Amino acid dipepetide frequency for Butyrivibrio sp. INlla14

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.263AlaAla: 6.263 ± 0.112
0.95AlaCys: 0.95 ± 0.027
4.952AlaAsp: 4.952 ± 0.074
5.095AlaGlu: 5.095 ± 0.088
3.236AlaPhe: 3.236 ± 0.05
5.528AlaGly: 5.528 ± 0.076
0.999AlaHis: 0.999 ± 0.029
5.56AlaIle: 5.56 ± 0.07
4.692AlaLys: 4.692 ± 0.073
6.544AlaLeu: 6.544 ± 0.074
2.214AlaMet: 2.214 ± 0.041
2.777AlaAsn: 2.777 ± 0.055
1.988AlaPro: 1.988 ± 0.047
2.318AlaGln: 2.318 ± 0.049
2.93AlaArg: 2.93 ± 0.057
4.515AlaSer: 4.515 ± 0.088
3.624AlaThr: 3.624 ± 0.07
5.333AlaVal: 5.333 ± 0.072
0.594AlaTrp: 0.594 ± 0.024
2.771AlaTyr: 2.771 ± 0.05
0.0AlaXaa: 0.0 ± 0.0
Cys
0.918CysAla: 0.918 ± 0.028
0.243CysCys: 0.243 ± 0.014
0.926CysAsp: 0.926 ± 0.029
0.812CysGlu: 0.812 ± 0.024
0.572CysPhe: 0.572 ± 0.024
1.349CysGly: 1.349 ± 0.037
0.28CysHis: 0.28 ± 0.016
0.994CysIle: 0.994 ± 0.027
0.82CysLys: 0.82 ± 0.029
1.04CysLeu: 1.04 ± 0.031
0.413CysMet: 0.413 ± 0.019
0.597CysAsn: 0.597 ± 0.023
0.542CysPro: 0.542 ± 0.023
0.355CysGln: 0.355 ± 0.019
0.537CysArg: 0.537 ± 0.024
0.845CysSer: 0.845 ± 0.028
0.625CysThr: 0.625 ± 0.023
0.872CysVal: 0.872 ± 0.027
0.107CysTrp: 0.107 ± 0.009
0.588CysTyr: 0.588 ± 0.021
0.0CysXaa: 0.0 ± 0.0
Asp
4.508AspAla: 4.508 ± 0.066
0.784AspCys: 0.784 ± 0.027
3.972AspAsp: 3.972 ± 0.062
5.649AspGlu: 5.649 ± 0.078
3.094AspPhe: 3.094 ± 0.055
4.796AspGly: 4.796 ± 0.082
0.954AspHis: 0.954 ± 0.031
5.276AspIle: 5.276 ± 0.076
4.908AspLys: 4.908 ± 0.063
4.736AspLeu: 4.736 ± 0.072
1.982AspMet: 1.982 ± 0.038
3.179AspAsn: 3.179 ± 0.05
2.047AspPro: 2.047 ± 0.047
1.451AspGln: 1.451 ± 0.035
2.577AspArg: 2.577 ± 0.051
3.747AspSer: 3.747 ± 0.061
3.246AspThr: 3.246 ± 0.062
4.213AspVal: 4.213 ± 0.068
0.649AspTrp: 0.649 ± 0.023
3.405AspTyr: 3.405 ± 0.063
0.0AspXaa: 0.0 ± 0.0
Glu
5.492GluAla: 5.492 ± 0.091
0.758GluCys: 0.758 ± 0.027
4.702GluAsp: 4.702 ± 0.076
6.121GluGlu: 6.121 ± 0.098
2.786GluPhe: 2.786 ± 0.044
4.351GluGly: 4.351 ± 0.063
1.262GluHis: 1.262 ± 0.033
5.614GluIle: 5.614 ± 0.071
6.61GluLys: 6.61 ± 0.089
6.503GluLeu: 6.503 ± 0.086
2.267GluMet: 2.267 ± 0.036
4.237GluAsn: 4.237 ± 0.053
1.784GluPro: 1.784 ± 0.042
2.175GluGln: 2.175 ± 0.044
2.885GluArg: 2.885 ± 0.057
3.665GluSer: 3.665 ± 0.056
3.607GluThr: 3.607 ± 0.069
4.417GluVal: 4.417 ± 0.071
0.656GluTrp: 0.656 ± 0.028
3.442GluTyr: 3.442 ± 0.058
0.0GluXaa: 0.0 ± 0.0
Phe
3.056PheAla: 3.056 ± 0.045
0.687PheCys: 0.687 ± 0.024
3.125PheAsp: 3.125 ± 0.048
2.884PheGlu: 2.884 ± 0.048
2.156PhePhe: 2.156 ± 0.057
3.112PheGly: 3.112 ± 0.052
0.711PheHis: 0.711 ± 0.024
3.219PheIle: 3.219 ± 0.05
2.549PheLys: 2.549 ± 0.053
3.827PheLeu: 3.827 ± 0.064
1.305PheMet: 1.305 ± 0.032
1.916PheAsn: 1.916 ± 0.041
1.322PhePro: 1.322 ± 0.031
1.0PheGln: 1.0 ± 0.027
1.597PheArg: 1.597 ± 0.036
2.965PheSer: 2.965 ± 0.056
2.382PheThr: 2.382 ± 0.046
3.269PheVal: 3.269 ± 0.054
0.492PheTrp: 0.492 ± 0.021
2.001PheTyr: 2.001 ± 0.043
0.0PheXaa: 0.0 ± 0.0
Gly
4.825GlyAla: 4.825 ± 0.081
1.082GlyCys: 1.082 ± 0.04
4.005GlyAsp: 4.005 ± 0.056
4.353GlyGlu: 4.353 ± 0.059
3.265GlyPhe: 3.265 ± 0.064
4.46GlyGly: 4.46 ± 0.079
1.247GlyHis: 1.247 ± 0.033
5.913GlyIle: 5.913 ± 0.08
5.355GlyLys: 5.355 ± 0.07
5.517GlyLeu: 5.517 ± 0.065
2.191GlyMet: 2.191 ± 0.046
3.492GlyAsn: 3.492 ± 0.059
1.252GlyPro: 1.252 ± 0.036
2.034GlyGln: 2.034 ± 0.04
2.865GlyArg: 2.865 ± 0.047
4.101GlySer: 4.101 ± 0.079
4.008GlyThr: 4.008 ± 0.065
4.698GlyVal: 4.698 ± 0.067
0.694GlyTrp: 0.694 ± 0.028
3.439GlyTyr: 3.439 ± 0.061
0.0GlyXaa: 0.0 ± 0.0
His
0.98HisAla: 0.98 ± 0.029
0.241HisCys: 0.241 ± 0.015
0.994HisAsp: 0.994 ± 0.03
1.112HisGlu: 1.112 ± 0.031
0.794HisPhe: 0.794 ± 0.028
1.22HisGly: 1.22 ± 0.032
0.37HisHis: 0.37 ± 0.028
1.283HisIle: 1.283 ± 0.031
1.008HisLys: 1.008 ± 0.029
1.306HisLeu: 1.306 ± 0.03
0.547HisMet: 0.547 ± 0.022
0.78HisAsn: 0.78 ± 0.028
0.712HisPro: 0.712 ± 0.024
0.453HisGln: 0.453 ± 0.019
0.708HisArg: 0.708 ± 0.024
0.926HisSer: 0.926 ± 0.028
0.792HisThr: 0.792 ± 0.025
1.099HisVal: 1.099 ± 0.027
0.156HisTrp: 0.156 ± 0.012
0.772HisTyr: 0.772 ± 0.024
0.0HisXaa: 0.0 ± 0.0
Ile
5.734IleAla: 5.734 ± 0.084
1.281IleCys: 1.281 ± 0.036
5.029IleAsp: 5.029 ± 0.061
4.898IleGlu: 4.898 ± 0.065
3.109IlePhe: 3.109 ± 0.06
4.914IleGly: 4.914 ± 0.075
1.199IleHis: 1.199 ± 0.036
5.681IleIle: 5.681 ± 0.084
4.983IleLys: 4.983 ± 0.078
6.498IleLeu: 6.498 ± 0.088
2.017IleMet: 2.017 ± 0.044
3.406IleAsn: 3.406 ± 0.051
3.06IlePro: 3.06 ± 0.055
1.892IleGln: 1.892 ± 0.039
3.41IleArg: 3.41 ± 0.057
5.521IleSer: 5.521 ± 0.07
4.498IleThr: 4.498 ± 0.072
5.121IleVal: 5.121 ± 0.079
0.629IleTrp: 0.629 ± 0.021
3.116IleTyr: 3.116 ± 0.05
0.0IleXaa: 0.0 ± 0.0
Lys
5.516LysAla: 5.516 ± 0.078
0.786LysCys: 0.786 ± 0.027
4.618LysAsp: 4.618 ± 0.063
6.665LysGlu: 6.665 ± 0.088
2.214LysPhe: 2.214 ± 0.04
4.205LysGly: 4.205 ± 0.062
1.054LysHis: 1.054 ± 0.035
4.852LysIle: 4.852 ± 0.072
6.526LysLys: 6.526 ± 0.096
5.728LysLeu: 5.728 ± 0.07
2.116LysMet: 2.116 ± 0.04
3.716LysAsn: 3.716 ± 0.063
1.955LysPro: 1.955 ± 0.041
1.872LysGln: 1.872 ± 0.047
3.149LysArg: 3.149 ± 0.054
3.826LysSer: 3.826 ± 0.069
3.638LysThr: 3.638 ± 0.054
4.485LysVal: 4.485 ± 0.067
0.73LysTrp: 0.73 ± 0.026
3.308LysTyr: 3.308 ± 0.059
0.0LysXaa: 0.0 ± 0.0
Leu
6.077LeuAla: 6.077 ± 0.081
1.274LeuCys: 1.274 ± 0.034
5.333LeuAsp: 5.333 ± 0.07
5.646LeuGlu: 5.646 ± 0.064
3.876LeuPhe: 3.876 ± 0.068
5.683LeuGly: 5.683 ± 0.066
1.367LeuHis: 1.367 ± 0.039
6.104LeuIle: 6.104 ± 0.084
5.795LeuLys: 5.795 ± 0.073
7.616LeuLeu: 7.616 ± 0.107
2.534LeuMet: 2.534 ± 0.055
3.764LeuAsn: 3.764 ± 0.057
2.946LeuPro: 2.946 ± 0.049
2.282LeuGln: 2.282 ± 0.047
3.487LeuArg: 3.487 ± 0.063
6.532LeuSer: 6.532 ± 0.088
4.522LeuThr: 4.522 ± 0.063
5.479LeuVal: 5.479 ± 0.071
0.697LeuTrp: 0.697 ± 0.026
3.351LeuTyr: 3.351 ± 0.054
0.0LeuXaa: 0.0 ± 0.0
Met
2.464MetAla: 2.464 ± 0.049
0.362MetCys: 0.362 ± 0.017
1.981MetAsp: 1.981 ± 0.044
2.055MetGlu: 2.055 ± 0.044
1.097MetPhe: 1.097 ± 0.029
1.988MetGly: 1.988 ± 0.04
0.509MetHis: 0.509 ± 0.02
2.178MetIle: 2.178 ± 0.044
2.178MetLys: 2.178 ± 0.041
2.531MetLeu: 2.531 ± 0.056
0.931MetMet: 0.931 ± 0.029
1.626MetAsn: 1.626 ± 0.037
1.096MetPro: 1.096 ± 0.03
1.047MetGln: 1.047 ± 0.03
1.216MetArg: 1.216 ± 0.035
1.885MetSer: 1.885 ± 0.033
1.629MetThr: 1.629 ± 0.033
1.871MetVal: 1.871 ± 0.039
0.253MetTrp: 0.253 ± 0.015
1.042MetTyr: 1.042 ± 0.028
0.0MetXaa: 0.0 ± 0.0
Asn
3.54AsnAla: 3.54 ± 0.066
0.622AsnCys: 0.622 ± 0.023
2.639AsnAsp: 2.639 ± 0.048
3.117AsnGlu: 3.117 ± 0.049
1.85AsnPhe: 1.85 ± 0.04
3.797AsnGly: 3.797 ± 0.063
0.806AsnHis: 0.806 ± 0.028
3.817AsnIle: 3.817 ± 0.054
3.174AsnLys: 3.174 ± 0.053
3.937AsnLeu: 3.937 ± 0.055
1.54AsnMet: 1.54 ± 0.036
2.336AsnAsn: 2.336 ± 0.053
2.022AsnPro: 2.022 ± 0.042
1.305AsnGln: 1.305 ± 0.038
1.949AsnArg: 1.949 ± 0.043
2.85AsnSer: 2.85 ± 0.056
2.576AsnThr: 2.576 ± 0.053
3.301AsnVal: 3.301 ± 0.051
0.493AsnTrp: 0.493 ± 0.022
2.226AsnTyr: 2.226 ± 0.048
0.0AsnXaa: 0.0 ± 0.0
Pro
2.214ProAla: 2.214 ± 0.049
0.371ProCys: 0.371 ± 0.019
2.431ProAsp: 2.431 ± 0.047
3.154ProGlu: 3.154 ± 0.048
1.42ProPhe: 1.42 ± 0.035
2.089ProGly: 2.089 ± 0.041
0.501ProHis: 0.501 ± 0.02
2.044ProIle: 2.044 ± 0.043
1.818ProLys: 1.818 ± 0.04
2.382ProLeu: 2.382 ± 0.041
0.887ProMet: 0.887 ± 0.029
1.236ProAsn: 1.236 ± 0.029
0.574ProPro: 0.574 ± 0.022
0.993ProGln: 0.993 ± 0.032
0.982ProArg: 0.982 ± 0.033
1.866ProSer: 1.866 ± 0.035
1.519ProThr: 1.519 ± 0.035
2.712ProVal: 2.712 ± 0.048
0.324ProTrp: 0.324 ± 0.016
1.409ProTyr: 1.409 ± 0.034
0.0ProXaa: 0.0 ± 0.0
Gln
2.031GlnAla: 2.031 ± 0.051
0.283GlnCys: 0.283 ± 0.016
1.697GlnAsp: 1.697 ± 0.039
2.223GlnGlu: 2.223 ± 0.041
1.06GlnPhe: 1.06 ± 0.031
1.713GlnGly: 1.713 ± 0.039
0.469GlnHis: 0.469 ± 0.02
2.369GlnIle: 2.369 ± 0.046
2.197GlnLys: 2.197 ± 0.049
2.343GlnLeu: 2.343 ± 0.041
1.018GlnMet: 1.018 ± 0.03
1.541GlnAsn: 1.541 ± 0.037
0.789GlnPro: 0.789 ± 0.033
1.037GlnGln: 1.037 ± 0.031
1.166GlnArg: 1.166 ± 0.033
1.466GlnSer: 1.466 ± 0.039
1.44GlnThr: 1.44 ± 0.039
1.722GlnVal: 1.722 ± 0.036
0.258GlnTrp: 0.258 ± 0.014
1.325GlnTyr: 1.325 ± 0.034
0.0GlnXaa: 0.0 ± 0.0
Arg
2.674ArgAla: 2.674 ± 0.043
0.533ArgCys: 0.533 ± 0.023
2.526ArgAsp: 2.526 ± 0.043
3.141ArgGlu: 3.141 ± 0.054
1.841ArgPhe: 1.841 ± 0.042
2.296ArgGly: 2.296 ± 0.048
0.749ArgHis: 0.749 ± 0.025
3.45ArgIle: 3.45 ± 0.052
3.236ArgLys: 3.236 ± 0.055
3.504ArgLeu: 3.504 ± 0.059
1.297ArgMet: 1.297 ± 0.03
2.194ArgAsn: 2.194 ± 0.046
1.247ArgPro: 1.247 ± 0.033
1.388ArgGln: 1.388 ± 0.034
1.82ArgArg: 1.82 ± 0.049
2.075ArgSer: 2.075 ± 0.05
1.985ArgThr: 1.985 ± 0.038
2.588ArgVal: 2.588 ± 0.053
0.351ArgTrp: 0.351 ± 0.017
1.871ArgTyr: 1.871 ± 0.037
0.0ArgXaa: 0.0 ± 0.0
Ser
4.29SerAla: 4.29 ± 0.068
0.726SerCys: 0.726 ± 0.026
4.341SerAsp: 4.341 ± 0.06
4.59SerGlu: 4.59 ± 0.083
3.325SerPhe: 3.325 ± 0.061
4.925SerGly: 4.925 ± 0.068
0.946SerHis: 0.946 ± 0.029
4.449SerIle: 4.449 ± 0.064
4.088SerLys: 4.088 ± 0.056
5.153SerLeu: 5.153 ± 0.07
1.735SerMet: 1.735 ± 0.042
2.781SerAsn: 2.781 ± 0.054
1.626SerPro: 1.626 ± 0.035
1.834SerGln: 1.834 ± 0.038
2.565SerArg: 2.565 ± 0.048
4.213SerSer: 4.213 ± 0.091
3.137SerThr: 3.137 ± 0.061
4.324SerVal: 4.324 ± 0.059
0.575SerTrp: 0.575 ± 0.027
2.72SerTyr: 2.72 ± 0.053
0.0SerXaa: 0.0 ± 0.0
Thr
3.935ThrAla: 3.935 ± 0.068
0.611ThrCys: 0.611 ± 0.02
3.586ThrAsp: 3.586 ± 0.062
3.635ThrGlu: 3.635 ± 0.057
2.303ThrPhe: 2.303 ± 0.05
4.316ThrGly: 4.316 ± 0.067
0.819ThrHis: 0.819 ± 0.025
4.076ThrIle: 4.076 ± 0.066
3.153ThrLys: 3.153 ± 0.053
4.482ThrLeu: 4.482 ± 0.069
1.395ThrMet: 1.395 ± 0.035
2.252ThrAsn: 2.252 ± 0.05
1.981ThrPro: 1.981 ± 0.041
1.418ThrGln: 1.418 ± 0.033
1.922ThrArg: 1.922 ± 0.049
3.245ThrSer: 3.245 ± 0.059
2.938ThrThr: 2.938 ± 0.064
4.167ThrVal: 4.167 ± 0.077
0.531ThrTrp: 0.531 ± 0.025
2.32ThrTyr: 2.32 ± 0.062
0.0ThrXaa: 0.0 ± 0.0
Val
4.849ValAla: 4.849 ± 0.071
1.084ValCys: 1.084 ± 0.028
4.427ValAsp: 4.427 ± 0.063
4.369ValGlu: 4.369 ± 0.072
3.113ValPhe: 3.113 ± 0.055
4.18ValGly: 4.18 ± 0.054
1.006ValHis: 1.006 ± 0.032
5.298ValIle: 5.298 ± 0.079
4.432ValLys: 4.432 ± 0.06
6.14ValLeu: 6.14 ± 0.081
2.003ValMet: 2.003 ± 0.041
3.215ValAsn: 3.215 ± 0.05
2.361ValPro: 2.361 ± 0.04
1.68ValGln: 1.68 ± 0.039
2.712ValArg: 2.712 ± 0.052
4.747ValSer: 4.747 ± 0.073
4.108ValThr: 4.108 ± 0.072
5.063ValVal: 5.063 ± 0.076
0.558ValTrp: 0.558 ± 0.022
2.805ValTyr: 2.805 ± 0.049
0.0ValXaa: 0.0 ± 0.0
Trp
0.607TrpAla: 0.607 ± 0.024
0.151TrpCys: 0.151 ± 0.011
0.605TrpAsp: 0.605 ± 0.021
0.611TrpGlu: 0.611 ± 0.026
0.424TrpPhe: 0.424 ± 0.021
0.723TrpGly: 0.723 ± 0.023
0.198TrpHis: 0.198 ± 0.013
0.708TrpIle: 0.708 ± 0.025
0.619TrpLys: 0.619 ± 0.023
0.819TrpLeu: 0.819 ± 0.027
0.293TrpMet: 0.293 ± 0.018
0.641TrpAsn: 0.641 ± 0.028
0.218TrpPro: 0.218 ± 0.013
0.328TrpGln: 0.328 ± 0.016
0.365TrpArg: 0.365 ± 0.018
0.485TrpSer: 0.485 ± 0.021
0.46TrpThr: 0.46 ± 0.021
0.497TrpVal: 0.497 ± 0.021
0.132TrpTrp: 0.132 ± 0.012
0.429TrpTyr: 0.429 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.91TyrAla: 2.91 ± 0.048
0.607TyrCys: 0.607 ± 0.026
3.285TyrAsp: 3.285 ± 0.055
3.203TyrGlu: 3.203 ± 0.044
2.038TyrPhe: 2.038 ± 0.041
3.151TyrGly: 3.151 ± 0.057
0.806TyrHis: 0.806 ± 0.026
3.11TyrIle: 3.11 ± 0.059
2.819TyrLys: 2.819 ± 0.051
3.761TyrLeu: 3.761 ± 0.061
1.254TyrMet: 1.254 ± 0.032
2.211TyrAsn: 2.211 ± 0.049
1.407TyrPro: 1.407 ± 0.036
1.283TyrGln: 1.283 ± 0.033
1.924TyrArg: 1.924 ± 0.043
2.865TyrSer: 2.865 ± 0.053
2.351TyrThr: 2.351 ± 0.052
2.921TyrVal: 2.921 ± 0.055
0.435TyrTrp: 0.435 ± 0.019
2.328TyrTyr: 2.328 ± 0.052
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3697 proteins (1242442 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski