Amino acid dipepetide frequency for Muribaculaceae bacterium Isolate-102 (HZI)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.924AlaAla: 6.924 ± 0.121	0.911AlaCys: 0.911 ± 0.033	4.972AlaAsp: 4.972 ± 0.078	4.723AlaGlu: 4.723 ± 0.079	2.932AlaPhe: 2.932 ± 0.058	5.217AlaGly: 5.217 ± 0.086	1.329AlaHis: 1.329 ± 0.034	5.582AlaIle: 5.582 ± 0.089	4.072AlaLys: 4.072 ± 0.072	7.481AlaLeu: 7.481 ± 0.101	2.543AlaMet: 2.543 ± 0.064	3.189AlaAsn: 3.189 ± 0.066	2.792AlaPro: 2.792 ± 0.061	2.563AlaGln: 2.563 ± 0.056	3.933AlaArg: 3.933 ± 0.073	5.159AlaSer: 5.159 ± 0.081	4.347AlaThr: 4.347 ± 0.083	5.688AlaVal: 5.688 ± 0.092	0.884AlaTrp: 0.884 ± 0.036	2.775AlaTyr: 2.775 ± 0.061	0.0AlaXaa: 0.0 ± 0.0
Cys	0.849CysAla: 0.849 ± 0.038	0.195CysCys: 0.195 ± 0.015	0.817CysAsp: 0.817 ± 0.031	0.638CysGlu: 0.638 ± 0.027	0.484CysPhe: 0.484 ± 0.021	1.037CysGly: 1.037 ± 0.039	0.318CysHis: 0.318 ± 0.018	0.833CysIle: 0.833 ± 0.029	0.535CysLys: 0.535 ± 0.022	0.927CysLeu: 0.927 ± 0.035	0.266CysMet: 0.266 ± 0.018	0.635CysAsn: 0.635 ± 0.029	0.523CysPro: 0.523 ± 0.027	0.306CysGln: 0.306 ± 0.018	0.764CysArg: 0.764 ± 0.032	0.837CysSer: 0.837 ± 0.031	0.594CysThr: 0.594 ± 0.024	0.801CysVal: 0.801 ± 0.03	0.139CysTrp: 0.139 ± 0.01	0.509CysTyr: 0.509 ± 0.025	0.0CysXaa: 0.0 ± 0.0
Asp	4.673AspAla: 4.673 ± 0.082	0.706AspCys: 0.706 ± 0.032	4.213AspAsp: 4.213 ± 0.072	4.246AspGlu: 4.246 ± 0.07	2.998AspPhe: 2.998 ± 0.056	4.674AspGly: 4.674 ± 0.087	0.877AspHis: 0.877 ± 0.034	5.03AspIle: 5.03 ± 0.072	3.752AspLys: 3.752 ± 0.071	4.555AspLeu: 4.555 ± 0.075	1.997AspMet: 1.997 ± 0.049	3.666AspAsn: 3.666 ± 0.073	2.15AspPro: 2.15 ± 0.052	1.098AspGln: 1.098 ± 0.033	3.144AspArg: 3.144 ± 0.06	3.893AspSer: 3.893 ± 0.081	3.113AspThr: 3.113 ± 0.06	3.807AspVal: 3.807 ± 0.072	0.839AspTrp: 0.839 ± 0.028	3.147AspTyr: 3.147 ± 0.055	0.0AspXaa: 0.0 ± 0.0
Glu	4.985GluAla: 4.985 ± 0.091	0.663GluCys: 0.663 ± 0.024	2.686GluAsp: 2.686 ± 0.051	3.94GluGlu: 3.94 ± 0.086	2.301GluPhe: 2.301 ± 0.048	3.734GluGly: 3.734 ± 0.062	1.22GluHis: 1.22 ± 0.041	4.549GluIle: 4.549 ± 0.068	3.883GluLys: 3.883 ± 0.083	5.833GluLeu: 5.833 ± 0.094	1.92GluMet: 1.92 ± 0.045	3.024GluAsn: 3.024 ± 0.071	1.989GluPro: 1.989 ± 0.046	2.096GluGln: 2.096 ± 0.045	3.579GluArg: 3.579 ± 0.066	3.563GluSer: 3.563 ± 0.069	2.632GluThr: 2.632 ± 0.06	4.018GluVal: 4.018 ± 0.075	0.888GluTrp: 0.888 ± 0.031	2.509GluTyr: 2.509 ± 0.05	0.0GluXaa: 0.0 ± 0.0
Phe	3.019PheAla: 3.019 ± 0.057	0.544PheCys: 0.544 ± 0.022	2.783PheAsp: 2.783 ± 0.06	2.055PheGlu: 2.055 ± 0.045	1.823PhePhe: 1.823 ± 0.053	3.093PheGly: 3.093 ± 0.065	0.776PheHis: 0.776 ± 0.028	3.074PheIle: 3.074 ± 0.06	2.239PheLys: 2.239 ± 0.045	3.321PheLeu: 3.321 ± 0.065	1.247PheMet: 1.247 ± 0.036	2.479PheAsn: 2.479 ± 0.057	1.65PhePro: 1.65 ± 0.043	0.938PheGln: 0.938 ± 0.032	2.122PheArg: 2.122 ± 0.051	3.053PheSer: 3.053 ± 0.064	2.543PheThr: 2.543 ± 0.056	2.502PheVal: 2.502 ± 0.048	0.487PheTrp: 0.487 ± 0.024	1.598PheTyr: 1.598 ± 0.043	0.0PheXaa: 0.0 ± 0.0
Gly	4.982GlyAla: 4.982 ± 0.091	1.066GlyCys: 1.066 ± 0.037	4.193GlyAsp: 4.193 ± 0.07	3.937GlyGlu: 3.937 ± 0.062	3.053GlyPhe: 3.053 ± 0.056	4.656GlyGly: 4.656 ± 0.099	1.457GlyHis: 1.457 ± 0.041	5.208GlyIle: 5.208 ± 0.081	4.389GlyLys: 4.389 ± 0.068	5.572GlyLeu: 5.572 ± 0.089	2.075GlyMet: 2.075 ± 0.052	3.654GlyAsn: 3.654 ± 0.075	1.504GlyPro: 1.504 ± 0.05	1.83GlyGln: 1.83 ± 0.045	3.551GlyArg: 3.551 ± 0.077	4.071GlySer: 4.071 ± 0.079	3.944GlyThr: 3.944 ± 0.074	5.215GlyVal: 5.215 ± 0.077	0.996GlyTrp: 0.996 ± 0.038	3.168GlyTyr: 3.168 ± 0.074	0.0GlyXaa: 0.0 ± 0.0
His	1.189HisAla: 1.189 ± 0.039	0.294HisCys: 0.294 ± 0.019	1.309HisAsp: 1.309 ± 0.04	1.056HisGlu: 1.056 ± 0.029	0.879HisPhe: 0.879 ± 0.035	1.428HisGly: 1.428 ± 0.038	0.485HisHis: 0.485 ± 0.032	1.489HisIle: 1.489 ± 0.041	0.991HisLys: 0.991 ± 0.037	1.7HisLeu: 1.7 ± 0.046	0.318HisMet: 0.318 ± 0.018	1.029HisAsn: 1.029 ± 0.031	1.051HisPro: 1.051 ± 0.037	0.506HisGln: 0.506 ± 0.026	1.153HisArg: 1.153 ± 0.04	1.227HisSer: 1.227 ± 0.038	0.92HisThr: 0.92 ± 0.031	1.081HisVal: 1.081 ± 0.035	0.225HisTrp: 0.225 ± 0.016	0.923HisTyr: 0.923 ± 0.033	0.0HisXaa: 0.0 ± 0.0
Ile	6.484IleAla: 6.484 ± 0.086	0.816IleCys: 0.816 ± 0.033	5.321IleAsp: 5.321 ± 0.087	4.611IleGlu: 4.611 ± 0.072	2.743IlePhe: 2.743 ± 0.06	4.849IleGly: 4.849 ± 0.086	1.18IleHis: 1.18 ± 0.039	4.92IleIle: 4.92 ± 0.105	4.103IleLys: 4.103 ± 0.073	5.224IleLeu: 5.224 ± 0.095	1.812IleMet: 1.812 ± 0.044	3.75IleAsn: 3.75 ± 0.074	3.113IlePro: 3.113 ± 0.063	1.522IleGln: 1.522 ± 0.041	2.989IleArg: 2.989 ± 0.067	4.506IleSer: 4.506 ± 0.076	4.324IleThr: 4.324 ± 0.064	5.137IleVal: 5.137 ± 0.088	0.623IleTrp: 0.623 ± 0.026	2.696IleTyr: 2.696 ± 0.066	0.0IleXaa: 0.0 ± 0.0
Lys	4.794LysAla: 4.794 ± 0.091	0.558LysCys: 0.558 ± 0.026	3.063LysAsp: 3.063 ± 0.071	4.051LysGlu: 4.051 ± 0.07	2.029LysPhe: 2.029 ± 0.052	3.811LysGly: 3.811 ± 0.063	1.104LysHis: 1.104 ± 0.032	3.765LysIle: 3.765 ± 0.075	3.404LysLys: 3.404 ± 0.081	4.867LysLeu: 4.867 ± 0.075	1.833LysMet: 1.833 ± 0.044	2.585LysAsn: 2.585 ± 0.056	2.224LysPro: 2.224 ± 0.054	1.758LysGln: 1.758 ± 0.048	3.16LysArg: 3.16 ± 0.06	3.755LysSer: 3.755 ± 0.077	2.712LysThr: 2.712 ± 0.062	3.778LysVal: 3.778 ± 0.064	0.8LysTrp: 0.8 ± 0.03	2.418LysTyr: 2.418 ± 0.057	0.0LysXaa: 0.0 ± 0.0
Leu	6.685LeuAla: 6.685 ± 0.103	1.242LeuCys: 1.242 ± 0.038	5.261LeuAsp: 5.261 ± 0.083	4.518LeuGlu: 4.518 ± 0.069	3.519LeuPhe: 3.519 ± 0.067	5.619LeuGly: 5.619 ± 0.1	1.694LeuHis: 1.694 ± 0.049	5.631LeuIle: 5.631 ± 0.096	5.189LeuLys: 5.189 ± 0.074	8.087LeuLeu: 8.087 ± 0.119	2.585LeuMet: 2.585 ± 0.058	4.511LeuAsn: 4.511 ± 0.078	4.085LeuPro: 4.085 ± 0.071	2.619LeuGln: 2.619 ± 0.058	4.786LeuArg: 4.786 ± 0.074	6.744LeuSer: 6.744 ± 0.102	5.268LeuThr: 5.268 ± 0.071	5.145LeuVal: 5.145 ± 0.084	1.069LeuTrp: 1.069 ± 0.037	3.393LeuTyr: 3.393 ± 0.071	0.0LeuXaa: 0.0 ± 0.0
Met	2.434MetAla: 2.434 ± 0.059	0.283MetCys: 0.283 ± 0.018	1.406MetAsp: 1.406 ± 0.036	1.657MetGlu: 1.657 ± 0.045	1.069MetPhe: 1.069 ± 0.036	1.883MetGly: 1.883 ± 0.05	0.525MetHis: 0.525 ± 0.024	1.717MetIle: 1.717 ± 0.039	2.219MetLys: 2.219 ± 0.051	2.842MetLeu: 2.842 ± 0.066	0.988MetMet: 0.988 ± 0.035	1.491MetAsn: 1.491 ± 0.037	1.428MetPro: 1.428 ± 0.043	0.904MetGln: 0.904 ± 0.029	1.64MetArg: 1.64 ± 0.05	2.209MetSer: 2.209 ± 0.053	1.85MetThr: 1.85 ± 0.048	1.625MetVal: 1.625 ± 0.038	0.327MetTrp: 0.327 ± 0.02	0.765MetTyr: 0.765 ± 0.03	0.0MetXaa: 0.0 ± 0.0
Asn	3.885AsnAla: 3.885 ± 0.064	0.5AsnCys: 0.5 ± 0.027	3.157AsnAsp: 3.157 ± 0.068	2.876AsnGlu: 2.876 ± 0.058	1.979AsnPhe: 1.979 ± 0.048	3.892AsnGly: 3.892 ± 0.076	1.015AsnHis: 1.015 ± 0.035	3.571AsnIle: 3.571 ± 0.068	2.546AsnLys: 2.546 ± 0.055	4.126AsnLeu: 4.126 ± 0.069	1.257AsnMet: 1.257 ± 0.036	2.632AsnAsn: 2.632 ± 0.085	2.773AsnPro: 2.773 ± 0.053	1.37AsnGln: 1.37 ± 0.041	2.892AsnArg: 2.892 ± 0.064	2.878AsnSer: 2.878 ± 0.062	2.48AsnThr: 2.48 ± 0.061	3.554AsnVal: 3.554 ± 0.06	0.615AsnTrp: 0.615 ± 0.026	2.128AsnTyr: 2.128 ± 0.044	0.0AsnXaa: 0.0 ± 0.0
Pro	3.189ProAla: 3.189 ± 0.064	0.421ProCys: 0.421 ± 0.018	3.246ProAsp: 3.246 ± 0.062	3.518ProGlu: 3.518 ± 0.07	1.656ProPhe: 1.656 ± 0.044	2.838ProGly: 2.838 ± 0.058	0.795ProHis: 0.795 ± 0.032	2.381ProIle: 2.381 ± 0.052	1.878ProLys: 1.878 ± 0.055	3.293ProLeu: 3.293 ± 0.069	1.081ProMet: 1.081 ± 0.032	1.492ProAsn: 1.492 ± 0.042	0.956ProPro: 0.956 ± 0.037	1.379ProGln: 1.379 ± 0.042	1.759ProArg: 1.759 ± 0.041	2.605ProSer: 2.605 ± 0.055	2.041ProThr: 2.041 ± 0.049	3.375ProVal: 3.375 ± 0.064	0.53ProTrp: 0.53 ± 0.024	1.715ProTyr: 1.715 ± 0.048	0.0ProXaa: 0.0 ± 0.0
Gln	2.253GlnAla: 2.253 ± 0.045	0.329GlnCys: 0.329 ± 0.019	1.222GlnAsp: 1.222 ± 0.034	1.623GlnGlu: 1.623 ± 0.044	1.276GlnPhe: 1.276 ± 0.043	1.801GlnGly: 1.801 ± 0.055	0.591GlnHis: 0.591 ± 0.026	1.869GlnIle: 1.869 ± 0.051	1.532GlnLys: 1.532 ± 0.041	3.014GlnLeu: 3.014 ± 0.067	0.902GlnMet: 0.902 ± 0.032	1.22GlnAsn: 1.22 ± 0.039	1.275GlnPro: 1.275 ± 0.043	1.257GlnGln: 1.257 ± 0.04	1.746GlnArg: 1.746 ± 0.045	1.985GlnSer: 1.985 ± 0.052	1.268GlnThr: 1.268 ± 0.036	1.689GlnVal: 1.689 ± 0.047	0.492GlnTrp: 0.492 ± 0.02	1.305GlnTyr: 1.305 ± 0.04	0.0GlnXaa: 0.0 ± 0.0
Arg	3.341ArgAla: 3.341 ± 0.056	0.576ArgCys: 0.576 ± 0.023	3.32ArgAsp: 3.32 ± 0.066	3.379ArgGlu: 3.379 ± 0.074	2.353ArgPhe: 2.353 ± 0.053	2.992ArgGly: 2.992 ± 0.066	1.396ArgHis: 1.396 ± 0.039	4.049ArgIle: 4.049 ± 0.064	3.25ArgLys: 3.25 ± 0.064	5.101ArgLeu: 5.101 ± 0.084	1.635ArgMet: 1.635 ± 0.044	2.982ArgAsn: 2.982 ± 0.056	1.909ArgPro: 1.909 ± 0.053	1.899ArgGln: 1.899 ± 0.054	3.444ArgArg: 3.444 ± 0.079	2.691ArgSer: 2.691 ± 0.053	2.481ArgThr: 2.481 ± 0.056	3.159ArgVal: 3.159 ± 0.057	0.725ArgTrp: 0.725 ± 0.032	2.705ArgTyr: 2.705 ± 0.065	0.0ArgXaa: 0.0 ± 0.0
Ser	4.791SerAla: 4.791 ± 0.084	0.808SerCys: 0.808 ± 0.033	3.932SerAsp: 3.932 ± 0.066	3.423SerGlu: 3.423 ± 0.065	2.828SerPhe: 2.828 ± 0.058	4.832SerGly: 4.832 ± 0.086	1.305SerHis: 1.305 ± 0.041	4.632SerIle: 4.632 ± 0.076	3.086SerLys: 3.086 ± 0.064	6.163SerLeu: 6.163 ± 0.094	1.917SerMet: 1.917 ± 0.049	2.682SerAsn: 2.682 ± 0.059	2.768SerPro: 2.768 ± 0.06	2.052SerGln: 2.052 ± 0.046	3.932SerArg: 3.932 ± 0.078	4.33SerSer: 4.33 ± 0.093	3.742SerThr: 3.742 ± 0.068	4.278SerVal: 4.278 ± 0.07	0.836SerTrp: 0.836 ± 0.033	2.651SerTyr: 2.651 ± 0.068	0.0SerXaa: 0.0 ± 0.0
Thr	4.434ThrAla: 4.434 ± 0.075	0.527ThrCys: 0.527 ± 0.023	3.441ThrAsp: 3.441 ± 0.067	2.787ThrGlu: 2.787 ± 0.058	2.563ThrPhe: 2.563 ± 0.047	4.151ThrGly: 4.151 ± 0.07	1.042ThrHis: 1.042 ± 0.039	3.991ThrIle: 3.991 ± 0.072	2.357ThrLys: 2.357 ± 0.055	5.401ThrLeu: 5.401 ± 0.081	1.358ThrMet: 1.358 ± 0.035	2.174ThrAsn: 2.174 ± 0.052	3.101ThrPro: 3.101 ± 0.055	1.451ThrGln: 1.451 ± 0.037	2.588ThrArg: 2.588 ± 0.062	3.463ThrSer: 3.463 ± 0.069	3.221ThrThr: 3.221 ± 0.063	4.452ThrVal: 4.452 ± 0.071	0.6ThrTrp: 0.6 ± 0.027	2.161ThrTyr: 2.161 ± 0.051	0.0ThrXaa: 0.0 ± 0.0
Val	5.446ValAla: 5.446 ± 0.093	0.823ValCys: 0.823 ± 0.032	4.67ValAsp: 4.67 ± 0.072	4.141ValGlu: 4.141 ± 0.064	2.488ValPhe: 2.488 ± 0.058	4.181ValGly: 4.181 ± 0.08	1.003ValHis: 1.003 ± 0.036	4.724ValIle: 4.724 ± 0.073	4.287ValLys: 4.287 ± 0.077	5.437ValLeu: 5.437 ± 0.089	2.047ValMet: 2.047 ± 0.044	3.621ValAsn: 3.621 ± 0.062	2.753ValPro: 2.753 ± 0.059	1.49ValGln: 1.49 ± 0.038	3.053ValArg: 3.053 ± 0.063	4.363ValSer: 4.363 ± 0.074	4.781ValThr: 4.781 ± 0.084	4.743ValVal: 4.743 ± 0.08	0.741ValTrp: 0.741 ± 0.03	2.575ValTyr: 2.575 ± 0.052	0.0ValXaa: 0.0 ± 0.0
Trp	0.826TrpAla: 0.826 ± 0.029	0.189TrpCys: 0.189 ± 0.013	0.767TrpAsp: 0.767 ± 0.029	0.688TrpGlu: 0.688 ± 0.029	0.516TrpPhe: 0.516 ± 0.026	0.996TrpGly: 0.996 ± 0.042	0.285TrpHis: 0.285 ± 0.017	0.868TrpIle: 0.868 ± 0.038	0.651TrpLys: 0.651 ± 0.027	1.293TrpLeu: 1.293 ± 0.038	0.392TrpMet: 0.392 ± 0.02	0.754TrpAsn: 0.754 ± 0.033	0.321TrpPro: 0.321 ± 0.018	0.481TrpGln: 0.481 ± 0.025	0.677TrpArg: 0.677 ± 0.028	0.78TrpSer: 0.78 ± 0.028	0.664TrpThr: 0.664 ± 0.029	0.719TrpVal: 0.719 ± 0.035	0.241TrpTrp: 0.241 ± 0.018	0.498TrpTyr: 0.498 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.836TyrAla: 2.836 ± 0.063	0.557TyrCys: 0.557 ± 0.025	2.8TyrAsp: 2.8 ± 0.059	2.144TyrGlu: 2.144 ± 0.044	1.856TyrPhe: 1.856 ± 0.045	2.836TyrGly: 2.836 ± 0.06	0.856TyrHis: 0.856 ± 0.031	2.842TyrIle: 2.842 ± 0.054	2.107TyrLys: 2.107 ± 0.049	3.412TyrLeu: 3.412 ± 0.074	1.09TyrMet: 1.09 ± 0.035	2.556TyrAsn: 2.556 ± 0.062	1.783TyrPro: 1.783 ± 0.046	1.129TyrGln: 1.129 ± 0.038	2.473TyrArg: 2.473 ± 0.054	2.876TyrSer: 2.876 ± 0.069	2.34TyrThr: 2.34 ± 0.048	2.599TyrVal: 2.599 ± 0.056	0.549TyrTrp: 0.549 ± 0.026	1.986TyrTyr: 1.986 ± 0.052	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2650 proteins (924913 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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