Amino acid dipepetide frequency for Desulfocucumis palustris

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.089AlaAla: 9.089 ± 0.153
0.954AlaCys: 0.954 ± 0.035
3.984AlaAsp: 3.984 ± 0.076
5.331AlaGlu: 5.331 ± 0.083
2.901AlaPhe: 2.901 ± 0.059
9.301AlaGly: 9.301 ± 0.122
1.132AlaHis: 1.132 ± 0.037
4.924AlaIle: 4.924 ± 0.083
3.732AlaLys: 3.732 ± 0.072
8.534AlaLeu: 8.534 ± 0.096
2.349AlaMet: 2.349 ± 0.053
2.469AlaAsn: 2.469 ± 0.049
2.735AlaPro: 2.735 ± 0.058
2.255AlaGln: 2.255 ± 0.05
5.185AlaArg: 5.185 ± 0.076
4.116AlaSer: 4.116 ± 0.069
3.312AlaThr: 3.312 ± 0.064
7.282AlaVal: 7.282 ± 0.11
0.768AlaTrp: 0.768 ± 0.031
2.288AlaTyr: 2.288 ± 0.05
0.0AlaXaa: 0.0 ± 0.0
Cys
0.937CysAla: 0.937 ± 0.032
0.258CysCys: 0.258 ± 0.015
0.567CysAsp: 0.567 ± 0.023
0.513CysGlu: 0.513 ± 0.023
0.513CysPhe: 0.513 ± 0.023
1.36CysGly: 1.36 ± 0.042
0.297CysHis: 0.297 ± 0.016
0.697CysIle: 0.697 ± 0.029
0.553CysLys: 0.553 ± 0.026
1.164CysLeu: 1.164 ± 0.031
0.264CysMet: 0.264 ± 0.016
0.43CysAsn: 0.43 ± 0.024
0.734CysPro: 0.734 ± 0.03
0.378CysGln: 0.378 ± 0.02
0.927CysArg: 0.927 ± 0.034
0.773CysSer: 0.773 ± 0.031
0.516CysThr: 0.516 ± 0.029
0.735CysVal: 0.735 ± 0.028
0.144CysTrp: 0.144 ± 0.012
0.419CysTyr: 0.419 ± 0.023
0.0CysXaa: 0.0 ± 0.0
Asp
3.26AspAla: 3.26 ± 0.056
0.614AspCys: 0.614 ± 0.025
2.189AspAsp: 2.189 ± 0.057
3.191AspGlu: 3.191 ± 0.061
2.251AspPhe: 2.251 ± 0.043
3.858AspGly: 3.858 ± 0.073
0.709AspHis: 0.709 ± 0.031
4.296AspIle: 4.296 ± 0.065
2.969AspLys: 2.969 ± 0.063
4.757AspLeu: 4.757 ± 0.067
1.6AspMet: 1.6 ± 0.037
2.074AspAsn: 2.074 ± 0.05
2.296AspPro: 2.296 ± 0.052
1.348AspGln: 1.348 ± 0.033
2.982AspArg: 2.982 ± 0.057
2.714AspSer: 2.714 ± 0.06
2.31AspThr: 2.31 ± 0.047
3.414AspVal: 3.414 ± 0.065
0.563AspTrp: 0.563 ± 0.027
2.037AspTyr: 2.037 ± 0.05
0.0AspXaa: 0.0 ± 0.0
Glu
5.508GluAla: 5.508 ± 0.081
0.586GluCys: 0.586 ± 0.024
3.201GluAsp: 3.201 ± 0.064
5.342GluGlu: 5.342 ± 0.094
2.22GluPhe: 2.22 ± 0.051
4.179GluGly: 4.179 ± 0.074
1.104GluHis: 1.104 ± 0.032
5.628GluIle: 5.628 ± 0.083
5.667GluLys: 5.667 ± 0.089
6.763GluLeu: 6.763 ± 0.096
2.067GluMet: 2.067 ± 0.048
3.093GluAsn: 3.093 ± 0.063
2.216GluPro: 2.216 ± 0.043
2.669GluGln: 2.669 ± 0.051
3.676GluArg: 3.676 ± 0.07
3.117GluSer: 3.117 ± 0.054
3.043GluThr: 3.043 ± 0.051
4.559GluVal: 4.559 ± 0.07
0.591GluTrp: 0.591 ± 0.021
2.179GluTyr: 2.179 ± 0.046
0.0GluXaa: 0.0 ± 0.0
Phe
2.822PheAla: 2.822 ± 0.059
0.597PheCys: 0.597 ± 0.024
2.006PheAsp: 2.006 ± 0.047
2.135PheGlu: 2.135 ± 0.049
1.952PhePhe: 1.952 ± 0.051
2.987PheGly: 2.987 ± 0.06
0.717PheHis: 0.717 ± 0.027
3.066PheIle: 3.066 ± 0.059
2.272PheLys: 2.272 ± 0.047
3.984PheLeu: 3.984 ± 0.075
1.053PheMet: 1.053 ± 0.031
1.902PheAsn: 1.902 ± 0.045
1.662PhePro: 1.662 ± 0.044
1.096PheGln: 1.096 ± 0.033
1.877PheArg: 1.877 ± 0.041
2.898PheSer: 2.898 ± 0.059
2.221PheThr: 2.221 ± 0.055
2.577PheVal: 2.577 ± 0.049
0.467PheTrp: 0.467 ± 0.025
1.517PheTyr: 1.517 ± 0.044
0.0PheXaa: 0.0 ± 0.0
Gly
6.362GlyAla: 6.362 ± 0.107
1.239GlyCys: 1.239 ± 0.042
3.96GlyAsp: 3.96 ± 0.074
5.476GlyGlu: 5.476 ± 0.08
3.448GlyPhe: 3.448 ± 0.056
6.574GlyGly: 6.574 ± 0.094
1.5GlyHis: 1.5 ± 0.043
6.064GlyIle: 6.064 ± 0.079
5.359GlyLys: 5.359 ± 0.076
8.106GlyLeu: 8.106 ± 0.099
2.425GlyMet: 2.425 ± 0.056
3.088GlyAsn: 3.088 ± 0.065
2.491GlyPro: 2.491 ± 0.057
2.675GlyGln: 2.675 ± 0.055
4.682GlyArg: 4.682 ± 0.083
4.435GlySer: 4.435 ± 0.066
4.139GlyThr: 4.139 ± 0.077
6.066GlyVal: 6.066 ± 0.086
0.883GlyTrp: 0.883 ± 0.029
3.056GlyTyr: 3.056 ± 0.06
0.0GlyXaa: 0.0 ± 0.0
His
1.002HisAla: 1.002 ± 0.035
0.307HisCys: 0.307 ± 0.018
0.755HisAsp: 0.755 ± 0.028
0.792HisGlu: 0.792 ± 0.029
0.774HisPhe: 0.774 ± 0.027
1.404HisGly: 1.404 ± 0.038
0.442HisHis: 0.442 ± 0.023
1.231HisIle: 1.231 ± 0.038
0.822HisLys: 0.822 ± 0.036
1.696HisLeu: 1.696 ± 0.047
0.444HisMet: 0.444 ± 0.02
0.723HisAsn: 0.723 ± 0.027
0.994HisPro: 0.994 ± 0.035
0.61HisGln: 0.61 ± 0.023
1.164HisArg: 1.164 ± 0.039
0.971HisSer: 0.971 ± 0.033
0.788HisThr: 0.788 ± 0.028
0.97HisVal: 0.97 ± 0.029
0.217HisTrp: 0.217 ± 0.015
0.632HisTyr: 0.632 ± 0.023
0.0HisXaa: 0.0 ± 0.0
Ile
5.607IleAla: 5.607 ± 0.085
0.871IleCys: 0.871 ± 0.03
3.533IleAsp: 3.533 ± 0.057
4.085IleGlu: 4.085 ± 0.073
2.959IlePhe: 2.959 ± 0.068
4.724IleGly: 4.724 ± 0.079
1.115IleHis: 1.115 ± 0.032
5.541IleIle: 5.541 ± 0.094
4.755IleLys: 4.755 ± 0.07
6.675IleLeu: 6.675 ± 0.094
1.953IleMet: 1.953 ± 0.046
3.68IleAsn: 3.68 ± 0.061
3.422IlePro: 3.422 ± 0.064
2.034IleGln: 2.034 ± 0.047
3.394IleArg: 3.394 ± 0.057
4.678IleSer: 4.678 ± 0.072
4.176IleThr: 4.176 ± 0.069
4.396IleVal: 4.396 ± 0.075
0.584IleTrp: 0.584 ± 0.026
2.405IleTyr: 2.405 ± 0.049
0.0IleXaa: 0.0 ± 0.0
Lys
4.62LysAla: 4.62 ± 0.072
0.659LysCys: 0.659 ± 0.025
3.085LysAsp: 3.085 ± 0.062
4.732LysGlu: 4.732 ± 0.072
1.853LysPhe: 1.853 ± 0.047
4.04LysGly: 4.04 ± 0.059
0.967LysHis: 0.967 ± 0.033
4.808LysIle: 4.808 ± 0.075
4.597LysLys: 4.597 ± 0.073
5.293LysLeu: 5.293 ± 0.076
1.88LysMet: 1.88 ± 0.04
3.048LysAsn: 3.048 ± 0.06
2.403LysPro: 2.403 ± 0.043
1.957LysGln: 1.957 ± 0.046
2.758LysArg: 2.758 ± 0.056
3.218LysSer: 3.218 ± 0.054
3.164LysThr: 3.164 ± 0.062
4.037LysVal: 4.037 ± 0.069
0.515LysTrp: 0.515 ± 0.025
2.262LysTyr: 2.262 ± 0.052
0.0LysXaa: 0.0 ± 0.0
Leu
9.325LeuAla: 9.325 ± 0.124
1.143LeuCys: 1.143 ± 0.039
4.937LeuAsp: 4.937 ± 0.068
6.992LeuGlu: 6.992 ± 0.098
4.041LeuPhe: 4.041 ± 0.083
7.464LeuGly: 7.464 ± 0.104
1.602LeuHis: 1.602 ± 0.042
6.071LeuIle: 6.071 ± 0.091
6.493LeuLys: 6.493 ± 0.081
10.588LeuLeu: 10.588 ± 0.17
2.57LeuMet: 2.57 ± 0.05
4.113LeuAsn: 4.113 ± 0.063
4.619LeuPro: 4.619 ± 0.074
3.171LeuGln: 3.171 ± 0.059
4.913LeuArg: 4.913 ± 0.085
6.309LeuSer: 6.309 ± 0.086
5.158LeuThr: 5.158 ± 0.069
6.9LeuVal: 6.9 ± 0.092
0.994LeuTrp: 0.994 ± 0.04
2.901LeuTyr: 2.901 ± 0.056
0.0LeuXaa: 0.0 ± 0.0
Met
2.762MetAla: 2.762 ± 0.049
0.231MetCys: 0.231 ± 0.013
1.502MetAsp: 1.502 ± 0.042
2.147MetGlu: 2.147 ± 0.043
1.028MetPhe: 1.028 ± 0.035
2.241MetGly: 2.241 ± 0.053
0.421MetHis: 0.421 ± 0.02
1.659MetIle: 1.659 ± 0.05
1.642MetLys: 1.642 ± 0.04
2.827MetLeu: 2.827 ± 0.051
0.69MetMet: 0.69 ± 0.024
1.081MetAsn: 1.081 ± 0.032
1.346MetPro: 1.346 ± 0.038
0.855MetGln: 0.855 ± 0.032
1.255MetArg: 1.255 ± 0.039
1.67MetSer: 1.67 ± 0.039
1.297MetThr: 1.297 ± 0.039
2.118MetVal: 2.118 ± 0.049
0.184MetTrp: 0.184 ± 0.014
0.648MetTyr: 0.648 ± 0.025
0.0MetXaa: 0.0 ± 0.0
Asn
2.665AsnAla: 2.665 ± 0.058
0.56AsnCys: 0.56 ± 0.026
1.83AsnAsp: 1.83 ± 0.049
2.162AsnGlu: 2.162 ± 0.047
1.685AsnPhe: 1.685 ± 0.045
2.908AsnGly: 2.908 ± 0.063
0.702AsnHis: 0.702 ± 0.027
3.741AsnIle: 3.741 ± 0.069
2.553AsnLys: 2.553 ± 0.053
3.897AsnLeu: 3.897 ± 0.061
1.199AsnMet: 1.199 ± 0.035
2.176AsnAsn: 2.176 ± 0.054
2.359AsnPro: 2.359 ± 0.052
1.281AsnGln: 1.281 ± 0.034
2.398AsnArg: 2.398 ± 0.053
2.482AsnSer: 2.482 ± 0.052
2.08AsnThr: 2.08 ± 0.046
2.672AsnVal: 2.672 ± 0.056
0.476AsnTrp: 0.476 ± 0.023
1.509AsnTyr: 1.509 ± 0.046
0.0AsnXaa: 0.0 ± 0.0
Pro
3.897ProAla: 3.897 ± 0.077
0.426ProCys: 0.426 ± 0.022
2.696ProAsp: 2.696 ± 0.064
3.981ProGlu: 3.981 ± 0.07
1.679ProPhe: 1.679 ± 0.039
5.189ProGly: 5.189 ± 0.092
0.683ProHis: 0.683 ± 0.028
1.863ProIle: 1.863 ± 0.043
1.637ProLys: 1.637 ± 0.042
4.117ProLeu: 4.117 ± 0.069
0.899ProMet: 0.899 ± 0.028
1.218ProAsn: 1.218 ± 0.04
1.906ProPro: 1.906 ± 0.046
1.228ProGln: 1.228 ± 0.037
2.069ProArg: 2.069 ± 0.049
2.089ProSer: 2.089 ± 0.042
1.496ProThr: 1.496 ± 0.042
4.18ProVal: 4.18 ± 0.07
0.444ProTrp: 0.444 ± 0.022
1.341ProTyr: 1.341 ± 0.038
0.0ProXaa: 0.0 ± 0.0
Gln
2.838GlnAla: 2.838 ± 0.051
0.309GlnCys: 0.309 ± 0.02
1.363GlnAsp: 1.363 ± 0.038
2.293GlnGlu: 2.293 ± 0.049
1.037GlnPhe: 1.037 ± 0.033
2.386GlnGly: 2.386 ± 0.055
0.477GlnHis: 0.477 ± 0.022
2.067GlnIle: 2.067 ± 0.048
2.268GlnLys: 2.268 ± 0.053
3.145GlnLeu: 3.145 ± 0.058
0.955GlnMet: 0.955 ± 0.03
1.319GlnAsn: 1.319 ± 0.039
1.205GlnPro: 1.205 ± 0.037
1.287GlnGln: 1.287 ± 0.038
1.744GlnArg: 1.744 ± 0.045
1.684GlnSer: 1.684 ± 0.039
1.415GlnThr: 1.415 ± 0.036
2.23GlnVal: 2.23 ± 0.048
0.367GlnTrp: 0.367 ± 0.02
1.014GlnTyr: 1.014 ± 0.031
0.0GlnXaa: 0.0 ± 0.0
Arg
4.133ArgAla: 4.133 ± 0.07
0.629ArgCys: 0.629 ± 0.025
2.944ArgAsp: 2.944 ± 0.054
5.107ArgGlu: 5.107 ± 0.089
2.059ArgPhe: 2.059 ± 0.043
3.906ArgGly: 3.906 ± 0.061
1.088ArgHis: 1.088 ± 0.036
3.71ArgIle: 3.71 ± 0.064
3.186ArgLys: 3.186 ± 0.056
5.885ArgLeu: 5.885 ± 0.086
1.475ArgMet: 1.475 ± 0.037
1.991ArgAsn: 1.991 ± 0.045
2.215ArgPro: 2.215 ± 0.053
2.2ArgGln: 2.2 ± 0.048
3.327ArgArg: 3.327 ± 0.085
2.493ArgSer: 2.493 ± 0.054
2.145ArgThr: 2.145 ± 0.046
4.01ArgVal: 4.01 ± 0.067
0.603ArgTrp: 0.603 ± 0.025
1.765ArgTyr: 1.765 ± 0.05
0.0ArgXaa: 0.0 ± 0.0
Ser
4.416SerAla: 4.416 ± 0.083
0.722SerCys: 0.722 ± 0.027
2.535SerAsp: 2.535 ± 0.051
3.14SerGlu: 3.14 ± 0.062
2.576SerPhe: 2.576 ± 0.052
5.821SerGly: 5.821 ± 0.084
0.99SerHis: 0.99 ± 0.031
3.882SerIle: 3.882 ± 0.071
2.715SerLys: 2.715 ± 0.055
6.048SerLeu: 6.048 ± 0.085
1.49SerMet: 1.49 ± 0.037
2.0SerAsn: 2.0 ± 0.052
2.758SerPro: 2.758 ± 0.056
1.764SerGln: 1.764 ± 0.043
3.595SerArg: 3.595 ± 0.06
3.514SerSer: 3.514 ± 0.075
2.532SerThr: 2.532 ± 0.05
3.921SerVal: 3.921 ± 0.07
0.577SerTrp: 0.577 ± 0.024
1.809SerTyr: 1.809 ± 0.048
0.0SerXaa: 0.0 ± 0.0
Thr
4.436ThrAla: 4.436 ± 0.082
0.545ThrCys: 0.545 ± 0.022
2.288ThrAsp: 2.288 ± 0.058
2.661ThrGlu: 2.661 ± 0.054
1.837ThrPhe: 1.837 ± 0.043
5.665ThrGly: 5.665 ± 0.082
0.79ThrHis: 0.79 ± 0.027
3.184ThrIle: 3.184 ± 0.062
1.909ThrLys: 1.909 ± 0.04
4.654ThrLeu: 4.654 ± 0.067
1.206ThrMet: 1.206 ± 0.034
1.67ThrAsn: 1.67 ± 0.047
2.533ThrPro: 2.533 ± 0.048
1.151ThrGln: 1.151 ± 0.035
2.49ThrArg: 2.49 ± 0.051
2.57ThrSer: 2.57 ± 0.059
2.386ThrThr: 2.386 ± 0.054
4.358ThrVal: 4.358 ± 0.085
0.424ThrTrp: 0.424 ± 0.021
1.417ThrTyr: 1.417 ± 0.041
0.0ThrXaa: 0.0 ± 0.0
Val
6.107ValAla: 6.107 ± 0.099
0.888ValCys: 0.888 ± 0.031
3.876ValAsp: 3.876 ± 0.066
4.901ValGlu: 4.901 ± 0.075
3.015ValPhe: 3.015 ± 0.062
4.643ValGly: 4.643 ± 0.079
1.089ValHis: 1.089 ± 0.033
5.272ValIle: 5.272 ± 0.083
4.383ValLys: 4.383 ± 0.071
7.525ValLeu: 7.525 ± 0.094
2.018ValMet: 2.018 ± 0.044
3.275ValAsn: 3.275 ± 0.063
3.125ValPro: 3.125 ± 0.057
1.91ValGln: 1.91 ± 0.045
3.655ValArg: 3.655 ± 0.077
4.453ValSer: 4.453 ± 0.067
3.93ValThr: 3.93 ± 0.073
5.63ValVal: 5.63 ± 0.087
0.634ValTrp: 0.634 ± 0.027
2.266ValTyr: 2.266 ± 0.042
0.0ValXaa: 0.0 ± 0.0
Trp
0.695TrpAla: 0.695 ± 0.028
0.125TrpCys: 0.125 ± 0.01
0.56TrpAsp: 0.56 ± 0.025
0.719TrpGlu: 0.719 ± 0.029
0.394TrpPhe: 0.394 ± 0.02
0.778TrpGly: 0.778 ± 0.029
0.212TrpHis: 0.212 ± 0.015
0.558TrpIle: 0.558 ± 0.026
0.576TrpLys: 0.576 ± 0.025
1.139TrpLeu: 1.139 ± 0.041
0.257TrpMet: 0.257 ± 0.017
0.429TrpAsn: 0.429 ± 0.022
0.422TrpPro: 0.422 ± 0.021
0.411TrpGln: 0.411 ± 0.022
0.599TrpArg: 0.599 ± 0.022
0.572TrpSer: 0.572 ± 0.026
0.408TrpThr: 0.408 ± 0.021
0.63TrpVal: 0.63 ± 0.024
0.153TrpTrp: 0.153 ± 0.013
0.323TrpTyr: 0.323 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.164TyrAla: 2.164 ± 0.047
0.515TyrCys: 0.515 ± 0.022
1.618TyrAsp: 1.618 ± 0.043
1.709TyrGlu: 1.709 ± 0.045
1.587TyrPhe: 1.587 ± 0.043
2.601TyrGly: 2.601 ± 0.047
0.702TyrHis: 0.702 ± 0.026
2.326TyrIle: 2.326 ± 0.048
1.807TyrLys: 1.807 ± 0.041
3.506TyrLeu: 3.506 ± 0.065
0.809TyrMet: 0.809 ± 0.031
1.555TyrAsn: 1.555 ± 0.048
1.598TyrPro: 1.598 ± 0.04
1.122TyrGln: 1.122 ± 0.034
2.18TyrArg: 2.18 ± 0.048
2.05TyrSer: 2.05 ± 0.045
1.659TyrThr: 1.659 ± 0.04
1.911TyrVal: 1.911 ± 0.042
0.369TyrTrp: 0.369 ± 0.019
1.405TyrTyr: 1.405 ± 0.042
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3959 proteins (1035266 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski