Amino acid dipepetide frequency for Criblamydia sequanensis CRIB-18

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.695AlaAla: 4.695 ± 0.086	0.808AlaCys: 0.808 ± 0.03	2.564AlaAsp: 2.564 ± 0.054	4.106AlaGlu: 4.106 ± 0.075	3.873AlaPhe: 3.873 ± 0.069	3.741AlaGly: 3.741 ± 0.098	1.297AlaHis: 1.297 ± 0.034	5.316AlaIle: 5.316 ± 0.08	5.279AlaLys: 5.279 ± 0.091	8.864AlaLeu: 8.864 ± 0.125	1.351AlaMet: 1.351 ± 0.041	2.544AlaAsn: 2.544 ± 0.056	2.334AlaPro: 2.334 ± 0.069	1.827AlaGln: 1.827 ± 0.052	2.432AlaArg: 2.432 ± 0.06	5.278AlaSer: 5.278 ± 0.079	2.823AlaThr: 2.823 ± 0.061	3.428AlaVal: 3.428 ± 0.075	0.6AlaTrp: 0.6 ± 0.029	2.201AlaTyr: 2.201 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	0.463CysAla: 0.463 ± 0.024	0.203CysCys: 0.203 ± 0.018	0.497CysAsp: 0.497 ± 0.027	0.581CysGlu: 0.581 ± 0.03	0.787CysPhe: 0.787 ± 0.032	0.682CysGly: 0.682 ± 0.038	0.302CysHis: 0.302 ± 0.02	0.642CysIle: 0.642 ± 0.029	0.634CysLys: 0.634 ± 0.028	1.487CysLeu: 1.487 ± 0.043	0.183CysMet: 0.183 ± 0.016	0.422CysAsn: 0.422 ± 0.026	0.52CysPro: 0.52 ± 0.03	0.409CysGln: 0.409 ± 0.024	0.473CysArg: 0.473 ± 0.023	0.703CysSer: 0.703 ± 0.031	0.405CysThr: 0.405 ± 0.025	0.484CysVal: 0.484 ± 0.028	0.117CysTrp: 0.117 ± 0.011	0.444CysTyr: 0.444 ± 0.024	0.0CysXaa: 0.0 ± 0.0
Asp	2.954AspAla: 2.954 ± 0.059	0.584AspCys: 0.584 ± 0.026	2.085AspAsp: 2.085 ± 0.063	3.946AspGlu: 3.946 ± 0.071	3.189AspPhe: 3.189 ± 0.057	2.702AspGly: 2.702 ± 0.066	1.02AspHis: 1.02 ± 0.035	3.183AspIle: 3.183 ± 0.067	3.544AspLys: 3.544 ± 0.068	6.286AspLeu: 6.286 ± 0.084	0.824AspMet: 0.824 ± 0.029	1.746AspAsn: 1.746 ± 0.054	2.754AspPro: 2.754 ± 0.059	1.571AspGln: 1.571 ± 0.037	2.238AspArg: 2.238 ± 0.046	3.315AspSer: 3.315 ± 0.063	1.956AspThr: 1.956 ± 0.042	2.43AspVal: 2.43 ± 0.059	0.731AspTrp: 0.731 ± 0.03	1.869AspTyr: 1.869 ± 0.047	0.0AspXaa: 0.0 ± 0.0
Glu	5.895GluAla: 5.895 ± 0.091	0.626GluCys: 0.626 ± 0.032	3.845GluAsp: 3.845 ± 0.07	7.47GluGlu: 7.47 ± 0.132	3.114GluPhe: 3.114 ± 0.07	4.462GluGly: 4.462 ± 0.075	1.14GluHis: 1.14 ± 0.034	6.234GluIle: 6.234 ± 0.101	8.236GluLys: 8.236 ± 0.131	7.241GluLeu: 7.241 ± 0.111	1.722GluMet: 1.722 ± 0.045	4.115GluAsn: 4.115 ± 0.072	2.233GluPro: 2.233 ± 0.048	1.754GluGln: 1.754 ± 0.04	3.298GluArg: 3.298 ± 0.075	4.896GluSer: 4.896 ± 0.087	4.034GluThr: 4.034 ± 0.077	4.264GluVal: 4.264 ± 0.092	0.76GluTrp: 0.76 ± 0.033	1.825GluTyr: 1.825 ± 0.049	0.0GluXaa: 0.0 ± 0.0
Phe	3.157PheAla: 3.157 ± 0.064	0.722PheCys: 0.722 ± 0.034	3.007PheAsp: 3.007 ± 0.068	3.822PheGlu: 3.822 ± 0.08	4.072PhePhe: 4.072 ± 0.096	3.318PheGly: 3.318 ± 0.074	1.05PheHis: 1.05 ± 0.032	4.102PheIle: 4.102 ± 0.072	3.962PheLys: 3.962 ± 0.072	6.803PheLeu: 6.803 ± 0.125	0.948PheMet: 0.948 ± 0.038	2.525PheAsn: 2.525 ± 0.063	2.251PhePro: 2.251 ± 0.054	1.987PheGln: 1.987 ± 0.052	1.974PheArg: 1.974 ± 0.048	4.825PheSer: 4.825 ± 0.082	2.428PheThr: 2.428 ± 0.055	2.614PheVal: 2.614 ± 0.062	0.635PheTrp: 0.635 ± 0.028	2.058PheTyr: 2.058 ± 0.057	0.0PheXaa: 0.0 ± 0.0
Gly	3.729GlyAla: 3.729 ± 0.076	0.726GlyCys: 0.726 ± 0.033	2.66GlyAsp: 2.66 ± 0.072	3.659GlyGlu: 3.659 ± 0.07	3.571GlyPhe: 3.571 ± 0.069	3.874GlyGly: 3.874 ± 0.114	1.252GlyHis: 1.252 ± 0.04	4.675GlyIle: 4.675 ± 0.073	4.913GlyLys: 4.913 ± 0.078	6.28GlyLeu: 6.28 ± 0.095	1.344GlyMet: 1.344 ± 0.04	2.389GlyAsn: 2.389 ± 0.071	1.929GlyPro: 1.929 ± 0.079	1.708GlyGln: 1.708 ± 0.041	2.462GlyArg: 2.462 ± 0.054	4.263GlySer: 4.263 ± 0.074	2.878GlyThr: 2.878 ± 0.08	3.624GlyVal: 3.624 ± 0.074	0.686GlyTrp: 0.686 ± 0.032	2.102GlyTyr: 2.102 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	1.141HisAla: 1.141 ± 0.039	0.242HisCys: 0.242 ± 0.017	0.921HisAsp: 0.921 ± 0.031	1.335HisGlu: 1.335 ± 0.041	1.396HisPhe: 1.396 ± 0.038	1.116HisGly: 1.116 ± 0.041	0.586HisHis: 0.586 ± 0.032	1.287HisIle: 1.287 ± 0.034	1.168HisLys: 1.168 ± 0.042	2.847HisLeu: 2.847 ± 0.056	0.295HisMet: 0.295 ± 0.019	0.691HisAsn: 0.691 ± 0.028	1.247HisPro: 1.247 ± 0.039	0.758HisGln: 0.758 ± 0.028	0.852HisArg: 0.852 ± 0.028	1.269HisSer: 1.269 ± 0.041	0.847HisThr: 0.847 ± 0.032	0.964HisVal: 0.964 ± 0.04	0.204HisTrp: 0.204 ± 0.016	0.828HisTyr: 0.828 ± 0.034	0.0HisXaa: 0.0 ± 0.0
Ile	5.481IleAla: 5.481 ± 0.091	0.733IleCys: 0.733 ± 0.034	4.062IleAsp: 4.062 ± 0.069	5.839IleGlu: 5.839 ± 0.082	3.754IlePhe: 3.754 ± 0.085	4.566IleGly: 4.566 ± 0.095	1.576IleHis: 1.576 ± 0.044	4.632IleIle: 4.632 ± 0.087	5.401IleLys: 5.401 ± 0.078	7.917IleLeu: 7.917 ± 0.113	1.102IleMet: 1.102 ± 0.035	3.07IleAsn: 3.07 ± 0.058	3.622IlePro: 3.622 ± 0.065	2.753IleGln: 2.753 ± 0.059	3.108IleArg: 3.108 ± 0.052	5.278IleSer: 5.278 ± 0.077	3.366IleThr: 3.366 ± 0.058	3.743IleVal: 3.743 ± 0.064	0.693IleTrp: 0.693 ± 0.032	2.242IleTyr: 2.242 ± 0.048	0.0IleXaa: 0.0 ± 0.0
Lys	5.923LysAla: 5.923 ± 0.088	0.542LysCys: 0.542 ± 0.028	4.515LysAsp: 4.515 ± 0.082	9.174LysGlu: 9.174 ± 0.137	2.541LysPhe: 2.541 ± 0.059	4.835LysGly: 4.835 ± 0.08	1.266LysHis: 1.266 ± 0.038	6.307LysIle: 6.307 ± 0.101	8.435LysLys: 8.435 ± 0.133	7.229LysLeu: 7.229 ± 0.096	1.808LysMet: 1.808 ± 0.044	4.767LysAsn: 4.767 ± 0.079	3.043LysPro: 3.043 ± 0.077	2.519LysGln: 2.519 ± 0.054	3.655LysArg: 3.655 ± 0.071	4.836LysSer: 4.836 ± 0.082	4.411LysThr: 4.411 ± 0.078	4.308LysVal: 4.308 ± 0.075	0.79LysTrp: 0.79 ± 0.031	1.779LysTyr: 1.779 ± 0.049	0.0LysXaa: 0.0 ± 0.0
Leu	7.531LeuAla: 7.531 ± 0.099	1.031LeuCys: 1.031 ± 0.038	5.507LeuAsp: 5.507 ± 0.078	8.596LeuGlu: 8.596 ± 0.129	6.743LeuPhe: 6.743 ± 0.122	6.35LeuGly: 6.35 ± 0.093	2.017LeuHis: 2.017 ± 0.046	8.446LeuIle: 8.446 ± 0.125	10.789LeuLys: 10.789 ± 0.157	11.952LeuLeu: 11.952 ± 0.154	2.237LeuMet: 2.237 ± 0.05	5.57LeuAsn: 5.57 ± 0.1	4.735LeuPro: 4.735 ± 0.069	3.684LeuGln: 3.684 ± 0.077	4.409LeuArg: 4.409 ± 0.081	9.711LeuSer: 9.711 ± 0.131	5.585LeuThr: 5.585 ± 0.08	5.315LeuVal: 5.315 ± 0.081	0.895LeuTrp: 0.895 ± 0.036	3.286LeuTyr: 3.286 ± 0.064	0.0LeuXaa: 0.0 ± 0.0
Met	1.705MetAla: 1.705 ± 0.047	0.158MetCys: 0.158 ± 0.015	1.017MetAsp: 1.017 ± 0.03	1.417MetGlu: 1.417 ± 0.041	0.551MetPhe: 0.551 ± 0.028	1.392MetGly: 1.392 ± 0.045	0.406MetHis: 0.406 ± 0.02	1.367MetIle: 1.367 ± 0.04	1.587MetLys: 1.587 ± 0.041	1.746MetLeu: 1.746 ± 0.045	0.447MetMet: 0.447 ± 0.023	1.008MetAsn: 1.008 ± 0.029	1.027MetPro: 1.027 ± 0.04	0.815MetGln: 0.815 ± 0.03	0.892MetArg: 0.892 ± 0.03	1.181MetSer: 1.181 ± 0.037	1.126MetThr: 1.126 ± 0.033	1.002MetVal: 1.002 ± 0.033	0.12MetTrp: 0.12 ± 0.012	0.361MetTyr: 0.361 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	2.768AsnAla: 2.768 ± 0.062	0.573AsnCys: 0.573 ± 0.029	2.041AsnAsp: 2.041 ± 0.054	3.629AsnGlu: 3.629 ± 0.071	2.623AsnPhe: 2.623 ± 0.065	2.56AsnGly: 2.56 ± 0.072	1.035AsnHis: 1.035 ± 0.034	2.883AsnIle: 2.883 ± 0.058	3.137AsnLys: 3.137 ± 0.06	5.682AsnLeu: 5.682 ± 0.09	0.774AsnMet: 0.774 ± 0.033	2.017AsnAsn: 2.017 ± 0.057	2.695AsnPro: 2.695 ± 0.057	1.91AsnGln: 1.91 ± 0.048	2.07AsnArg: 2.07 ± 0.048	2.899AsnSer: 2.899 ± 0.072	1.892AsnThr: 1.892 ± 0.063	2.152AsnVal: 2.152 ± 0.048	0.6AsnTrp: 0.6 ± 0.031	1.606AsnTyr: 1.606 ± 0.045	0.0AsnXaa: 0.0 ± 0.0
Pro	2.207ProAla: 2.207 ± 0.083	0.496ProCys: 0.496 ± 0.027	2.105ProAsp: 2.105 ± 0.046	3.181ProGlu: 3.181 ± 0.055	2.859ProPhe: 2.859 ± 0.065	2.246ProGly: 2.246 ± 0.058	0.841ProHis: 0.841 ± 0.034	3.212ProIle: 3.212 ± 0.069	3.412ProLys: 3.412 ± 0.062	5.146ProLeu: 5.146 ± 0.078	0.721ProMet: 0.721 ± 0.03	1.93ProAsn: 1.93 ± 0.048	1.708ProPro: 1.708 ± 0.057	1.26ProGln: 1.26 ± 0.043	1.316ProArg: 1.316 ± 0.05	3.266ProSer: 3.266 ± 0.067	1.869ProThr: 1.869 ± 0.048	2.261ProVal: 2.261 ± 0.053	0.451ProTrp: 0.451 ± 0.025	1.533ProTyr: 1.533 ± 0.049	0.0ProXaa: 0.0 ± 0.0
Gln	2.519GlnAla: 2.519 ± 0.056	0.2GlnCys: 0.2 ± 0.016	1.641GlnAsp: 1.641 ± 0.044	3.185GlnGlu: 3.185 ± 0.066	1.545GlnPhe: 1.545 ± 0.048	2.084GlnGly: 2.084 ± 0.057	0.524GlnHis: 0.524 ± 0.026	2.528GlnIle: 2.528 ± 0.052	3.321GlnLys: 3.321 ± 0.059	2.822GlnLeu: 2.822 ± 0.061	0.721GlnMet: 0.721 ± 0.033	1.908GlnAsn: 1.908 ± 0.05	1.008GlnPro: 1.008 ± 0.036	0.869GlnGln: 0.869 ± 0.033	1.229GlnArg: 1.229 ± 0.037	2.055GlnSer: 2.055 ± 0.059	1.716GlnThr: 1.716 ± 0.047	1.862GlnVal: 1.862 ± 0.046	0.233GlnTrp: 0.233 ± 0.021	0.91GlnTyr: 0.91 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	2.449ArgAla: 2.449 ± 0.05	0.4ArgCys: 0.4 ± 0.023	1.99ArgAsp: 1.99 ± 0.053	3.281ArgGlu: 3.281 ± 0.073	2.435ArgPhe: 2.435 ± 0.056	2.134ArgGly: 2.134 ± 0.057	0.861ArgHis: 0.861 ± 0.034	3.211ArgIle: 3.211 ± 0.057	3.434ArgLys: 3.434 ± 0.06	4.542ArgLeu: 4.542 ± 0.074	0.95ArgMet: 0.95 ± 0.037	1.946ArgAsn: 1.946 ± 0.047	1.445ArgPro: 1.445 ± 0.052	1.429ArgGln: 1.429 ± 0.04	1.729ArgArg: 1.729 ± 0.05	2.628ArgSer: 2.628 ± 0.066	1.787ArgThr: 1.787 ± 0.047	2.282ArgVal: 2.282 ± 0.054	0.438ArgTrp: 0.438 ± 0.021	1.471ArgTyr: 1.471 ± 0.051	0.0ArgXaa: 0.0 ± 0.0
Ser	3.818SerAla: 3.818 ± 0.075	0.884SerCys: 0.884 ± 0.036	3.342SerAsp: 3.342 ± 0.071	4.804SerGlu: 4.804 ± 0.08	5.072SerPhe: 5.072 ± 0.078	4.103SerGly: 4.103 ± 0.085	1.672SerHis: 1.672 ± 0.048	4.953SerIle: 4.953 ± 0.083	5.613SerLys: 5.613 ± 0.087	10.087SerLeu: 10.087 ± 0.142	1.345SerMet: 1.345 ± 0.04	2.968SerAsn: 2.968 ± 0.08	3.06SerPro: 3.06 ± 0.058	2.73SerGln: 2.73 ± 0.066	2.798SerArg: 2.798 ± 0.067	5.578SerSer: 5.578 ± 0.113	2.814SerThr: 2.814 ± 0.062	3.181SerVal: 3.181 ± 0.062	0.784SerTrp: 0.784 ± 0.029	2.695SerTyr: 2.695 ± 0.062	0.0SerXaa: 0.0 ± 0.0
Thr	3.017ThrAla: 3.017 ± 0.068	0.485ThrCys: 0.485 ± 0.025	1.976ThrAsp: 1.976 ± 0.046	2.656ThrGlu: 2.656 ± 0.052	2.568ThrPhe: 2.568 ± 0.062	3.046ThrGly: 3.046 ± 0.066	1.125ThrHis: 1.125 ± 0.036	3.434ThrIle: 3.434 ± 0.061	3.082ThrLys: 3.082 ± 0.058	6.561ThrLeu: 6.561 ± 0.092	0.757ThrMet: 0.757 ± 0.028	1.839ThrAsn: 1.839 ± 0.053	2.503ThrPro: 2.503 ± 0.057	1.445ThrGln: 1.445 ± 0.045	1.791ThrArg: 1.791 ± 0.043	3.413ThrSer: 3.413 ± 0.077	2.254ThrThr: 2.254 ± 0.055	2.582ThrVal: 2.582 ± 0.069	0.442ThrTrp: 0.442 ± 0.026	1.576ThrTyr: 1.576 ± 0.052	0.0ThrXaa: 0.0 ± 0.0
Val	3.413ValAla: 3.413 ± 0.061	0.556ValCys: 0.556 ± 0.03	2.746ValAsp: 2.746 ± 0.055	3.559ValGlu: 3.559 ± 0.077	2.992ValPhe: 2.992 ± 0.057	2.987ValGly: 2.987 ± 0.067	1.019ValHis: 1.019 ± 0.037	3.966ValIle: 3.966 ± 0.078	3.8ValLys: 3.8 ± 0.071	5.745ValLeu: 5.745 ± 0.09	1.076ValMet: 1.076 ± 0.034	2.185ValAsn: 2.185 ± 0.064	2.062ValPro: 2.062 ± 0.049	1.593ValGln: 1.593 ± 0.046	2.087ValArg: 2.087 ± 0.052	4.095ValSer: 4.095 ± 0.083	2.633ValThr: 2.633 ± 0.073	2.947ValVal: 2.947 ± 0.071	0.462ValTrp: 0.462 ± 0.025	1.664ValTyr: 1.664 ± 0.049	0.0ValXaa: 0.0 ± 0.0
Trp	0.519TrpAla: 0.519 ± 0.026	0.112TrpCys: 0.112 ± 0.012	0.657TrpAsp: 0.657 ± 0.034	0.658TrpGlu: 0.658 ± 0.03	0.476TrpPhe: 0.476 ± 0.027	0.585TrpGly: 0.585 ± 0.028	0.248TrpHis: 0.248 ± 0.017	0.735TrpIle: 0.735 ± 0.03	0.895TrpLys: 0.895 ± 0.032	1.189TrpLeu: 1.189 ± 0.042	0.268TrpMet: 0.268 ± 0.018	0.552TrpAsn: 0.552 ± 0.027	0.343TrpPro: 0.343 ± 0.022	0.453TrpGln: 0.453 ± 0.024	0.454TrpArg: 0.454 ± 0.023	0.505TrpSer: 0.505 ± 0.025	0.446TrpThr: 0.446 ± 0.022	0.651TrpVal: 0.651 ± 0.03	0.122TrpTrp: 0.122 ± 0.011	0.265TrpTyr: 0.265 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.976TyrAla: 1.976 ± 0.055	0.359TyrCys: 0.359 ± 0.021	1.748TyrAsp: 1.748 ± 0.076	2.268TyrGlu: 2.268 ± 0.054	2.098TyrPhe: 2.098 ± 0.067	1.944TyrGly: 1.944 ± 0.047	0.756TyrHis: 0.756 ± 0.029	1.823TyrIle: 1.823 ± 0.045	2.043TyrLys: 2.043 ± 0.055	3.965TyrLeu: 3.965 ± 0.08	0.449TyrMet: 0.449 ± 0.021	1.353TyrAsn: 1.353 ± 0.045	1.5TyrPro: 1.5 ± 0.045	1.406TyrGln: 1.406 ± 0.041	1.573TyrArg: 1.573 ± 0.046	2.308TyrSer: 2.308 ± 0.06	1.286TyrThr: 1.286 ± 0.048	1.491TyrVal: 1.491 ± 0.043	0.366TyrTrp: 0.366 ± 0.022	1.222TyrTyr: 1.222 ± 0.045	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2418 proteins (885973 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---