Amino acid dipepetide frequency for Ruminiclostridium hungatei (Clostridium hungatei)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.26AlaAla: 7.26 ± 0.097	0.871AlaCys: 0.871 ± 0.027	3.88AlaAsp: 3.88 ± 0.064	4.78AlaGlu: 4.78 ± 0.064	3.138AlaPhe: 3.138 ± 0.053	6.678AlaGly: 6.678 ± 0.088	0.928AlaHis: 0.928 ± 0.027	5.43AlaIle: 5.43 ± 0.076	4.163AlaLys: 4.163 ± 0.059	6.882AlaLeu: 6.882 ± 0.079	1.93AlaMet: 1.93 ± 0.038	2.759AlaAsn: 2.759 ± 0.048	1.952AlaPro: 1.952 ± 0.05	2.128AlaGln: 2.128 ± 0.043	3.081AlaArg: 3.081 ± 0.044	4.071AlaSer: 4.071 ± 0.061	3.146AlaThr: 3.146 ± 0.106	6.315AlaVal: 6.315 ± 0.073	0.559AlaTrp: 0.559 ± 0.023	2.611AlaTyr: 2.611 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	0.808CysAla: 0.808 ± 0.026	0.223CysCys: 0.223 ± 0.014	0.628CysAsp: 0.628 ± 0.024	0.703CysGlu: 0.703 ± 0.025	0.548CysPhe: 0.548 ± 0.022	1.212CysGly: 1.212 ± 0.029	0.247CysHis: 0.247 ± 0.014	1.018CysIle: 1.018 ± 0.026	0.726CysLys: 0.726 ± 0.022	1.033CysLeu: 1.033 ± 0.028	0.359CysMet: 0.359 ± 0.018	0.598CysAsn: 0.598 ± 0.02	0.511CysPro: 0.511 ± 0.02	0.272CysGln: 0.272 ± 0.014	0.649CysArg: 0.649 ± 0.022	0.924CysSer: 0.924 ± 0.023	0.693CysThr: 0.693 ± 0.03	0.706CysVal: 0.706 ± 0.026	0.123CysTrp: 0.123 ± 0.01	0.449CysTyr: 0.449 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	3.422AspAla: 3.422 ± 0.054	0.709AspCys: 0.709 ± 0.027	2.217AspAsp: 2.217 ± 0.049	3.559AspGlu: 3.559 ± 0.053	2.768AspPhe: 2.768 ± 0.051	3.935AspGly: 3.935 ± 0.065	0.594AspHis: 0.594 ± 0.021	5.412AspIle: 5.412 ± 0.08	4.052AspLys: 4.052 ± 0.058	4.148AspLeu: 4.148 ± 0.062	1.595AspMet: 1.595 ± 0.04	2.804AspAsn: 2.804 ± 0.05	1.586AspPro: 1.586 ± 0.035	1.033AspGln: 1.033 ± 0.03	2.509AspArg: 2.509 ± 0.049	3.678AspSer: 3.678 ± 0.055	2.937AspThr: 2.937 ± 0.046	3.309AspVal: 3.309 ± 0.053	0.535AspTrp: 0.535 ± 0.024	2.512AspTyr: 2.512 ± 0.046	0.0AspXaa: 0.0 ± 0.0
Glu	5.306GluAla: 5.306 ± 0.079	0.643GluCys: 0.643 ± 0.022	3.388GluAsp: 3.388 ± 0.054	5.177GluGlu: 5.177 ± 0.083	2.596GluPhe: 2.596 ± 0.043	4.046GluGly: 4.046 ± 0.07	1.081GluHis: 1.081 ± 0.034	5.745GluIle: 5.745 ± 0.077	5.93GluLys: 5.93 ± 0.08	6.813GluLeu: 6.813 ± 0.081	1.818GluMet: 1.818 ± 0.037	4.106GluAsn: 4.106 ± 0.055	1.728GluPro: 1.728 ± 0.032	2.329GluGln: 2.329 ± 0.04	2.762GluArg: 2.762 ± 0.054	3.281GluSer: 3.281 ± 0.057	3.245GluThr: 3.245 ± 0.058	4.354GluVal: 4.354 ± 0.058	0.559GluTrp: 0.559 ± 0.022	2.856GluTyr: 2.856 ± 0.049	0.0GluXaa: 0.0 ± 0.0
Phe	2.803PheAla: 2.803 ± 0.047	0.632PheCys: 0.632 ± 0.024	2.695PheAsp: 2.695 ± 0.043	2.816PheGlu: 2.816 ± 0.051	1.92PhePhe: 1.92 ± 0.047	3.097PheGly: 3.097 ± 0.055	0.647PheHis: 0.647 ± 0.023	3.668PheIle: 3.668 ± 0.061	2.947PheLys: 2.947 ± 0.05	3.734PheLeu: 3.734 ± 0.069	1.12PheMet: 1.12 ± 0.03	2.228PheAsn: 2.228 ± 0.045	1.361PhePro: 1.361 ± 0.036	1.122PheGln: 1.122 ± 0.03	1.645PheArg: 1.645 ± 0.037	3.361PheSer: 3.361 ± 0.054	2.53PheThr: 2.53 ± 0.041	2.672PheVal: 2.672 ± 0.05	0.424PheTrp: 0.424 ± 0.02	1.736PheTyr: 1.736 ± 0.035	0.0PheXaa: 0.0 ± 0.0
Gly	5.019GlyAla: 5.019 ± 0.11	1.033GlyCys: 1.033 ± 0.034	3.617GlyAsp: 3.617 ± 0.062	4.452GlyGlu: 4.452 ± 0.059	3.371GlyPhe: 3.371 ± 0.053	5.025GlyGly: 5.025 ± 0.074	1.205GlyHis: 1.205 ± 0.037	6.676GlyIle: 6.676 ± 0.072	5.39GlyLys: 5.39 ± 0.068	6.292GlyLeu: 6.292 ± 0.067	2.122GlyMet: 2.122 ± 0.044	3.691GlyAsn: 3.691 ± 0.068	1.616GlyPro: 1.616 ± 0.079	2.202GlyGln: 2.202 ± 0.042	3.242GlyArg: 3.242 ± 0.056	4.616GlySer: 4.616 ± 0.073	4.382GlyThr: 4.382 ± 0.073	4.686GlyVal: 4.686 ± 0.06	0.706GlyTrp: 0.706 ± 0.025	3.097GlyTyr: 3.097 ± 0.054	0.0GlyXaa: 0.0 ± 0.0
His	0.827HisAla: 0.827 ± 0.025	0.241HisCys: 0.241 ± 0.013	0.723HisAsp: 0.723 ± 0.023	0.884HisGlu: 0.884 ± 0.028	0.695HisPhe: 0.695 ± 0.023	1.134HisGly: 1.134 ± 0.032	0.306HisHis: 0.306 ± 0.015	1.339HisIle: 1.339 ± 0.037	1.005HisLys: 1.005 ± 0.025	1.261HisLeu: 1.261 ± 0.034	0.458HisMet: 0.458 ± 0.02	0.742HisAsn: 0.742 ± 0.024	0.674HisPro: 0.674 ± 0.024	0.431HisGln: 0.431 ± 0.018	0.755HisArg: 0.755 ± 0.024	0.941HisSer: 0.941 ± 0.027	0.841HisThr: 0.841 ± 0.024	0.861HisVal: 0.861 ± 0.027	0.159HisTrp: 0.159 ± 0.01	0.6HisTyr: 0.6 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	5.783IleAla: 5.783 ± 0.085	1.136IleCys: 1.136 ± 0.028	4.662IleAsp: 4.662 ± 0.064	5.205IleGlu: 5.205 ± 0.071	3.438IlePhe: 3.438 ± 0.061	5.026IleGly: 5.026 ± 0.062	1.163IleHis: 1.163 ± 0.033	6.674IleIle: 6.674 ± 0.097	5.744IleLys: 5.744 ± 0.07	7.38IleLeu: 7.38 ± 0.094	1.942IleMet: 1.942 ± 0.044	4.522IleAsn: 4.522 ± 0.064	3.374IlePro: 3.374 ± 0.064	2.153IleGln: 2.153 ± 0.043	3.513IleArg: 3.513 ± 0.062	6.213IleSer: 6.213 ± 0.077	4.698IleThr: 4.698 ± 0.07	5.101IleVal: 5.101 ± 0.079	0.638IleTrp: 0.638 ± 0.023	2.962IleTyr: 2.962 ± 0.044	0.0IleXaa: 0.0 ± 0.0
Lys	5.492LysAla: 5.492 ± 0.067	0.711LysCys: 0.711 ± 0.024	3.957LysAsp: 3.957 ± 0.061	5.239LysGlu: 5.239 ± 0.077	2.192LysPhe: 2.192 ± 0.043	4.435LysGly: 4.435 ± 0.056	0.997LysHis: 0.997 ± 0.027	5.461LysIle: 5.461 ± 0.069	5.654LysLys: 5.654 ± 0.081	6.662LysLeu: 6.662 ± 0.07	1.957LysMet: 1.957 ± 0.038	4.225LysAsn: 4.225 ± 0.069	2.347LysPro: 2.347 ± 0.043	2.196LysGln: 2.196 ± 0.042	2.803LysArg: 2.803 ± 0.048	4.269LysSer: 4.269 ± 0.048	3.914LysThr: 3.914 ± 0.061	4.684LysVal: 4.684 ± 0.063	0.622LysTrp: 0.622 ± 0.025	3.224LysTyr: 3.224 ± 0.045	0.0LysXaa: 0.0 ± 0.0
Leu	6.455LeuAla: 6.455 ± 0.068	1.162LeuCys: 1.162 ± 0.028	4.996LeuAsp: 4.996 ± 0.063	6.578LeuGlu: 6.578 ± 0.09	3.915LeuPhe: 3.915 ± 0.076	6.288LeuGly: 6.288 ± 0.079	1.264LeuHis: 1.264 ± 0.036	6.622LeuIle: 6.622 ± 0.087	7.324LeuLys: 7.324 ± 0.078	9.007LeuLeu: 9.007 ± 0.119	2.377LeuMet: 2.377 ± 0.047	4.503LeuAsn: 4.503 ± 0.063	3.489LeuPro: 3.489 ± 0.056	2.722LeuGln: 2.722 ± 0.05	3.708LeuArg: 3.708 ± 0.054	6.922LeuSer: 6.922 ± 0.081	4.821LeuThr: 4.821 ± 0.061	5.894LeuVal: 5.894 ± 0.077	0.79LeuTrp: 0.79 ± 0.026	3.248LeuTyr: 3.248 ± 0.052	0.0LeuXaa: 0.0 ± 0.0
Met	1.995MetAla: 1.995 ± 0.037	0.27MetCys: 0.27 ± 0.014	1.56MetAsp: 1.56 ± 0.028	1.979MetGlu: 1.979 ± 0.049	0.969MetPhe: 0.969 ± 0.027	1.947MetGly: 1.947 ± 0.037	0.385MetHis: 0.385 ± 0.017	1.713MetIle: 1.713 ± 0.038	2.21MetLys: 2.21 ± 0.041	2.695MetLeu: 2.695 ± 0.053	0.578MetMet: 0.578 ± 0.022	1.433MetAsn: 1.433 ± 0.033	0.995MetPro: 0.995 ± 0.029	0.826MetGln: 0.826 ± 0.027	0.982MetArg: 0.982 ± 0.025	1.792MetSer: 1.792 ± 0.034	1.356MetThr: 1.356 ± 0.032	1.716MetVal: 1.716 ± 0.038	0.17MetTrp: 0.17 ± 0.012	0.814MetTyr: 0.814 ± 0.029	0.0MetXaa: 0.0 ± 0.0
Asn	3.324AsnAla: 3.324 ± 0.057	0.65AsnCys: 0.65 ± 0.025	2.342AsnAsp: 2.342 ± 0.047	3.059AsnGlu: 3.059 ± 0.05	2.032AsnPhe: 2.032 ± 0.039	3.777AsnGly: 3.777 ± 0.067	0.697AsnHis: 0.697 ± 0.02	4.954AsnIle: 4.954 ± 0.063	3.472AsnLys: 3.472 ± 0.051	4.344AsnLeu: 4.344 ± 0.062	1.446AsnMet: 1.446 ± 0.034	2.871AsnAsn: 2.871 ± 0.052	2.21AsnPro: 2.21 ± 0.046	1.41AsnGln: 1.41 ± 0.032	2.238AsnArg: 2.238 ± 0.046	3.748AsnSer: 3.748 ± 0.058	3.021AsnThr: 3.021 ± 0.054	3.069AsnVal: 3.069 ± 0.045	0.493AsnTrp: 0.493 ± 0.02	2.102AsnTyr: 2.102 ± 0.041	0.0AsnXaa: 0.0 ± 0.0
Pro	2.736ProAla: 2.736 ± 0.054	0.37ProCys: 0.37 ± 0.018	2.164ProAsp: 2.164 ± 0.038	3.073ProGlu: 3.073 ± 0.048	1.53ProPhe: 1.53 ± 0.035	2.71ProGly: 2.71 ± 0.049	0.583ProHis: 0.583 ± 0.021	2.011ProIle: 2.011 ± 0.043	1.753ProLys: 1.753 ± 0.037	2.717ProLeu: 2.717 ± 0.049	0.747ProMet: 0.747 ± 0.022	1.259ProAsn: 1.259 ± 0.031	0.853ProPro: 0.853 ± 0.028	1.152ProGln: 1.152 ± 0.038	1.111ProArg: 1.111 ± 0.033	2.021ProSer: 2.021 ± 0.039	1.494ProThr: 1.494 ± 0.067	3.243ProVal: 3.243 ± 0.064	0.319ProTrp: 0.319 ± 0.018	1.405ProTyr: 1.405 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	2.236GlnAla: 2.236 ± 0.043	0.288GlnCys: 0.288 ± 0.015	1.358GlnAsp: 1.358 ± 0.033	2.163GlnGlu: 2.163 ± 0.046	1.118GlnPhe: 1.118 ± 0.029	1.936GlnGly: 1.936 ± 0.051	0.45GlnHis: 0.45 ± 0.021	2.208GlnIle: 2.208 ± 0.036	2.406GlnLys: 2.406 ± 0.046	2.939GlnLeu: 2.939 ± 0.048	0.902GlnMet: 0.902 ± 0.029	1.585GlnAsn: 1.585 ± 0.035	0.988GlnPro: 0.988 ± 0.025	1.197GlnGln: 1.197 ± 0.038	1.263GlnArg: 1.263 ± 0.031	1.73GlnSer: 1.73 ± 0.035	1.4GlnThr: 1.4 ± 0.035	1.988GlnVal: 1.988 ± 0.038	0.324GlnTrp: 0.324 ± 0.017	1.287GlnTyr: 1.287 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	2.661ArgAla: 2.661 ± 0.052	0.479ArgCys: 0.479 ± 0.019	2.215ArgAsp: 2.215 ± 0.044	3.404ArgGlu: 3.404 ± 0.051	1.854ArgPhe: 1.854 ± 0.037	2.384ArgGly: 2.384 ± 0.046	0.757ArgHis: 0.757 ± 0.027	3.62ArgIle: 3.62 ± 0.055	3.139ArgLys: 3.139 ± 0.054	4.508ArgLeu: 4.508 ± 0.063	1.168ArgMet: 1.168 ± 0.03	2.337ArgAsn: 2.337 ± 0.043	1.327ArgPro: 1.327 ± 0.041	1.599ArgGln: 1.599 ± 0.032	1.909ArgArg: 1.909 ± 0.044	2.082ArgSer: 2.082 ± 0.036	2.109ArgThr: 2.109 ± 0.041	2.684ArgVal: 2.684 ± 0.05	0.347ArgTrp: 0.347 ± 0.019	1.764ArgTyr: 1.764 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	4.496SerAla: 4.496 ± 0.067	0.773SerCys: 0.773 ± 0.024	3.443SerAsp: 3.443 ± 0.059	4.211SerGlu: 4.211 ± 0.061	3.146SerPhe: 3.146 ± 0.05	5.799SerGly: 5.799 ± 0.075	1.044SerHis: 1.044 ± 0.027	5.436SerIle: 5.436 ± 0.065	4.166SerLys: 4.166 ± 0.06	5.871SerLeu: 5.871 ± 0.077	1.689SerMet: 1.689 ± 0.034	3.053SerAsn: 3.053 ± 0.052	2.105SerPro: 2.105 ± 0.04	2.163SerGln: 2.163 ± 0.04	3.064SerArg: 3.064 ± 0.046	4.665SerSer: 4.665 ± 0.073	3.232SerThr: 3.232 ± 0.052	4.555SerVal: 4.555 ± 0.061	0.634SerTrp: 0.634 ± 0.025	2.494SerTyr: 2.494 ± 0.046	0.0SerXaa: 0.0 ± 0.0
Thr	4.533ThrAla: 4.533 ± 0.082	0.597ThrCys: 0.597 ± 0.025	2.874ThrAsp: 2.874 ± 0.046	3.064ThrGlu: 3.064 ± 0.058	2.19ThrPhe: 2.19 ± 0.037	5.384ThrGly: 5.384 ± 0.13	0.784ThrHis: 0.784 ± 0.025	3.993ThrIle: 3.993 ± 0.064	2.758ThrLys: 2.758 ± 0.049	4.719ThrLeu: 4.719 ± 0.065	1.139ThrMet: 1.139 ± 0.031	2.241ThrAsn: 2.241 ± 0.044	2.112ThrPro: 2.112 ± 0.05	1.446ThrGln: 1.446 ± 0.038	2.176ThrArg: 2.176 ± 0.048	3.296ThrSer: 3.296 ± 0.056	2.739ThrThr: 2.739 ± 0.063	4.467ThrVal: 4.467 ± 0.074	0.467ThrTrp: 0.467 ± 0.025	2.192ThrTyr: 2.192 ± 0.051	0.0ThrXaa: 0.0 ± 0.0
Val	4.511ValAla: 4.511 ± 0.064	0.937ValCys: 0.937 ± 0.026	3.627ValAsp: 3.627 ± 0.06	4.331ValGlu: 4.331 ± 0.063	3.332ValPhe: 3.332 ± 0.054	4.109ValGly: 4.109 ± 0.056	0.95ValHis: 0.95 ± 0.029	5.549ValIle: 5.549 ± 0.076	4.836ValLys: 4.836 ± 0.071	6.613ValLeu: 6.613 ± 0.089	1.75ValMet: 1.75 ± 0.041	3.479ValAsn: 3.479 ± 0.061	2.411ValPro: 2.411 ± 0.04	1.973ValGln: 1.973 ± 0.041	2.744ValArg: 2.744 ± 0.042	4.901ValSer: 4.901 ± 0.071	3.911ValThr: 3.911 ± 0.073	4.617ValVal: 4.617 ± 0.062	0.613ValTrp: 0.613 ± 0.025	2.571ValTyr: 2.571 ± 0.049	0.0ValXaa: 0.0 ± 0.0
Trp	0.557TrpAla: 0.557 ± 0.022	0.127TrpCys: 0.127 ± 0.009	0.533TrpAsp: 0.533 ± 0.024	0.597TrpGlu: 0.597 ± 0.023	0.406TrpPhe: 0.406 ± 0.016	0.709TrpGly: 0.709 ± 0.027	0.164TrpHis: 0.164 ± 0.012	0.602TrpIle: 0.602 ± 0.022	0.623TrpLys: 0.623 ± 0.024	0.869TrpLeu: 0.869 ± 0.031	0.266TrpMet: 0.266 ± 0.015	0.557TrpAsn: 0.557 ± 0.02	0.219TrpPro: 0.219 ± 0.015	0.33TrpGln: 0.33 ± 0.016	0.342TrpArg: 0.342 ± 0.017	0.615TrpSer: 0.615 ± 0.025	0.433TrpThr: 0.433 ± 0.025	0.542TrpVal: 0.542 ± 0.021	0.123TrpTrp: 0.123 ± 0.01	0.37TrpTyr: 0.37 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.339TyrAla: 2.339 ± 0.031	0.582TyrCys: 0.582 ± 0.022	2.435TyrAsp: 2.435 ± 0.072	2.489TyrGlu: 2.489 ± 0.041	2.001TyrPhe: 2.001 ± 0.037	2.807TyrGly: 2.807 ± 0.053	0.631TyrHis: 0.631 ± 0.021	3.193TyrIle: 3.193 ± 0.051	2.739TyrLys: 2.739 ± 0.04	3.6TyrLeu: 3.6 ± 0.056	1.02TyrMet: 1.02 ± 0.026	2.264TyrAsn: 2.264 ± 0.048	1.394TyrPro: 1.394 ± 0.036	1.083TyrGln: 1.083 ± 0.031	1.851TyrArg: 1.851 ± 0.039	2.914TyrSer: 2.914 ± 0.052	2.272TyrThr: 2.272 ± 0.052	2.298TyrVal: 2.298 ± 0.037	0.381TyrTrp: 0.381 ± 0.018	1.743TyrTyr: 1.743 ± 0.042	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4233 proteins (1387579 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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