Amino acid dipepetide frequency for Pajaroellobacter abortibovis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.451AlaAla: 7.451 ± 0.163	1.44AlaCys: 1.44 ± 0.061	3.227AlaAsp: 3.227 ± 0.094	4.435AlaGlu: 4.435 ± 0.099	3.758AlaPhe: 3.758 ± 0.095	5.36AlaGly: 5.36 ± 0.117	2.362AlaHis: 2.362 ± 0.068	5.591AlaIle: 5.591 ± 0.117	3.543AlaLys: 3.543 ± 0.093	10.443AlaLeu: 10.443 ± 0.17	1.89AlaMet: 1.89 ± 0.06	2.057AlaAsn: 2.057 ± 0.074	3.424AlaPro: 3.424 ± 0.088	3.555AlaGln: 3.555 ± 0.087	5.698AlaArg: 5.698 ± 0.123	6.106AlaSer: 6.106 ± 0.112	3.939AlaThr: 3.939 ± 0.094	5.507AlaVal: 5.507 ± 0.118	1.18AlaTrp: 1.18 ± 0.051	2.566AlaTyr: 2.566 ± 0.078	0.0AlaXaa: 0.0 ± 0.0
Cys	1.082CysAla: 1.082 ± 0.052	0.237CysCys: 0.237 ± 0.024	0.674CysAsp: 0.674 ± 0.037	0.708CysGlu: 0.708 ± 0.037	0.718CysPhe: 0.718 ± 0.038	1.082CysGly: 1.082 ± 0.049	0.412CysHis: 0.412 ± 0.029	0.931CysIle: 0.931 ± 0.041	0.523CysLys: 0.523 ± 0.033	1.347CysLeu: 1.347 ± 0.052	0.334CysMet: 0.334 ± 0.027	0.37CysAsn: 0.37 ± 0.027	0.73CysPro: 0.73 ± 0.043	0.523CysGln: 0.523 ± 0.035	0.76CysArg: 0.76 ± 0.039	1.114CysSer: 1.114 ± 0.048	0.73CysThr: 0.73 ± 0.039	0.953CysVal: 0.953 ± 0.043	0.201CysTrp: 0.201 ± 0.025	0.352CysTyr: 0.352 ± 0.027	0.0CysXaa: 0.0 ± 0.0
Asp	3.519AspAla: 3.519 ± 0.082	0.517AspCys: 0.517 ± 0.034	1.53AspAsp: 1.53 ± 0.057	2.777AspGlu: 2.777 ± 0.074	1.9AspPhe: 1.9 ± 0.059	2.887AspGly: 2.887 ± 0.088	1.076AspHis: 1.076 ± 0.044	2.692AspIle: 2.692 ± 0.075	1.659AspLys: 1.659 ± 0.067	4.604AspLeu: 4.604 ± 0.106	0.887AspMet: 0.887 ± 0.041	0.885AspAsn: 0.885 ± 0.043	3.124AspPro: 3.124 ± 0.084	1.964AspGln: 1.964 ± 0.068	3.09AspArg: 3.09 ± 0.084	2.539AspSer: 2.539 ± 0.082	2.053AspThr: 2.053 ± 0.065	3.143AspVal: 3.143 ± 0.08	0.666AspTrp: 0.666 ± 0.035	1.104AspTyr: 1.104 ± 0.052	0.0AspXaa: 0.0 ± 0.0
Glu	5.813GluAla: 5.813 ± 0.122	0.647GluCys: 0.647 ± 0.037	2.65GluAsp: 2.65 ± 0.074	5.877GluGlu: 5.877 ± 0.152	1.884GluPhe: 1.884 ± 0.065	5.089GluGly: 5.089 ± 0.113	1.615GluHis: 1.615 ± 0.053	3.937GluIle: 3.937 ± 0.103	4.188GluLys: 4.188 ± 0.102	6.102GluLeu: 6.102 ± 0.125	1.464GluMet: 1.464 ± 0.052	1.854GluAsn: 1.854 ± 0.053	2.354GluPro: 2.354 ± 0.075	3.601GluGln: 3.601 ± 0.096	4.803GluArg: 4.803 ± 0.106	3.35GluSer: 3.35 ± 0.081	2.897GluThr: 2.897 ± 0.083	4.554GluVal: 4.554 ± 0.101	1.005GluTrp: 1.005 ± 0.048	1.395GluTyr: 1.395 ± 0.054	0.0GluXaa: 0.0 ± 0.0
Phe	3.348PheAla: 3.348 ± 0.091	0.702PheCys: 0.702 ± 0.04	2.017PheAsp: 2.017 ± 0.059	2.471PheGlu: 2.471 ± 0.074	2.419PhePhe: 2.419 ± 0.084	3.004PheGly: 3.004 ± 0.072	1.273PheHis: 1.273 ± 0.057	2.157PheIle: 2.157 ± 0.073	1.498PheLys: 1.498 ± 0.051	5.419PheLeu: 5.419 ± 0.135	0.844PheMet: 0.844 ± 0.038	1.21PheAsn: 1.21 ± 0.05	2.266PhePro: 2.266 ± 0.063	1.653PheGln: 1.653 ± 0.057	2.258PheArg: 2.258 ± 0.073	3.539PheSer: 3.539 ± 0.091	1.876PheThr: 1.876 ± 0.071	2.712PheVal: 2.712 ± 0.081	0.539PheTrp: 0.539 ± 0.036	1.383PheTyr: 1.383 ± 0.058	0.0PheXaa: 0.0 ± 0.0
Gly	5.758GlyAla: 5.758 ± 0.116	1.19GlyCys: 1.19 ± 0.045	3.307GlyAsp: 3.307 ± 0.077	4.817GlyGlu: 4.817 ± 0.116	3.124GlyPhe: 3.124 ± 0.084	6.591GlyGly: 6.591 ± 0.212	1.576GlyHis: 1.576 ± 0.065	5.29GlyIle: 5.29 ± 0.109	3.816GlyLys: 3.816 ± 0.085	7.011GlyLeu: 7.011 ± 0.114	1.846GlyMet: 1.846 ± 0.058	1.974GlyAsn: 1.974 ± 0.065	2.507GlyPro: 2.507 ± 0.073	2.515GlyGln: 2.515 ± 0.078	4.23GlyArg: 4.23 ± 0.1	4.391GlySer: 4.391 ± 0.101	3.744GlyThr: 3.744 ± 0.09	5.358GlyVal: 5.358 ± 0.13	1.204GlyTrp: 1.204 ± 0.054	2.029GlyTyr: 2.029 ± 0.066	0.006GlyXaa: 0.006 ± 0.003
His	2.477HisAla: 2.477 ± 0.074	0.336HisCys: 0.336 ± 0.025	0.959HisAsp: 0.959 ± 0.041	1.375HisGlu: 1.375 ± 0.055	1.345HisPhe: 1.345 ± 0.058	1.699HisGly: 1.699 ± 0.053	0.931HisHis: 0.931 ± 0.055	1.432HisIle: 1.432 ± 0.055	0.867HisLys: 0.867 ± 0.046	3.271HisLeu: 3.271 ± 0.088	0.565HisMet: 0.565 ± 0.036	0.607HisAsn: 0.607 ± 0.034	2.021HisPro: 2.021 ± 0.068	1.454HisGln: 1.454 ± 0.068	1.697HisArg: 1.697 ± 0.057	1.685HisSer: 1.685 ± 0.063	1.379HisThr: 1.379 ± 0.059	1.944HisVal: 1.944 ± 0.075	0.366HisTrp: 0.366 ± 0.025	0.776HisTyr: 0.776 ± 0.038	0.0HisXaa: 0.0 ± 0.0
Ile	6.158IleAla: 6.158 ± 0.117	0.881IleCys: 0.881 ± 0.041	3.193IleAsp: 3.193 ± 0.078	4.258IleGlu: 4.258 ± 0.098	2.173IlePhe: 2.173 ± 0.075	4.821IleGly: 4.821 ± 0.115	2.037IleHis: 2.037 ± 0.066	2.708IleIle: 2.708 ± 0.075	2.475IleLys: 2.475 ± 0.067	6.243IleLeu: 6.243 ± 0.144	0.951IleMet: 0.951 ± 0.048	1.699IleAsn: 1.699 ± 0.057	3.961IlePro: 3.961 ± 0.098	3.092IleGln: 3.092 ± 0.078	3.985IleArg: 3.985 ± 0.085	3.872IleSer: 3.872 ± 0.094	3.08IleThr: 3.08 ± 0.091	4.162IleVal: 4.162 ± 0.1	0.585IleTrp: 0.585 ± 0.031	1.458IleTyr: 1.458 ± 0.055	0.0IleXaa: 0.0 ± 0.0
