Amino acid dipepetide frequency for Plasmodium yoelii yoelii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	1.022AlaAla: 1.022 ± 0.033	0.484AlaCys: 0.484 ± 0.013	1.263AlaAsp: 1.263 ± 0.025	1.573AlaGlu: 1.573 ± 0.033	1.355AlaPhe: 1.355 ± 0.024	1.156AlaGly: 1.156 ± 0.032	0.582AlaHis: 0.582 ± 0.016	2.341AlaIle: 2.341 ± 0.032	2.323AlaLys: 2.323 ± 0.03	2.269AlaLeu: 2.269 ± 0.034	0.43AlaMet: 0.43 ± 0.012	2.442AlaAsn: 2.442 ± 0.033	0.712AlaPro: 0.712 ± 0.026	0.817AlaGln: 0.817 ± 0.02	0.751AlaArg: 0.751 ± 0.025	2.012AlaSer: 2.012 ± 0.032	1.176AlaThr: 1.176 ± 0.023	0.996AlaVal: 0.996 ± 0.032	0.158AlaTrp: 0.158 ± 0.008	1.273AlaTyr: 1.273 ± 0.022	0.012AlaXaa: 0.012 ± 0.002
Cys	0.491CysAla: 0.491 ± 0.012	0.29CysCys: 0.29 ± 0.01	1.135CysAsp: 1.135 ± 0.022	1.243CysGlu: 1.243 ± 0.023	0.862CysPhe: 0.862 ± 0.015	0.677CysGly: 0.677 ± 0.016	0.282CysHis: 0.282 ± 0.009	1.693CysIle: 1.693 ± 0.025	1.608CysLys: 1.608 ± 0.023	1.672CysLeu: 1.672 ± 0.029	0.319CysMet: 0.319 ± 0.011	1.804CysAsn: 1.804 ± 0.029	0.569CysPro: 0.569 ± 0.016	0.385CysGln: 0.385 ± 0.012	0.448CysArg: 0.448 ± 0.013	1.483CysSer: 1.483 ± 0.026	0.797CysThr: 0.797 ± 0.016	0.816CysVal: 0.816 ± 0.017	0.075CysTrp: 0.075 ± 0.004	0.796CysTyr: 0.796 ± 0.016	0.007CysXaa: 0.007 ± 0.001
Asp	1.753AspAla: 1.753 ± 0.033	0.732AspCys: 0.732 ± 0.017	4.779AspAsp: 4.779 ± 0.075	5.438AspGlu: 5.438 ± 0.066	2.342AspPhe: 2.342 ± 0.032	2.046AspGly: 2.046 ± 0.032	0.975AspHis: 0.975 ± 0.018	6.631AspIle: 6.631 ± 0.051	6.352AspLys: 6.352 ± 0.065	3.837AspLeu: 3.837 ± 0.04	1.131AspMet: 1.131 ± 0.018	7.02AspAsn: 7.02 ± 0.066	1.202AspPro: 1.202 ± 0.021	1.616AspGln: 1.616 ± 0.027	1.287AspArg: 1.287 ± 0.033	4.038AspSer: 4.038 ± 0.043	2.593AspThr: 2.593 ± 0.03	2.574AspVal: 2.574 ± 0.04	0.223AspTrp: 0.223 ± 0.008	2.686AspTyr: 2.686 ± 0.029	0.033AspXaa: 0.033 ± 0.004
Glu	1.685GluAla: 1.685 ± 0.038	1.027GluCys: 1.027 ± 0.017	4.06GluAsp: 4.06 ± 0.055	6.459GluGlu: 6.459 ± 0.132	2.331GluPhe: 2.331 ± 0.032	1.87GluGly: 1.87 ± 0.032	1.415GluHis: 1.415 ± 0.029	6.39GluIle: 6.39 ± 0.061	10.355GluLys: 10.355 ± 0.101	4.988GluLeu: 4.988 ± 0.049	1.387GluMet: 1.387 ± 0.026	10.675GluAsn: 10.675 ± 0.105	1.091GluPro: 1.091 ± 0.029	2.466GluGln: 2.466 ± 0.068	1.882GluArg: 1.882 ± 0.035	4.014GluSer: 4.014 ± 0.071	2.974GluThr: 2.974 ± 0.047	2.113GluVal: 2.113 ± 0.044	0.338GluTrp: 0.338 ± 0.01	3.497GluTyr: 3.497 ± 0.034	0.025GluXaa: 0.025 ± 0.003
Phe	0.995PheAla: 0.995 ± 0.019	0.874PheCys: 0.874 ± 0.018	2.753PheAsp: 2.753 ± 0.025	2.889PheGlu: 2.889 ± 0.032	3.648PhePhe: 3.648 ± 0.054	1.708PheGly: 1.708 ± 0.033	0.974PheHis: 0.974 ± 0.022	4.672PheIle: 4.672 ± 0.05	4.24PheLys: 4.24 ± 0.039	4.935PheLeu: 4.935 ± 0.053	0.905PheMet: 0.905 ± 0.02	4.258PheAsn: 4.258 ± 0.04	1.316PhePro: 1.316 ± 0.021	1.247PheGln: 1.247 ± 0.02	1.242PheArg: 1.242 ± 0.022	3.767PheSer: 3.767 ± 0.048	1.724PheThr: 1.724 ± 0.025	2.149PheVal: 2.149 ± 0.029	0.244PheTrp: 0.244 ± 0.008	3.286PheTyr: 3.286 ± 0.045	0.022PheXaa: 0.022 ± 0.003
Gly	1.102GlyAla: 1.102 ± 0.029	0.662GlyCys: 0.662 ± 0.015	2.068GlyAsp: 2.068 ± 0.034	2.482GlyGlu: 2.482 ± 0.045	1.498GlyPhe: 1.498 ± 0.025	1.79GlyGly: 1.79 ± 0.04	0.67GlyHis: 0.67 ± 0.015	3.066GlyIle: 3.066 ± 0.038	3.586GlyLys: 3.586 ± 0.036	2.103GlyLeu: 2.103 ± 0.036	0.66GlyMet: 0.66 ± 0.022	4.08GlyAsn: 4.08 ± 0.068	0.631GlyPro: 0.631 ± 0.025	0.955GlyGln: 0.955 ± 0.041	1.073GlyArg: 1.073 ± 0.031	2.44GlySer: 2.44 ± 0.041	1.517GlyThr: 1.517 ± 0.029	1.522GlyVal: 1.522 ± 0.029	0.2GlyTrp: 0.2 ± 0.009	1.635GlyTyr: 1.635 ± 0.025	0.013GlyXaa: 0.013 ± 0.002
His	0.566HisAla: 0.566 ± 0.015	0.269HisCys: 0.269 ± 0.009	1.048HisAsp: 1.048 ± 0.019	1.146HisGlu: 1.146 ± 0.026	1.171HisPhe: 1.171 ± 0.021	0.668HisGly: 0.668 ± 0.018	0.464HisHis: 0.464 ± 0.013	2.303HisIle: 2.303 ± 0.029	1.718HisLys: 1.718 ± 0.024	1.684HisLeu: 1.684 ± 0.024	0.482HisMet: 0.482 ± 0.011	2.081HisAsn: 2.081 ± 0.034	0.576HisPro: 0.576 ± 0.015	0.474HisGln: 0.474 ± 0.014	0.541HisArg: 0.541 ± 0.017	1.252HisSer: 1.252 ± 0.022	0.965HisThr: 0.965 ± 0.023	0.905HisVal: 0.905 ± 0.02	0.09HisTrp: 0.09 ± 0.005	0.888HisTyr: 0.888 ± 0.018	0.008HisXaa: 0.008 ± 0.002
Ile	2.213IleAla: 2.213 ± 0.029	1.895IleCys: 1.895 ± 0.026	5.541IleAsp: 5.541 ± 0.051	6.126IleGlu: 6.126 ± 0.055	5.438IlePhe: 5.438 ± 0.061	2.71IleGly: 2.71 ± 0.032	1.95IleHis: 1.95 ± 0.022	8.78IleIle: 8.78 ± 0.073	10.776IleLys: 10.776 ± 0.076	8.321IleLeu: 8.321 ± 0.068	1.607IleMet: 1.607 ± 0.026	12.334IleAsn: 12.334 ± 0.091	2.703IlePro: 2.703 ± 0.037	2.788IleGln: 2.788 ± 0.028	2.305IleArg: 2.305 ± 0.028	7.298IleSer: 7.298 ± 0.047	3.72IleThr: 3.72 ± 0.039	3.35IleVal: 3.35 ± 0.038	0.638IleTrp: 0.638 ± 0.015	5.914IleTyr: 5.914 ± 0.067	0.049IleXaa: 0.049 ± 0.004
Lys	2.063LysAla: 2.063 ± 0.033	1.955LysCys: 1.955 ± 0.027	5.846LysAsp: 5.846 ± 0.053	8.609LysGlu: 8.609 ± 0.084	3.835LysPhe: 3.835 ± 0.037	3.338LysGly: 3.338 ± 0.035	2.163LysHis: 2.163 ± 0.031	10.853LysIle: 10.853 ± 0.073	18.524LysLys: 18.524 ± 0.148	8.11LysLeu: 8.11 ± 0.06	2.374LysMet: 2.374 ± 0.03	16.955LysAsn: 16.955 ± 0.122	1.666LysPro: 1.666 ± 0.033	3.157LysGln: 3.157 ± 0.051	3.683LysArg: 3.683 ± 0.041	6.448LysSer: 6.448 ± 0.059	4.837LysThr: 4.837 ± 0.049	3.154LysVal: 3.154 ± 0.039	0.606LysTrp: 0.606 ± 0.016	6.842LysTyr: 6.842 ± 0.064	0.074LysXaa: 0.074 ± 0.005
Leu	2.125LeuAla: 2.125 ± 0.035	1.854LeuCys: 1.854 ± 0.028	3.818LeuAsp: 3.818 ± 0.042	4.577LeuGlu: 4.577 ± 0.046	4.837LeuPhe: 4.837 ± 0.052	2.545LeuGly: 2.545 ± 0.035	1.526LeuHis: 1.526 ± 0.026	6.674LeuIle: 6.674 ± 0.065	9.268LeuLys: 9.268 ± 0.059	7.337LeuLeu: 7.337 ± 0.062	1.292LeuMet: 1.292 ± 0.021	8.971LeuAsn: 8.971 ± 0.06	2.125LeuPro: 2.125 ± 0.03	2.123LeuGln: 2.123 ± 0.025	2.378LeuArg: 2.378 ± 0.033	6.438LeuSer: 6.438 ± 0.059	3.057LeuThr: 3.057 ± 0.034	2.627LeuVal: 2.627 ± 0.034	0.637LeuTrp: 0.637 ± 0.013	4.486LeuTyr: 4.486 ± 0.053	0.031LeuXaa: 0.031 ± 0.003
Met	0.534MetAla: 0.534 ± 0.014	0.385MetCys: 0.385 ± 0.011	1.25MetAsp: 1.25 ± 0.022	1.255MetGlu: 1.255 ± 0.023	0.89MetPhe: 0.89 ± 0.019	0.715MetGly: 0.715 ± 0.018	0.556MetHis: 0.556 ± 0.011	1.43MetIle: 1.43 ± 0.023	2.032MetLys: 2.032 ± 0.025	1.642MetLeu: 1.642 ± 0.025	0.379MetMet: 0.379 ± 0.011	2.627MetAsn: 2.627 ± 0.038	0.532MetPro: 0.532 ± 0.021	0.566MetGln: 0.566 ± 0.015	0.523MetArg: 0.523 ± 0.014	1.349MetSer: 1.349 ± 0.021	0.65MetThr: 0.65 ± 0.013	0.603MetVal: 0.603 ± 0.014	0.122MetTrp: 0.122 ± 0.006	1.04MetTyr: 1.04 ± 0.018	0.008MetXaa: 0.008 ± 0.001
Asn	2.813AsnAla: 2.813 ± 0.039	1.975AsnCys: 1.975 ± 0.033	8.575AsnAsp: 8.575 ± 0.076	9.716AsnGlu: 9.716 ± 0.093	5.448AsnPhe: 5.448 ± 0.059	4.347AsnGly: 4.347 ± 0.062	1.793AsnHis: 1.793 ± 0.029	13.917AsnIle: 13.917 ± 0.101	14.361AsnLys: 14.361 ± 0.1	8.402AsnLeu: 8.402 ± 0.061	2.817AsnMet: 2.817 ± 0.043	19.466AsnAsn: 19.466 ± 0.273	2.125AsnPro: 2.125 ± 0.041	2.884AsnGln: 2.884 ± 0.042	2.544AsnArg: 2.544 ± 0.034	9.155AsnSer: 9.155 ± 0.097	5.605AsnThr: 5.605 ± 0.058	5.134AsnVal: 5.134 ± 0.047	0.393AsnTrp: 0.393 ± 0.012	6.449AsnTyr: 6.449 ± 0.068	0.073AsnXaa: 0.073 ± 0.005
Pro	0.638ProAla: 0.638 ± 0.032	0.34ProCys: 0.34 ± 0.011	1.222ProAsp: 1.222 ± 0.021	1.356ProGlu: 1.356 ± 0.032	1.312ProPhe: 1.312 ± 0.02	0.786ProGly: 0.786 ± 0.03	0.544ProHis: 0.544 ± 0.014	2.125ProIle: 2.125 ± 0.028	1.939ProLys: 1.939 ± 0.029	1.952ProLeu: 1.952 ± 0.03	0.367ProMet: 0.367 ± 0.013	2.571ProAsn: 2.571 ± 0.042	0.929ProPro: 0.929 ± 0.03	0.827ProGln: 0.827 ± 0.025	0.613ProArg: 0.613 ± 0.018	1.809ProSer: 1.809 ± 0.034	1.115ProThr: 1.115 ± 0.022	0.985ProVal: 0.985 ± 0.03	0.154ProTrp: 0.154 ± 0.007	1.166ProTyr: 1.166 ± 0.021	0.011ProXaa: 0.011 ± 0.002
Gln	0.71GlnAla: 0.71 ± 0.022	0.411GlnCys: 0.411 ± 0.013	1.226GlnAsp: 1.226 ± 0.023	1.562GlnGlu: 1.562 ± 0.03	1.21GlnPhe: 1.21 ± 0.019	0.83GlnGly: 0.83 ± 0.035	0.596GlnHis: 0.596 ± 0.017	2.993GlnIle: 2.993 ± 0.035	3.377GlnLys: 3.377 ± 0.032	2.064GlnLeu: 2.064 ± 0.025	0.554GlnMet: 0.554 ± 0.015	4.531GlnAsn: 4.531 ± 0.063	0.644GlnPro: 0.644 ± 0.028	0.966GlnGln: 0.966 ± 0.131	0.798GlnArg: 0.798 ± 0.023	1.628GlnSer: 1.628 ± 0.027	1.403GlnThr: 1.403 ± 0.027	1.049GlnVal: 1.049 ± 0.038	0.157GlnTrp: 0.157 ± 0.008	1.247GlnTyr: 1.247 ± 0.023	0.012GlnXaa: 0.012 ± 0.002
Arg	0.803ArgAla: 0.803 ± 0.024	0.465ArgCys: 0.465 ± 0.012	1.475ArgAsp: 1.475 ± 0.039	1.944ArgGlu: 1.944 ± 0.038	1.104ArgPhe: 1.104 ± 0.02	1.079ArgGly: 1.079 ± 0.028	0.597ArgHis: 0.597 ± 0.018	2.254ArgIle: 2.254 ± 0.031	3.442ArgLys: 3.442 ± 0.038	1.825ArgLeu: 1.825 ± 0.032	0.525ArgMet: 0.525 ± 0.011	3.064ArgAsn: 3.064 ± 0.039	0.589ArgPro: 0.589 ± 0.022	0.755ArgGln: 0.755 ± 0.017	1.299ArgArg: 1.299 ± 0.043	1.795ArgSer: 1.795 ± 0.034	1.105ArgThr: 1.105 ± 0.02	1.001ArgVal: 1.001 ± 0.022	0.165ArgTrp: 0.165 ± 0.008	1.25ArgTyr: 1.25 ± 0.024	0.013ArgXaa: 0.013 ± 0.002
Ser	1.781SerAla: 1.781 ± 0.028	1.105SerCys: 1.105 ± 0.021	4.485SerAsp: 4.485 ± 0.052	5.151SerGlu: 5.151 ± 0.067	3.51SerPhe: 3.51 ± 0.039	2.79SerGly: 2.79 ± 0.04	1.347SerHis: 1.347 ± 0.022	6.714SerIle: 6.714 ± 0.051	6.713SerLys: 6.713 ± 0.054	5.674SerLeu: 5.674 ± 0.056	1.255SerMet: 1.255 ± 0.02	8.617SerAsn: 8.617 ± 0.087	1.703SerPro: 1.703 ± 0.034	2.099SerGln: 2.099 ± 0.029	1.802SerArg: 1.802 ± 0.036	6.872SerSer: 6.872 ± 0.082	3.36SerThr: 3.36 ± 0.035	2.74SerVal: 2.74 ± 0.035	0.309SerTrp: 0.309 ± 0.01	3.961SerTyr: 3.961 ± 0.038	0.027SerXaa: 0.027 ± 0.003
Thr	0.999ThrAla: 0.999 ± 0.021	0.766ThrCys: 0.766 ± 0.015	2.518ThrAsp: 2.518 ± 0.04	2.788ThrGlu: 2.788 ± 0.045	2.059ThrPhe: 2.059 ± 0.025	1.449ThrGly: 1.449 ± 0.03	1.039ThrHis: 1.039 ± 0.018	3.861ThrIle: 3.861 ± 0.04	4.571ThrLys: 4.571 ± 0.049	3.439ThrLeu: 3.439 ± 0.035	0.646ThrMet: 0.646 ± 0.014	5.595ThrAsn: 5.595 ± 0.052	1.378ThrPro: 1.378 ± 0.029	1.382ThrGln: 1.382 ± 0.023	0.97ThrArg: 0.97 ± 0.021	3.383ThrSer: 3.383 ± 0.035	2.134ThrThr: 2.134 ± 0.044	1.534ThrVal: 1.534 ± 0.031	0.214ThrTrp: 0.214 ± 0.008	2.237ThrTyr: 2.237 ± 0.027	0.016ThrXaa: 0.016 ± 0.002
Val	1.286ValAla: 1.286 ± 0.028	0.846ValCys: 0.846 ± 0.018	2.341ValAsp: 2.341 ± 0.025	2.949ValGlu: 2.949 ± 0.072	1.683ValPhe: 1.683 ± 0.028	1.427ValGly: 1.427 ± 0.031	0.842ValHis: 0.842 ± 0.021	3.151ValIle: 3.151 ± 0.034	3.649ValLys: 3.649 ± 0.037	3.291ValLeu: 3.291 ± 0.043	0.627ValMet: 0.627 ± 0.014	3.884ValAsn: 3.884 ± 0.042	1.03ValPro: 1.03 ± 0.025	1.102ValGln: 1.102 ± 0.024	1.01ValArg: 1.01 ± 0.017	2.731ValSer: 2.731 ± 0.032	1.646ValThr: 1.646 ± 0.03	1.591ValVal: 1.591 ± 0.032	0.224ValTrp: 0.224 ± 0.009	1.845ValTyr: 1.845 ± 0.026	0.013ValXaa: 0.013 ± 0.002
Trp	0.154TrpAla: 0.154 ± 0.008	0.102TrpCys: 0.102 ± 0.006	0.313TrpAsp: 0.313 ± 0.01	0.321TrpGlu: 0.321 ± 0.011	0.224TrpPhe: 0.224 ± 0.008	0.267TrpGly: 0.267 ± 0.01	0.079TrpHis: 0.079 ± 0.005	0.451TrpIle: 0.451 ± 0.013	0.555TrpLys: 0.555 ± 0.013	0.729TrpLeu: 0.729 ± 0.017	0.102TrpMet: 0.102 ± 0.006	0.514TrpAsn: 0.514 ± 0.013	0.12TrpPro: 0.12 ± 0.006	0.086TrpGln: 0.086 ± 0.005	0.207TrpArg: 0.207 ± 0.009	0.331TrpSer: 0.331 ± 0.011	0.182TrpThr: 0.182 ± 0.008	0.24TrpVal: 0.24 ± 0.009	0.043TrpTrp: 0.043 ± 0.004	0.189TrpTyr: 0.189 ± 0.008	0.004TrpXaa: 0.004 ± 0.001
Tyr	1.403TyrAla: 1.403 ± 0.018	1.008TyrCys: 1.008 ± 0.02	3.552TyrAsp: 3.552 ± 0.037	3.434TyrGlu: 3.434 ± 0.036	3.068TyrPhe: 3.068 ± 0.041	1.541TyrGly: 1.541 ± 0.025	0.893TyrHis: 0.893 ± 0.018	6.105TyrIle: 6.105 ± 0.068	5.639TyrLys: 5.639 ± 0.054	4.417TyrLeu: 4.417 ± 0.054	1.222TyrMet: 1.222 ± 0.017	6.422TyrAsn: 6.422 ± 0.064	1.109TyrPro: 1.109 ± 0.021	1.253TyrGln: 1.253 ± 0.023	1.177TyrArg: 1.177 ± 0.02	3.742TyrSer: 3.742 ± 0.043	2.402TyrThr: 2.402 ± 0.033	2.073TyrVal: 2.073 ± 0.027	0.218TyrTrp: 0.218 ± 0.008	2.954TyrTyr: 2.954 ± 0.041	0.027TyrXaa: 0.027 ± 0.003
Xaa	0.009XaaAla: 0.009 ± 0.002	0.006XaaCys: 0.006 ± 0.002	0.023XaaAsp: 0.023 ± 0.003	0.025XaaGlu: 0.025 ± 0.003	0.023XaaPhe: 0.023 ± 0.003	0.014XaaGly: 0.014 ± 0.002	0.011XaaHis: 0.011 ± 0.002	0.05XaaIle: 0.05 ± 0.004	0.067XaaLys: 0.067 ± 0.005	0.035XaaLeu: 0.035 ± 0.003	0.01XaaMet: 0.01 ± 0.002	0.079XaaAsn: 0.079 ± 0.005	0.012XaaPro: 0.012 ± 0.002	0.021XaaGln: 0.021 ± 0.002	0.015XaaArg: 0.015 ± 0.002	0.027XaaSer: 0.027 ± 0.003	0.017XaaThr: 0.017 ± 0.002	0.014XaaVal: 0.014 ± 0.002	0.002XaaTrp: 0.002 ± 0.001	0.02XaaTyr: 0.02 ± 0.003	0.03XaaXaa: 0.03 ± 0.005

Statistics based on 7741 proteins (3378133 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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