Amino acid dipepetide frequency for Candidatus Azoamicus ciliaticola

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.14AlaAla: 2.14 ± 0.186
0.524AlaCys: 0.524 ± 0.088
1.594AlaAsp: 1.594 ± 0.158
1.736AlaGlu: 1.736 ± 0.155
2.195AlaPhe: 2.195 ± 0.194
2.304AlaGly: 2.304 ± 0.208
0.732AlaHis: 0.732 ± 0.081
3.931AlaIle: 3.931 ± 0.236
3.134AlaLys: 3.134 ± 0.191
4.106AlaLeu: 4.106 ± 0.191
1.048AlaMet: 1.048 ± 0.114
2.107AlaAsn: 2.107 ± 0.15
0.874AlaPro: 0.874 ± 0.107
0.972AlaGln: 0.972 ± 0.117
1.485AlaArg: 1.485 ± 0.134
2.282AlaSer: 2.282 ± 0.173
1.583AlaThr: 1.583 ± 0.139
2.337AlaVal: 2.337 ± 0.208
0.251AlaTrp: 0.251 ± 0.059
1.627AlaTyr: 1.627 ± 0.142
0.0AlaXaa: 0.0 ± 0.0
Cys
0.491CysAla: 0.491 ± 0.086
0.164CysCys: 0.164 ± 0.041
0.764CysAsp: 0.764 ± 0.086
0.601CysGlu: 0.601 ± 0.075
1.223CysPhe: 1.223 ± 0.116
0.895CysGly: 0.895 ± 0.107
0.36CysHis: 0.36 ± 0.061
1.561CysIle: 1.561 ± 0.131
1.157CysLys: 1.157 ± 0.124
1.299CysLeu: 1.299 ± 0.109
0.295CysMet: 0.295 ± 0.054
0.939CysAsn: 0.939 ± 0.121
0.47CysPro: 0.47 ± 0.09
0.153CysGln: 0.153 ± 0.042
0.349CysArg: 0.349 ± 0.061
1.07CysSer: 1.07 ± 0.105
0.535CysThr: 0.535 ± 0.083
1.114CysVal: 1.114 ± 0.115
0.076CysTrp: 0.076 ± 0.032
0.699CysTyr: 0.699 ± 0.101
0.0CysXaa: 0.0 ± 0.0
Asp
1.725AspAla: 1.725 ± 0.151
0.688AspCys: 0.688 ± 0.094
2.599AspAsp: 2.599 ± 0.183
2.806AspGlu: 2.806 ± 0.198
4.117AspPhe: 4.117 ± 0.249
2.446AspGly: 2.446 ± 0.179
0.644AspHis: 0.644 ± 0.08
6.049AspIle: 6.049 ± 0.313
4.99AspLys: 4.99 ± 0.259
5.755AspLeu: 5.755 ± 0.268
0.808AspMet: 0.808 ± 0.098
3.178AspAsn: 3.178 ± 0.19
1.037AspPro: 1.037 ± 0.112
0.753AspGln: 0.753 ± 0.083
1.387AspArg: 1.387 ± 0.121
3.363AspSer: 3.363 ± 0.23
1.507AspThr: 1.507 ± 0.146
3.363AspVal: 3.363 ± 0.202
0.349AspTrp: 0.349 ± 0.072
2.151AspTyr: 2.151 ± 0.136
0.0AspXaa: 0.0 ± 0.0
Glu
1.671GluAla: 1.671 ± 0.134
0.852GluCys: 0.852 ± 0.105
1.922GluAsp: 1.922 ± 0.154
2.566GluGlu: 2.566 ± 0.225
2.577GluPhe: 2.577 ± 0.196
1.66GluGly: 1.66 ± 0.137
0.677GluHis: 0.677 ± 0.077
6.705GluIle: 6.705 ± 0.377
7.447GluLys: 7.447 ± 0.411
5.034GluLeu: 5.034 ± 0.236
1.114GluMet: 1.114 ± 0.098
4.455GluAsn: 4.455 ± 0.294
1.026GluPro: 1.026 ± 0.111
1.223GluGln: 1.223 ± 0.133
1.551GluArg: 1.551 ± 0.139
2.784GluSer: 2.784 ± 0.192
2.249GluThr: 2.249 ± 0.169
2.206GluVal: 2.206 ± 0.159
0.317GluTrp: 0.317 ± 0.061
1.867GluTyr: 1.867 ± 0.132
0.0GluXaa: 0.0 ± 0.0
Phe
1.998PheAla: 1.998 ± 0.172
1.463PheCys: 1.463 ± 0.131
3.702PheAsp: 3.702 ± 0.246
2.632PheGlu: 2.632 ± 0.173
7.666PhePhe: 7.666 ± 0.482
3.571PheGly: 3.571 ± 0.234
0.775PheHis: 0.775 ± 0.103
7.578PheIle: 7.578 ± 0.381
5.165PheLys: 5.165 ± 0.312
9.238PheLeu: 9.238 ± 0.501
1.092PheMet: 1.092 ± 0.102
5.394PheAsn: 5.394 ± 0.315
1.278PhePro: 1.278 ± 0.11
0.688PheGln: 0.688 ± 0.081
1.387PheArg: 1.387 ± 0.139
5.886PheSer: 5.886 ± 0.4
1.955PheThr: 1.955 ± 0.127
3.603PheVal: 3.603 ± 0.278
0.546PheTrp: 0.546 ± 0.082
3.658PheTyr: 3.658 ± 0.278
0.0PheXaa: 0.0 ± 0.0
Gly
2.49GlyAla: 2.49 ± 0.199
0.95GlyCys: 0.95 ± 0.105
2.511GlyAsp: 2.511 ± 0.19
2.501GlyGlu: 2.501 ± 0.189
3.658GlyPhe: 3.658 ± 0.238
3.451GlyGly: 3.451 ± 0.255
0.841GlyHis: 0.841 ± 0.1
5.973GlyIle: 5.973 ± 0.271
4.641GlyLys: 4.641 ± 0.256
4.422GlyLeu: 4.422 ± 0.234
1.289GlyMet: 1.289 ± 0.145
2.588GlyAsn: 2.588 ± 0.18
1.19GlyPro: 1.19 ± 0.123
0.961GlyGln: 0.961 ± 0.114
1.944GlyArg: 1.944 ± 0.177
3.385GlySer: 3.385 ± 0.219
1.856GlyThr: 1.856 ± 0.139
3.789GlyVal: 3.789 ± 0.282
0.491GlyTrp: 0.491 ± 0.091
1.856GlyTyr: 1.856 ± 0.137
0.0GlyXaa: 0.0 ± 0.0
His
0.721HisAla: 0.721 ± 0.091
0.197HisCys: 0.197 ± 0.047
0.59HisAsp: 0.59 ± 0.075
0.786HisGlu: 0.786 ± 0.085
0.808HisPhe: 0.808 ± 0.108
0.983HisGly: 0.983 ± 0.087
0.251HisHis: 0.251 ± 0.057
1.693HisIle: 1.693 ± 0.137
1.114HisLys: 1.114 ± 0.113
1.376HisLeu: 1.376 ± 0.11
0.317HisMet: 0.317 ± 0.048
0.939HisAsn: 0.939 ± 0.115
0.59HisPro: 0.59 ± 0.08
0.24HisGln: 0.24 ± 0.049
0.47HisArg: 0.47 ± 0.073
0.961HisSer: 0.961 ± 0.106
0.732HisThr: 0.732 ± 0.089
0.983HisVal: 0.983 ± 0.105
0.087HisTrp: 0.087 ± 0.028
0.513HisTyr: 0.513 ± 0.074
0.0HisXaa: 0.0 ± 0.0
Ile
4.215IleAla: 4.215 ± 0.237
1.474IleCys: 1.474 ± 0.139
6.126IleAsp: 6.126 ± 0.268
6.519IleGlu: 6.519 ± 0.352
7.884IlePhe: 7.884 ± 0.392
5.907IleGly: 5.907 ± 0.271
1.365IleHis: 1.365 ± 0.123
15.298IleIle: 15.298 ± 0.819
14.949IleLys: 14.949 ± 0.818
12.252IleLeu: 12.252 ± 0.424
2.02IleMet: 2.02 ± 0.153
10.581IleAsn: 10.581 ± 0.453
3.33IlePro: 3.33 ± 0.204
2.097IleGln: 2.097 ± 0.17
3.178IleArg: 3.178 ± 0.18
8.845IleSer: 8.845 ± 0.32
5.929IleThr: 5.929 ± 0.389
4.728IleVal: 4.728 ± 0.244
0.874IleTrp: 0.874 ± 0.108
4.641IleTyr: 4.641 ± 0.231
0.0IleXaa: 0.0 ± 0.0
Lys
2.828LysAla: 2.828 ± 0.192
1.289LysCys: 1.289 ± 0.11
4.979LysAsp: 4.979 ± 0.251
5.58LysGlu: 5.58 ± 0.302
4.794LysPhe: 4.794 ± 0.333
2.916LysGly: 2.916 ± 0.193
1.572LysHis: 1.572 ± 0.144
15.768LysIle: 15.768 ± 0.726
13.901LysLys: 13.901 ± 0.666
8.659LysLeu: 8.659 ± 0.344
2.391LysMet: 2.391 ± 0.168
13.06LysAsn: 13.06 ± 0.714
1.649LysPro: 1.649 ± 0.154
2.097LysGln: 2.097 ± 0.193
2.817LysArg: 2.817 ± 0.185
6.432LysSer: 6.432 ± 0.253
5.056LysThr: 5.056 ± 0.302
4.357LysVal: 4.357 ± 0.231
0.611LysTrp: 0.611 ± 0.077
4.499LysTyr: 4.499 ± 0.255
0.0LysXaa: 0.0 ± 0.0
Leu
4.149LeuAla: 4.149 ± 0.207
1.278LeuCys: 1.278 ± 0.11
5.449LeuAsp: 5.449 ± 0.293
5.165LeuGlu: 5.165 ± 0.236
7.393LeuPhe: 7.393 ± 0.405
5.023LeuGly: 5.023 ± 0.26
1.813LeuHis: 1.813 ± 0.152
11.575LeuIle: 11.575 ± 0.44
10.417LeuLys: 10.417 ± 0.332
9.751LeuLeu: 9.751 ± 0.367
1.955LeuMet: 1.955 ± 0.151
8.899LeuAsn: 8.899 ± 0.392
2.752LeuPro: 2.752 ± 0.169
2.064LeuGln: 2.064 ± 0.137
2.577LeuArg: 2.577 ± 0.165
7.928LeuSer: 7.928 ± 0.308
4.575LeuThr: 4.575 ± 0.224
4.532LeuVal: 4.532 ± 0.262
0.59LeuTrp: 0.59 ± 0.087
3.516LeuTyr: 3.516 ± 0.193
0.0LeuXaa: 0.0 ± 0.0
Met
1.005MetAla: 1.005 ± 0.13
0.218MetCys: 0.218 ± 0.047
0.961MetAsp: 0.961 ± 0.103
0.786MetGlu: 0.786 ± 0.083
1.07MetPhe: 1.07 ± 0.123
1.157MetGly: 1.157 ± 0.099
0.349MetHis: 0.349 ± 0.062
1.856MetIle: 1.856 ± 0.137
2.053MetLys: 2.053 ± 0.151
1.987MetLeu: 1.987 ± 0.159
0.371MetMet: 0.371 ± 0.06
1.343MetAsn: 1.343 ± 0.127
0.83MetPro: 0.83 ± 0.102
0.415MetGln: 0.415 ± 0.07
0.775MetArg: 0.775 ± 0.103
1.627MetSer: 1.627 ± 0.145
0.961MetThr: 0.961 ± 0.112
1.005MetVal: 1.005 ± 0.119
0.098MetTrp: 0.098 ± 0.034
0.764MetTyr: 0.764 ± 0.085
0.0MetXaa: 0.0 ± 0.0
Asn
1.998AsnAla: 1.998 ± 0.145
0.874AsnCys: 0.874 ± 0.094
3.986AsnAsp: 3.986 ± 0.261
4.302AsnGlu: 4.302 ± 0.247
5.787AsnPhe: 5.787 ± 0.356
3.527AsnGly: 3.527 ± 0.19
0.721AsnHis: 0.721 ± 0.084
11.487AsnIle: 11.487 ± 0.569
10.232AsnLys: 10.232 ± 0.515
7.917AsnLeu: 7.917 ± 0.304
1.354AsnMet: 1.354 ± 0.111
6.792AsnAsn: 6.792 ± 0.353
1.834AsnPro: 1.834 ± 0.135
1.245AsnGln: 1.245 ± 0.105
1.758AsnArg: 1.758 ± 0.131
4.717AsnSer: 4.717 ± 0.238
3.461AsnThr: 3.461 ± 0.221
4.411AsnVal: 4.411 ± 0.253
0.524AsnTrp: 0.524 ± 0.091
3.614AsnTyr: 3.614 ± 0.206
0.0AsnXaa: 0.0 ± 0.0
Pro
0.994ProAla: 0.994 ± 0.119
0.339ProCys: 0.339 ± 0.061
1.223ProAsp: 1.223 ± 0.122
1.223ProGlu: 1.223 ± 0.086
1.638ProPhe: 1.638 ± 0.146
1.682ProGly: 1.682 ± 0.13
0.371ProHis: 0.371 ± 0.062
3.068ProIle: 3.068 ± 0.154
1.703ProLys: 1.703 ± 0.132
2.61ProLeu: 2.61 ± 0.202
0.546ProMet: 0.546 ± 0.073
1.561ProAsn: 1.561 ± 0.129
0.688ProPro: 0.688 ± 0.075
0.513ProGln: 0.513 ± 0.077
0.611ProArg: 0.611 ± 0.083
1.616ProSer: 1.616 ± 0.141
1.081ProThr: 1.081 ± 0.102
1.649ProVal: 1.649 ± 0.141
0.24ProTrp: 0.24 ± 0.051
1.092ProTyr: 1.092 ± 0.126
0.0ProXaa: 0.0 ± 0.0
Gln
0.906GlnAla: 0.906 ± 0.108
0.229GlnCys: 0.229 ± 0.046
0.874GlnAsp: 0.874 ± 0.091
1.168GlnGlu: 1.168 ± 0.128
1.048GlnPhe: 1.048 ± 0.101
0.83GlnGly: 0.83 ± 0.099
0.306GlnHis: 0.306 ± 0.063
2.064GlnIle: 2.064 ± 0.194
2.239GlnLys: 2.239 ± 0.166
1.66GlnLeu: 1.66 ± 0.13
0.426GlnMet: 0.426 ± 0.076
1.594GlnAsn: 1.594 ± 0.167
0.535GlnPro: 0.535 ± 0.089
0.502GlnGln: 0.502 ± 0.089
0.721GlnArg: 0.721 ± 0.102
1.114GlnSer: 1.114 ± 0.111
0.917GlnThr: 0.917 ± 0.1
0.895GlnVal: 0.895 ± 0.096
0.142GlnTrp: 0.142 ± 0.032
0.764GlnTyr: 0.764 ± 0.1
0.0GlnXaa: 0.0 ± 0.0
Arg
1.398ArgAla: 1.398 ± 0.15
0.415ArgCys: 0.415 ± 0.071
1.387ArgAsp: 1.387 ± 0.128
1.343ArgGlu: 1.343 ± 0.123
1.769ArgPhe: 1.769 ± 0.141
1.703ArgGly: 1.703 ± 0.158
0.557ArgHis: 0.557 ± 0.072
3.09ArgIle: 3.09 ± 0.193
2.708ArgLys: 2.708 ± 0.178
2.741ArgLeu: 2.741 ± 0.161
0.579ArgMet: 0.579 ± 0.079
1.605ArgAsn: 1.605 ± 0.138
0.732ArgPro: 0.732 ± 0.108
0.895ArgGln: 0.895 ± 0.106
1.125ArgArg: 1.125 ± 0.108
1.922ArgSer: 1.922 ± 0.186
1.179ArgThr: 1.179 ± 0.1
1.9ArgVal: 1.9 ± 0.162
0.186ArgTrp: 0.186 ± 0.045
1.278ArgTyr: 1.278 ± 0.111
0.0ArgXaa: 0.0 ± 0.0
Ser
2.664SerAla: 2.664 ± 0.173
0.808SerCys: 0.808 ± 0.094
3.734SerAsp: 3.734 ± 0.222
3.505SerGlu: 3.505 ± 0.204
5.503SerPhe: 5.503 ± 0.332
4.39SerGly: 4.39 ± 0.251
0.874SerHis: 0.874 ± 0.092
8.026SerIle: 8.026 ± 0.342
6.421SerLys: 6.421 ± 0.304
7.567SerLeu: 7.567 ± 0.34
1.256SerMet: 1.256 ± 0.122
5.187SerAsn: 5.187 ± 0.286
1.518SerPro: 1.518 ± 0.135
1.157SerGln: 1.157 ± 0.117
2.107SerArg: 2.107 ± 0.184
5.099SerSer: 5.099 ± 0.297
2.522SerThr: 2.522 ± 0.18
3.953SerVal: 3.953 ± 0.258
0.557SerTrp: 0.557 ± 0.082
2.73SerTyr: 2.73 ± 0.198
0.0SerXaa: 0.0 ± 0.0
Thr
1.856ThrAla: 1.856 ± 0.164
0.71ThrCys: 0.71 ± 0.087
2.129ThrAsp: 2.129 ± 0.145
2.064ThrGlu: 2.064 ± 0.165
2.577ThrPhe: 2.577 ± 0.166
2.61ThrGly: 2.61 ± 0.178
0.841ThrHis: 0.841 ± 0.091
4.728ThrIle: 4.728 ± 0.307
3.953ThrLys: 3.953 ± 0.253
4.553ThrLeu: 4.553 ± 0.28
0.732ThrMet: 0.732 ± 0.074
3.079ThrAsn: 3.079 ± 0.209
1.332ThrPro: 1.332 ± 0.136
1.201ThrGln: 1.201 ± 0.13
1.136ThrArg: 1.136 ± 0.108
2.73ThrSer: 2.73 ± 0.185
2.37ThrThr: 2.37 ± 0.199
2.009ThrVal: 2.009 ± 0.153
0.339ThrTrp: 0.339 ± 0.074
1.878ThrTyr: 1.878 ± 0.154
0.0ThrXaa: 0.0 ± 0.0
Val
2.042ValAla: 2.042 ± 0.175
0.884ValCys: 0.884 ± 0.119
2.817ValAsp: 2.817 ± 0.198
2.49ValGlu: 2.49 ± 0.175
4.029ValPhe: 4.029 ± 0.26
3.265ValGly: 3.265 ± 0.254
0.601ValHis: 0.601 ± 0.07
6.028ValIle: 6.028 ± 0.293
4.051ValLys: 4.051 ± 0.265
5.58ValLeu: 5.58 ± 0.28
1.081ValMet: 1.081 ± 0.103
3.451ValAsn: 3.451 ± 0.233
1.594ValPro: 1.594 ± 0.162
0.961ValGln: 0.961 ± 0.115
1.714ValArg: 1.714 ± 0.153
4.139ValSer: 4.139 ± 0.222
2.239ValThr: 2.239 ± 0.192
3.472ValVal: 3.472 ± 0.251
0.47ValTrp: 0.47 ± 0.082
2.053ValTyr: 2.053 ± 0.165
0.0ValXaa: 0.0 ± 0.0
Trp
0.251TrpAla: 0.251 ± 0.059
0.109TrpCys: 0.109 ± 0.033
0.317TrpAsp: 0.317 ± 0.07
0.382TrpGlu: 0.382 ± 0.069
0.404TrpPhe: 0.404 ± 0.069
0.437TrpGly: 0.437 ± 0.075
0.153TrpHis: 0.153 ± 0.042
0.753TrpIle: 0.753 ± 0.101
0.688TrpLys: 0.688 ± 0.094
0.863TrpLeu: 0.863 ± 0.108
0.218TrpMet: 0.218 ± 0.055
0.48TrpAsn: 0.48 ± 0.088
0.186TrpPro: 0.186 ± 0.048
0.229TrpGln: 0.229 ± 0.056
0.197TrpArg: 0.197 ± 0.051
0.382TrpSer: 0.382 ± 0.072
0.262TrpThr: 0.262 ± 0.054
0.306TrpVal: 0.306 ± 0.055
0.12TrpTrp: 0.12 ± 0.042
0.437TrpTyr: 0.437 ± 0.077
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.42TyrAla: 1.42 ± 0.116
0.753TyrCys: 0.753 ± 0.091
2.053TyrAsp: 2.053 ± 0.143
1.747TyrGlu: 1.747 ± 0.136
3.134TyrPhe: 3.134 ± 0.245
2.031TyrGly: 2.031 ± 0.138
0.546TyrHis: 0.546 ± 0.074
4.979TyrIle: 4.979 ± 0.264
4.291TyrLys: 4.291 ± 0.275
4.029TyrLeu: 4.029 ± 0.199
0.732TyrMet: 0.732 ± 0.105
3.309TyrAsn: 3.309 ± 0.211
1.005TyrPro: 1.005 ± 0.114
0.568TyrGln: 0.568 ± 0.081
1.223TyrArg: 1.223 ± 0.115
3.298TyrSer: 3.298 ± 0.205
1.856TyrThr: 1.856 ± 0.151
2.348TyrVal: 2.348 ± 0.137
0.306TyrTrp: 0.306 ± 0.064
1.693TyrTyr: 1.693 ± 0.157
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 310 proteins (91580 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski