Amino acid dipepetide frequency for Vibrio phage phiV208

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.155AlaAla: 6.155 ± 1.484
0.215AlaCys: 0.215 ± 0.132
4.366AlaAsp: 4.366 ± 0.56
4.294AlaGlu: 4.294 ± 0.97
1.718AlaPhe: 1.718 ± 0.298
4.294AlaGly: 4.294 ± 0.643
1.145AlaHis: 1.145 ± 0.238
5.868AlaIle: 5.868 ± 0.685
5.725AlaLys: 5.725 ± 0.682
5.797AlaLeu: 5.797 ± 0.587
3.364AlaMet: 3.364 ± 0.689
5.797AlaAsn: 5.797 ± 0.715
2.505AlaPro: 2.505 ± 0.469
2.075AlaGln: 2.075 ± 0.389
3.936AlaArg: 3.936 ± 0.706
5.511AlaSer: 5.511 ± 0.656
4.509AlaThr: 4.509 ± 0.908
4.652AlaVal: 4.652 ± 0.68
1.217AlaTrp: 1.217 ± 0.339
2.791AlaTyr: 2.791 ± 0.526
0.0AlaXaa: 0.0 ± 0.0
Cys
0.787CysAla: 0.787 ± 0.282
0.286CysCys: 0.286 ± 0.129
1.073CysAsp: 1.073 ± 0.323
1.288CysGlu: 1.288 ± 0.257
0.143CysPhe: 0.143 ± 0.093
1.503CysGly: 1.503 ± 0.419
0.215CysHis: 0.215 ± 0.109
0.573CysIle: 0.573 ± 0.192
0.787CysLys: 0.787 ± 0.257
0.859CysLeu: 0.859 ± 0.247
0.215CysMet: 0.215 ± 0.142
0.573CysAsn: 0.573 ± 0.182
0.215CysPro: 0.215 ± 0.104
0.286CysGln: 0.286 ± 0.15
0.358CysArg: 0.358 ± 0.178
0.429CysSer: 0.429 ± 0.16
0.644CysThr: 0.644 ± 0.232
0.716CysVal: 0.716 ± 0.249
0.429CysTrp: 0.429 ± 0.2
0.859CysTyr: 0.859 ± 0.268
0.0CysXaa: 0.0 ± 0.0
Asp
4.723AspAla: 4.723 ± 0.737
1.217AspCys: 1.217 ± 0.386
4.58AspAsp: 4.58 ± 0.589
4.509AspGlu: 4.509 ± 0.637
3.364AspPhe: 3.364 ± 0.567
5.582AspGly: 5.582 ± 1.066
1.073AspHis: 1.073 ± 0.279
4.151AspIle: 4.151 ± 0.589
3.865AspLys: 3.865 ± 0.548
5.725AspLeu: 5.725 ± 0.655
1.932AspMet: 1.932 ± 0.352
3.077AspAsn: 3.077 ± 0.489
3.149AspPro: 3.149 ± 0.623
2.219AspGln: 2.219 ± 0.438
3.077AspArg: 3.077 ± 0.446
3.578AspSer: 3.578 ± 0.524
3.006AspThr: 3.006 ± 0.611
2.934AspVal: 2.934 ± 0.402
1.002AspTrp: 1.002 ± 0.282
1.861AspTyr: 1.861 ± 0.332
0.0AspXaa: 0.0 ± 0.0
Glu
5.725GluAla: 5.725 ± 0.782
0.859GluCys: 0.859 ± 0.25
3.578GluAsp: 3.578 ± 0.575
5.153GluGlu: 5.153 ± 1.364
3.22GluPhe: 3.22 ± 0.553
3.507GluGly: 3.507 ± 0.595
1.36GluHis: 1.36 ± 0.288
6.012GluIle: 6.012 ± 0.666
5.582GluLys: 5.582 ± 0.787
6.513GluLeu: 6.513 ± 0.62
2.29GluMet: 2.29 ± 0.461
2.934GluAsn: 2.934 ± 0.399
2.362GluPro: 2.362 ± 0.422
4.008GluGln: 4.008 ± 0.67
4.938GluArg: 4.938 ± 0.887
5.654GluSer: 5.654 ± 0.608
3.793GluThr: 3.793 ± 0.55
4.366GluVal: 4.366 ± 0.622
1.503GluTrp: 1.503 ± 0.31
3.292GluTyr: 3.292 ± 0.418
0.0GluXaa: 0.0 ± 0.0
Phe
2.576PheAla: 2.576 ± 0.48
0.286PheCys: 0.286 ± 0.138
2.934PheAsp: 2.934 ± 0.418
2.29PheGlu: 2.29 ± 0.361
0.93PhePhe: 0.93 ± 0.247
3.292PheGly: 3.292 ± 0.371
0.429PheHis: 0.429 ± 0.16
2.576PheIle: 2.576 ± 0.462
3.435PheLys: 3.435 ± 0.426
1.646PheLeu: 1.646 ± 0.352
0.716PheMet: 0.716 ± 0.228
2.147PheAsn: 2.147 ± 0.393
0.716PhePro: 0.716 ± 0.219
1.36PheGln: 1.36 ± 0.267
1.36PheArg: 1.36 ± 0.287
2.29PheSer: 2.29 ± 0.347
2.075PheThr: 2.075 ± 0.418
2.29PheVal: 2.29 ± 0.414
0.573PheTrp: 0.573 ± 0.177
1.36PheTyr: 1.36 ± 0.388
0.0PheXaa: 0.0 ± 0.0
Gly
4.795GlyAla: 4.795 ± 0.705
1.217GlyCys: 1.217 ± 0.309
5.01GlyAsp: 5.01 ± 0.693
5.439GlyGlu: 5.439 ± 0.659
2.505GlyPhe: 2.505 ± 0.379
5.296GlyGly: 5.296 ± 0.729
1.217GlyHis: 1.217 ± 0.298
3.65GlyIle: 3.65 ± 0.59
4.867GlyLys: 4.867 ± 0.654
4.652GlyLeu: 4.652 ± 0.411
2.075GlyMet: 2.075 ± 0.429
3.077GlyAsn: 3.077 ± 0.497
1.002GlyPro: 1.002 ± 0.326
2.863GlyGln: 2.863 ± 0.584
3.435GlyArg: 3.435 ± 0.393
4.008GlySer: 4.008 ± 0.755
3.865GlyThr: 3.865 ± 0.931
4.58GlyVal: 4.58 ± 0.44
1.288GlyTrp: 1.288 ± 0.263
4.151GlyTyr: 4.151 ± 0.535
0.0GlyXaa: 0.0 ± 0.0
His
1.288HisAla: 1.288 ± 0.314
0.215HisCys: 0.215 ± 0.136
1.145HisAsp: 1.145 ± 0.315
1.431HisGlu: 1.431 ± 0.321
0.859HisPhe: 0.859 ± 0.248
1.718HisGly: 1.718 ± 0.471
0.429HisHis: 0.429 ± 0.183
1.36HisIle: 1.36 ± 0.318
1.002HisLys: 1.002 ± 0.278
1.574HisLeu: 1.574 ± 0.448
0.573HisMet: 0.573 ± 0.184
0.859HisAsn: 0.859 ± 0.287
1.002HisPro: 1.002 ± 0.285
0.501HisGln: 0.501 ± 0.233
0.501HisArg: 0.501 ± 0.185
0.787HisSer: 0.787 ± 0.263
0.644HisThr: 0.644 ± 0.238
0.286HisVal: 0.286 ± 0.13
0.286HisTrp: 0.286 ± 0.13
0.716HisTyr: 0.716 ± 0.231
0.0HisXaa: 0.0 ± 0.0
Ile
4.938IleAla: 4.938 ± 0.739
0.501IleCys: 0.501 ± 0.201
4.867IleAsp: 4.867 ± 0.756
6.513IleGlu: 6.513 ± 0.712
1.431IlePhe: 1.431 ± 0.353
5.296IleGly: 5.296 ± 0.647
1.36IleHis: 1.36 ± 0.312
3.865IleIle: 3.865 ± 0.68
4.151IleLys: 4.151 ± 0.527
4.151IleLeu: 4.151 ± 0.524
1.288IleMet: 1.288 ± 0.296
4.222IleAsn: 4.222 ± 0.533
2.362IlePro: 2.362 ± 0.441
3.149IleGln: 3.149 ± 0.572
2.433IleArg: 2.433 ± 0.328
3.793IleSer: 3.793 ± 0.506
2.934IleThr: 2.934 ± 0.468
3.435IleVal: 3.435 ± 0.541
0.93IleTrp: 0.93 ± 0.263
1.861IleTyr: 1.861 ± 0.386
0.0IleXaa: 0.0 ± 0.0
Lys
6.083LysAla: 6.083 ± 0.996
1.002LysCys: 1.002 ± 0.311
4.222LysAsp: 4.222 ± 0.559
5.511LysGlu: 5.511 ± 0.888
2.433LysPhe: 2.433 ± 0.408
4.723LysGly: 4.723 ± 0.535
1.646LysHis: 1.646 ± 0.423
3.865LysIle: 3.865 ± 0.562
5.01LysLys: 5.01 ± 0.94
5.153LysLeu: 5.153 ± 0.728
1.861LysMet: 1.861 ± 0.37
2.362LysAsn: 2.362 ± 0.399
2.505LysPro: 2.505 ± 0.431
3.507LysGln: 3.507 ± 0.543
4.151LysArg: 4.151 ± 0.775
4.795LysSer: 4.795 ± 0.395
3.292LysThr: 3.292 ± 0.5
5.01LysVal: 5.01 ± 0.712
0.859LysTrp: 0.859 ± 0.285
2.29LysTyr: 2.29 ± 0.436
0.0LysXaa: 0.0 ± 0.0
Leu
5.725LeuAla: 5.725 ± 0.766
0.286LeuCys: 0.286 ± 0.123
5.94LeuAsp: 5.94 ± 0.554
4.652LeuGlu: 4.652 ± 0.584
2.505LeuPhe: 2.505 ± 0.348
4.008LeuGly: 4.008 ± 0.493
0.859LeuHis: 0.859 ± 0.218
4.867LeuIle: 4.867 ± 0.633
5.153LeuLys: 5.153 ± 0.742
5.153LeuLeu: 5.153 ± 0.693
2.075LeuMet: 2.075 ± 0.524
5.01LeuAsn: 5.01 ± 0.651
2.576LeuPro: 2.576 ± 0.35
2.147LeuGln: 2.147 ± 0.334
3.149LeuArg: 3.149 ± 0.573
5.868LeuSer: 5.868 ± 0.52
4.294LeuThr: 4.294 ± 0.624
4.58LeuVal: 4.58 ± 0.515
0.93LeuTrp: 0.93 ± 0.273
2.72LeuTyr: 2.72 ± 0.377
0.0LeuXaa: 0.0 ± 0.0
Met
2.433MetAla: 2.433 ± 0.459
0.573MetCys: 0.573 ± 0.187
1.431MetAsp: 1.431 ± 0.361
1.646MetGlu: 1.646 ± 0.401
0.93MetPhe: 0.93 ± 0.284
1.503MetGly: 1.503 ± 0.357
0.573MetHis: 0.573 ± 0.228
1.718MetIle: 1.718 ± 0.374
2.219MetLys: 2.219 ± 0.474
2.004MetLeu: 2.004 ± 0.421
1.073MetMet: 1.073 ± 0.272
1.145MetAsn: 1.145 ± 0.347
1.431MetPro: 1.431 ± 0.34
1.503MetGln: 1.503 ± 0.412
0.93MetArg: 0.93 ± 0.272
2.576MetSer: 2.576 ± 0.536
2.219MetThr: 2.219 ± 0.379
1.431MetVal: 1.431 ± 0.329
0.358MetTrp: 0.358 ± 0.176
0.859MetTyr: 0.859 ± 0.22
0.0MetXaa: 0.0 ± 0.0
Asn
3.865AsnAla: 3.865 ± 0.561
0.93AsnCys: 0.93 ± 0.277
2.863AsnAsp: 2.863 ± 0.592
4.867AsnGlu: 4.867 ± 0.729
2.362AsnPhe: 2.362 ± 0.378
4.652AsnGly: 4.652 ± 0.529
1.217AsnHis: 1.217 ± 0.302
2.934AsnIle: 2.934 ± 0.517
2.505AsnLys: 2.505 ± 0.541
3.865AsnLeu: 3.865 ± 0.56
1.145AsnMet: 1.145 ± 0.262
3.077AsnAsn: 3.077 ± 0.587
2.29AsnPro: 2.29 ± 0.426
2.075AsnGln: 2.075 ± 0.356
2.075AsnArg: 2.075 ± 0.418
3.936AsnSer: 3.936 ± 0.543
2.72AsnThr: 2.72 ± 0.459
2.433AsnVal: 2.433 ± 0.653
0.93AsnTrp: 0.93 ± 0.363
1.789AsnTyr: 1.789 ± 0.363
0.0AsnXaa: 0.0 ± 0.0
Pro
2.433ProAla: 2.433 ± 0.445
0.358ProCys: 0.358 ± 0.16
2.505ProAsp: 2.505 ± 0.395
3.006ProGlu: 3.006 ± 0.555
1.145ProPhe: 1.145 ± 0.259
1.073ProGly: 1.073 ± 0.252
0.429ProHis: 0.429 ± 0.169
1.718ProIle: 1.718 ± 0.331
1.646ProLys: 1.646 ± 0.326
2.934ProLeu: 2.934 ± 0.364
1.217ProMet: 1.217 ± 0.269
1.718ProAsn: 1.718 ± 0.31
1.073ProPro: 1.073 ± 0.355
1.789ProGln: 1.789 ± 0.416
2.004ProArg: 2.004 ± 0.384
2.863ProSer: 2.863 ± 0.68
2.147ProThr: 2.147 ± 0.436
2.576ProVal: 2.576 ± 0.419
0.859ProTrp: 0.859 ± 0.209
1.431ProTyr: 1.431 ± 0.32
0.0ProXaa: 0.0 ± 0.0
Gln
3.65GlnAla: 3.65 ± 0.611
0.716GlnCys: 0.716 ± 0.243
1.503GlnAsp: 1.503 ± 0.334
3.292GlnGlu: 3.292 ± 0.556
1.145GlnPhe: 1.145 ± 0.301
2.576GlnGly: 2.576 ± 0.341
0.93GlnHis: 0.93 ± 0.329
2.576GlnIle: 2.576 ± 0.469
2.147GlnLys: 2.147 ± 0.379
3.578GlnLeu: 3.578 ± 0.696
0.787GlnMet: 0.787 ± 0.242
2.004GlnAsn: 2.004 ± 0.392
1.932GlnPro: 1.932 ± 0.491
2.791GlnGln: 2.791 ± 0.782
2.075GlnArg: 2.075 ± 0.515
3.435GlnSer: 3.435 ± 0.547
1.861GlnThr: 1.861 ± 0.476
2.791GlnVal: 2.791 ± 0.453
0.429GlnTrp: 0.429 ± 0.162
2.147GlnTyr: 2.147 ± 0.438
0.0GlnXaa: 0.0 ± 0.0
Arg
2.648ArgAla: 2.648 ± 0.496
0.501ArgCys: 0.501 ± 0.222
2.863ArgAsp: 2.863 ± 0.435
4.867ArgGlu: 4.867 ± 0.763
1.861ArgPhe: 1.861 ± 0.336
3.149ArgGly: 3.149 ± 0.494
0.716ArgHis: 0.716 ± 0.234
3.077ArgIle: 3.077 ± 0.423
5.153ArgLys: 5.153 ± 0.808
3.22ArgLeu: 3.22 ± 0.402
1.646ArgMet: 1.646 ± 0.325
1.718ArgAsn: 1.718 ± 0.403
0.787ArgPro: 0.787 ± 0.27
2.219ArgGln: 2.219 ± 0.556
2.219ArgArg: 2.219 ± 0.403
2.362ArgSer: 2.362 ± 0.422
2.433ArgThr: 2.433 ± 0.513
3.149ArgVal: 3.149 ± 0.761
0.644ArgTrp: 0.644 ± 0.214
1.503ArgTyr: 1.503 ± 0.372
0.0ArgXaa: 0.0 ± 0.0
Ser
5.081SerAla: 5.081 ± 0.697
0.93SerCys: 0.93 ± 0.281
4.008SerAsp: 4.008 ± 0.511
5.654SerGlu: 5.654 ± 0.523
3.22SerPhe: 3.22 ± 0.524
4.867SerGly: 4.867 ± 0.689
1.002SerHis: 1.002 ± 0.276
3.721SerIle: 3.721 ± 0.525
5.582SerLys: 5.582 ± 0.8
4.652SerLeu: 4.652 ± 0.525
1.718SerMet: 1.718 ± 0.326
3.721SerAsn: 3.721 ± 0.777
2.72SerPro: 2.72 ± 0.435
2.863SerGln: 2.863 ± 0.444
3.077SerArg: 3.077 ± 0.444
4.222SerSer: 4.222 ± 0.778
2.791SerThr: 2.791 ± 0.616
4.867SerVal: 4.867 ± 0.689
0.859SerTrp: 0.859 ± 0.247
2.219SerTyr: 2.219 ± 0.383
0.0SerXaa: 0.0 ± 0.0
Thr
4.723ThrAla: 4.723 ± 0.705
0.573ThrCys: 0.573 ± 0.22
3.292ThrAsp: 3.292 ± 0.396
4.151ThrGlu: 4.151 ± 0.521
2.219ThrPhe: 2.219 ± 0.413
4.652ThrGly: 4.652 ± 0.499
0.859ThrHis: 0.859 ± 0.235
3.077ThrIle: 3.077 ± 0.589
3.721ThrLys: 3.721 ± 0.489
4.437ThrLeu: 4.437 ± 0.586
1.789ThrMet: 1.789 ± 0.407
2.433ThrAsn: 2.433 ± 0.532
3.006ThrPro: 3.006 ± 0.547
1.646ThrGln: 1.646 ± 0.325
2.219ThrArg: 2.219 ± 0.474
2.576ThrSer: 2.576 ± 0.653
3.507ThrThr: 3.507 ± 0.599
4.151ThrVal: 4.151 ± 0.831
0.358ThrTrp: 0.358 ± 0.154
1.718ThrTyr: 1.718 ± 0.257
0.0ThrXaa: 0.0 ± 0.0
Val
5.01ValAla: 5.01 ± 0.731
0.644ValCys: 0.644 ± 0.213
4.509ValAsp: 4.509 ± 0.608
4.652ValGlu: 4.652 ± 0.558
1.718ValPhe: 1.718 ± 0.311
4.222ValGly: 4.222 ± 0.62
0.93ValHis: 0.93 ± 0.306
4.795ValIle: 4.795 ± 0.52
4.294ValLys: 4.294 ± 0.46
3.292ValLeu: 3.292 ± 0.42
1.718ValMet: 1.718 ± 0.347
3.865ValAsn: 3.865 ± 0.576
1.574ValPro: 1.574 ± 0.363
2.362ValGln: 2.362 ± 0.434
2.29ValArg: 2.29 ± 0.369
4.652ValSer: 4.652 ± 0.707
5.01ValThr: 5.01 ± 0.643
4.079ValVal: 4.079 ± 0.472
1.145ValTrp: 1.145 ± 0.26
1.718ValTyr: 1.718 ± 0.436
0.0ValXaa: 0.0 ± 0.0
Trp
1.073TrpAla: 1.073 ± 0.284
0.501TrpCys: 0.501 ± 0.232
1.002TrpAsp: 1.002 ± 0.237
1.002TrpGlu: 1.002 ± 0.249
0.501TrpPhe: 0.501 ± 0.201
0.573TrpGly: 0.573 ± 0.194
0.573TrpHis: 0.573 ± 0.245
1.002TrpIle: 1.002 ± 0.317
1.073TrpLys: 1.073 ± 0.287
0.859TrpLeu: 0.859 ± 0.229
0.286TrpMet: 0.286 ± 0.135
0.787TrpAsn: 0.787 ± 0.262
0.358TrpPro: 0.358 ± 0.162
1.288TrpGln: 1.288 ± 0.256
0.644TrpArg: 0.644 ± 0.206
0.859TrpSer: 0.859 ± 0.261
0.644TrpThr: 0.644 ± 0.208
1.646TrpVal: 1.646 ± 0.347
0.358TrpTrp: 0.358 ± 0.171
0.501TrpTyr: 0.501 ± 0.207
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.29TyrAla: 2.29 ± 0.365
0.429TyrCys: 0.429 ± 0.157
2.934TyrAsp: 2.934 ± 0.382
2.433TyrGlu: 2.433 ± 0.426
1.073TyrPhe: 1.073 ± 0.253
2.505TyrGly: 2.505 ± 0.478
0.215TyrHis: 0.215 ± 0.112
2.075TyrIle: 2.075 ± 0.411
2.362TyrLys: 2.362 ± 0.446
2.433TyrLeu: 2.433 ± 0.44
0.716TyrMet: 0.716 ± 0.195
2.004TyrAsn: 2.004 ± 0.321
1.36TyrPro: 1.36 ± 0.345
1.718TyrGln: 1.718 ± 0.352
1.861TyrArg: 1.861 ± 0.336
3.578TyrSer: 3.578 ± 0.438
2.72TyrThr: 2.72 ± 0.438
2.505TyrVal: 2.505 ± 0.484
0.573TyrTrp: 0.573 ± 0.205
1.073TyrTyr: 1.073 ± 0.305
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 76 proteins (13974 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski