Amino acid dipepetide frequency for Porcine rotavirus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.216AlaAla: 4.216 ± 0.875
0.176AlaCys: 0.176 ± 0.189
4.041AlaAsp: 4.041 ± 0.78
5.095AlaGlu: 5.095 ± 1.323
2.811AlaPhe: 2.811 ± 0.928
2.284AlaGly: 2.284 ± 0.668
0.703AlaHis: 0.703 ± 0.243
6.149AlaIle: 6.149 ± 0.652
4.919AlaLys: 4.919 ± 1.117
6.325AlaLeu: 6.325 ± 1.071
1.581AlaMet: 1.581 ± 0.362
4.568AlaAsn: 4.568 ± 1.018
1.581AlaPro: 1.581 ± 0.744
2.811AlaGln: 2.811 ± 0.678
4.216AlaArg: 4.216 ± 0.476
4.041AlaSer: 4.041 ± 0.793
5.271AlaThr: 5.271 ± 0.981
1.933AlaVal: 1.933 ± 0.924
0.703AlaTrp: 0.703 ± 0.245
1.581AlaTyr: 1.581 ± 0.534
0.0AlaXaa: 0.0 ± 0.0
Cys
0.527CysAla: 0.527 ± 0.26
0.176CysCys: 0.176 ± 0.18
0.703CysAsp: 0.703 ± 0.378
1.23CysGlu: 1.23 ± 0.459
0.351CysPhe: 0.351 ± 0.194
1.054CysGly: 1.054 ± 0.72
0.176CysHis: 0.176 ± 0.156
1.054CysIle: 1.054 ± 0.333
0.703CysLys: 0.703 ± 0.355
0.878CysLeu: 0.878 ± 0.281
0.351CysMet: 0.351 ± 0.353
1.054CysAsn: 1.054 ± 0.708
0.176CysPro: 0.176 ± 0.143
0.527CysGln: 0.527 ± 0.264
0.527CysArg: 0.527 ± 0.363
1.054CysSer: 1.054 ± 0.556
0.527CysThr: 0.527 ± 0.395
0.527CysVal: 0.527 ± 0.338
0.0CysTrp: 0.0 ± 0.0
1.054CysTyr: 1.054 ± 0.38
0.0CysXaa: 0.0 ± 0.0
Asp
3.689AspAla: 3.689 ± 0.862
0.176AspCys: 0.176 ± 0.18
4.392AspAsp: 4.392 ± 0.792
4.216AspGlu: 4.216 ± 0.657
2.108AspPhe: 2.108 ± 0.431
3.338AspGly: 3.338 ± 0.592
0.527AspHis: 0.527 ± 0.381
4.919AspIle: 4.919 ± 0.847
3.865AspLys: 3.865 ± 1.015
6.852AspLeu: 6.852 ± 0.666
1.054AspMet: 1.054 ± 0.443
3.162AspAsn: 3.162 ± 0.659
2.635AspPro: 2.635 ± 0.535
1.757AspGln: 1.757 ± 0.595
3.338AspArg: 3.338 ± 1.025
4.041AspSer: 4.041 ± 1.034
2.811AspThr: 2.811 ± 0.938
4.568AspVal: 4.568 ± 0.846
1.054AspTrp: 1.054 ± 0.475
1.757AspTyr: 1.757 ± 0.687
0.0AspXaa: 0.0 ± 0.0
Glu
3.689GluAla: 3.689 ± 1.242
0.351GluCys: 0.351 ± 0.221
3.514GluAsp: 3.514 ± 0.776
3.338GluGlu: 3.338 ± 0.953
3.338GluPhe: 3.338 ± 0.498
2.635GluGly: 2.635 ± 0.772
0.703GluHis: 0.703 ± 0.45
5.095GluIle: 5.095 ± 0.76
5.446GluLys: 5.446 ± 0.895
5.622GluLeu: 5.622 ± 0.776
1.757GluMet: 1.757 ± 0.677
3.514GluAsn: 3.514 ± 0.953
1.933GluPro: 1.933 ± 0.598
2.635GluGln: 2.635 ± 0.709
3.162GluArg: 3.162 ± 0.743
5.798GluSer: 5.798 ± 1.264
3.162GluThr: 3.162 ± 0.667
3.162GluVal: 3.162 ± 0.313
0.703GluTrp: 0.703 ± 0.245
2.987GluTyr: 2.987 ± 0.528
0.0GluXaa: 0.0 ± 0.0
Phe
3.162PheAla: 3.162 ± 0.504
1.23PheCys: 1.23 ± 0.658
3.514PheAsp: 3.514 ± 1.15
2.811PheGlu: 2.811 ± 0.59
1.054PhePhe: 1.054 ± 0.428
2.284PheGly: 2.284 ± 0.554
0.878PheHis: 0.878 ± 0.458
2.987PheIle: 2.987 ± 0.524
2.811PheLys: 2.811 ± 0.723
3.162PheLeu: 3.162 ± 0.676
0.351PheMet: 0.351 ± 0.315
3.338PheAsn: 3.338 ± 0.712
1.757PhePro: 1.757 ± 0.76
1.581PheGln: 1.581 ± 0.384
2.635PheArg: 2.635 ± 1.036
2.284PheSer: 2.284 ± 0.448
2.987PheThr: 2.987 ± 0.713
3.514PheVal: 3.514 ± 0.893
0.351PheTrp: 0.351 ± 0.239
1.581PheTyr: 1.581 ± 0.474
0.0PheXaa: 0.0 ± 0.0
Gly
2.284GlyAla: 2.284 ± 0.625
0.0GlyCys: 0.0 ± 0.0
1.757GlyAsp: 1.757 ± 0.291
2.635GlyGlu: 2.635 ± 0.755
2.284GlyPhe: 2.284 ± 0.814
2.635GlyGly: 2.635 ± 0.877
1.405GlyHis: 1.405 ± 0.433
3.514GlyIle: 3.514 ± 0.419
2.284GlyLys: 2.284 ± 0.462
2.811GlyLeu: 2.811 ± 0.723
0.527GlyMet: 0.527 ± 0.235
1.405GlyAsn: 1.405 ± 0.41
1.054GlyPro: 1.054 ± 0.41
1.405GlyGln: 1.405 ± 0.479
2.987GlyArg: 2.987 ± 0.612
2.46GlySer: 2.46 ± 0.53
3.162GlyThr: 3.162 ± 0.689
2.46GlyVal: 2.46 ± 0.595
0.351GlyTrp: 0.351 ± 0.269
1.405GlyTyr: 1.405 ± 0.345
0.0GlyXaa: 0.0 ± 0.0
His
1.405HisAla: 1.405 ± 0.455
0.0HisCys: 0.0 ± 0.0
0.878HisAsp: 0.878 ± 0.322
1.23HisGlu: 1.23 ± 0.558
1.054HisPhe: 1.054 ± 0.43
1.054HisGly: 1.054 ± 0.387
0.176HisHis: 0.176 ± 0.18
1.054HisIle: 1.054 ± 0.642
0.878HisLys: 0.878 ± 0.309
1.933HisLeu: 1.933 ± 0.483
0.703HisMet: 0.703 ± 0.34
1.23HisAsn: 1.23 ± 0.421
0.878HisPro: 0.878 ± 0.328
0.0HisGln: 0.0 ± 0.0
0.527HisArg: 0.527 ± 0.324
1.933HisSer: 1.933 ± 0.318
1.757HisThr: 1.757 ± 0.752
0.527HisVal: 0.527 ± 0.252
0.176HisTrp: 0.176 ± 0.189
1.23HisTyr: 1.23 ± 0.559
0.0HisXaa: 0.0 ± 0.0
Ile
6.676IleAla: 6.676 ± 1.207
1.405IleCys: 1.405 ± 0.306
4.568IleAsp: 4.568 ± 0.65
4.919IleGlu: 4.919 ± 0.838
3.338IlePhe: 3.338 ± 0.796
3.689IleGly: 3.689 ± 0.798
1.405IleHis: 1.405 ± 0.37
5.798IleIle: 5.798 ± 0.527
5.271IleLys: 5.271 ± 1.292
5.271IleLeu: 5.271 ± 0.809
1.933IleMet: 1.933 ± 0.68
5.798IleAsn: 5.798 ± 0.865
3.865IlePro: 3.865 ± 0.751
2.987IleGln: 2.987 ± 1.128
5.446IleArg: 5.446 ± 0.746
7.379IleSer: 7.379 ± 1.54
3.689IleThr: 3.689 ± 0.677
3.514IleVal: 3.514 ± 0.776
0.527IleTrp: 0.527 ± 0.395
2.46IleTyr: 2.46 ± 0.549
0.0IleXaa: 0.0 ± 0.0
Lys
3.514LysAla: 3.514 ± 0.703
1.757LysCys: 1.757 ± 0.686
3.338LysAsp: 3.338 ± 0.959
4.743LysGlu: 4.743 ± 0.747
2.284LysPhe: 2.284 ± 0.884
1.581LysGly: 1.581 ± 0.446
1.757LysHis: 1.757 ± 0.588
6.5LysIle: 6.5 ± 1.574
4.919LysLys: 4.919 ± 1.333
3.514LysLeu: 3.514 ± 0.521
2.811LysMet: 2.811 ± 0.602
3.689LysAsn: 3.689 ± 0.395
1.933LysPro: 1.933 ± 0.295
3.338LysGln: 3.338 ± 0.573
3.162LysArg: 3.162 ± 0.98
4.041LysSer: 4.041 ± 0.646
5.798LysThr: 5.798 ± 0.805
5.271LysVal: 5.271 ± 0.946
0.176LysTrp: 0.176 ± 0.158
2.811LysTyr: 2.811 ± 0.781
0.0LysXaa: 0.0 ± 0.0
Leu
5.798LeuAla: 5.798 ± 0.858
1.054LeuCys: 1.054 ± 0.446
4.216LeuAsp: 4.216 ± 0.878
4.568LeuGlu: 4.568 ± 0.823
3.338LeuPhe: 3.338 ± 0.526
2.635LeuGly: 2.635 ± 0.551
1.757LeuHis: 1.757 ± 0.304
5.973LeuIle: 5.973 ± 1.025
5.446LeuLys: 5.446 ± 0.87
7.027LeuLeu: 7.027 ± 0.978
1.581LeuMet: 1.581 ± 0.574
4.743LeuAsn: 4.743 ± 0.813
3.338LeuPro: 3.338 ± 0.578
4.392LeuGln: 4.392 ± 0.729
4.392LeuArg: 4.392 ± 0.811
7.73LeuSer: 7.73 ± 0.844
6.149LeuThr: 6.149 ± 0.765
5.271LeuVal: 5.271 ± 0.705
0.351LeuTrp: 0.351 ± 0.243
2.46LeuTyr: 2.46 ± 0.664
0.0LeuXaa: 0.0 ± 0.0
Met
2.108MetAla: 2.108 ± 0.48
0.527MetCys: 0.527 ± 0.409
1.581MetAsp: 1.581 ± 0.551
1.757MetGlu: 1.757 ± 0.453
1.23MetPhe: 1.23 ± 0.553
0.878MetGly: 0.878 ± 0.214
0.351MetHis: 0.351 ± 0.173
2.635MetIle: 2.635 ± 0.481
1.581MetLys: 1.581 ± 0.448
3.162MetLeu: 3.162 ± 0.69
0.878MetMet: 0.878 ± 0.316
1.933MetAsn: 1.933 ± 0.427
1.405MetPro: 1.405 ± 0.443
0.527MetGln: 0.527 ± 0.281
1.581MetArg: 1.581 ± 0.575
2.284MetSer: 2.284 ± 0.532
1.23MetThr: 1.23 ± 0.444
1.933MetVal: 1.933 ± 0.74
0.0MetTrp: 0.0 ± 0.0
1.23MetTyr: 1.23 ± 0.469
0.0MetXaa: 0.0 ± 0.0
Asn
4.041AsnAla: 4.041 ± 0.753
0.703AsnCys: 0.703 ± 0.245
4.919AsnAsp: 4.919 ± 0.882
2.811AsnGlu: 2.811 ± 0.712
2.635AsnPhe: 2.635 ± 0.734
2.46AsnGly: 2.46 ± 0.525
1.405AsnHis: 1.405 ± 0.413
4.568AsnIle: 4.568 ± 0.95
3.689AsnLys: 3.689 ± 0.916
4.743AsnLeu: 4.743 ± 0.871
2.284AsnMet: 2.284 ± 0.43
4.743AsnAsn: 4.743 ± 1.101
3.338AsnPro: 3.338 ± 1.161
1.933AsnGln: 1.933 ± 0.564
3.162AsnArg: 3.162 ± 0.454
6.149AsnSer: 6.149 ± 0.868
3.338AsnThr: 3.338 ± 0.801
5.095AsnVal: 5.095 ± 0.745
0.878AsnTrp: 0.878 ± 0.313
2.811AsnTyr: 2.811 ± 0.548
0.0AsnXaa: 0.0 ± 0.0
Pro
2.987ProAla: 2.987 ± 0.79
0.351ProCys: 0.351 ± 0.253
1.23ProAsp: 1.23 ± 0.406
2.46ProGlu: 2.46 ± 0.246
1.405ProPhe: 1.405 ± 0.54
1.23ProGly: 1.23 ± 0.548
0.351ProHis: 0.351 ± 0.317
3.338ProIle: 3.338 ± 0.723
2.108ProLys: 2.108 ± 0.625
2.811ProLeu: 2.811 ± 1.07
1.405ProMet: 1.405 ± 0.384
2.987ProAsn: 2.987 ± 0.653
1.581ProPro: 1.581 ± 0.57
2.284ProGln: 2.284 ± 0.366
0.703ProArg: 0.703 ± 0.269
3.162ProSer: 3.162 ± 0.67
2.635ProThr: 2.635 ± 0.599
4.041ProVal: 4.041 ± 0.784
0.351ProTrp: 0.351 ± 0.243
2.108ProTyr: 2.108 ± 0.538
0.0ProXaa: 0.0 ± 0.0
Gln
1.23GlnAla: 1.23 ± 0.517
0.527GlnCys: 0.527 ± 0.31
1.23GlnAsp: 1.23 ± 0.375
2.108GlnGlu: 2.108 ± 0.58
1.581GlnPhe: 1.581 ± 0.536
1.405GlnGly: 1.405 ± 0.326
1.405GlnHis: 1.405 ± 0.312
4.041GlnIle: 4.041 ± 0.644
3.338GlnLys: 3.338 ± 1.248
5.271GlnLeu: 5.271 ± 0.756
0.703GlnMet: 0.703 ± 0.257
3.162GlnAsn: 3.162 ± 0.758
1.23GlnPro: 1.23 ± 0.428
1.933GlnGln: 1.933 ± 0.647
2.284GlnArg: 2.284 ± 0.473
1.581GlnSer: 1.581 ± 0.468
1.581GlnThr: 1.581 ± 0.361
2.987GlnVal: 2.987 ± 0.799
0.351GlnTrp: 0.351 ± 0.173
1.054GlnTyr: 1.054 ± 0.473
0.0GlnXaa: 0.0 ± 0.0
Arg
3.162ArgAla: 3.162 ± 1.059
1.23ArgCys: 1.23 ± 0.602
3.865ArgAsp: 3.865 ± 1.072
3.514ArgGlu: 3.514 ± 0.767
2.635ArgPhe: 2.635 ± 0.431
1.581ArgGly: 1.581 ± 0.51
0.527ArgHis: 0.527 ± 0.243
4.568ArgIle: 4.568 ± 1.051
3.338ArgLys: 3.338 ± 0.828
3.162ArgLeu: 3.162 ± 0.927
2.987ArgMet: 2.987 ± 0.887
3.162ArgAsn: 3.162 ± 0.442
1.581ArgPro: 1.581 ± 0.613
2.811ArgGln: 2.811 ± 0.546
3.162ArgArg: 3.162 ± 1.137
3.162ArgSer: 3.162 ± 0.475
4.568ArgThr: 4.568 ± 0.654
2.987ArgVal: 2.987 ± 0.889
0.527ArgTrp: 0.527 ± 0.231
1.933ArgTyr: 1.933 ± 0.332
0.0ArgXaa: 0.0 ± 0.0
Ser
6.676SerAla: 6.676 ± 1.097
0.527SerCys: 0.527 ± 0.309
4.919SerAsp: 4.919 ± 0.989
3.865SerGlu: 3.865 ± 1.083
4.216SerPhe: 4.216 ± 0.618
2.987SerGly: 2.987 ± 0.671
1.054SerHis: 1.054 ± 0.345
6.149SerIle: 6.149 ± 1.181
5.973SerLys: 5.973 ± 0.731
5.798SerLeu: 5.798 ± 1.119
1.757SerMet: 1.757 ± 0.216
4.041SerAsn: 4.041 ± 0.592
2.46SerPro: 2.46 ± 0.623
2.811SerGln: 2.811 ± 0.605
3.514SerArg: 3.514 ± 0.608
3.162SerSer: 3.162 ± 1.15
3.514SerThr: 3.514 ± 0.599
4.216SerVal: 4.216 ± 0.76
0.703SerTrp: 0.703 ± 0.342
2.635SerTyr: 2.635 ± 0.537
0.0SerXaa: 0.0 ± 0.0
Thr
3.338ThrAla: 3.338 ± 0.755
0.878ThrCys: 0.878 ± 0.309
4.392ThrAsp: 4.392 ± 0.607
2.811ThrGlu: 2.811 ± 0.653
3.162ThrPhe: 3.162 ± 0.561
2.108ThrGly: 2.108 ± 0.953
1.405ThrHis: 1.405 ± 0.389
5.622ThrIle: 5.622 ± 0.991
3.865ThrLys: 3.865 ± 0.551
5.798ThrLeu: 5.798 ± 1.333
2.46ThrMet: 2.46 ± 0.48
4.568ThrAsn: 4.568 ± 0.829
3.865ThrPro: 3.865 ± 0.707
1.405ThrGln: 1.405 ± 0.613
2.987ThrArg: 2.987 ± 0.899
3.338ThrSer: 3.338 ± 0.636
5.798ThrThr: 5.798 ± 0.84
4.568ThrVal: 4.568 ± 1.132
0.176ThrTrp: 0.176 ± 0.194
1.933ThrTyr: 1.933 ± 0.586
0.0ThrXaa: 0.0 ± 0.0
Val
4.041ValAla: 4.041 ± 1.145
0.878ValCys: 0.878 ± 0.476
4.041ValAsp: 4.041 ± 0.92
4.743ValGlu: 4.743 ± 1.196
3.338ValPhe: 3.338 ± 0.84
1.23ValGly: 1.23 ± 0.437
1.054ValHis: 1.054 ± 0.583
3.865ValIle: 3.865 ± 0.892
4.041ValLys: 4.041 ± 0.685
4.743ValLeu: 4.743 ± 1.005
2.108ValMet: 2.108 ± 0.519
4.743ValAsn: 4.743 ± 0.6
3.865ValPro: 3.865 ± 0.513
2.635ValGln: 2.635 ± 0.516
3.689ValArg: 3.689 ± 0.649
3.689ValSer: 3.689 ± 0.927
3.689ValThr: 3.689 ± 0.794
2.811ValVal: 2.811 ± 0.584
0.0ValTrp: 0.0 ± 0.0
2.284ValTyr: 2.284 ± 0.299
0.0ValXaa: 0.0 ± 0.0
Trp
0.527TrpAla: 0.527 ± 0.351
0.176TrpCys: 0.176 ± 0.18
0.351TrpAsp: 0.351 ± 0.253
0.351TrpGlu: 0.351 ± 0.248
0.176TrpPhe: 0.176 ± 0.159
0.0TrpGly: 0.0 ± 0.0
0.176TrpHis: 0.176 ± 0.159
0.351TrpIle: 0.351 ± 0.231
1.054TrpLys: 1.054 ± 0.235
1.054TrpLeu: 1.054 ± 0.341
0.351TrpMet: 0.351 ± 0.204
0.351TrpAsn: 0.351 ± 0.215
0.176TrpPro: 0.176 ± 0.189
0.176TrpGln: 0.176 ± 0.158
1.054TrpArg: 1.054 ± 0.351
0.527TrpSer: 0.527 ± 0.236
0.351TrpThr: 0.351 ± 0.213
0.176TrpVal: 0.176 ± 0.18
0.0TrpTrp: 0.0 ± 0.0
0.176TrpTyr: 0.176 ± 0.213
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.933TyrAla: 1.933 ± 0.625
0.527TyrCys: 0.527 ± 0.346
2.987TyrAsp: 2.987 ± 0.567
3.338TyrGlu: 3.338 ± 0.877
1.933TyrPhe: 1.933 ± 0.298
1.757TyrGly: 1.757 ± 0.349
1.405TyrHis: 1.405 ± 0.462
1.757TyrIle: 1.757 ± 0.533
1.405TyrLys: 1.405 ± 0.764
2.284TyrLeu: 2.284 ± 0.693
1.054TyrMet: 1.054 ± 0.411
3.514TyrAsn: 3.514 ± 0.741
0.878TyrPro: 0.878 ± 0.315
1.054TyrGln: 1.054 ± 0.376
1.933TyrArg: 1.933 ± 0.594
3.162TyrSer: 3.162 ± 0.516
2.46TyrThr: 2.46 ± 0.723
1.933TyrVal: 1.933 ± 0.407
0.176TyrTrp: 0.176 ± 0.159
1.23TyrTyr: 1.23 ± 0.381
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 11 proteins (5693 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski