Amino acid dipepetide frequency for Acaryochloris phage A-HIS2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.329AlaAla: 6.329 ± 1.577
0.969AlaCys: 0.969 ± 0.255
4.504AlaAsp: 4.504 ± 0.569
4.447AlaGlu: 4.447 ± 0.894
2.851AlaPhe: 2.851 ± 0.437
5.417AlaGly: 5.417 ± 0.84
1.596AlaHis: 1.596 ± 0.284
4.276AlaIle: 4.276 ± 0.465
3.535AlaLys: 3.535 ± 0.553
8.039AlaLeu: 8.039 ± 1.363
1.425AlaMet: 1.425 ± 0.315
3.991AlaAsn: 3.991 ± 0.722
2.281AlaPro: 2.281 ± 0.408
3.478AlaGln: 3.478 ± 0.607
2.737AlaArg: 2.737 ± 0.471
4.732AlaSer: 4.732 ± 0.693
3.877AlaThr: 3.877 ± 0.642
4.276AlaVal: 4.276 ± 0.82
0.855AlaTrp: 0.855 ± 0.181
2.737AlaTyr: 2.737 ± 0.363
0.0AlaXaa: 0.0 ± 0.0
Cys
0.798CysAla: 0.798 ± 0.229
0.285CysCys: 0.285 ± 0.133
0.798CysAsp: 0.798 ± 0.293
0.627CysGlu: 0.627 ± 0.21
0.741CysPhe: 0.741 ± 0.202
0.912CysGly: 0.912 ± 0.319
0.399CysHis: 0.399 ± 0.133
0.513CysIle: 0.513 ± 0.174
0.684CysLys: 0.684 ± 0.198
1.254CysLeu: 1.254 ± 0.296
0.342CysMet: 0.342 ± 0.132
0.627CysAsn: 0.627 ± 0.211
0.798CysPro: 0.798 ± 0.203
0.399CysGln: 0.399 ± 0.166
0.798CysArg: 0.798 ± 0.26
0.741CysSer: 0.741 ± 0.203
0.399CysThr: 0.399 ± 0.168
0.741CysVal: 0.741 ± 0.171
0.171CysTrp: 0.171 ± 0.109
0.513CysTyr: 0.513 ± 0.196
0.0CysXaa: 0.0 ± 0.0
Asp
4.846AspAla: 4.846 ± 0.459
1.653AspCys: 1.653 ± 0.32
3.763AspAsp: 3.763 ± 0.511
3.991AspGlu: 3.991 ± 0.429
3.421AspPhe: 3.421 ± 0.635
4.561AspGly: 4.561 ± 0.687
1.996AspHis: 1.996 ± 0.407
2.737AspIle: 2.737 ± 0.421
2.281AspLys: 2.281 ± 0.318
6.386AspLeu: 6.386 ± 0.622
1.482AspMet: 1.482 ± 0.326
2.737AspAsn: 2.737 ± 0.431
4.846AspPro: 4.846 ± 0.733
2.395AspGln: 2.395 ± 0.292
3.535AspArg: 3.535 ± 0.412
2.965AspSer: 2.965 ± 0.411
3.022AspThr: 3.022 ± 0.578
3.421AspVal: 3.421 ± 0.448
0.912AspTrp: 0.912 ± 0.295
2.68AspTyr: 2.68 ± 0.399
0.0AspXaa: 0.0 ± 0.0
Glu
5.474GluAla: 5.474 ± 0.887
0.798GluCys: 0.798 ± 0.274
4.561GluAsp: 4.561 ± 0.557
4.162GluGlu: 4.162 ± 0.543
3.079GluPhe: 3.079 ± 0.332
3.478GluGly: 3.478 ± 0.425
1.14GluHis: 1.14 ± 0.249
5.245GluIle: 5.245 ± 0.492
3.364GluLys: 3.364 ± 0.59
6.158GluLeu: 6.158 ± 0.759
1.254GluMet: 1.254 ± 0.287
3.763GluAsn: 3.763 ± 0.511
1.425GluPro: 1.425 ± 0.484
1.539GluGln: 1.539 ± 0.327
3.307GluArg: 3.307 ± 0.573
3.592GluSer: 3.592 ± 0.531
4.39GluThr: 4.39 ± 0.623
4.048GluVal: 4.048 ± 0.496
0.969GluTrp: 0.969 ± 0.267
3.079GluTyr: 3.079 ± 0.422
0.0GluXaa: 0.0 ± 0.0
Phe
2.395PheAla: 2.395 ± 0.414
0.627PheCys: 0.627 ± 0.191
3.592PheAsp: 3.592 ± 0.407
2.68PheGlu: 2.68 ± 0.428
1.368PhePhe: 1.368 ± 0.261
3.25PheGly: 3.25 ± 0.51
0.798PheHis: 0.798 ± 0.228
1.882PheIle: 1.882 ± 0.352
1.882PheLys: 1.882 ± 0.378
4.219PheLeu: 4.219 ± 0.46
0.969PheMet: 0.969 ± 0.243
2.452PheAsn: 2.452 ± 0.362
1.767PhePro: 1.767 ± 0.418
1.254PheGln: 1.254 ± 0.23
2.281PheArg: 2.281 ± 0.33
2.794PheSer: 2.794 ± 0.473
4.048PheThr: 4.048 ± 0.471
2.338PheVal: 2.338 ± 0.49
0.342PheTrp: 0.342 ± 0.127
1.825PheTyr: 1.825 ± 0.317
0.0PheXaa: 0.0 ± 0.0
Gly
4.96GlyAla: 4.96 ± 0.82
0.969GlyCys: 0.969 ± 0.275
4.846GlyAsp: 4.846 ± 0.464
3.022GlyGlu: 3.022 ± 0.408
3.934GlyPhe: 3.934 ± 0.555
4.105GlyGly: 4.105 ± 1.154
0.855GlyHis: 0.855 ± 0.262
6.272GlyIle: 6.272 ± 0.535
3.706GlyLys: 3.706 ± 0.532
6.386GlyLeu: 6.386 ± 0.563
1.368GlyMet: 1.368 ± 0.27
4.162GlyAsn: 4.162 ± 0.524
1.539GlyPro: 1.539 ± 0.227
2.395GlyGln: 2.395 ± 0.433
3.478GlyArg: 3.478 ± 0.448
6.899GlySer: 6.899 ± 1.23
4.561GlyThr: 4.561 ± 1.01
4.504GlyVal: 4.504 ± 0.521
0.855GlyTrp: 0.855 ± 0.266
2.794GlyTyr: 2.794 ± 0.389
0.0GlyXaa: 0.0 ± 0.0
His
0.57HisAla: 0.57 ± 0.188
0.285HisCys: 0.285 ± 0.128
1.311HisAsp: 1.311 ± 0.324
1.254HisGlu: 1.254 ± 0.285
1.026HisPhe: 1.026 ± 0.235
1.482HisGly: 1.482 ± 0.385
0.114HisHis: 0.114 ± 0.073
0.912HisIle: 0.912 ± 0.147
1.254HisLys: 1.254 ± 0.292
2.281HisLeu: 2.281 ± 0.41
0.57HisMet: 0.57 ± 0.156
1.254HisAsn: 1.254 ± 0.298
0.741HisPro: 0.741 ± 0.177
0.399HisGln: 0.399 ± 0.169
0.684HisArg: 0.684 ± 0.201
1.482HisSer: 1.482 ± 0.37
1.197HisThr: 1.197 ± 0.238
0.912HisVal: 0.912 ± 0.291
0.57HisTrp: 0.57 ± 0.147
0.513HisTyr: 0.513 ± 0.153
0.0HisXaa: 0.0 ± 0.0
Ile
4.504IleAla: 4.504 ± 0.441
0.342IleCys: 0.342 ± 0.135
3.25IleAsp: 3.25 ± 0.4
3.364IleGlu: 3.364 ± 0.47
1.71IlePhe: 1.71 ± 0.255
3.136IleGly: 3.136 ± 0.382
0.741IleHis: 0.741 ± 0.246
2.566IleIle: 2.566 ± 0.46
2.566IleLys: 2.566 ± 0.392
5.987IleLeu: 5.987 ± 0.689
1.539IleMet: 1.539 ± 0.344
2.851IleAsn: 2.851 ± 0.388
3.25IlePro: 3.25 ± 0.425
3.022IleGln: 3.022 ± 0.445
2.509IleArg: 2.509 ± 0.322
4.333IleSer: 4.333 ± 0.513
5.474IleThr: 5.474 ± 0.586
3.25IleVal: 3.25 ± 0.493
0.798IleTrp: 0.798 ± 0.186
1.482IleTyr: 1.482 ± 0.304
0.0IleXaa: 0.0 ± 0.0
Lys
5.017LysAla: 5.017 ± 0.729
0.399LysCys: 0.399 ± 0.168
2.053LysAsp: 2.053 ± 0.316
3.364LysGlu: 3.364 ± 0.432
1.882LysPhe: 1.882 ± 0.335
2.566LysGly: 2.566 ± 0.561
1.311LysHis: 1.311 ± 0.307
2.68LysIle: 2.68 ± 0.407
2.737LysLys: 2.737 ± 0.613
4.675LysLeu: 4.675 ± 0.643
1.197LysMet: 1.197 ± 0.289
1.71LysAsn: 1.71 ± 0.342
2.224LysPro: 2.224 ± 0.515
2.281LysGln: 2.281 ± 0.415
3.136LysArg: 3.136 ± 0.554
2.908LysSer: 2.908 ± 0.501
3.706LysThr: 3.706 ± 0.6
3.079LysVal: 3.079 ± 0.421
0.627LysTrp: 0.627 ± 0.173
2.11LysTyr: 2.11 ± 0.458
0.0LysXaa: 0.0 ± 0.0
Leu
6.956LeuAla: 6.956 ± 0.645
0.969LeuCys: 0.969 ± 0.29
5.588LeuAsp: 5.588 ± 0.536
7.07LeuGlu: 7.07 ± 1.078
2.566LeuPhe: 2.566 ± 0.46
8.381LeuGly: 8.381 ± 0.785
1.825LeuHis: 1.825 ± 0.448
3.649LeuIle: 3.649 ± 0.443
4.903LeuLys: 4.903 ± 0.67
7.013LeuLeu: 7.013 ± 0.746
2.224LeuMet: 2.224 ± 0.369
4.96LeuAsn: 4.96 ± 0.734
4.39LeuPro: 4.39 ± 0.577
3.307LeuGln: 3.307 ± 0.532
5.987LeuArg: 5.987 ± 0.576
5.474LeuSer: 5.474 ± 0.533
8.951LeuThr: 8.951 ± 0.672
6.215LeuVal: 6.215 ± 0.584
1.425LeuTrp: 1.425 ± 0.306
3.136LeuTyr: 3.136 ± 0.449
0.0LeuXaa: 0.0 ± 0.0
Met
1.254MetAla: 1.254 ± 0.306
0.342MetCys: 0.342 ± 0.142
1.026MetAsp: 1.026 ± 0.236
1.083MetGlu: 1.083 ± 0.301
0.741MetPhe: 0.741 ± 0.233
1.653MetGly: 1.653 ± 0.395
0.342MetHis: 0.342 ± 0.128
1.996MetIle: 1.996 ± 0.417
1.14MetLys: 1.14 ± 0.231
1.825MetLeu: 1.825 ± 0.338
0.342MetMet: 0.342 ± 0.125
0.855MetAsn: 0.855 ± 0.213
1.026MetPro: 1.026 ± 0.268
0.57MetGln: 0.57 ± 0.2
1.254MetArg: 1.254 ± 0.336
1.596MetSer: 1.596 ± 0.388
2.452MetThr: 2.452 ± 0.428
1.539MetVal: 1.539 ± 0.28
0.342MetTrp: 0.342 ± 0.133
0.969MetTyr: 0.969 ± 0.269
0.0MetXaa: 0.0 ± 0.0
Asn
3.364AsnAla: 3.364 ± 0.34
0.684AsnCys: 0.684 ± 0.288
3.25AsnAsp: 3.25 ± 0.554
2.623AsnGlu: 2.623 ± 0.466
2.11AsnPhe: 2.11 ± 0.331
3.649AsnGly: 3.649 ± 0.621
1.311AsnHis: 1.311 ± 0.275
2.281AsnIle: 2.281 ± 0.348
1.939AsnLys: 1.939 ± 0.366
5.359AsnLeu: 5.359 ± 0.529
0.969AsnMet: 0.969 ± 0.225
2.053AsnAsn: 2.053 ± 0.404
2.965AsnPro: 2.965 ± 0.426
1.825AsnGln: 1.825 ± 0.494
2.737AsnArg: 2.737 ± 0.391
2.452AsnSer: 2.452 ± 0.338
3.25AsnThr: 3.25 ± 0.494
3.25AsnVal: 3.25 ± 0.36
0.513AsnTrp: 0.513 ± 0.193
1.882AsnTyr: 1.882 ± 0.468
0.0AsnXaa: 0.0 ± 0.0
Pro
2.395ProAla: 2.395 ± 0.329
0.399ProCys: 0.399 ± 0.146
3.136ProAsp: 3.136 ± 0.45
3.991ProGlu: 3.991 ± 0.499
1.425ProPhe: 1.425 ± 0.269
3.877ProGly: 3.877 ± 0.609
0.627ProHis: 0.627 ± 0.172
1.368ProIle: 1.368 ± 0.285
2.908ProLys: 2.908 ± 0.625
2.794ProLeu: 2.794 ± 0.41
1.083ProMet: 1.083 ± 0.278
1.767ProAsn: 1.767 ± 0.382
1.596ProPro: 1.596 ± 0.465
1.939ProGln: 1.939 ± 0.305
2.338ProArg: 2.338 ± 0.411
2.566ProSer: 2.566 ± 0.319
2.224ProThr: 2.224 ± 0.391
3.877ProVal: 3.877 ± 0.539
0.741ProTrp: 0.741 ± 0.232
0.855ProTyr: 0.855 ± 0.2
0.0ProXaa: 0.0 ± 0.0
Gln
4.219GlnAla: 4.219 ± 0.784
0.741GlnCys: 0.741 ± 0.214
1.882GlnAsp: 1.882 ± 0.294
3.421GlnGlu: 3.421 ± 0.471
1.596GlnPhe: 1.596 ± 0.299
3.82GlnGly: 3.82 ± 0.581
0.342GlnHis: 0.342 ± 0.162
2.737GlnIle: 2.737 ± 0.48
1.653GlnLys: 1.653 ± 0.325
2.908GlnLeu: 2.908 ± 0.561
0.855GlnMet: 0.855 ± 0.251
1.482GlnAsn: 1.482 ± 0.287
1.368GlnPro: 1.368 ± 0.266
0.855GlnGln: 0.855 ± 0.245
2.167GlnArg: 2.167 ± 0.361
2.281GlnSer: 2.281 ± 0.331
2.338GlnThr: 2.338 ± 0.321
2.965GlnVal: 2.965 ± 0.429
0.513GlnTrp: 0.513 ± 0.178
0.684GlnTyr: 0.684 ± 0.2
0.0GlnXaa: 0.0 ± 0.0
Arg
3.364ArgAla: 3.364 ± 0.458
0.513ArgCys: 0.513 ± 0.126
2.965ArgAsp: 2.965 ± 0.384
3.649ArgGlu: 3.649 ± 0.629
2.11ArgPhe: 2.11 ± 0.34
3.136ArgGly: 3.136 ± 0.388
0.513ArgHis: 0.513 ± 0.162
3.364ArgIle: 3.364 ± 0.496
3.307ArgLys: 3.307 ± 0.658
4.789ArgLeu: 4.789 ± 0.54
1.14ArgMet: 1.14 ± 0.285
2.224ArgAsn: 2.224 ± 0.391
1.767ArgPro: 1.767 ± 0.396
1.882ArgGln: 1.882 ± 0.393
2.509ArgArg: 2.509 ± 0.432
3.592ArgSer: 3.592 ± 0.527
2.623ArgThr: 2.623 ± 0.37
3.934ArgVal: 3.934 ± 0.46
0.513ArgTrp: 0.513 ± 0.181
2.395ArgTyr: 2.395 ± 0.389
0.0ArgXaa: 0.0 ± 0.0
Ser
3.649SerAla: 3.649 ± 0.63
0.741SerCys: 0.741 ± 0.264
3.877SerAsp: 3.877 ± 0.487
4.276SerGlu: 4.276 ± 0.66
2.908SerPhe: 2.908 ± 0.416
5.93SerGly: 5.93 ± 1.272
0.912SerHis: 0.912 ± 0.202
3.592SerIle: 3.592 ± 0.408
2.851SerLys: 2.851 ± 0.429
6.614SerLeu: 6.614 ± 0.663
1.767SerMet: 1.767 ± 0.388
2.509SerAsn: 2.509 ± 0.464
2.851SerPro: 2.851 ± 0.387
3.706SerGln: 3.706 ± 0.418
2.794SerArg: 2.794 ± 0.455
4.561SerSer: 4.561 ± 0.561
4.96SerThr: 4.96 ± 0.553
3.877SerVal: 3.877 ± 0.494
0.855SerTrp: 0.855 ± 0.195
2.224SerTyr: 2.224 ± 0.411
0.0SerXaa: 0.0 ± 0.0
Thr
4.96ThrAla: 4.96 ± 0.923
0.456ThrCys: 0.456 ± 0.17
4.105ThrAsp: 4.105 ± 0.386
4.618ThrGlu: 4.618 ± 0.709
3.478ThrPhe: 3.478 ± 0.423
4.96ThrGly: 4.96 ± 0.793
1.14ThrHis: 1.14 ± 0.269
4.276ThrIle: 4.276 ± 0.652
2.509ThrLys: 2.509 ± 0.448
8.153ThrLeu: 8.153 ± 0.974
1.71ThrMet: 1.71 ± 0.307
1.882ThrAsn: 1.882 ± 0.318
2.68ThrPro: 2.68 ± 0.466
3.592ThrGln: 3.592 ± 0.426
3.193ThrArg: 3.193 ± 0.489
4.846ThrSer: 4.846 ± 0.72
4.276ThrThr: 4.276 ± 0.719
5.245ThrVal: 5.245 ± 0.594
1.254ThrTrp: 1.254 ± 0.265
2.623ThrTyr: 2.623 ± 0.411
0.0ThrXaa: 0.0 ± 0.0
Val
4.903ValAla: 4.903 ± 0.727
0.684ValCys: 0.684 ± 0.202
5.359ValAsp: 5.359 ± 0.664
3.421ValGlu: 3.421 ± 0.418
3.421ValPhe: 3.421 ± 0.425
3.478ValGly: 3.478 ± 0.445
1.596ValHis: 1.596 ± 0.424
4.219ValIle: 4.219 ± 0.542
4.162ValLys: 4.162 ± 0.627
5.188ValLeu: 5.188 ± 0.587
0.969ValMet: 0.969 ± 0.221
4.447ValAsn: 4.447 ± 0.428
2.623ValPro: 2.623 ± 0.384
1.939ValGln: 1.939 ± 0.374
2.281ValArg: 2.281 ± 0.507
4.561ValSer: 4.561 ± 0.614
4.561ValThr: 4.561 ± 0.586
2.965ValVal: 2.965 ± 0.431
0.741ValTrp: 0.741 ± 0.182
2.452ValTyr: 2.452 ± 0.401
0.0ValXaa: 0.0 ± 0.0
Trp
0.456TrpAla: 0.456 ± 0.148
0.342TrpCys: 0.342 ± 0.154
0.798TrpAsp: 0.798 ± 0.224
1.026TrpGlu: 1.026 ± 0.231
0.741TrpPhe: 0.741 ± 0.211
0.741TrpGly: 0.741 ± 0.214
0.171TrpHis: 0.171 ± 0.1
0.57TrpIle: 0.57 ± 0.193
1.026TrpLys: 1.026 ± 0.239
1.71TrpLeu: 1.71 ± 0.41
0.228TrpMet: 0.228 ± 0.109
0.627TrpAsn: 0.627 ± 0.218
0.342TrpPro: 0.342 ± 0.132
0.57TrpGln: 0.57 ± 0.177
0.684TrpArg: 0.684 ± 0.183
0.912TrpSer: 0.912 ± 0.255
1.026TrpThr: 1.026 ± 0.269
1.368TrpVal: 1.368 ± 0.266
0.171TrpTrp: 0.171 ± 0.099
0.57TrpTyr: 0.57 ± 0.182
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.939TyrAla: 1.939 ± 0.316
0.342TyrCys: 0.342 ± 0.135
2.965TyrAsp: 2.965 ± 0.409
2.737TyrGlu: 2.737 ± 0.378
1.653TyrPhe: 1.653 ± 0.258
3.079TyrGly: 3.079 ± 0.367
1.083TyrHis: 1.083 ± 0.248
1.539TyrIle: 1.539 ± 0.324
1.254TyrLys: 1.254 ± 0.235
3.25TyrLeu: 3.25 ± 0.464
0.855TyrMet: 0.855 ± 0.248
2.11TyrAsn: 2.11 ± 0.268
1.425TyrPro: 1.425 ± 0.298
1.482TyrGln: 1.482 ± 0.359
1.882TyrArg: 1.882 ± 0.339
2.224TyrSer: 2.224 ± 0.412
2.623TyrThr: 2.623 ± 0.368
2.167TyrVal: 2.167 ± 0.372
0.912TyrTrp: 0.912 ± 0.231
1.311TyrTyr: 1.311 ± 0.297
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 104 proteins (17540 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski