Amino acid dipepetide frequency for Pseudooceanicola lipolyticus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.001AlaAla: 18.001 ± 0.159	1.143AlaCys: 1.143 ± 0.031	6.993AlaAsp: 6.993 ± 0.072	8.751AlaGlu: 8.751 ± 0.095	4.288AlaPhe: 4.288 ± 0.06	11.04AlaGly: 11.04 ± 0.103	2.283AlaHis: 2.283 ± 0.04	5.839AlaIle: 5.839 ± 0.067	3.343AlaLys: 3.343 ± 0.053	14.299AlaLeu: 14.299 ± 0.12	3.737AlaMet: 3.737 ± 0.05	2.576AlaAsn: 2.576 ± 0.04	6.096AlaPro: 6.096 ± 0.067	4.731AlaGln: 4.731 ± 0.057	9.398AlaArg: 9.398 ± 0.097	5.337AlaSer: 5.337 ± 0.059	5.883AlaThr: 5.883 ± 0.064	8.643AlaVal: 8.643 ± 0.095	1.462AlaTrp: 1.462 ± 0.034	2.597AlaTyr: 2.597 ± 0.039	0.0AlaXaa: 0.0 ± 0.0
Cys	1.154CysAla: 1.154 ± 0.027	0.12CysCys: 0.12 ± 0.01	0.67CysAsp: 0.67 ± 0.022	0.44CysGlu: 0.44 ± 0.016	0.339CysPhe: 0.339 ± 0.015	0.96CysGly: 0.96 ± 0.026	0.278CysHis: 0.278 ± 0.014	0.404CysIle: 0.404 ± 0.019	0.191CysLys: 0.191 ± 0.011	0.908CysLeu: 0.908 ± 0.03	0.159CysMet: 0.159 ± 0.011	0.238CysAsn: 0.238 ± 0.013	0.504CysPro: 0.504 ± 0.022	0.225CysGln: 0.225 ± 0.012	0.602CysArg: 0.602 ± 0.021	0.444CysSer: 0.444 ± 0.019	0.441CysThr: 0.441 ± 0.017	0.621CysVal: 0.621 ± 0.021	0.125CysTrp: 0.125 ± 0.01	0.223CysTyr: 0.223 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	6.881AspAla: 6.881 ± 0.07	0.553AspCys: 0.553 ± 0.022	3.212AspAsp: 3.212 ± 0.067	3.463AspGlu: 3.463 ± 0.066	2.303AspPhe: 2.303 ± 0.035	5.479AspGly: 5.479 ± 0.093	1.372AspHis: 1.372 ± 0.035	3.015AspIle: 3.015 ± 0.048	1.625AspLys: 1.625 ± 0.037	6.72AspLeu: 6.72 ± 0.068	1.602AspMet: 1.602 ± 0.035	1.27AspAsn: 1.27 ± 0.031	3.721AspPro: 3.721 ± 0.052	1.952AspGln: 1.952 ± 0.036	4.53AspArg: 4.53 ± 0.062	2.522AspSer: 2.522 ± 0.047	3.044AspThr: 3.044 ± 0.049	3.891AspVal: 3.891 ± 0.06	1.153AspTrp: 1.153 ± 0.026	1.606AspTyr: 1.606 ± 0.033	0.0AspXaa: 0.0 ± 0.0
Glu	8.147GluAla: 8.147 ± 0.098	0.355GluCys: 0.355 ± 0.015	3.289GluAsp: 3.289 ± 0.06	3.341GluGlu: 3.341 ± 0.058	1.94GluPhe: 1.94 ± 0.038	4.524GluGly: 4.524 ± 0.064	1.076GluHis: 1.076 ± 0.028	3.786GluIle: 3.786 ± 0.055	1.948GluLys: 1.948 ± 0.043	5.453GluLeu: 5.453 ± 0.059	1.805GluMet: 1.805 ± 0.036	1.636GluAsn: 1.636 ± 0.032	2.569GluPro: 2.569 ± 0.042	2.09GluGln: 2.09 ± 0.034	4.328GluArg: 4.328 ± 0.053	2.271GluSer: 2.271 ± 0.036	3.849GluThr: 3.849 ± 0.051	4.349GluVal: 4.349 ± 0.055	0.666GluTrp: 0.666 ± 0.021	1.092GluTyr: 1.092 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	4.666PheAla: 4.666 ± 0.055	0.439PheCys: 0.439 ± 0.016	2.969PheAsp: 2.969 ± 0.05	2.184PheGlu: 2.184 ± 0.039	1.454PhePhe: 1.454 ± 0.039	3.769PheGly: 3.769 ± 0.058	0.746PheHis: 0.746 ± 0.024	1.587PheIle: 1.587 ± 0.034	0.843PheLys: 0.843 ± 0.027	3.546PheLeu: 3.546 ± 0.054	0.817PheMet: 0.817 ± 0.023	1.01PheAsn: 1.01 ± 0.027	1.586PhePro: 1.586 ± 0.03	1.046PheGln: 1.046 ± 0.026	2.336PheArg: 2.336 ± 0.04	2.176PheSer: 2.176 ± 0.043	2.03PheThr: 2.03 ± 0.043	2.705PheVal: 2.705 ± 0.044	0.546PheTrp: 0.546 ± 0.021	0.907PheTyr: 0.907 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	10.282GlyAla: 10.282 ± 0.09	0.853GlyCys: 0.853 ± 0.021	4.727GlyAsp: 4.727 ± 0.071	4.722GlyGlu: 4.722 ± 0.063	3.752GlyPhe: 3.752 ± 0.048	7.81GlyGly: 7.81 ± 0.116	1.963GlyHis: 1.963 ± 0.035	4.582GlyIle: 4.582 ± 0.065	2.946GlyLys: 2.946 ± 0.051	9.415GlyLeu: 9.415 ± 0.097	2.562GlyMet: 2.562 ± 0.046	2.163GlyAsn: 2.163 ± 0.05	3.771GlyPro: 3.771 ± 0.044	3.217GlyGln: 3.217 ± 0.056	6.099GlyArg: 6.099 ± 0.078	4.338GlySer: 4.338 ± 0.074	4.727GlyThr: 4.727 ± 0.069	6.222GlyVal: 6.222 ± 0.072	1.497GlyTrp: 1.497 ± 0.031	2.336GlyTyr: 2.336 ± 0.038	0.0GlyXaa: 0.0 ± 0.0
His	2.35HisAla: 2.35 ± 0.037	0.229HisCys: 0.229 ± 0.012	1.278HisAsp: 1.278 ± 0.037	0.984HisGlu: 0.984 ± 0.026	0.785HisPhe: 0.785 ± 0.023	1.883HisGly: 1.883 ± 0.034	0.53HisHis: 0.53 ± 0.021	0.953HisIle: 0.953 ± 0.024	0.462HisLys: 0.462 ± 0.017	2.128HisLeu: 2.128 ± 0.04	0.519HisMet: 0.519 ± 0.018	0.46HisAsn: 0.46 ± 0.018	1.429HisPro: 1.429 ± 0.027	0.583HisGln: 0.583 ± 0.02	1.437HisArg: 1.437 ± 0.033	0.944HisSer: 0.944 ± 0.026	0.835HisThr: 0.835 ± 0.025	1.493HisVal: 1.493 ± 0.035	0.341HisTrp: 0.341 ± 0.013	0.541HisTyr: 0.541 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	7.158IleAla: 7.158 ± 0.069	0.632IleCys: 0.632 ± 0.019	3.438IleAsp: 3.438 ± 0.053	3.42IleGlu: 3.42 ± 0.043	1.706IlePhe: 1.706 ± 0.035	4.946IleGly: 4.946 ± 0.061	0.907IleHis: 0.907 ± 0.025	2.073IleIle: 2.073 ± 0.038	1.235IleLys: 1.235 ± 0.03	4.772IleLeu: 4.772 ± 0.067	0.995IleMet: 0.995 ± 0.027	1.289IleAsn: 1.289 ± 0.03	2.302IlePro: 2.302 ± 0.042	1.205IleGln: 1.205 ± 0.029	3.338IleArg: 3.338 ± 0.051	2.887IleSer: 2.887 ± 0.047	2.842IleThr: 2.842 ± 0.043	3.608IleVal: 3.608 ± 0.051	0.704IleTrp: 0.704 ± 0.022	1.121IleTyr: 1.121 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	3.531LysAla: 3.531 ± 0.058	0.164LysCys: 0.164 ± 0.01	1.575LysAsp: 1.575 ± 0.034	1.376LysGlu: 1.376 ± 0.037	0.862LysPhe: 0.862 ± 0.022	2.405LysGly: 2.405 ± 0.048	0.549LysHis: 0.549 ± 0.019	1.536LysIle: 1.536 ± 0.034	1.022LysLys: 1.022 ± 0.031	2.805LysLeu: 2.805 ± 0.048	0.776LysMet: 0.776 ± 0.022	0.685LysAsn: 0.685 ± 0.025	1.663LysPro: 1.663 ± 0.035	0.875LysGln: 0.875 ± 0.027	1.954LysArg: 1.954 ± 0.041	1.721LysSer: 1.721 ± 0.033	1.84LysThr: 1.84 ± 0.041	2.071LysVal: 2.071 ± 0.037	0.332LysTrp: 0.332 ± 0.016	0.563LysTyr: 0.563 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	13.589LeuAla: 13.589 ± 0.126	1.021LeuCys: 1.021 ± 0.03	6.26LeuAsp: 6.26 ± 0.065	5.399LeuGlu: 5.399 ± 0.063	3.653LeuPhe: 3.653 ± 0.056	8.725LeuGly: 8.725 ± 0.088	1.946LeuHis: 1.946 ± 0.04	5.235LeuIle: 5.235 ± 0.07	3.1LeuLys: 3.1 ± 0.058	9.491LeuLeu: 9.491 ± 0.11	2.66LeuMet: 2.66 ± 0.045	2.778LeuAsn: 2.778 ± 0.047	5.795LeuPro: 5.795 ± 0.071	2.966LeuGln: 2.966 ± 0.051	7.369LeuArg: 7.369 ± 0.083	6.592LeuSer: 6.592 ± 0.071	5.969LeuThr: 5.969 ± 0.061	7.153LeuVal: 7.153 ± 0.081	1.242LeuTrp: 1.242 ± 0.033	2.008LeuTyr: 2.008 ± 0.04	0.0LeuXaa: 0.0 ± 0.0
Met	3.411MetAla: 3.411 ± 0.048	0.191MetCys: 0.191 ± 0.009	1.274MetAsp: 1.274 ± 0.025	1.283MetGlu: 1.283 ± 0.03	0.802MetPhe: 0.802 ± 0.026	2.077MetGly: 2.077 ± 0.037	0.46MetHis: 0.46 ± 0.017	1.506MetIle: 1.506 ± 0.032	0.982MetLys: 0.982 ± 0.028	2.711MetLeu: 2.711 ± 0.046	0.765MetMet: 0.765 ± 0.026	0.784MetAsn: 0.784 ± 0.023	1.459MetPro: 1.459 ± 0.033	0.992MetGln: 0.992 ± 0.024	1.929MetArg: 1.929 ± 0.034	1.683MetSer: 1.683 ± 0.032	2.061MetThr: 2.061 ± 0.041	1.84MetVal: 1.84 ± 0.04	0.224MetTrp: 0.224 ± 0.013	0.359MetTyr: 0.359 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.025AsnAla: 3.025 ± 0.045	0.258AsnCys: 0.258 ± 0.011	1.41AsnAsp: 1.41 ± 0.041	1.083AsnGlu: 1.083 ± 0.03	0.934AsnPhe: 0.934 ± 0.026	2.338AsnGly: 2.338 ± 0.058	0.501AsnHis: 0.501 ± 0.017	1.293AsnIle: 1.293 ± 0.027	0.589AsnLys: 0.589 ± 0.019	2.522AsnLeu: 2.522 ± 0.043	0.67AsnMet: 0.67 ± 0.021	0.643AsnAsn: 0.643 ± 0.022	1.798AsnPro: 1.798 ± 0.037	0.714AsnGln: 0.714 ± 0.02	1.818AsnArg: 1.818 ± 0.038	1.136AsnSer: 1.136 ± 0.034	1.269AsnThr: 1.269 ± 0.034	1.712AsnVal: 1.712 ± 0.033	0.418AsnTrp: 0.418 ± 0.018	0.687AsnTyr: 0.687 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	6.189ProAla: 6.189 ± 0.08	0.358ProCys: 0.358 ± 0.014	4.015ProAsp: 4.015 ± 0.059	4.358ProGlu: 4.358 ± 0.06	1.923ProPhe: 1.923 ± 0.032	4.972ProGly: 4.972 ± 0.066	1.055ProHis: 1.055 ± 0.025	2.132ProIle: 2.132 ± 0.041	1.428ProLys: 1.428 ± 0.034	4.714ProLeu: 4.714 ± 0.062	1.287ProMet: 1.287 ± 0.033	1.223ProAsn: 1.223 ± 0.03	2.469ProPro: 2.469 ± 0.048	1.784ProGln: 1.784 ± 0.034	3.07ProArg: 3.07 ± 0.055	2.349ProSer: 2.349 ± 0.04	2.318ProThr: 2.318 ± 0.038	4.448ProVal: 4.448 ± 0.055	0.645ProTrp: 0.645 ± 0.02	1.17ProTyr: 1.17 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	4.426GlnAla: 4.426 ± 0.062	0.202GlnCys: 0.202 ± 0.012	1.809GlnAsp: 1.809 ± 0.04	1.571GlnGlu: 1.571 ± 0.036	1.116GlnPhe: 1.116 ± 0.026	2.755GlnGly: 2.755 ± 0.037	0.641GlnHis: 0.641 ± 0.023	1.969GlnIle: 1.969 ± 0.037	1.042GlnLys: 1.042 ± 0.029	3.01GlnLeu: 3.01 ± 0.047	1.073GlnMet: 1.073 ± 0.029	0.853GlnAsn: 0.853 ± 0.026	1.732GlnPro: 1.732 ± 0.036	1.263GlnGln: 1.263 ± 0.037	2.378GlnArg: 2.378 ± 0.046	1.806GlnSer: 1.806 ± 0.034	1.762GlnThr: 1.762 ± 0.033	2.546GlnVal: 2.546 ± 0.05	0.386GlnTrp: 0.386 ± 0.017	0.596GlnTyr: 0.596 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	8.734ArgAla: 8.734 ± 0.093	0.546ArgCys: 0.546 ± 0.021	4.538ArgAsp: 4.538 ± 0.069	3.836ArgGlu: 3.836 ± 0.056	2.881ArgPhe: 2.881 ± 0.04	4.859ArgGly: 4.859 ± 0.059	1.585ArgHis: 1.585 ± 0.03	3.974ArgIle: 3.974 ± 0.05	2.125ArgLys: 2.125 ± 0.04	7.899ArgLeu: 7.899 ± 0.09	1.941ArgMet: 1.941 ± 0.034	1.783ArgAsn: 1.783 ± 0.042	3.588ArgPro: 3.588 ± 0.052	2.564ArgGln: 2.564 ± 0.044	5.438ArgArg: 5.438 ± 0.083	3.42ArgSer: 3.42 ± 0.044	2.986ArgThr: 2.986 ± 0.046	4.783ArgVal: 4.783 ± 0.058	0.899ArgTrp: 0.899 ± 0.025	1.647ArgTyr: 1.647 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	5.919SerAla: 5.919 ± 0.058	0.436SerCys: 0.436 ± 0.022	3.232SerAsp: 3.232 ± 0.052	2.937SerGlu: 2.937 ± 0.05	2.335SerPhe: 2.335 ± 0.043	5.53SerGly: 5.53 ± 0.065	1.073SerHis: 1.073 ± 0.028	2.338SerIle: 2.338 ± 0.033	1.322SerLys: 1.322 ± 0.032	4.885SerLeu: 4.885 ± 0.061	1.315SerMet: 1.315 ± 0.032	1.32SerAsn: 1.32 ± 0.03	2.512SerPro: 2.512 ± 0.038	1.566SerGln: 1.566 ± 0.032	3.331SerArg: 3.331 ± 0.052	2.516SerSer: 2.516 ± 0.042	2.464SerThr: 2.464 ± 0.04	3.775SerVal: 3.775 ± 0.054	0.718SerTrp: 0.718 ± 0.023	1.355SerTyr: 1.355 ± 0.028	0.0SerXaa: 0.0 ± 0.0
Thr	6.313ThrAla: 6.313 ± 0.069	0.501ThrCys: 0.501 ± 0.017	2.999ThrAsp: 2.999 ± 0.055	2.998ThrGlu: 2.998 ± 0.044	1.911ThrPhe: 1.911 ± 0.04	5.712ThrGly: 5.712 ± 0.079	1.03ThrHis: 1.03 ± 0.025	2.573ThrIle: 2.573 ± 0.042	1.162ThrLys: 1.162 ± 0.03	6.04ThrLeu: 6.04 ± 0.064	1.197ThrMet: 1.197 ± 0.028	1.15ThrAsn: 1.15 ± 0.031	3.354ThrPro: 3.354 ± 0.047	1.564ThrGln: 1.564 ± 0.03	3.585ThrArg: 3.585 ± 0.044	2.597ThrSer: 2.597 ± 0.045	2.744ThrThr: 2.744 ± 0.044	4.195ThrVal: 4.195 ± 0.05	0.672ThrTrp: 0.672 ± 0.028	1.264ThrTyr: 1.264 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	8.707ValAla: 8.707 ± 0.09	0.654ValCys: 0.654 ± 0.022	3.864ValAsp: 3.864 ± 0.056	4.512ValGlu: 4.512 ± 0.052	2.896ValPhe: 2.896 ± 0.046	5.098ValGly: 5.098 ± 0.061	1.311ValHis: 1.311 ± 0.031	4.171ValIle: 4.171 ± 0.054	1.983ValLys: 1.983 ± 0.039	7.691ValLeu: 7.691 ± 0.079	2.074ValMet: 2.074 ± 0.042	1.982ValAsn: 1.982 ± 0.045	3.738ValPro: 3.738 ± 0.049	2.253ValGln: 2.253 ± 0.039	4.272ValArg: 4.272 ± 0.051	4.184ValSer: 4.184 ± 0.053	4.635ValThr: 4.635 ± 0.054	5.534ValVal: 5.534 ± 0.072	0.911ValTrp: 0.911 ± 0.022	1.457ValTyr: 1.457 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.332TrpAla: 1.332 ± 0.034	0.141TrpCys: 0.141 ± 0.01	0.736TrpAsp: 0.736 ± 0.02	0.641TrpGlu: 0.641 ± 0.021	0.554TrpPhe: 0.554 ± 0.021	0.936TrpGly: 0.936 ± 0.024	0.331TrpHis: 0.331 ± 0.015	0.705TrpIle: 0.705 ± 0.02	0.423TrpLys: 0.423 ± 0.018	1.601TrpLeu: 1.601 ± 0.038	0.359TrpMet: 0.359 ± 0.014	0.396TrpAsn: 0.396 ± 0.017	0.696TrpPro: 0.696 ± 0.025	0.647TrpGln: 0.647 ± 0.021	1.125TrpArg: 1.125 ± 0.03	0.781TrpSer: 0.781 ± 0.022	0.78TrpThr: 0.78 ± 0.021	0.817TrpVal: 0.817 ± 0.022	0.215TrpTrp: 0.215 ± 0.011	0.278TrpTyr: 0.278 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.626TyrAla: 2.626 ± 0.042	0.251TyrCys: 0.251 ± 0.013	1.626TyrAsp: 1.626 ± 0.032	1.213TyrGlu: 1.213 ± 0.029	0.931TyrPhe: 0.931 ± 0.025	2.167TyrGly: 2.167 ± 0.041	0.526TyrHis: 0.526 ± 0.02	0.909TyrIle: 0.909 ± 0.024	0.532TyrLys: 0.532 ± 0.016	2.341TyrLeu: 2.341 ± 0.045	0.479TyrMet: 0.479 ± 0.019	0.577TyrAsn: 0.577 ± 0.019	1.126TyrPro: 1.126 ± 0.027	0.701TyrGln: 0.701 ± 0.022	1.687TyrArg: 1.687 ± 0.034	1.174TyrSer: 1.174 ± 0.025	1.084TyrThr: 1.084 ± 0.026	1.522TyrVal: 1.522 ± 0.033	0.338TyrTrp: 0.338 ± 0.016	0.592TyrTyr: 0.592 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5156 proteins (1548121 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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