0.087	1.757IleMet: 1.757 ± 0.04	4.353IleAsn: 4.353 ± 0.064	3.465IlePro: 3.465 ± 0.059	2.261IleGln: 2.261 ± 0.045	3.631IleArg: 3.631 ± 0.052	5.912IleSer: 5.912 ± 0.07	4.684IleThr: 4.684 ± 0.061	5.277IleVal: 5.277 ± 0.075	0.656IleTrp: 0.656 ± 0.026	2.489IleTyr: 2.489 ± 0.046	0.0IleXaa: 0.0 ± 0.0
Lys	4.798LysAla: 4.798 ± 0.064	0.834LysCys: 0.834 ± 0.028	4.464LysAsp: 4.464 ± 0.07	6.665LysGlu: 6.665 ± 0.084	2.517LysPhe: 2.517 ± 0.051	4.779LysGly: 4.779 ± 0.066	1.538LysHis: 1.538 ± 0.038	6.508LysIle: 6.508 ± 0.081	7.187LysLys: 7.187 ± 0.101	6.585LysLeu: 6.585 ± 0.093	1.979LysMet: 1.979 ± 0.044	4.081LysAsn: 4.081 ± 0.065	2.538LysPro: 2.538 ± 0.045	2.579LysGln: 2.579 ± 0.053	3.916LysArg: 3.916 ± 0.059	4.677LysSer: 4.677 ± 0.067	4.22LysThr: 4.22 ± 0.068	4.803LysVal: 4.803 ± 0.062	0.758LysTrp: 0.758 ± 0.028	2.832LysTyr: 2.832 ± 0.054	0.0LysXaa: 0.0 ± 0.0
Leu	5.827LeuAla: 5.827 ± 0.084	1.097LeuCys: 1.097 ± 0.033	5.211LeuAsp: 5.211 ± 0.062	6.244LeuGlu: 6.244 ± 0.092	4.089LeuPhe: 4.089 ± 0.058	5.834LeuGly: 5.834 ± 0.089	1.724LeuHis: 1.724 ± 0.039	6.826LeuIle: 6.826 ± 0.088	7.569LeuLys: 7.569 ± 0.079	8.395LeuLeu: 8.395 ± 0.096	1.981LeuMet: 1.981 ± 0.043	4.657LeuAsn: 4.657 ± 0.064	3.752LeuPro: 3.752 ± 0.064	2.827LeuGln: 2.827 ± 0.054	4.323LeuArg: 4.323 ± 0.066	6.893LeuSer: 6.893 ± 0.084	4.727LeuThr: 4.727 ± 0.064	5.306LeuVal: 5.306 ± 0.065	0.804LeuTrp: 0.804 ± 0.027	2.722LeuTyr: 2.722 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	1.789MetAla: 1.789 ± 0.038	0.256MetCys: 0.256 ± 0.014	1.417MetAsp: 1.417 ± 0.033	1.592MetGlu: 1.592 ± 0.038	0.913MetPhe: 0.913 ± 0.027	1.617MetGly: 1.617 ± 0.043	0.441MetHis: 0.441 ± 0.019	1.76MetIle: 1.76 ± 0.038	2.144MetLys: 2.144 ± 0.043	2.058MetLeu: 2.058 ± 0.046	0.574MetMet: 0.574 ± 0.021	1.207MetAsn: 1.207 ± 0.034	1.014MetPro: 1.014 ± 0.029	0.726MetGln: 0.726 ± 0.026	1.082MetArg: 1.082 ± 0.032	1.665MetSer: 1.665 ± 0.037	1.209MetThr: 1.209 ± 0.032	1.657MetVal: 1.657 ± 0.034	0.22MetTrp: 0.22 ± 0.014	0.609MetTyr: 0.609 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	2.976AsnAla: 2.976 ± 0.047	0.647AsnCys: 0.647 ± 0.021	2.591AsnAsp: 2.591 ± 0.054	3.103AsnGlu: 3.103 ± 0.051	1.909AsnPhe: 1.909 ± 0.042	3.231AsnGly: 3.231 ± 0.066	0.955AsnHis: 0.955 ± 0.029	4.747AsnIle: 4.747 ± 0.074	3.743AsnLys: 3.743 ± 0.061	4.643AsnLeu: 4.643 ± 0.083	1.252AsnMet: 1.252 ± 0.033	2.905AsnAsn: 2.905 ± 0.06	2.306AsnPro: 2.306 ± 0.044	1.405AsnGln: 1.405 ± 0.034	2.385AsnArg: 2.385 ± 0.043	3.035AsnSer: 3.035 ± 0.053	2.711AsnThr: 2.711 ± 0.047	3.304AsnVal: 3.304 ± 0.058	0.503AsnTrp: 0.503 ± 0.021	1.765AsnTyr: 1.765 ± 0.036	0.0AsnXaa: 0.0 ± 0.0
Pro	2.007ProAla: 2.007 ± 0.042	0.381ProCys: 0.381 ± 0.019	2.899ProAsp: 2.899 ± 0.054	3.358ProGlu: 3.358 ± 0.054	1.821ProPhe: 1.821 ± 0.043	2.812ProGly: 2.812 ± 0.056	0.754ProHis: 0.754 ± 0.028	2.372ProIle: 2.372 ± 0.043	2.056ProLys: 2.056 ± 0.044	3.23ProLeu: 3.23 ± 0.046	0.725ProMet: 0.725 ± 0.025	1.393ProAsn: 1.393 ± 0.034	1.241ProPro: 1.241 ± 0.037	1.048ProGln: 1.048 ± 0.03	1.336ProArg: 1.336 ± 0.032	2.181ProSer: 2.181 ± 0.043	1.682ProThr: 1.682 ± 0.041	2.935ProVal: 2.935 ± 0.047	0.388ProTrp: 0.388 ± 0.02	1.26ProTyr: 1.26 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	1.84GlnAla: 1.84 ± 0.04	0.307GlnCys: 0.307 ± 0.018	1.562GlnAsp: 1.562 ± 0.036	2.206GlnGlu: 2.206 ± 0.05	1.156GlnPhe: 1.156 ± 0.031	1.82GlnGly: 1.82 ± 0.045	0.586GlnHis: 0.586 ± 0.022	2.499GlnIle: 2.499 ± 0.049	2.556GlnLys: 2.556 ± 0.049	2.695GlnLeu: 2.695 ± 0.043	0.775GlnMet: 0.775 ± 0.021	1.469GlnAsn: 1.469 ± 0.034	0.943GlnPro: 0.943 ± 0.029	1.049GlnGln: 1.049 ± 0.034	1.514GlnArg: 1.514 ± 0.037	1.842GlnSer: 1.842 ± 0.035	1.54GlnThr: 1.54 ± 0.034	1.816GlnVal: 1.816 ± 0.039	0.341GlnTrp: 0.341 ± 0.018	1.038GlnTyr: 1.038 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	2.463ArgAla: 2.463 ± 0.046	0.565ArgCys: 0.565 ± 0.023	2.58ArgAsp: 2.58 ± 0.049	3.65ArgGlu: 3.65 ± 0.063	2.126ArgPhe: 2.126 ± 0.05	2.707ArgGly: 2.707 ± 0.05	0.942ArgHis: 0.942 ± 0.029	3.783ArgIle: 3.783 ± 0.061	4.038ArgLys: 4.038 ± 0.065	4.44ArgLeu: 4.44 ± 0.061	1.208ArgMet: 1.208 ± 0.028	2.358ArgAsn: 2.358 ± 0.038	1.469ArgPro: 1.469 ± 0.038	1.527ArgGln: 1.527 ± 0.035	2.277ArgArg: 2.277 ± 0.052	2.564ArgSer: 2.564 ± 0.042	2.173ArgThr: 2.173 ± 0.044	3.057ArgVal: 3.057 ± 0.05	0.507ArgTrp: 0.507 ± 0.024	1.749ArgTyr: 1.749 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	3.76SerAla: 3.76 ± 0.056	0.831SerCys: 0.831 ± 0.028	3.683SerAsp: 3.683 ± 0.061	4.411SerGlu: 4.411 ± 0.058	3.052SerPhe: 3.052 ± 0.052	5.123SerGly: 5.123 ± 0.077	1.302SerHis: 1.302 ± 0.034	5.316SerIle: 5.316 ± 0.069	4.57SerLys: 4.57 ± 0.065	6.105SerLeu: 6.105 ± 0.083	1.537SerMet: 1.537 ± 0.036	3.052SerAsn: 3.052 ± 0.054	2.384SerPro: 2.384 ± 0.05	1.973SerGln: 1.973 ± 0.043	2.916SerArg: 2.916 ± 0.052	4.315SerSer: 4.315 ± 0.066	3.395SerThr: 3.395 ± 0.052	4.327SerVal: 4.327 ± 0.067	0.662SerTrp: 0.662 ± 0.024	2.187SerTyr: 2.187 ± 0.042	0.0SerXaa: 0.0 ± 0.0
Thr	3.348ThrAla: 3.348 ± 0.06	0.591ThrCys: 0.591 ± 0.026	3.016ThrAsp: 3.016 ± 0.052	3.437ThrGlu: 3.437 ± 0.055	2.259ThrPhe: 2.259 ± 0.04	4.558ThrGly: 4.558 ± 0.071	1.051ThrHis: 1.051 ± 0.028	4.458ThrIle: 4.458 ± 0.073	3.398ThrLys: 3.398 ± 0.064	4.932ThrLeu: 4.932 ± 0.062	1.152ThrMet: 1.152 ± 0.031	2.418ThrAsn: 2.418 ± 0.045	2.186ThrPro: 2.186 ± 0.054	1.417ThrGln: 1.417 ± 0.029	2.216ThrArg: 2.216 ± 0.041	3.225ThrSer: 3.225 ± 0.061	2.908ThrThr: 2.908 ± 0.055	3.758ThrVal: 3.758 ± 0.064	0.495ThrTrp: 0.495 ± 0.021	1.642ThrTyr: 1.642 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	4.052ValAla: 4.052 ± 0.061	0.906ValCys: 0.906 ± 0.027	3.976ValAsp: 3.976 ± 0.064	4.462ValGlu: 4.462 ± 0.06	3.113ValPhe: 3.113 ± 0.049	4.121ValGly: 4.121 ± 0.065	1.243ValHis: 1.243 ± 0.031	5.288ValIle: 5.288 ± 0.077	4.901ValLys: 4.901 ± 0.068	6.068ValLeu: 6.068 ± 0.076	1.55ValMet: 1.55 ± 0.035	3.304ValAsn: 3.304 ± 0.056	2.38ValPro: 2.38 ± 0.047	1.795ValGln: 1.795 ± 0.043	2.989ValArg: 2.989 ± 0.05	4.726ValSer: 4.726 ± 0.072	3.646ValThr: 3.646 ± 0.066	4.765ValVal: 4.765 ± 0.079	0.659ValTrp: 0.659 ± 0.024	2.1ValTyr: 2.1 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	0.562TrpAla: 0.562 ± 0.02	0.141TrpCys: 0.141 ± 0.011	0.63TrpAsp: 0.63 ± 0.024	0.653TrpGlu: 0.653 ± 0.025	0.456TrpPhe: 0.456 ± 0.021	0.678TrpGly: 0.678 ± 0.024	0.24TrpHis: 0.24 ± 0.014	0.732TrpIle: 0.732 ± 0.026	0.844TrpLys: 0.844 ± 0.028	0.958TrpLeu: 0.958 ± 0.031	0.253TrpMet: 0.253 ± 0.013	0.613TrpAsn: 0.613 ± 0.028	0.321TrpPro: 0.321 ± 0.016	0.389TrpGln: 0.389 ± 0.016	0.561TrpArg: 0.561 ± 0.023	0.647TrpSer: 0.647 ± 0.026	0.49TrpThr: 0.49 ± 0.025	0.623TrpVal: 0.623 ± 0.023	0.141TrpTrp: 0.141 ± 0.012	0.321TrpTyr: 0.321 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.947TyrAla: 1.947 ± 0.043	0.524TyrCys: 0.524 ± 0.021	2.113TyrAsp: 2.113 ± 0.048	2.169TyrGlu: 2.169 ± 0.046	1.627TyrPhe: 1.627 ± 0.037	2.392TyrGly: 2.392 ± 0.051	0.773TyrHis: 0.773 ± 0.026	2.525TyrIle: 2.525 ± 0.043	2.65TyrLys: 2.65 ± 0.051	3.248TyrLeu: 3.248 ± 0.058	0.71TyrMet: 0.71 ± 0.022	1.823TyrAsn: 1.823 ± 0.046	1.32TyrPro: 1.32 ± 0.033	1.123TyrGln: 1.123 ± 0.028	1.759TyrArg: 1.759 ± 0.04	2.252TyrSer: 2.252 ± 0.042	1.709TyrThr: 1.709 ± 0.034	2.03TyrVal: 2.03 ± 0.043	0.458TyrTrp: 0.458 ± 0.02	1.397TyrTyr: 1.397 ± 0.032	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3991 proteins (1248076 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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