Lys	3.796LysAla: 3.796 ± 0.096	0.378LysCys: 0.378 ± 0.029	1.874LysAsp: 1.874 ± 0.071	4.043LysGlu: 4.043 ± 0.101	1.001LysPhe: 1.001 ± 0.043	4.021LysGly: 4.021 ± 0.093	0.933LysHis: 0.933 ± 0.047	2.913LysIle: 2.913 ± 0.095	3.502LysLys: 3.502 ± 0.105	3.993LysLeu: 3.993 ± 0.086	1.194LysMet: 1.194 ± 0.052	1.606LysAsn: 1.606 ± 0.061	1.97LysPro: 1.97 ± 0.061	2.177LysGln: 2.177 ± 0.072	3.305LysArg: 3.305 ± 0.076	2.451LysSer: 2.451 ± 0.064	2.377LysThr: 2.377 ± 0.07	2.964LysVal: 2.964 ± 0.094	0.639LysTrp: 0.639 ± 0.038	0.891LysTyr: 0.891 ± 0.04	0.0LysXaa: 0.0 ± 0.0
Leu	9.747LeuAla: 9.747 ± 0.159	1.663LeuCys: 1.663 ± 0.064	4.799LeuAsp: 4.799 ± 0.105	7.035LeuGlu: 7.035 ± 0.131	5.445LeuPhe: 5.445 ± 0.138	7.554LeuGly: 7.554 ± 0.151	3.06LeuHis: 3.06 ± 0.079	6.366LeuIle: 6.366 ± 0.129	4.741LeuLys: 4.741 ± 0.116	12.2LeuLeu: 12.2 ± 0.224	2.308LeuMet: 2.308 ± 0.073	2.948LeuAsn: 2.948 ± 0.084	5.636LeuPro: 5.636 ± 0.123	4.655LeuGln: 4.655 ± 0.101	6.621LeuArg: 6.621 ± 0.139	8.459LeuSer: 8.459 ± 0.14	5.702LeuThr: 5.702 ± 0.127	6.894LeuVal: 6.894 ± 0.126	1.446LeuTrp: 1.446 ± 0.065	2.678LeuTyr: 2.678 ± 0.09	0.0LeuXaa: 0.0 ± 0.0
Met	1.82MetAla: 1.82 ± 0.055	0.203MetCys: 0.203 ± 0.02	1.062MetAsp: 1.062 ± 0.052	1.508MetGlu: 1.508 ± 0.054	0.627MetPhe: 0.627 ± 0.035	1.82MetGly: 1.82 ± 0.056	0.573MetHis: 0.573 ± 0.035	1.538MetIle: 1.538 ± 0.056	1.212MetLys: 1.212 ± 0.047	2.306MetLeu: 2.306 ± 0.069	0.615MetMet: 0.615 ± 0.042	0.796MetAsn: 0.796 ± 0.04	0.949MetPro: 0.949 ± 0.046	0.951MetGln: 0.951 ± 0.044	1.55MetArg: 1.55 ± 0.059	1.385MetSer: 1.385 ± 0.048	1.247MetThr: 1.247 ± 0.047	1.564MetVal: 1.564 ± 0.056	0.251MetTrp: 0.251 ± 0.021	0.416MetTyr: 0.416 ± 0.028	0.0MetXaa: 0.0 ± 0.0
Asn	2.423AsnAla: 2.423 ± 0.074	0.37AsnCys: 0.37 ± 0.026	1.05AsnAsp: 1.05 ± 0.047	1.504AsnGlu: 1.504 ± 0.06	0.957AsnPhe: 0.957 ± 0.045	1.812AsnGly: 1.812 ± 0.068	0.871AsnHis: 0.871 ± 0.042	1.578AsnIle: 1.578 ± 0.059	1.08AsnLys: 1.08 ± 0.056	2.948AsnLeu: 2.948 ± 0.078	0.591AsnMet: 0.591 ± 0.035	0.78AsnAsn: 0.78 ± 0.048	2.099AsnPro: 2.099 ± 0.071	1.397AsnGln: 1.397 ± 0.058	1.934AsnArg: 1.934 ± 0.074	1.721AsnSer: 1.721 ± 0.056	1.417AsnThr: 1.417 ± 0.059	1.747AsnVal: 1.747 ± 0.053	0.352AsnTrp: 0.352 ± 0.025	0.734AsnTyr: 0.734 ± 0.043	0.0AsnXaa: 0.0 ± 0.0
Pro	3.217ProAla: 3.217 ± 0.08	0.591ProCys: 0.591 ± 0.032	2.161ProAsp: 2.161 ± 0.085	3.157ProGlu: 3.157 ± 0.085	2.893ProPhe: 2.893 ± 0.087	2.817ProGly: 2.817 ± 0.072	1.602ProHis: 1.602 ± 0.058	3.135ProIle: 3.135 ± 0.088	1.868ProLys: 1.868 ± 0.064	6.279ProLeu: 6.279 ± 0.121	1.104ProMet: 1.104 ± 0.045	1.454ProAsn: 1.454 ± 0.055	3.742ProPro: 3.742 ± 0.115	1.926ProGln: 1.926 ± 0.059	2.312ProArg: 2.312 ± 0.078	5.185ProSer: 5.185 ± 0.117	2.829ProThr: 2.829 ± 0.077	3.07ProVal: 3.07 ± 0.088	0.736ProTrp: 0.736 ± 0.043	1.53ProTyr: 1.53 ± 0.057	0.0ProXaa: 0.0 ± 0.0
Gln	4.287GlnAla: 4.287 ± 0.094	0.519GlnCys: 0.519 ± 0.036	1.727GlnAsp: 1.727 ± 0.055	3.587GlnGlu: 3.587 ± 0.087	1.47GlnPhe: 1.47 ± 0.052	3.257GlnGly: 3.257 ± 0.089	0.981GlnHis: 0.981 ± 0.045	2.608GlnIle: 2.608 ± 0.071	2.728GlnLys: 2.728 ± 0.078	4.311GlnLeu: 4.311 ± 0.095	0.995GlnMet: 0.995 ± 0.047	1.212GlnAsn: 1.212 ± 0.053	1.691GlnPro: 1.691 ± 0.057	2.266GlnGln: 2.266 ± 0.072	2.775GlnArg: 2.775 ± 0.07	2.578GlnSer: 2.578 ± 0.065	1.978GlnThr: 1.978 ± 0.065	3.135GlnVal: 3.135 ± 0.09	0.74GlnTrp: 0.74 ± 0.044	0.842GlnTyr: 0.842 ± 0.045	0.0GlnXaa: 0.0 ± 0.0
Arg	5.197ArgAla: 5.197 ± 0.123	0.824ArgCys: 0.824 ± 0.043	2.654ArgAsp: 2.654 ± 0.084	4.349ArgGlu: 4.349 ± 0.103	2.847ArgPhe: 2.847 ± 0.076	4.568ArgGly: 4.568 ± 0.096	1.478ArgHis: 1.478 ± 0.057	4.365ArgIle: 4.365 ± 0.099	3.014ArgLys: 3.014 ± 0.083	6.81ArgLeu: 6.81 ± 0.123	1.711ArgMet: 1.711 ± 0.056	1.721ArgAsn: 1.721 ± 0.055	2.449ArgPro: 2.449 ± 0.08	2.328ArgGln: 2.328 ± 0.069	4.1ArgArg: 4.1 ± 0.105	4.071ArgSer: 4.071 ± 0.096	3.088ArgThr: 3.088 ± 0.081	4.638ArgVal: 4.638 ± 0.1	1.044ArgTrp: 1.044 ± 0.054	1.852ArgTyr: 1.852 ± 0.06	0.002ArgXaa: 0.002 ± 0.002
Ser	4.892SerAla: 4.892 ± 0.101	1.011SerCys: 1.011 ± 0.053	2.562SerAsp: 2.562 ± 0.074	3.625SerGlu: 3.625 ± 0.082	3.615SerPhe: 3.615 ± 0.089	4.124SerGly: 4.124 ± 0.097	1.982SerHis: 1.982 ± 0.057	4.636SerIle: 4.636 ± 0.101	2.811SerLys: 2.811 ± 0.078	8.808SerLeu: 8.808 ± 0.153	1.701SerMet: 1.701 ± 0.059	1.822SerAsn: 1.822 ± 0.061	4.488SerPro: 4.488 ± 0.106	2.702SerGln: 2.702 ± 0.071	3.897SerArg: 3.897 ± 0.092	6.669SerSer: 6.669 ± 0.124	3.559SerThr: 3.559 ± 0.082	4.252SerVal: 4.252 ± 0.091	0.937SerTrp: 0.937 ± 0.047	1.802SerTyr: 1.802 ± 0.055	0.0SerXaa: 0.0 ± 0.0
Thr	3.868ThrAla: 3.868 ± 0.097	0.746ThrCys: 0.746 ± 0.043	1.974ThrAsp: 1.974 ± 0.067	2.64ThrGlu: 2.64 ± 0.072	2.021ThrPhe: 2.021 ± 0.066	3.551ThrGly: 3.551 ± 0.082	1.502ThrHis: 1.502 ± 0.058	3.273ThrIle: 3.273 ± 0.078	2.101ThrLys: 2.101 ± 0.067	6.09ThrLeu: 6.09 ± 0.125	1.001ThrMet: 1.001 ± 0.048	1.45ThrAsn: 1.45 ± 0.07	2.99ThrPro: 2.99 ± 0.08	1.978ThrGln: 1.978 ± 0.063	2.769ThrArg: 2.769 ± 0.073	3.762ThrSer: 3.762 ± 0.092	2.622ThrThr: 2.622 ± 0.081	3.263ThrVal: 3.263 ± 0.077	0.633ThrTrp: 0.633 ± 0.038	1.413ThrTyr: 1.413 ± 0.048	0.0ThrXaa: 0.0 ± 0.0
Val	5.62ValAla: 5.62 ± 0.118	0.959ValCys: 0.959 ± 0.049	3.472ValAsp: 3.472 ± 0.088	4.51ValGlu: 4.51 ± 0.109	2.672ValPhe: 2.672 ± 0.07	5.282ValGly: 5.282 ± 0.13	1.806ValHis: 1.806 ± 0.07	4.092ValIle: 4.092 ± 0.095	2.69ValLys: 2.69 ± 0.085	7.286ValLeu: 7.286 ± 0.133	1.46ValMet: 1.46 ± 0.051	1.763ValAsn: 1.763 ± 0.062	3.199ValPro: 3.199 ± 0.083	2.988ValGln: 2.988 ± 0.085	4.544ValArg: 4.544 ± 0.098	4.59ValSer: 4.59 ± 0.1	3.124ValThr: 3.124 ± 0.085	5.091ValVal: 5.091 ± 0.123	0.836ValTrp: 0.836 ± 0.045	1.613ValTyr: 1.613 ± 0.06	0.0ValXaa: 0.0 ± 0.0
Trp	0.788TrpAla: 0.788 ± 0.045	0.187TrpCys: 0.187 ± 0.019	0.567TrpAsp: 0.567 ± 0.034	0.774TrpGlu: 0.774 ± 0.04	0.545TrpPhe: 0.545 ± 0.033	0.981TrpGly: 0.981 ± 0.051	0.312TrpHis: 0.312 ± 0.025	1.391TrpIle: 1.391 ± 0.065	0.865TrpLys: 0.865 ± 0.044	1.621TrpLeu: 1.621 ± 0.064	0.47TrpMet: 0.47 ± 0.032	0.533TrpAsn: 0.533 ± 0.036	0.477TrpPro: 0.477 ± 0.026	0.505TrpGln: 0.505 ± 0.041	0.836TrpArg: 0.836 ± 0.043	0.899TrpSer: 0.899 ± 0.046	0.718TrpThr: 0.718 ± 0.043	1.011TrpVal: 1.011 ± 0.047	0.237TrpTrp: 0.237 ± 0.023	0.267TrpTyr: 0.267 ± 0.025	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.272TyrAla: 2.272 ± 0.07	0.378TyrCys: 0.378 ± 0.029	1.156TyrAsp: 1.156 ± 0.042	1.629TyrGlu: 1.629 ± 0.06	1.172TyrPhe: 1.172 ± 0.047	1.968TyrGly: 1.968 ± 0.059	0.804TyrHis: 0.804 ± 0.04	1.158TyrIle: 1.158 ± 0.046	0.848TyrLys: 0.848 ± 0.043	2.861TyrLeu: 2.861 ± 0.091	0.46TyrMet: 0.46 ± 0.029	0.623TyrAsn: 0.623 ± 0.036	1.532TyrPro: 1.532 ± 0.05	1.456TyrGln: 1.456 ± 0.056	1.946TyrArg: 1.946 ± 0.067	1.528TyrSer: 1.528 ± 0.061	1.289TyrThr: 1.289 ± 0.051	1.633TyrVal: 1.633 ± 0.063	0.386TyrTrp: 0.386 ± 0.029	0.76TyrTyr: 0.76 ± 0.047	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.002XaaGly: 0.002 ± 0.002	0.0XaaHis: 0.0 ± 0.0	0.002XaaIle: 0.002 ± 0.002	0.002XaaLys: 0.002 ± 0.002	0.002XaaLeu: 0.002 ± 0.002	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 1745 proteins (497364 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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