Amino acid dipepetide frequency for Acholeplasma laidlawii (strain PG-8A)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.457AlaAla: 3.457 ± 0.136
0.279AlaCys: 0.279 ± 0.027
2.67AlaAsp: 2.67 ± 0.093
2.65AlaGlu: 2.65 ± 0.105
3.065AlaPhe: 3.065 ± 0.09
3.466AlaGly: 3.466 ± 0.103
1.272AlaHis: 1.272 ± 0.056
5.4AlaIle: 5.4 ± 0.142
4.439AlaLys: 4.439 ± 0.131
6.774AlaLeu: 6.774 ± 0.148
1.467AlaMet: 1.467 ± 0.065
2.695AlaAsn: 2.695 ± 0.083
1.651AlaPro: 1.651 ± 0.065
1.817AlaGln: 1.817 ± 0.061
2.081AlaArg: 2.081 ± 0.074
3.876AlaSer: 3.876 ± 0.108
3.32AlaThr: 3.32 ± 0.093
3.814AlaVal: 3.814 ± 0.11
0.445AlaTrp: 0.445 ± 0.035
2.861AlaTyr: 2.861 ± 0.102
0.0AlaXaa: 0.0 ± 0.0
Cys
0.184CysAla: 0.184 ± 0.022
0.027CysCys: 0.027 ± 0.007
0.239CysAsp: 0.239 ± 0.025
0.226CysGlu: 0.226 ± 0.022
0.144CysPhe: 0.144 ± 0.016
0.355CysGly: 0.355 ± 0.032
0.109CysHis: 0.109 ± 0.016
0.312CysIle: 0.312 ± 0.024
0.244CysLys: 0.244 ± 0.026
0.299CysLeu: 0.299 ± 0.028
0.071CysMet: 0.071 ± 0.013
0.16CysAsn: 0.16 ± 0.018
0.173CysPro: 0.173 ± 0.019
0.098CysGln: 0.098 ± 0.016
0.091CysArg: 0.091 ± 0.014
0.233CysSer: 0.233 ± 0.024
0.191CysThr: 0.191 ± 0.019
0.202CysVal: 0.202 ± 0.02
0.02CysTrp: 0.02 ± 0.007
0.137CysTyr: 0.137 ± 0.016
0.0CysXaa: 0.0 ± 0.0
Asp
3.803AspAla: 3.803 ± 0.107
0.215AspCys: 0.215 ± 0.021
3.297AspAsp: 3.297 ± 0.105
4.343AspGlu: 4.343 ± 0.108
3.204AspPhe: 3.204 ± 0.076
3.466AspGly: 3.466 ± 0.117
1.21AspHis: 1.21 ± 0.051
5.533AspIle: 5.533 ± 0.107
4.698AspLys: 4.698 ± 0.126
6.307AspLeu: 6.307 ± 0.143
1.425AspMet: 1.425 ± 0.058
2.868AspAsn: 2.868 ± 0.083
1.813AspPro: 1.813 ± 0.069
1.881AspGln: 1.881 ± 0.065
1.788AspArg: 1.788 ± 0.069
3.127AspSer: 3.127 ± 0.088
3.34AspThr: 3.34 ± 0.109
4.226AspVal: 4.226 ± 0.115
0.441AspTrp: 0.441 ± 0.03
3.125AspTyr: 3.125 ± 0.085
0.0AspXaa: 0.0 ± 0.0
Glu
4.31GluAla: 4.31 ± 0.107
0.144GluCys: 0.144 ± 0.017
3.736GluAsp: 3.736 ± 0.1
3.976GluGlu: 3.976 ± 0.096
2.819GluPhe: 2.819 ± 0.078
3.495GluGly: 3.495 ± 0.102
1.361GluHis: 1.361 ± 0.064
5.573GluIle: 5.573 ± 0.1
4.957GluLys: 4.957 ± 0.131
6.446GluLeu: 6.446 ± 0.148
1.713GluMet: 1.713 ± 0.061
3.464GluAsn: 3.464 ± 0.096
1.731GluPro: 1.731 ± 0.073
2.065GluGln: 2.065 ± 0.072
2.238GluArg: 2.238 ± 0.08
3.694GluSer: 3.694 ± 0.09
4.029GluThr: 4.029 ± 0.111
5.097GluVal: 5.097 ± 0.123
0.386GluTrp: 0.386 ± 0.026
2.314GluTyr: 2.314 ± 0.072
0.0GluXaa: 0.0 ± 0.0
Phe
2.384PheAla: 2.384 ± 0.08
0.16PheCys: 0.16 ± 0.02
3.599PheAsp: 3.599 ± 0.093
3.455PheGlu: 3.455 ± 0.098
2.083PhePhe: 2.083 ± 0.078
3.244PheGly: 3.244 ± 0.096
0.722PheHis: 0.722 ± 0.039
4.771PheIle: 4.771 ± 0.127
3.874PheLys: 3.874 ± 0.101
4.133PheLeu: 4.133 ± 0.114
1.334PheMet: 1.334 ± 0.06
3.284PheAsn: 3.284 ± 0.079
1.099PhePro: 1.099 ± 0.049
1.199PheGln: 1.199 ± 0.046
1.465PheArg: 1.465 ± 0.059
3.178PheSer: 3.178 ± 0.087
2.814PheThr: 2.814 ± 0.082
3.355PheVal: 3.355 ± 0.096
0.29PheTrp: 0.29 ± 0.027
1.988PheTyr: 1.988 ± 0.079
0.0PheXaa: 0.0 ± 0.0
Gly
3.727GlyAla: 3.727 ± 0.108
0.284GlyCys: 0.284 ± 0.027
3.063GlyAsp: 3.063 ± 0.088
3.213GlyGlu: 3.213 ± 0.098
3.391GlyPhe: 3.391 ± 0.082
3.792GlyGly: 3.792 ± 0.124
1.314GlyHis: 1.314 ± 0.062
5.764GlyIle: 5.764 ± 0.132
4.275GlyLys: 4.275 ± 0.1
6.041GlyLeu: 6.041 ± 0.119
1.556GlyMet: 1.556 ± 0.057
2.743GlyAsn: 2.743 ± 0.101
1.35GlyPro: 1.35 ± 0.066
2.076GlyGln: 2.076 ± 0.079
1.919GlyArg: 1.919 ± 0.08
3.73GlySer: 3.73 ± 0.097
3.699GlyThr: 3.699 ± 0.115
4.49GlyVal: 4.49 ± 0.114
0.616GlyTrp: 0.616 ± 0.046
3.02GlyTyr: 3.02 ± 0.099
0.0GlyXaa: 0.0 ± 0.0
His
1.332HisAla: 1.332 ± 0.06
0.075HisCys: 0.075 ± 0.012
1.208HisAsp: 1.208 ± 0.048
1.385HisGlu: 1.385 ± 0.053
0.955HisPhe: 0.955 ± 0.053
1.263HisGly: 1.263 ± 0.05
0.565HisHis: 0.565 ± 0.044
2.05HisIle: 2.05 ± 0.065
1.591HisLys: 1.591 ± 0.063
2.07HisLeu: 2.07 ± 0.079
0.51HisMet: 0.51 ± 0.04
1.017HisAsn: 1.017 ± 0.059
0.904HisPro: 0.904 ± 0.044
0.824HisGln: 0.824 ± 0.043
0.652HisArg: 0.652 ± 0.04
0.891HisSer: 0.891 ± 0.046
1.194HisThr: 1.194 ± 0.048
1.363HisVal: 1.363 ± 0.061
0.131HisTrp: 0.131 ± 0.016
0.915HisTyr: 0.915 ± 0.047
0.0HisXaa: 0.0 ± 0.0
Ile
5.267IleAla: 5.267 ± 0.147
0.363IleCys: 0.363 ± 0.029
6.081IleAsp: 6.081 ± 0.126
6.236IleGlu: 6.236 ± 0.115
4.102IlePhe: 4.102 ± 0.13
5.62IleGly: 5.62 ± 0.128
1.81IleHis: 1.81 ± 0.065
7.603IleIle: 7.603 ± 0.168
7.116IleLys: 7.116 ± 0.137
8.729IleLeu: 8.729 ± 0.182
2.099IleMet: 2.099 ± 0.072
4.578IleAsn: 4.578 ± 0.114
3.074IlePro: 3.074 ± 0.085
2.668IleGln: 2.668 ± 0.077
2.941IleArg: 2.941 ± 0.083
5.646IleSer: 5.646 ± 0.123
5.462IleThr: 5.462 ± 0.118
5.739IleVal: 5.739 ± 0.12
0.567IleTrp: 0.567 ± 0.037
3.931IleTyr: 3.931 ± 0.112
0.0IleXaa: 0.0 ± 0.0
Lys
4.323LysAla: 4.323 ± 0.102
0.14LysCys: 0.14 ± 0.02
5.735LysAsp: 5.735 ± 0.122
6.054LysGlu: 6.054 ± 0.153
2.743LysPhe: 2.743 ± 0.082
3.865LysGly: 3.865 ± 0.096
1.999LysHis: 1.999 ± 0.078
5.943LysIle: 5.943 ± 0.131
6.495LysLys: 6.495 ± 0.158
7.486LysLeu: 7.486 ± 0.171
2.234LysMet: 2.234 ± 0.07
4.461LysAsn: 4.461 ± 0.104
2.407LysPro: 2.407 ± 0.089
2.595LysGln: 2.595 ± 0.095
3.012LysArg: 3.012 ± 0.098
4.569LysSer: 4.569 ± 0.117
4.66LysThr: 4.66 ± 0.106
5.33LysVal: 5.33 ± 0.111
0.556LysTrp: 0.556 ± 0.039
3.592LysTyr: 3.592 ± 0.11
0.0LysXaa: 0.0 ± 0.0
Leu
5.474LeuAla: 5.474 ± 0.133
0.319LeuCys: 0.319 ± 0.03
6.602LeuAsp: 6.602 ± 0.113
6.684LeuGlu: 6.684 ± 0.146
4.618LeuPhe: 4.618 ± 0.123
6.147LeuGly: 6.147 ± 0.132
1.624LeuHis: 1.624 ± 0.063
8.826LeuIle: 8.826 ± 0.221
8.321LeuLys: 8.321 ± 0.189
9.252LeuLeu: 9.252 ± 0.189
2.657LeuMet: 2.657 ± 0.08
6.371LeuAsn: 6.371 ± 0.116
3.344LeuPro: 3.344 ± 0.087
2.446LeuGln: 2.446 ± 0.084
3.207LeuArg: 3.207 ± 0.089
7.226LeuSer: 7.226 ± 0.128
5.972LeuThr: 5.972 ± 0.138
6.367LeuVal: 6.367 ± 0.133
0.658LeuTrp: 0.658 ± 0.04
3.949LeuTyr: 3.949 ± 0.111
0.0LeuXaa: 0.0 ± 0.0
Met
1.412MetAla: 1.412 ± 0.067
0.115MetCys: 0.115 ± 0.016
1.658MetAsp: 1.658 ± 0.075
1.283MetGlu: 1.283 ± 0.053
1.159MetPhe: 1.159 ± 0.058
1.456MetGly: 1.456 ± 0.054
0.496MetHis: 0.496 ± 0.038
2.577MetIle: 2.577 ± 0.089
2.236MetLys: 2.236 ± 0.065
2.251MetLeu: 2.251 ± 0.065
0.878MetMet: 0.878 ± 0.044
1.611MetAsn: 1.611 ± 0.059
0.835MetPro: 0.835 ± 0.044
0.702MetGln: 0.702 ± 0.04
0.871MetArg: 0.871 ± 0.041
1.631MetSer: 1.631 ± 0.068
1.551MetThr: 1.551 ± 0.059
1.62MetVal: 1.62 ± 0.056
0.171MetTrp: 0.171 ± 0.019
0.982MetTyr: 0.982 ± 0.049
0.0MetXaa: 0.0 ± 0.0
Asn
2.91AsnAla: 2.91 ± 0.091
0.164AsnCys: 0.164 ± 0.018
3.304AsnAsp: 3.304 ± 0.085
3.951AsnGlu: 3.951 ± 0.097
2.531AsnPhe: 2.531 ± 0.079
3.118AsnGly: 3.118 ± 0.115
1.436AsnHis: 1.436 ± 0.062
4.875AsnIle: 4.875 ± 0.131
4.292AsnLys: 4.292 ± 0.106
5.664AsnLeu: 5.664 ± 0.105
1.319AsnMet: 1.319 ± 0.053
3.016AsnAsn: 3.016 ± 0.099
2.311AsnPro: 2.311 ± 0.082
2.451AsnGln: 2.451 ± 0.072
1.959AsnArg: 1.959 ± 0.056
2.522AsnSer: 2.522 ± 0.088
2.837AsnThr: 2.837 ± 0.087
3.304AsnVal: 3.304 ± 0.106
0.468AsnTrp: 0.468 ± 0.03
2.914AsnTyr: 2.914 ± 0.106
0.0AsnXaa: 0.0 ± 0.0
Pro
1.432ProAla: 1.432 ± 0.067
0.086ProCys: 0.086 ± 0.013
1.589ProAsp: 1.589 ± 0.063
1.997ProGlu: 1.997 ± 0.067
1.802ProPhe: 1.802 ± 0.064
1.784ProGly: 1.784 ± 0.075
0.623ProHis: 0.623 ± 0.039
2.628ProIle: 2.628 ± 0.079
2.415ProLys: 2.415 ± 0.078
2.972ProLeu: 2.972 ± 0.084
0.729ProMet: 0.729 ± 0.042
1.994ProAsn: 1.994 ± 0.07
0.585ProPro: 0.585 ± 0.036
0.86ProGln: 0.86 ± 0.049
0.864ProArg: 0.864 ± 0.05
1.939ProSer: 1.939 ± 0.061
2.023ProThr: 2.023 ± 0.074
2.309ProVal: 2.309 ± 0.084
0.244ProTrp: 0.244 ± 0.025
1.578ProTyr: 1.578 ± 0.057
0.0ProXaa: 0.0 ± 0.0
Gln
1.999GlnAla: 1.999 ± 0.066
0.078GlnCys: 0.078 ± 0.013
1.531GlnAsp: 1.531 ± 0.053
1.678GlnGlu: 1.678 ± 0.072
1.458GlnPhe: 1.458 ± 0.056
1.755GlnGly: 1.755 ± 0.055
0.499GlnHis: 0.499 ± 0.039
2.954GlnIle: 2.954 ± 0.067
2.48GlnLys: 2.48 ± 0.088
3.045GlnLeu: 3.045 ± 0.089
0.988GlnMet: 0.988 ± 0.057
1.948GlnAsn: 1.948 ± 0.065
0.727GlnPro: 0.727 ± 0.04
0.973GlnGln: 0.973 ± 0.048
1.101GlnArg: 1.101 ± 0.053
2.103GlnSer: 2.103 ± 0.085
2.054GlnThr: 2.054 ± 0.08
2.132GlnVal: 2.132 ± 0.073
0.237GlnTrp: 0.237 ± 0.026
1.321GlnTyr: 1.321 ± 0.053
0.0GlnXaa: 0.0 ± 0.0
Arg
1.93ArgAla: 1.93 ± 0.074
0.122ArgCys: 0.122 ± 0.017
1.658ArgAsp: 1.658 ± 0.072
1.762ArgGlu: 1.762 ± 0.074
1.782ArgPhe: 1.782 ± 0.069
1.775ArgGly: 1.775 ± 0.07
0.765ArgHis: 0.765 ± 0.041
3.087ArgIle: 3.087 ± 0.085
2.562ArgLys: 2.562 ± 0.092
3.568ArgLeu: 3.568 ± 0.106
0.979ArgMet: 0.979 ± 0.047
1.775ArgAsn: 1.775 ± 0.062
1.05ArgPro: 1.05 ± 0.058
1.254ArgGln: 1.254 ± 0.054
1.396ArgArg: 1.396 ± 0.069
1.83ArgSer: 1.83 ± 0.068
1.888ArgThr: 1.888 ± 0.066
2.347ArgVal: 2.347 ± 0.074
0.208ArgTrp: 0.208 ± 0.023
1.618ArgTyr: 1.618 ± 0.057
0.0ArgXaa: 0.0 ± 0.0
Ser
3.158SerAla: 3.158 ± 0.077
0.233SerCys: 0.233 ± 0.022
3.368SerAsp: 3.368 ± 0.091
3.384SerGlu: 3.384 ± 0.076
3.368SerPhe: 3.368 ± 0.104
4.306SerGly: 4.306 ± 0.124
1.168SerHis: 1.168 ± 0.051
5.804SerIle: 5.804 ± 0.121
5.172SerLys: 5.172 ± 0.117
6.163SerLeu: 6.163 ± 0.132
1.536SerMet: 1.536 ± 0.062
3.931SerAsn: 3.931 ± 0.12
1.549SerPro: 1.549 ± 0.056
1.755SerGln: 1.755 ± 0.066
1.983SerArg: 1.983 ± 0.066
3.845SerSer: 3.845 ± 0.098
3.373SerThr: 3.373 ± 0.09
3.945SerVal: 3.945 ± 0.098
0.432SerTrp: 0.432 ± 0.032
2.918SerTyr: 2.918 ± 0.091
0.0SerXaa: 0.0 ± 0.0
Thr
3.122ThrAla: 3.122 ± 0.095
0.199ThrCys: 0.199 ± 0.021
3.049ThrAsp: 3.049 ± 0.077
2.899ThrGlu: 2.899 ± 0.088
2.963ThrPhe: 2.963 ± 0.087
3.75ThrGly: 3.75 ± 0.109
1.483ThrHis: 1.483 ± 0.053
5.445ThrIle: 5.445 ± 0.146
4.567ThrLys: 4.567 ± 0.109
6.387ThrLeu: 6.387 ± 0.162
1.197ThrMet: 1.197 ± 0.055
3.273ThrAsn: 3.273 ± 0.111
2.278ThrPro: 2.278 ± 0.075
1.62ThrGln: 1.62 ± 0.059
1.726ThrArg: 1.726 ± 0.067
3.858ThrSer: 3.858 ± 0.097
3.699ThrThr: 3.699 ± 0.113
3.865ThrVal: 3.865 ± 0.124
0.565ThrTrp: 0.565 ± 0.041
3.275ThrTyr: 3.275 ± 0.113
0.0ThrXaa: 0.0 ± 0.0
Val
4.049ValAla: 4.049 ± 0.11
0.304ValCys: 0.304 ± 0.033
4.239ValAsp: 4.239 ± 0.103
4.481ValGlu: 4.481 ± 0.115
3.528ValPhe: 3.528 ± 0.096
4.337ValGly: 4.337 ± 0.116
1.157ValHis: 1.157 ± 0.051
6.165ValIle: 6.165 ± 0.12
4.773ValLys: 4.773 ± 0.117
6.961ValLeu: 6.961 ± 0.128
1.498ValMet: 1.498 ± 0.067
3.229ValAsn: 3.229 ± 0.096
1.939ValPro: 1.939 ± 0.074
1.642ValGln: 1.642 ± 0.066
2.274ValArg: 2.274 ± 0.069
4.789ValSer: 4.789 ± 0.122
4.168ValThr: 4.168 ± 0.146
5.385ValVal: 5.385 ± 0.145
0.556ValTrp: 0.556 ± 0.034
2.983ValTyr: 2.983 ± 0.096
0.0ValXaa: 0.0 ± 0.0
Trp
0.383TrpAla: 0.383 ± 0.033
0.031TrpCys: 0.031 ± 0.007
0.432TrpAsp: 0.432 ± 0.036
0.355TrpGlu: 0.355 ± 0.03
0.496TrpPhe: 0.496 ± 0.038
0.474TrpGly: 0.474 ± 0.036
0.197TrpHis: 0.197 ± 0.021
0.685TrpIle: 0.685 ± 0.042
0.363TrpLys: 0.363 ± 0.026
0.804TrpLeu: 0.804 ± 0.048
0.204TrpMet: 0.204 ± 0.019
0.434TrpAsn: 0.434 ± 0.033
0.177TrpPro: 0.177 ± 0.022
0.273TrpGln: 0.273 ± 0.027
0.246TrpArg: 0.246 ± 0.027
0.452TrpSer: 0.452 ± 0.034
0.363TrpThr: 0.363 ± 0.031
0.523TrpVal: 0.523 ± 0.031
0.086TrpTrp: 0.086 ± 0.014
0.39TrpTyr: 0.39 ± 0.031
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.843TyrAla: 2.843 ± 0.092
0.175TyrCys: 0.175 ± 0.02
3.051TyrAsp: 3.051 ± 0.089
3.537TyrGlu: 3.537 ± 0.091
2.22TyrPhe: 2.22 ± 0.08
2.595TyrGly: 2.595 ± 0.079
1.086TyrHis: 1.086 ± 0.053
3.636TyrIle: 3.636 ± 0.097
3.328TyrLys: 3.328 ± 0.081
4.713TyrLeu: 4.713 ± 0.123
1.101TyrMet: 1.101 ± 0.049
2.493TyrAsn: 2.493 ± 0.12
1.456TyrPro: 1.456 ± 0.053
1.859TyrGln: 1.859 ± 0.07
1.542TyrArg: 1.542 ± 0.065
2.251TyrSer: 2.251 ± 0.096
2.582TyrThr: 2.582 ± 0.103
3.047TyrVal: 3.047 ± 0.106
0.293TyrTrp: 0.293 ± 0.025
2.096TyrTyr: 2.096 ± 0.106
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1380 proteins (451261 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski