Amino acid dipepetide frequency for Flavobacterium aquatile LMG 4008 = ATCC 11947

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.738AlaAla: 3.738 ± 0.084	0.516AlaCys: 0.516 ± 0.026	3.109AlaAsp: 3.109 ± 0.061	3.764AlaGlu: 3.764 ± 0.078	3.298AlaPhe: 3.298 ± 0.058	3.818AlaGly: 3.818 ± 0.082	0.944AlaHis: 0.944 ± 0.034	5.343AlaIle: 5.343 ± 0.075	4.906AlaLys: 4.906 ± 0.086	5.701AlaLeu: 5.701 ± 0.077	1.462AlaMet: 1.462 ± 0.04	3.693AlaAsn: 3.693 ± 0.068	1.81AlaPro: 1.81 ± 0.055	2.389AlaGln: 2.389 ± 0.056	1.75AlaArg: 1.75 ± 0.045	4.092AlaSer: 4.092 ± 0.071	4.178AlaThr: 4.178 ± 0.096	3.903AlaVal: 3.903 ± 0.066	0.538AlaTrp: 0.538 ± 0.027	2.103AlaTyr: 2.103 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	0.447CysAla: 0.447 ± 0.026	0.105CysCys: 0.105 ± 0.011	0.467CysAsp: 0.467 ± 0.027	0.475CysGlu: 0.475 ± 0.025	0.457CysPhe: 0.457 ± 0.02	0.606CysGly: 0.606 ± 0.033	0.197CysHis: 0.197 ± 0.017	0.609CysIle: 0.609 ± 0.028	0.531CysLys: 0.531 ± 0.025	0.64CysLeu: 0.64 ± 0.027	0.128CysMet: 0.128 ± 0.012	0.473CysAsn: 0.473 ± 0.025	0.356CysPro: 0.356 ± 0.023	0.249CysGln: 0.249 ± 0.015	0.187CysArg: 0.187 ± 0.014	0.623CysSer: 0.623 ± 0.031	0.439CysThr: 0.439 ± 0.027	0.43CysVal: 0.43 ± 0.026	0.05CysTrp: 0.05 ± 0.008	0.32CysTyr: 0.32 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	3.62AspAla: 3.62 ± 0.07	0.433AspCys: 0.433 ± 0.023	2.812AspAsp: 2.812 ± 0.069	3.881AspGlu: 3.881 ± 0.072	3.762AspPhe: 3.762 ± 0.064	3.539AspGly: 3.539 ± 0.072	0.672AspHis: 0.672 ± 0.025	4.098AspIle: 4.098 ± 0.058	4.626AspLys: 4.626 ± 0.08	5.028AspLeu: 5.028 ± 0.08	0.985AspMet: 0.985 ± 0.033	3.145AspAsn: 3.145 ± 0.059	1.283AspPro: 1.283 ± 0.048	1.286AspGln: 1.286 ± 0.035	1.606AspArg: 1.606 ± 0.04	2.999AspSer: 2.999 ± 0.065	2.61AspThr: 2.61 ± 0.057	3.6AspVal: 3.6 ± 0.066	0.689AspTrp: 0.689 ± 0.03	2.852AspTyr: 2.852 ± 0.055	0.0AspXaa: 0.0 ± 0.0
Glu	3.918GluAla: 3.918 ± 0.081	0.366GluCys: 0.366 ± 0.02	3.243GluAsp: 3.243 ± 0.06	4.446GluGlu: 4.446 ± 0.081	3.106GluPhe: 3.106 ± 0.06	3.179GluGly: 3.179 ± 0.058	1.007GluHis: 1.007 ± 0.034	6.116GluIle: 6.116 ± 0.08	6.351GluLys: 6.351 ± 0.103	5.95GluLeu: 5.95 ± 0.085	1.696GluMet: 1.696 ± 0.051	5.287GluAsn: 5.287 ± 0.065	1.469GluPro: 1.469 ± 0.037	2.172GluGln: 2.172 ± 0.053	2.234GluArg: 2.234 ± 0.059	3.251GluSer: 3.251 ± 0.057	3.718GluThr: 3.718 ± 0.072	4.289GluVal: 4.289 ± 0.066	0.542GluTrp: 0.542 ± 0.024	2.354GluTyr: 2.354 ± 0.056	0.0GluXaa: 0.0 ± 0.0
