Amino acid dipepetide frequency for Chitinophaga skermanii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.511AlaAla: 7.511 ± 0.087	0.894AlaCys: 0.894 ± 0.044	4.014AlaAsp: 4.014 ± 0.054	4.028AlaGlu: 4.028 ± 0.063	3.721AlaPhe: 3.721 ± 0.049	5.675AlaGly: 5.675 ± 0.079	1.487AlaHis: 1.487 ± 0.035	5.589AlaIle: 5.589 ± 0.066	4.82AlaLys: 4.82 ± 0.072	7.257AlaLeu: 7.257 ± 0.068	2.083AlaMet: 2.083 ± 0.041	4.352AlaAsn: 4.352 ± 0.08	2.946AlaPro: 2.946 ± 0.063	3.556AlaGln: 3.556 ± 0.047	2.751AlaArg: 2.751 ± 0.042	4.678AlaSer: 4.678 ± 0.079	5.327AlaThr: 5.327 ± 0.131	5.138AlaVal: 5.138 ± 0.077	0.902AlaTrp: 0.902 ± 0.025	3.3AlaTyr: 3.3 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	0.621CysAla: 0.621 ± 0.027	0.172CysCys: 0.172 ± 0.01	0.438CysAsp: 0.438 ± 0.059	0.402CysGlu: 0.402 ± 0.018	0.404CysPhe: 0.404 ± 0.014	0.703CysGly: 0.703 ± 0.073	0.174CysHis: 0.174 ± 0.012	0.635CysIle: 0.635 ± 0.021	0.496CysLys: 0.496 ± 0.017	0.825CysLeu: 0.825 ± 0.023	0.243CysMet: 0.243 ± 0.014	0.431CysAsn: 0.431 ± 0.019	0.319CysPro: 0.319 ± 0.017	0.223CysGln: 0.223 ± 0.011	0.282CysArg: 0.282 ± 0.013	0.545CysSer: 0.545 ± 0.028	0.518CysThr: 0.518 ± 0.02	0.518CysVal: 0.518 ± 0.019	0.105CysTrp: 0.105 ± 0.008	0.37CysTyr: 0.37 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	4.13AspAla: 4.13 ± 0.056	0.36AspCys: 0.36 ± 0.023	2.403AspAsp: 2.403 ± 0.044	3.125AspGlu: 3.125 ± 0.056	2.648AspPhe: 2.648 ± 0.04	3.516AspGly: 3.516 ± 0.06	0.998AspHis: 0.998 ± 0.025	3.674AspIle: 3.674 ± 0.048	3.269AspLys: 3.269 ± 0.052	4.24AspLeu: 4.24 ± 0.06	1.199AspMet: 1.199 ± 0.028	2.525AspAsn: 2.525 ± 0.054	2.192AspPro: 2.192 ± 0.052	1.724AspGln: 1.724 ± 0.033	1.997AspArg: 1.997 ± 0.031	2.705AspSer: 2.705 ± 0.062	2.898AspThr: 2.898 ± 0.078	3.61AspVal: 3.61 ± 0.046	0.739AspTrp: 0.739 ± 0.021	2.419AspTyr: 2.419 ± 0.043	0.0AspXaa: 0.0 ± 0.0
Glu	4.255GluAla: 4.255 ± 0.064	0.34GluCys: 0.34 ± 0.02	2.661GluAsp: 2.661 ± 0.044	3.61GluGlu: 3.61 ± 0.067	2.175GluPhe: 2.175 ± 0.039	3.268GluGly: 3.268 ± 0.052	1.187GluHis: 1.187 ± 0.03	3.752GluIle: 3.752 ± 0.063	4.521GluLys: 4.521 ± 0.066	5.128GluLeu: 5.128 ± 0.067	1.507GluMet: 1.507 ± 0.034	3.004GluAsn: 3.004 ± 0.042	1.647GluPro: 1.647 ± 0.031	2.62GluGln: 2.62 ± 0.047	2.429GluArg: 2.429 ± 0.045	2.522GluSer: 2.522 ± 0.037	2.721GluThr: 2.721 ± 0.043	3.751GluVal: 3.751 ± 0.054	0.663GluTrp: 0.663 ± 0.022	1.983GluTyr: 