Amino acid dipepetide frequency for Gillisia sp. Hel1_33_143

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.609AlaAla: 4.609 ± 0.093	0.516AlaCys: 0.516 ± 0.024	3.299AlaAsp: 3.299 ± 0.062	4.236AlaGlu: 4.236 ± 0.077	3.039AlaPhe: 3.039 ± 0.063	4.247AlaGly: 4.247 ± 0.078	1.064AlaHis: 1.064 ± 0.035	5.506AlaIle: 5.506 ± 0.086	4.771AlaLys: 4.771 ± 0.077	6.324AlaLeu: 6.324 ± 0.098	1.625AlaMet: 1.625 ± 0.043	3.331AlaAsn: 3.331 ± 0.062	1.942AlaPro: 1.942 ± 0.044	2.492AlaGln: 2.492 ± 0.05	2.086AlaArg: 2.086 ± 0.049	4.11AlaSer: 4.11 ± 0.078	3.599AlaThr: 3.599 ± 0.075	4.172AlaVal: 4.172 ± 0.073	0.597AlaTrp: 0.597 ± 0.026	2.359AlaTyr: 2.359 ± 0.056	0.0AlaXaa: 0.0 ± 0.0
Cys	0.448CysAla: 0.448 ± 0.026	0.095CysCys: 0.095 ± 0.011	0.425CysAsp: 0.425 ± 0.034	0.448CysGlu: 0.448 ± 0.022	0.343CysPhe: 0.343 ± 0.019	0.587CysGly: 0.587 ± 0.027	0.153CysHis: 0.153 ± 0.015	0.532CysIle: 0.532 ± 0.024	0.439CysLys: 0.439 ± 0.021	0.591CysLeu: 0.591 ± 0.024	0.12CysMet: 0.12 ± 0.009	0.41CysAsn: 0.41 ± 0.019	0.316CysPro: 0.316 ± 0.022	0.183CysGln: 0.183 ± 0.015	0.211CysArg: 0.211 ± 0.011	0.501CysSer: 0.501 ± 0.029	0.369CysThr: 0.369 ± 0.025	0.366CysVal: 0.366 ± 0.019	0.047CysTrp: 0.047 ± 0.007	0.285CysTyr: 0.285 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	3.693AspAla: 3.693 ± 0.068	0.362AspCys: 0.362 ± 0.021	2.795AspAsp: 2.795 ± 0.055	3.814AspGlu: 3.814 ± 0.076	3.53AspPhe: 3.53 ± 0.064	3.536AspGly: 3.536 ± 0.075	1.125AspHis: 1.125 ± 0.036	4.345AspIle: 4.345 ± 0.061	4.246AspLys: 4.246 ± 0.063	5.945AspLeu: 5.945 ± 0.076	1.137AspMet: 1.137 ± 0.032	3.056AspAsn: 3.056 ± 0.076	1.917AspPro: 1.917 ± 0.069	1.731AspGln: 1.731 ± 0.05	2.018AspArg: 2.018 ± 0.043	3.286AspSer: 3.286 ± 0.071	2.786AspThr: 2.786 ± 0.059	3.506AspVal: 3.506 ± 0.063	0.677AspTrp: 0.677 ± 0.026	2.744AspTyr: 2.744 ± 0.064	0.0AspXaa: 0.0 ± 0.0
Glu	4.446GluAla: 4.446 ± 0.079	0.369GluCys: 0.369 ± 0.022	4.26GluAsp: 4.26 ± 0.083	5.562GluGlu: 5.562 ± 0.099	3.179GluPhe: 3.179 ± 0.061	3.873GluGly: 3.873 ± 0.07	1.173GluHis: 1.173 ± 0.036	6.156GluIle: 6.156 ± 0.102	5.89GluLys: 5.89 ± 0.1	6.528GluLeu: 6.528 ± 0.097	1.771GluMet: 1.771 ± 0.039	5.052GluAsn: 5.052 ± 0.072	1.57GluPro: 1.57 ± 0.038	2.379GluGln: 2.379 ± 0.053	2.679GluArg: 2.679 ± 0.056	3.47GluSer: 3.47 ± 0.065	3.338GluThr: 3.338 ± 0.06	4.579GluVal: 4.579 ± 0.057	0.584GluTrp: 0.584 ± 0.023	2.491GluTyr: 2.491 ± 0.052	0.0GluXaa: 0.0 ± 0.0
Phe	2.9PheAla: 2.9 ± 0.057	0.403PheCys: 0.403 ± 0.018	3.02PheAsp: 3.02 ± 0.061	3.56PheGlu: 3.56 ± 0.057	2.655PhePhe: 2.655 ± 0.069	3.58PheGly: 3.58 ± 0.073	0.822PheHis: 0.822 ± 0.03	3.992PheIle: 3.992 ± 0.073	4.019PheLys: 4.019 ± 0.069	4.874PheLeu: 4.874 ± 0.094	1.06PheMet: 1.06 ± 0.035	3.311PheAsn: 3.311 ± 0.061	1.737PhePro: 1.737 ± 0.042	1.753PheGln: 1.753 ± 0.041	1.625PheArg: 1.625 ± 0.042	4.077PheSer: 4.077 ± 0.071	2.933PheThr: 2.933 ± 0.064	2.739PheVal: 2.739 ± 0.052	0.599PheTrp: 0.599 ± 0.03	2.123PheTyr: 2.123 ± 0.047	0.0PheXaa: 0.0 ± 0.0
Gly	4.151GlyAla: 4.151 ± 0.075	0.525GlyCys: 0.525 ± 0.03	3.425GlyAsp: 3.425 ± 0.074	3.828GlyGlu: 3.828 ± 0.063	3.565GlyPhe: 3.565 ± 0.065	4.308GlyGly: 4.308 ± 0.092	1.079GlyHis: 1.079 ± 0.036	5.534GlyIle: 5.534 ± 0.092	4.852GlyLys: 4.852 ± 0.076	5.657GlyLeu: 5.657 ± 0.087	1.652GlyMet: 1.652 ± 0.048	3.606GlyAsn: 3.606 ± 0.084	1.244GlyPro: 1.244 ± 0.037	1.682GlyGln: 1.682 ± 0.041	2.04GlyArg: 2.04 ± 0.05	3.974GlySer: 3.974 ± 0.074	3.716GlyThr: 3.716 ± 0.078	4.169GlyVal: 4.169 ± 0.073	0.715GlyTrp: 0.715 ± 0.026	2.708GlyTyr: 2.708 ± 0.058	0.0GlyXaa: 0.0 ± 0.0
His	0.897HisAla: 0.897 ± 0.031	0.184HisCys: 0.184 ± 0.012	0.797HisAsp: 0.797 ± 0.028	0.936HisGlu: 0.936 ± 0.031	1.078HisPhe: 1.078 ± 0.031	1.032HisGly: 1.032 ± 0.031	0.43HisHis: 0.43 ± 0.02	1.35HisIle: 1.35 ± 0.041	1.13HisLys: 1.13 ± 0.035	1.849HisLeu: 1.849 ± 0.051	0.319HisMet: 0.319 ± 0.016	0.908HisAsn: 0.908 ± 0.032	0.866HisPro: 0.866 ± 0.032	0.709HisGln: 0.709 ± 0.031	0.64HisArg: 0.64 ± 0.027	1.138HisSer: 1.138 ± 0.037	0.91HisThr: 0.91 ± 0.031	0.799HisVal: 0.799 ± 0.029	0.209HisTrp: 0.209 ± 0.015	0.762HisTyr: 0.762 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	5.814IleAla: 5.814 ± 0.091	0.615IleCys: 0.615 ± 0.024	4.89IleAsp: 4.89 ± 0.068	5.558IleGlu: 5.558 ± 0.077	4.092IlePhe: 4.092 ± 0.074	5.048IleGly: 5.048 ± 0.09	1.333IleHis: 1.333 ± 0.035	6.423IleIle: 6.423 ± 0.101	5.921IleLys: 5.921 ± 0.072	7.873IleLeu: 7.873 ± 0.106	1.501IleMet: 1.501 ± 0.038	4.596IleAsn: 4.596 ± 0.074	3.308IlePro: 3.308 ± 0.062	2.567IleGln: 2.567 ± 0.053	2.622IleArg: 2.622 ± 0.051	6.406IleSer: 6.406 ± 0.088	4.753IleThr: 4.753 ± 0.083	4.518IleVal: 4.518 ± 0.079	0.719IleTrp: 0.719 ± 0.028	2.992IleTyr: 2.992 ± 0.063	0.0IleXaa: 0.0 ± 0.0
Lys	4.905LysAla: 4.905 ± 0.076	0.326LysCys: 0.326 ± 0.017	4.986LysAsp: 4.986 ± 0.085	6.54LysGlu: 6.54 ± 0.092	3.249LysPhe: 3.249 ± 0.053	4.299LysGly: 4.299 ± 0.064	1.279LysHis: 1.279 ± 0.041	6.783LysIle: 6.783 ± 0.086	6.646LysLys: 6.646 ± 0.106	6.919LysLeu: 6.919 ± 0.086	2.183LysMet: 2.183 ± 0.056	5.404LysAsn: 5.404 ± 0.086	2.336LysPro: 2.336 ± 0.053	2.518LysGln: 2.518 ± 0.054	2.956LysArg: 2.956 ± 0.051	4.61LysSer: 4.61 ± 0.07	4.166LysThr: 4.166 ± 0.072	4.692LysVal: 4.692 ± 0.067	0.738LysTrp: 0.738 ± 0.03	3.044LysTyr: 3.044 ± 0.063	0.0LysXaa: 0.0 ± 0.0
Leu	5.958LeuAla: 5.958 ± 0.093	0.617LeuCys: 0.617 ± 0.027	5.429LeuAsp: 5.429 ± 0.076	6.713LeuGlu: 6.713 ± 0.088	4.749LeuPhe: 4.749 ± 0.09	5.981LeuGly: 5.981 ± 0.074	1.524LeuHis: 1.524 ± 0.039	7.651LeuIle: 7.651 ± 0.117	8.389LeuLys: 8.389 ± 0.092	9.147LeuLeu: 9.147 ± 0.126	2.18LeuMet: 2.18 ± 0.055	5.866LeuAsn: 5.866 ± 0.102	3.492LeuPro: 3.492 ± 0.057	3.452LeuGln: 3.452 ± 0.071	3.453LeuArg: 3.453 ± 0.06	6.753LeuSer: 6.753 ± 0.084	4.887LeuThr: 4.887 ± 0.076	5.408LeuVal: 5.408 ± 0.089	0.807LeuTrp: 0.807 ± 0.03	3.194LeuTyr: 3.194 ± 0.069	0.0LeuXaa: 0.0 ± 0.0
Met	1.671MetAla: 1.671 ± 0.041	0.114MetCys: 0.114 ± 0.011	1.239MetAsp: 1.239 ± 0.042	1.545MetGlu: 1.545 ± 0.033	0.916MetPhe: 0.916 ± 0.031	1.426MetGly: 1.426 ± 0.044	0.407MetHis: 0.407 ± 0.02	1.641MetIle: 1.641 ± 0.044	2.333MetLys: 2.333 ± 0.056	2.06MetLeu: 2.06 ± 0.047	0.677MetMet: 0.677 ± 0.036	1.397MetAsn: 1.397 ± 0.034	0.844MetPro: 0.844 ± 0.027	0.894MetGln: 0.894 ± 0.033	0.888MetArg: 0.888 ± 0.027	1.424MetSer: 1.424 ± 0.039	1.075MetThr: 1.075 ± 0.031	1.474MetVal: 1.474 ± 0.043	0.156MetTrp: 0.156 ± 0.013	0.688MetTyr: 0.688 ± 0.028	0.0MetXaa: 0.0 ± 0.0
Asn	3.692AsnAla: 3.692 ± 0.061	0.395AsnCys: 0.395 ± 0.023	3.126AsnAsp: 3.126 ± 0.069	3.702AsnGlu: 3.702 ± 0.063	3.423AsnPhe: 3.423 ± 0.064	3.709AsnGly: 3.709 ± 0.097	0.933AsnHis: 0.933 ± 0.031	4.975AsnIle: 4.975 ± 0.07	4.367AsnLys: 4.367 ± 0.067	5.767AsnLeu: 5.767 ± 0.087	1.332AsnMet: 1.332 ± 0.031	3.792AsnAsn: 3.792 ± 0.083	2.456AsnPro: 2.456 ± 0.052	1.987AsnGln: 1.987 ± 0.052	2.263AsnArg: 2.263 ± 0.056	4.429AsnSer: 4.429 ± 0.086	3.404AsnThr: 3.404 ± 0.066	3.381AsnVal: 3.381 ± 0.071	0.752AsnTrp: 0.752 ± 0.027	2.849AsnTyr: 2.849 ± 0.063	0.0AsnXaa: 0.0 ± 0.0
Pro	1.855ProAla: 1.855 ± 0.048	0.199ProCys: 0.199 ± 0.015	1.998ProAsp: 1.998 ± 0.048	2.975ProGlu: 2.975 ± 0.064	1.812ProPhe: 1.812 ± 0.042	1.897ProGly: 1.897 ± 0.044	0.551ProHis: 0.551 ± 0.023	2.62ProIle: 2.62 ± 0.05	2.442ProLys: 2.442 ± 0.052	2.955ProLeu: 2.955 ± 0.049	0.757ProMet: 0.757 ± 0.029	1.991ProAsn: 1.991 ± 0.053	0.789ProPro: 0.789 ± 0.031	1.214ProGln: 1.214 ± 0.034	0.939ProArg: 0.939 ± 0.038	2.181ProSer: 2.181 ± 0.055	1.817ProThr: 1.817 ± 0.035	2.369ProVal: 2.369 ± 0.048	0.314ProTrp: 0.314 ± 0.019	1.368ProTyr: 1.368 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	2.087GlnAla: 2.087 ± 0.049	0.161GlnCys: 0.161 ± 0.012	1.828GlnAsp: 1.828 ± 0.041	2.546GlnGlu: 2.546 ± 0.057	1.648GlnPhe: 1.648 ± 0.043	1.739GlnGly: 1.739 ± 0.041	0.554GlnHis: 0.554 ± 0.023	2.723GlnIle: 2.723 ± 0.047	2.889GlnLys: 2.889 ± 0.058	3.462GlnLeu: 3.462 ± 0.056	0.809GlnMet: 0.809 ± 0.03	2.242GlnAsn: 2.242 ± 0.053	1.08GlnPro: 1.08 ± 0.03	1.502GlnGln: 1.502 ± 0.044	1.296GlnArg: 1.296 ± 0.037	1.85GlnSer: 1.85 ± 0.044	1.772GlnThr: 1.772 ± 0.044	1.953GlnVal: 1.953 ± 0.048	0.314GlnTrp: 0.314 ± 0.019	1.269GlnTyr: 1.269 ± 0.042	0.0GlnXaa: 0.0 ± 0.0
Arg	2.124ArgAla: 2.124 ± 0.043	0.199ArgCys: 0.199 ± 0.015	1.913ArgAsp: 1.913 ± 0.05	2.397ArgGlu: 2.397 ± 0.052	1.861ArgPhe: 1.861 ± 0.046	1.959ArgGly: 1.959 ± 0.041	0.553ArgHis: 0.553 ± 0.023	2.994ArgIle: 2.994 ± 0.056	2.983ArgLys: 2.983 ± 0.059	3.24ArgLeu: 3.24 ± 0.06	0.925ArgMet: 0.925 ± 0.029	2.189ArgAsn: 2.189 ± 0.052	1.064ArgPro: 1.064 ± 0.037	1.051ArgGln: 1.051 ± 0.033	1.338ArgArg: 1.338 ± 0.038	2.438ArgSer: 2.438 ± 0.057	1.89ArgThr: 1.89 ± 0.044	2.068ArgVal: 2.068 ± 0.042	0.364ArgTrp: 0.364 ± 0.02	1.482ArgTyr: 1.482 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	3.978SerAla: 3.978 ± 0.073	0.621SerCys: 0.621 ± 0.032	3.494SerAsp: 3.494 ± 0.059	4.737SerGlu: 4.737 ± 0.067	3.782SerPhe: 3.782 ± 0.062	4.484SerGly: 4.484 ± 0.071	1.069SerHis: 1.069 ± 0.034	5.414SerIle: 5.414 ± 0.079	5.328SerLys: 5.328 ± 0.075	6.423SerLeu: 6.423 ± 0.082	1.392SerMet: 1.392 ± 0.042	3.987SerAsn: 3.987 ± 0.085	2.047SerPro: 2.047 ± 0.048	2.142SerGln: 2.142 ± 0.044	2.296SerArg: 2.296 ± 0.045	4.639SerSer: 4.639 ± 0.086	3.565SerThr: 3.565 ± 0.063	3.973SerVal: 3.973 ± 0.069	0.67SerTrp: 0.67 ± 0.029	2.921SerTyr: 2.921 ± 0.062	0.0SerXaa: 0.0 ± 0.0
Thr	3.607ThrAla: 3.607 ± 0.069	0.347ThrCys: 0.347 ± 0.021	3.029ThrAsp: 3.029 ± 0.071	3.324ThrGlu: 3.324 ± 0.062	2.769ThrPhe: 2.769 ± 0.06	3.913ThrGly: 3.913 ± 0.068	0.993ThrHis: 0.993 ± 0.033	4.445ThrIle: 4.445 ± 0.08	3.59ThrLys: 3.59 ± 0.059	5.04ThrLeu: 5.04 ± 0.056	0.974ThrMet: 0.974 ± 0.036	3.008ThrAsn: 3.008 ± 0.07	2.269ThrPro: 2.269 ± 0.051	1.782ThrGln: 1.782 ± 0.043	1.664ThrArg: 1.664 ± 0.039	3.965ThrSer: 3.965 ± 0.065	3.178ThrThr: 3.178 ± 0.085	3.516ThrVal: 3.516 ± 0.08	0.504ThrTrp: 0.504 ± 0.024	2.273ThrTyr: 2.273 ± 0.066	0.0ThrXaa: 0.0 ± 0.0
Val	4.2ValAla: 4.2 ± 0.085	0.422ValCys: 0.422 ± 0.022	3.503ValAsp: 3.503 ± 0.062	4.013ValGlu: 4.013 ± 0.065	3.082ValPhe: 3.082 ± 0.063	3.702ValGly: 3.702 ± 0.065	0.965ValHis: 0.965 ± 0.03	4.973ValIle: 4.973 ± 0.067	4.402ValLys: 4.402 ± 0.072	5.977ValLeu: 5.977 ± 0.084	1.373ValMet: 1.373 ± 0.04	3.409ValAsn: 3.409 ± 0.06	2.055ValPro: 2.055 ± 0.049	1.845ValGln: 1.845 ± 0.043	2.014ValArg: 2.014 ± 0.047	4.333ValSer: 4.333 ± 0.065	3.302ValThr: 3.302 ± 0.079	3.947ValVal: 3.947 ± 0.077	0.512ValTrp: 0.512 ± 0.023	2.203ValTyr: 2.203 ± 0.048	0.0ValXaa: 0.0 ± 0.0
Trp	0.546TrpAla: 0.546 ± 0.029	0.076TrpCys: 0.076 ± 0.008	0.553TrpAsp: 0.553 ± 0.026	0.64TrpGlu: 0.64 ± 0.024	0.558TrpPhe: 0.558 ± 0.025	0.573TrpGly: 0.573 ± 0.022	0.202TrpHis: 0.202 ± 0.016	0.757TrpIle: 0.757 ± 0.031	0.818TrpLys: 0.818 ± 0.031	0.989TrpLeu: 0.989 ± 0.036	0.333TrpMet: 0.333 ± 0.018	0.676TrpAsn: 0.676 ± 0.033	0.235TrpPro: 0.235 ± 0.017	0.371TrpGln: 0.371 ± 0.019	0.386TrpArg: 0.386 ± 0.022	0.569TrpSer: 0.569 ± 0.03	0.461TrpThr: 0.461 ± 0.025	0.589TrpVal: 0.589 ± 0.026	0.153TrpTrp: 0.153 ± 0.013	0.416TrpTyr: 0.416 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.346TyrAla: 2.346 ± 0.049	0.322TyrCys: 0.322 ± 0.018	2.239TyrAsp: 2.239 ± 0.053	2.275TyrGlu: 2.275 ± 0.045	2.453TyrPhe: 2.453 ± 0.058	2.537TyrGly: 2.537 ± 0.061	0.734TyrHis: 0.734 ± 0.028	2.734TyrIle: 2.734 ± 0.053	3.125TyrLys: 3.125 ± 0.057	4.033TyrLeu: 4.033 ± 0.07	0.748TyrMet: 0.748 ± 0.028	2.505TyrAsn: 2.505 ± 0.066	1.477TyrPro: 1.477 ± 0.039	1.468TyrGln: 1.468 ± 0.047	1.618TyrArg: 1.618 ± 0.045	2.809TyrSer: 2.809 ± 0.058	2.267TyrThr: 2.267 ± 0.076	2.013TyrVal: 2.013 ± 0.049	0.467TyrTrp: 0.467 ± 0.021	1.825TyrTyr: 1.825 ± 0.045	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3141 proteins (1034711 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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