Phe	3.223PheAla: 3.223 ± 0.059	0.504PheCys: 0.504 ± 0.024	3.447PheAsp: 3.447 ± 0.071	3.656PheGlu: 3.656 ± 0.072	2.973PhePhe: 2.973 ± 0.077	3.876PheGly: 3.876 ± 0.067	0.86PheHis: 0.86 ± 0.028	4.333PheIle: 4.333 ± 0.068	3.934PheLys: 3.934 ± 0.065	4.931PheLeu: 4.931 ± 0.088	1.132PheMet: 1.132 ± 0.041	3.509PheAsn: 3.509 ± 0.064	1.785PhePro: 1.785 ± 0.045	1.757PheGln: 1.757 ± 0.04	1.561PheArg: 1.561 ± 0.037	4.44PheSer: 4.44 ± 0.077	3.361PheThr: 3.361 ± 0.072	3.285PheVal: 3.285 ± 0.058	0.596PheTrp: 0.596 ± 0.029	2.368PheTyr: 2.368 ± 0.06	0.0PheXaa: 0.0 ± 0.0
Gly	3.697GlyAla: 3.697 ± 0.068	0.607GlyCys: 0.607 ± 0.028	2.917GlyAsp: 2.917 ± 0.06	3.282GlyGlu: 3.282 ± 0.065	3.753GlyPhe: 3.753 ± 0.068	4.084GlyGly: 4.084 ± 0.08	1.017GlyHis: 1.017 ± 0.033	5.377GlyIle: 5.377 ± 0.089	5.197GlyLys: 5.197 ± 0.079	5.372GlyLeu: 5.372 ± 0.073	1.467GlyMet: 1.467 ± 0.04	3.747GlyAsn: 3.747 ± 0.072	1.152GlyPro: 1.152 ± 0.038	1.748GlyGln: 1.748 ± 0.045	1.761GlyArg: 1.761 ± 0.052	3.939GlySer: 3.939 ± 0.081	4.224GlyThr: 4.224 ± 0.109	3.921GlyVal: 3.921 ± 0.078	0.671GlyTrp: 0.671 ± 0.032	2.628GlyTyr: 2.628 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	0.827HisAla: 0.827 ± 0.03	0.163HisCys: 0.163 ± 0.014	0.843HisAsp: 0.843 ± 0.031	0.922HisGlu: 0.922 ± 0.028	1.148HisPhe: 1.148 ± 0.035	0.93HisGly: 0.93 ± 0.037	0.393HisHis: 0.393 ± 0.021	1.239HisIle: 1.239 ± 0.037	1.086HisLys: 1.086 ± 0.034	1.591HisLeu: 1.591 ± 0.044	0.299HisMet: 0.299 ± 0.017	0.958HisAsn: 0.958 ± 0.036	0.723HisPro: 0.723 ± 0.025	0.661HisGln: 0.661 ± 0.028	0.559HisArg: 0.559 ± 0.026	1.009HisSer: 1.009 ± 0.035	0.764HisThr: 0.764 ± 0.028	0.821HisVal: 0.821 ± 0.029	0.179HisTrp: 0.179 ± 0.014	0.812HisTyr: 0.812 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	5.798IleAla: 5.798 ± 0.087	0.697IleCys: 0.697 ± 0.027	4.986IleAsp: 4.986 ± 0.079	5.876IleGlu: 5.876 ± 0.081	3.897IlePhe: 3.897 ± 0.075	5.261IleGly: 5.261 ± 0.079	1.323IleHis: 1.323 ± 0.038	6.95IleIle: 6.95 ± 0.113	6.245IleLys: 6.245 ± 0.084	7.466IleLeu: 7.466 ± 0.111	1.421IleMet: 1.421 ± 0.036	5.204IleAsn: 5.204 ± 0.082	3.266IlePro: 3.266 ± 0.06	2.743IleGln: 2.743 ± 0.052	2.468IleArg: 2.468 ± 0.046	6.112IleSer: 6.112 ± 0.085	5.125IleThr: 5.125 ± 0.081	5.241IleVal: 5.241 ± 0.083	0.679IleTrp: 0.679 ± 0.028	2.969IleTyr: 2.969 ± 0.064	0.0IleXaa: 0.0 ± 0.0
Lys	4.861LysAla: 4.861 ± 0.076	0.423LysCys: 0.423 ± 0.021	4.349LysAsp: 4.349 ± 0.084	6.202LysGlu: 6.202 ± 0.094	3.485LysPhe: 3.485 ± 0.069	4.306LysGly: 4.306 ± 0.073	1.201LysHis: 1.201 ± 0.042	7.337LysIle: 7.337 ± 0.102	7.315LysLys: 7.315 ± 0.108	6.921LysLeu: 6.921 ± 0.111	2.386LysMet: 2.386 ± 0.056	5.996LysAsn: 5.996 ± 0.087	2.613LysPro: 2.613 ± 0.055	2.652LysGln: 2.652 ± 0.058	2.581LysArg: 2.581 ± 0.053	5.275LysSer: 5.275 ± 0.087	4.805LysThr: 4.805 ± 0.077	5.116LysVal: 5.116 ± 0.087	0.8LysTrp: 0.8 ± 0.026	3.233LysTyr: 3.233 ± 0.059	0.0LysXaa: 0.0 ± 0.0
Leu	5.479LeuAla: 5.479 ± 0.077	0.637LeuCys: 0.637 ± 0.03	4.838LeuAsp: 4.838 ± 0.076	6.023LeuGlu: 6.023 ± 0.079	5.28LeuPhe: 5.28 ± 0.093	5.353LeuGly: 5.353 ± 0.084	1.479LeuHis: 1.479 ± 0.041	7.068LeuIle: 7.068 ± 0.111	7.684LeuLys: 7.684 ± 0.121	8.582LeuLeu: 8.582 ± 0.12	2.062LeuMet: 2.062 ± 0.054	5.873LeuAsn: 5.873 ± 0.078	3.47LeuPro: 3.47 ± 0.065	3.203LeuGln: 3.203 ± 0.067	2.747LeuArg: 2.747 ± 0.058	6.641LeuSer: 6.641 ± 0.082	5.022LeuThr: 5.022 ± 0.092	5.436LeuVal: 5.436 ± 0.074	0.722LeuTrp: 0.722 ± 0.029	3.167LeuTyr: 3.167 ± 0.063	0.0LeuXaa: 0.0 ± 0.0
Met	1.479MetAla: 1.479 ± 0.048	0.136MetCys: 0.136 ± 0.012	1.077MetAsp: 1.077 ± 0.031	1.344MetGlu: 1.344 ± 0.036	0.912MetPhe: 0.912 ± 0.028	1.286MetGly: 1.286 ± 0.046	0.38MetHis: 0.38 ± 0.019	1.676MetIle: 1.676 ± 0.048	2.357MetLys: 2.357 ± 0.049	1.82MetLeu: 1.82 ± 0.044	0.629MetMet: 0.629 ± 0.028	1.449MetAsn: 1.449 ± 0.037	0.802MetPro: 0.802 ± 0.03	0.863MetGln: 0.863 ± 0.033	0.785MetArg: 0.785 ± 0.026	1.501MetSer: 1.501 ± 0.041	1.181MetThr: 1.181 ± 0.039	1.324MetVal: 1.324 ± 0.037	0.165MetTrp: 0.165 ± 0.013	0.736MetTyr: 0.736 ± 0.03	0.0MetXaa: 0.0 ± 0.0
Asn	3.937AsnAla: 3.937 ± 0.064	0.586AsnCys: 0.586 ± 0.025	3.556AsnAsp: 3.556 ± 0.063	4.089AsnGlu: 4.089 ± 0.073	3.662AsnPhe: 3.662 ± 0.069	4.222AsnGly: 4.222 ± 0.081	1.176AsnHis: 1.176 ± 0.035	4.857AsnIle: 4.857 ± 0.07	4.855AsnLys: 4.855 ± 0.084	6.103AsnLeu: 6.103 ± 0.09	1.212AsnMet: 1.212 ± 0.039	4.43AsnAsn: 4.43 ± 0.096	3.108AsnPro: 3.108 ± 0.067	2.593AsnGln: 2.593 ± 0.057	2.098AsnArg: 2.098 ± 0.048	4.587AsnSer: 4.587 ± 0.082	3.628AsnThr: 3.628 ± 0.075	3.943AsnVal: 3.943 ± 0.075	0.859AsnTrp: 0.859 ± 0.034	3.258AsnTyr: 3.258 ± 0.065	0.0AsnXaa: 0.0 ± 0.0
Pro	1.877ProAla: 1.877 ± 0.061	0.2ProCys: 0.2 ± 0.014	1.685ProAsp: 1.685 ± 0.04	2.482ProGlu: 2.482 ± 0.051	1.949ProPhe: 1.949 ± 0.05	1.655ProGly: 1.655 ± 0.048	0.497ProHis: 0.497 ± 0.022	2.952ProIle: 2.952 ± 0.055	2.63ProLys: 2.63 ± 0.056	2.719ProLeu: 2.719 ± 0.055	0.757ProMet: 0.757 ± 0.033	2.547ProAsn: 2.547 ± 0.058	0.725ProPro: 0.725 ± 0.035	1.083ProGln: 1.083 ± 0.035	0.827ProArg: 0.827 ± 0.029	2.158ProSer: 2.158 ± 0.051	2.278ProThr: 2.278 ± 0.068	2.173ProVal: 2.173 ± 0.049	0.255ProTrp: 0.255 ± 0.016	1.251ProTyr: 1.251 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	1.892GlnAla: 1.892 ± 0.042	0.183GlnCys: 0.183 ± 0.015	1.599GlnAsp: 1.599 ± 0.04	2.25GlnGlu: 2.25 ± 0.051	1.851GlnPhe: 1.851 ± 0.044	1.627GlnGly: 1.627 ± 0.042	0.547GlnHis: 0.547 ± 0.026	2.876GlnIle: 2.876 ± 0.066	3.016GlnLys: 3.016 ± 0.066	3.432GlnLeu: 3.432 ± 0.065	0.834GlnMet: 0.834 ± 0.03	2.576GlnAsn: 2.576 ± 0.053	1.01GlnPro: 1.01 ± 0.034	1.268GlnGln: 1.268 ± 0.041	1.047GlnArg: 1.047 ± 0.034	2.054GlnSer: 2.054 ± 0.047	1.945GlnThr: 1.945 ± 0.055	1.96GlnVal: 1.96 ± 0.05	0.307GlnTrp: 0.307 ± 0.019	1.369GlnTyr: 1.369 ± 0.041	0.0GlnXaa: 0.0 ± 0.0
Arg	1.711ArgAla: 1.711 ± 0.042	0.187ArgCys: 0.187 ± 0.015	1.511ArgAsp: 1.511 ± 0.041	1.975ArgGlu: 1.975 ± 0.042	1.745ArgPhe: 1.745 ± 0.048	1.659ArgGly: 1.659 ± 0.044	0.502ArgHis: 0.502 ± 0.024	2.758ArgIle: 2.758 ± 0.057	2.67ArgLys: 2.67 ± 0.061	2.867ArgLeu: 2.867 ± 0.058	0.885ArgMet: 0.885 ± 0.03	2.051ArgAsn: 2.051 ± 0.048	0.935ArgPro: 0.935 ± 0.029	0.919ArgGln: 0.919 ± 0.035	1.07ArgArg: 1.07 ± 0.039	1.605ArgSer: 1.605 ± 0.052	1.66ArgThr: 1.66 ± 0.039	1.901ArgVal: 1.901 ± 0.047	0.322ArgTrp: 0.322 ± 0.018	1.348ArgTyr: 1.348 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	3.7SerAla: 3.7 ± 0.069	0.679SerCys: 0.679 ± 0.027	3.622SerAsp: 3.622 ± 0.064	4.072SerGlu: 4.072 ± 0.076	4.156SerPhe: 4.156 ± 0.071	4.596SerGly: 4.596 ± 0.096	1.043SerHis: 1.043 ± 0.033	5.545SerIle: 5.545 ± 0.081	5.479SerLys: 5.479 ± 0.09	5.869SerLeu: 5.869 ± 0.087	1.274SerMet: 1.274 ± 0.036	4.584SerAsn: 4.584 ± 0.084	2.001SerPro: 2.001 ± 0.047	2.438SerGln: 2.438 ± 0.054	1.967SerArg: 1.967 ± 0.044	4.543SerSer: 4.543 ± 0.087	3.918SerThr: 3.918 ± 0.091	4.149SerVal: 4.149 ± 0.08	0.674SerTrp: 0.674 ± 0.03	2.713SerTyr: 2.713 ± 0.064	0.0SerXaa: 0.0 ± 0.0
Thr	3.713ThrAla: 3.713 ± 0.103	0.414ThrCys: 0.414 ± 0.028	3.082ThrAsp: 3.082 ± 0.058	3.336ThrGlu: 3.336 ± 0.058	3.417ThrPhe: 3.417 ± 0.072	3.891ThrGly: 3.891 ± 0.091	0.873ThrHis: 0.873 ± 0.03	5.72ThrIle: 5.72 ± 0.097	4.275ThrLys: 4.275 ± 0.074	5.316ThrLeu: 5.316 ± 0.078	0.983ThrMet: 0.983 ± 0.031	3.873ThrAsn: 3.873 ± 0.076	2.494ThrPro: 2.494 ± 0.075	1.925ThrGln: 1.925 ± 0.048	1.487ThrArg: 1.487 ± 0.04	4.28ThrSer: 4.28 ± 0.092	4.054ThrThr: 4.054 ± 0.13	3.739ThrVal: 3.739 ± 0.094	0.569ThrTrp: 0.569 ± 0.027	2.246ThrTyr: 2.246 ± 0.06	0.0ThrXaa: 0.0 ± 0.0
Val	4.3ValAla: 4.3 ± 0.064	0.509ValCys: 0.509 ± 0.022	3.582ValAsp: 3.582 ± 0.06	3.841ValGlu: 3.841 ± 0.067	3.43ValPhe: 3.43 ± 0.056	3.76ValGly: 3.76 ± 0.074	0.89ValHis: 0.89 ± 0.032	5.161ValIle: 5.161 ± 0.086	4.724ValLys: 4.724 ± 0.071	5.729ValLeu: 5.729 ± 0.083	1.296ValMet: 1.296 ± 0.039	3.853ValAsn: 3.853 ± 0.075	2.067ValPro: 2.067 ± 0.051	1.739ValGln: 1.739 ± 0.046	1.843ValArg: 1.843 ± 0.047	4.513ValSer: 4.513 ± 0.064	3.897ValThr: 3.897 ± 0.094	4.341ValVal: 4.341 ± 0.083	0.542ValTrp: 0.542 ± 0.022	2.398ValTyr: 2.398 ± 0.049	0.0ValXaa: 0.0 ± 0.0
Trp	0.563TrpAla: 0.563 ± 0.027	0.092TrpCys: 0.092 ± 0.011	0.525TrpAsp: 0.525 ± 0.027	0.57TrpGlu: 0.57 ± 0.023	0.577TrpPhe: 0.577 ± 0.032	0.521TrpGly: 0.521 ± 0.028	0.195TrpHis: 0.195 ± 0.014	0.763TrpIle: 0.763 ± 0.034	0.834TrpLys: 0.834 ± 0.027	0.878TrpLeu: 0.878 ± 0.03	0.292TrpMet: 0.292 ± 0.017	0.752TrpAsn: 0.752 ± 0.028	0.203TrpPro: 0.203 ± 0.017	0.401TrpGln: 0.401 ± 0.021	0.319TrpArg: 0.319 ± 0.018	0.615TrpSer: 0.615 ± 0.026	0.549TrpThr: 0.549 ± 0.026	0.528TrpVal: 0.528 ± 0.024	0.123TrpTrp: 0.123 ± 0.013	0.42TrpTyr: 0.42 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.275TyrAla: 2.275 ± 0.05	0.352TyrCys: 0.352 ± 0.017	2.277TyrAsp: 2.277 ± 0.051	2.209TyrGlu: 2.209 ± 0.049	2.672TyrPhe: 2.672 ± 0.061	2.392TyrGly: 2.392 ± 0.054	0.732TyrHis: 0.732 ± 0.028	2.951TyrIle: 2.951 ± 0.054	3.141TyrLys: 3.141 ± 0.058	3.851TyrLeu: 3.851 ± 0.065	0.701TyrMet: 0.701 ± 0.032	2.759TyrAsn: 2.759 ± 0.057	1.427TyrPro: 1.427 ± 0.042	1.555TyrGln: 1.555 ± 0.043	1.383TyrArg: 1.383 ± 0.04	2.784TyrSer: 2.784 ± 0.056	2.332TyrThr: 2.332 ± 0.059	2.313TyrVal: 2.313 ± 0.058	0.439TyrTrp: 0.439 ± 0.018	1.891TyrTyr: 1.891 ± 0.054	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2995 proteins (982436 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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