1.983 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	3.485PheAla: 3.485 ± 0.058	0.418PheCys: 0.418 ± 0.016	2.771PheAsp: 2.771 ± 0.046	2.714PheGlu: 2.714 ± 0.042	2.359PhePhe: 2.359 ± 0.045	3.152PheGly: 3.152 ± 0.05	0.89PheHis: 0.89 ± 0.022	3.353PheIle: 3.353 ± 0.053	2.906PheLys: 2.906 ± 0.052	4.082PheLeu: 4.082 ± 0.066	1.18PheMet: 1.18 ± 0.026	2.857PheAsn: 2.857 ± 0.05	1.788PhePro: 1.788 ± 0.033	1.63PheGln: 1.63 ± 0.031	1.781PheArg: 1.781 ± 0.036	3.235PheSer: 3.235 ± 0.05	3.446PheThr: 3.446 ± 0.064	3.124PheVal: 3.124 ± 0.055	0.527PheTrp: 0.527 ± 0.02	2.034PheTyr: 2.034 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	4.972GlyAla: 4.972 ± 0.069	0.632GlyCys: 0.632 ± 0.029	3.367GlyAsp: 3.367 ± 0.05	3.499GlyGlu: 3.499 ± 0.053	3.464GlyPhe: 3.464 ± 0.06	4.842GlyGly: 4.842 ± 0.088	1.204GlyHis: 1.204 ± 0.028	5.133GlyIle: 5.133 ± 0.064	5.033GlyLys: 5.033 ± 0.073	5.668GlyLeu: 5.668 ± 0.065	1.83GlyMet: 1.83 ± 0.036	4.006GlyAsn: 4.006 ± 0.091	1.594GlyPro: 1.594 ± 0.056	2.274GlyGln: 2.274 ± 0.041	2.354GlyArg: 2.354 ± 0.04	3.959GlySer: 3.959 ± 0.072	4.578GlyThr: 4.578 ± 0.102	4.562GlyVal: 4.562 ± 0.065	0.968GlyTrp: 0.968 ± 0.025	3.094GlyTyr: 3.094 ± 0.051	0.0GlyXaa: 0.0 ± 0.0
His	1.563HisAla: 1.563 ± 0.033	0.197HisCys: 0.197 ± 0.01	0.967HisAsp: 0.967 ± 0.024	1.07HisGlu: 1.07 ± 0.027	1.255HisPhe: 1.255 ± 0.029	1.18HisGly: 1.18 ± 0.031	0.655HisHis: 0.655 ± 0.022	1.519HisIle: 1.519 ± 0.032	1.065HisLys: 1.065 ± 0.027	1.987HisLeu: 1.987 ± 0.038	0.428HisMet: 0.428 ± 0.016	1.05HisAsn: 1.05 ± 0.024	1.118HisPro: 1.118 ± 0.028	0.866HisGln: 0.866 ± 0.025	0.823HisArg: 0.823 ± 0.025	1.017HisSer: 1.017 ± 0.025	1.231HisThr: 1.231 ± 0.033	1.241HisVal: 1.241 ± 0.029	0.278HisTrp: 0.278 ± 0.012	0.949HisTyr: 0.949 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	5.922IleAla: 5.922 ± 0.065	0.674IleCys: 0.674 ± 0.022	3.992IleAsp: 3.992 ± 0.05	3.789IleGlu: 3.789 ± 0.054	2.914IlePhe: 2.914 ± 0.055	4.571IleGly: 4.571 ± 0.058	1.408IleHis: 1.408 ± 0.034	4.666IleIle: 4.666 ± 0.072	3.918IleLys: 3.918 ± 0.06	5.85IleLeu: 5.85 ± 0.071	1.449IleMet: 1.449 ± 0.035	3.763IleAsn: 3.763 ± 0.048	3.322IlePro: 3.322 ± 0.057	2.726IleGln: 2.726 ± 0.045	2.742IleArg: 2.742 ± 0.045	4.368IleSer: 4.368 ± 0.057	4.907IleThr: 4.907 ± 0.102	4.708IleVal: 4.708 ± 0.064	0.659IleTrp: 0.659 ± 0.022	2.486IleTyr: 2.486 ± 0.039	0.0IleXaa: 0.0 ± 0.0
Lys	5.058LysAla: 5.058 ± 0.073	0.309LysCys: 0.309 ± 0.014	3.785LysAsp: 3.785 ± 0.052	4.308LysGlu: 4.308 ± 0.067	2.354LysPhe: 2.354 ± 0.04	4.207LysGly: 4.207 ± 0.059	1.389LysHis: 1.389 ± 0.025	4.235LysIle: 4.235 ± 0.058	4.771LysLys: 4.771 ± 0.075	5.472LysLeu: 5.472 ± 0.075	1.881LysMet: 1.881 ± 0.043	3.614LysAsn: 3.614 ± 0.054	2.661LysPro: 2.661 ± 0.048	2.934LysGln: 2.934 ± 0.044	2.635LysArg: 2.635 ± 0.046	3.508LysSer: 3.508 ± 0.048	3.629LysThr: 3.629 ± 0.05	4.385LysVal: 4.385 ± 0.055	0.788LysTrp: 0.788 ± 0.023	2.65LysTyr: 2.65 ± 0.046	0.0LysXaa: 0.0 ± 0.0
Leu	7.058LeuAla: 7.058 ± 0.081	0.919LeuCys: 0.919 ± 0.035	4.408LeuAsp: 4.408 ± 0.06	4.685LeuGlu: 4.685 ± 0.068	4.307LeuPhe: 4.307 ± 0.065	5.651LeuGly: 5.651 ± 0.071	2.133LeuHis: 2.133 ± 0.041	5.238LeuIle: 5.238 ± 0.069	5.752LeuLys: 5.752 ± 0.078	9.485LeuLeu: 9.485 ± 0.111	2.259LeuMet: 2.259 ± 0.043	4.66LeuAsn: 4.66 ± 0.056	4.391LeuPro: 4.391 ± 0.06	5.153LeuGln: 5.153 ± 0.061	3.817LeuArg: 3.817 ± 0.052	6.087LeuSer: 6.087 ± 0.07	5.327LeuThr: 5.327 ± 0.062	5.894LeuVal: 5.894 ± 0.066	0.846LeuTrp: 0.846 ± 0.026	3.407LeuTyr: 3.407 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	1.915MetAla: 1.915 ± 0.036	0.172MetCys: 0.172 ± 0.01	1.189MetAsp: 1.189 ± 0.029	1.518MetGlu: 1.518 ± 0.031	0.943MetPhe: 0.943 ± 0.027	1.586MetGly: 1.586 ± 0.035	0.633MetHis: 0.633 ± 0.019	1.442MetIle: 1.442 ± 0.031	2.1MetLys: 2.1 ± 0.041	2.431MetLeu: 2.431 ± 0.047	0.761MetMet: 0.761 ± 0.021	1.401MetAsn: 1.401 ± 0.033	1.226MetPro: 1.226 ± 0.029	1.408MetGln: 1.408 ± 0.03	1.172MetArg: 1.172 ± 0.026	1.383MetSer: 1.383 ± 0.032	1.121MetThr: 1.121 ± 0.023	1.581MetVal: 1.581 ± 0.03	0.212MetTrp: 0.212 ± 0.011	0.842MetTyr: 0.842 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	4.314AsnAla: 4.314 ± 0.083	0.448AsnCys: 0.448 ± 0.05	2.987AsnAsp: 2.987 ± 0.078	3.017AsnGlu: 3.017 ± 0.04	2.591AsnPhe: 2.591 ± 0.046	4.262AsnGly: 4.262 ± 0.086	0.907AsnHis: 0.907 ± 0.022	4.335AsnIle: 4.335 ± 0.068	3.409AsnLys: 3.409 ± 0.052	4.489AsnLeu: 4.489 ± 0.057	1.336AsnMet: 1.336 ± 0.032	3.576AsnAsn: 3.576 ± 0.061	2.607AsnPro: 2.607 ± 0.051	1.833AsnGln: 1.833 ± 0.037	2.213AsnArg: 2.213 ± 0.04	2.993AsnSer: 2.993 ± 0.044	3.773AsnThr: 3.773 ± 0.082	3.635AsnVal: 3.635 ± 0.086	0.762AsnTrp: 0.762 ± 0.025	2.537AsnTyr: 2.537 ± 0.052	0.0AsnXaa: 0.0 ± 0.0
Pro	3.923ProAla: 3.923 ± 0.096	0.255ProCys: 0.255 ± 0.013	1.729ProAsp: 1.729 ± 0.037	2.028ProGlu: 2.028 ± 0.035	1.973ProPhe: 1.973 ± 0.04	3.286ProGly: 3.286 ± 0.047	0.762ProHis: 0.762 ± 0.021	2.621ProIle: 2.621 ± 0.04	2.223ProLys: 2.223 ± 0.042	3.455ProLeu: 3.455 ± 0.049	0.889ProMet: 0.889 ± 0.021	2.408ProAsn: 2.408 ± 0.044	1.302ProPro: 1.302 ± 0.042	1.585ProGln: 1.585 ± 0.033	1.304ProArg: 1.304 ± 0.03	2.715ProSer: 2.715 ± 0.059	2.825ProThr: 2.825 ± 0.062	3.364ProVal: 3.364 ± 0.074	0.444ProTrp: 0.444 ± 0.019	1.67ProTyr: 1.67 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	3.513GlnAla: 3.513 ± 0.048	0.259GlnCys: 0.259 ± 0.013	1.711GlnAsp: 1.711 ± 0.034	2.084GlnGlu: 2.084 ± 0.038	2.056GlnPhe: 2.056 ± 0.037	2.191GlnGly: 2.191 ± 0.036	1.255GlnHis: 1.255 ± 0.03	2.407GlnIle: 2.407 ± 0.036	2.448GlnLys: 2.448 ± 0.053	4.615GlnLeu: 4.615 ± 0.065	1.035GlnMet: 1.035 ± 0.025	1.98GlnAsn: 1.98 ± 0.036	1.903GlnPro: 1.903 ± 0.035	3.087GlnGln: 3.087 ± 0.058	1.726GlnArg: 1.726 ± 0.035	2.282GlnSer: 2.282 ± 0.037	2.42GlnThr: 2.42 ± 0.04	2.939GlnVal: 2.939 ± 0.044	0.53GlnTrp: 0.53 ± 0.019	2.01GlnTyr: 2.01 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	2.638ArgAla: 2.638 ± 0.04	0.241ArgCys: 0.241 ± 0.012	1.953ArgAsp: 1.953 ± 0.042	2.295ArgGlu: 2.295 ± 0.041	2.107ArgPhe: 2.107 ± 0.033	2.218ArgGly: 2.218 ± 0.037	0.706ArgHis: 0.706 ± 0.02	2.967ArgIle: 2.967 ± 0.041	2.76ArgLys: 2.76 ± 0.047	3.657ArgLeu: 3.657 ± 0.052	1.183ArgMet: 1.183 ± 0.024	2.291ArgAsn: 2.291 ± 0.038	1.356ArgPro: 1.356 ± 0.027	1.403ArgGln: 1.403 ± 0.03	1.582ArgArg: 1.582 ± 0.036	2.132ArgSer: 2.132 ± 0.039	2.21ArgThr: 2.21 ± 0.046	2.616ArgVal: 2.616 ± 0.039	0.62ArgTrp: 0.62 ± 0.023	1.842ArgTyr: 1.842 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	4.438SerAla: 4.438 ± 0.061	0.531SerCys: 0.531 ± 0.03	2.569SerAsp: 2.569 ± 0.048	2.602SerGlu: 2.602 ± 0.043	3.308SerPhe: 3.308 ± 0.046	4.151SerGly: 4.151 ± 0.075	1.085SerHis: 1.085 ± 0.025	4.547SerIle: 4.547 ± 0.056	3.58SerLys: 3.58 ± 0.047	5.768SerLeu: 5.768 ± 0.062	1.457SerMet: 1.457 ± 0.029	3.384SerAsn: 3.384 ± 0.068	2.272SerPro: 2.272 ± 0.04	2.045SerGln: 2.045 ± 0.038	2.136SerArg: 2.136 ± 0.039	3.738SerSer: 3.738 ± 0.06	4.04SerThr: 4.04 ± 0.082	3.871SerVal: 3.871 ± 0.053	0.716SerTrp: 0.716 ± 0.023	2.677SerTyr: 2.677 ± 0.046	0.0SerXaa: 0.0 ± 0.0
Thr	5.49ThrAla: 5.49 ± 0.135	0.458ThrCys: 0.458 ± 0.022	2.902ThrAsp: 2.902 ± 0.071	2.651ThrGlu: 2.651 ± 0.041	3.068ThrPhe: 3.068 ± 0.05	4.835ThrGly: 4.835 ± 0.092	1.126ThrHis: 1.126 ± 0.023	4.826ThrIle: 4.826 ± 0.109	3.455ThrLys: 3.455 ± 0.051	5.838ThrLeu: 5.838 ± 0.066	1.277ThrMet: 1.277 ± 0.029	3.342ThrAsn: 3.342 ± 0.071	3.202ThrPro: 3.202 ± 0.071	2.315ThrGln: 2.315 ± 0.045	2.151ThrArg: 2.151 ± 0.041	3.734ThrSer: 3.734 ± 0.069	4.321ThrThr: 4.321 ± 0.111	4.683ThrVal: 4.683 ± 0.133	0.866ThrTrp: 0.866 ± 0.035	2.769ThrTyr: 2.769 ± 0.065	0.0ThrXaa: 0.0 ± 0.0
Val	5.354ValAla: 5.354 ± 0.073	0.644ValCys: 0.644 ± 0.028	3.605ValAsp: 3.605 ± 0.05	3.484ValGlu: 3.484 ± 0.059	3.188ValPhe: 3.188 ± 0.042	4.22ValGly: 4.22 ± 0.058	1.311ValHis: 1.311 ± 0.03	4.556ValIle: 4.556 ± 0.063	4.576ValLys: 4.576 ± 0.054	6.245ValLeu: 6.245 ± 0.073	1.71ValMet: 1.71 ± 0.03	3.984ValAsn: 3.984 ± 0.072	2.842ValPro: 2.842 ± 0.056	2.724ValGln: 2.724 ± 0.038	2.524ValArg: 2.524 ± 0.041	4.182ValSer: 4.182 ± 0.065	4.402ValThr: 4.402 ± 0.111	4.821ValVal: 4.821 ± 0.068	0.686ValTrp: 0.686 ± 0.021	2.614ValTyr: 2.614 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	0.769TrpAla: 0.769 ± 0.02	0.124TrpCys: 0.124 ± 0.008	0.608TrpAsp: 0.608 ± 0.021	0.694TrpGlu: 0.694 ± 0.023	0.559TrpPhe: 0.559 ± 0.018	0.842TrpGly: 0.842 ± 0.026	0.294TrpHis: 0.294 ± 0.011	0.693TrpIle: 0.693 ± 0.022	0.836TrpLys: 0.836 ± 0.021	1.189TrpLeu: 1.189 ± 0.032	0.41TrpMet: 0.41 ± 0.018	0.679TrpAsn: 0.679 ± 0.02	0.364TrpPro: 0.364 ± 0.016	0.671TrpGln: 0.671 ± 0.022	0.537TrpArg: 0.537 ± 0.019	0.676TrpSer: 0.676 ± 0.021	0.676TrpThr: 0.676 ± 0.036	0.749TrpVal: 0.749 ± 0.022	0.23TrpTrp: 0.23 ± 0.012	0.496TrpTyr: 0.496 ± 0.027	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.1TyrAla: 3.1 ± 0.051	0.379TyrCys: 0.379 ± 0.016	2.31TyrAsp: 2.31 ± 0.038	2.14TyrGlu: 2.14 ± 0.037	2.339TyrPhe: 2.339 ± 0.042	2.677TyrGly: 2.677 ± 0.047	0.853TyrHis: 0.853 ± 0.02	2.647TyrIle: 2.647 ± 0.044	2.635TyrLys: 2.635 ± 0.042	3.801TyrLeu: 3.801 ± 0.058	0.917TyrMet: 0.917 ± 0.027	2.718TyrAsn: 2.718 ± 0.051	1.709TyrPro: 1.709 ± 0.036	1.674TyrGln: 1.674 ± 0.035	1.822TyrArg: 1.822 ± 0.04	2.455TyrSer: 2.455 ± 0.04	2.937TyrThr: 2.937 ± 0.066	2.481TyrVal: 2.481 ± 0.039	0.555TyrTrp: 0.555 ± 0.018	2.132TyrTyr: 2.132 ± 0.045	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5113 proteins (1778925 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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