Amino acid dipepetide frequency for Sulfuricella denitrificans (strain DSM 22764 / NBRC 105220 / skB26)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.942AlaAla: 11.942 ± 0.141
1.219AlaCys: 1.219 ± 0.041
5.278AlaAsp: 5.278 ± 0.074
6.795AlaGlu: 6.795 ± 0.1
3.527AlaPhe: 3.527 ± 0.068
8.383AlaGly: 8.383 ± 0.12
2.276AlaHis: 2.276 ± 0.047
5.611AlaIle: 5.611 ± 0.085
4.535AlaLys: 4.535 ± 0.083
11.834AlaLeu: 11.834 ± 0.136
3.055AlaMet: 3.055 ± 0.063
3.049AlaAsn: 3.049 ± 0.062
3.909AlaPro: 3.909 ± 0.076
4.275AlaGln: 4.275 ± 0.079
6.183AlaArg: 6.183 ± 0.098
5.575AlaSer: 5.575 ± 0.082
5.001AlaThr: 5.001 ± 0.077
7.375AlaVal: 7.375 ± 0.089
1.346AlaTrp: 1.346 ± 0.041
2.568AlaTyr: 2.568 ± 0.065
0.0AlaXaa: 0.0 ± 0.0
Cys
0.966CysAla: 0.966 ± 0.034
0.13CysCys: 0.13 ± 0.014
0.582CysAsp: 0.582 ± 0.031
0.556CysGlu: 0.556 ± 0.028
0.334CysPhe: 0.334 ± 0.02
1.034CysGly: 1.034 ± 0.038
0.491CysHis: 0.491 ± 0.054
0.433CysIle: 0.433 ± 0.026
0.314CysLys: 0.314 ± 0.019
0.93CysLeu: 0.93 ± 0.036
0.203CysMet: 0.203 ± 0.014
0.315CysAsn: 0.315 ± 0.016
0.557CysPro: 0.557 ± 0.032
0.31CysGln: 0.31 ± 0.019
0.598CysArg: 0.598 ± 0.026
0.585CysSer: 0.585 ± 0.032
0.504CysThr: 0.504 ± 0.023
0.684CysVal: 0.684 ± 0.033
0.118CysTrp: 0.118 ± 0.011
0.265CysTyr: 0.265 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
5.276AspAla: 5.276 ± 0.068
0.498AspCys: 0.498 ± 0.023
2.609AspAsp: 2.609 ± 0.052
3.47AspGlu: 3.47 ± 0.064
2.313AspPhe: 2.313 ± 0.053
4.109AspGly: 4.109 ± 0.075
1.151AspHis: 1.151 ± 0.038
3.071AspIle: 3.071 ± 0.063
2.412AspLys: 2.412 ± 0.058
5.554AspLeu: 5.554 ± 0.079
1.427AspMet: 1.427 ± 0.037
1.635AspAsn: 1.635 ± 0.05
2.621AspPro: 2.621 ± 0.054
1.784AspGln: 1.784 ± 0.041
2.893AspArg: 2.893 ± 0.057
2.716AspSer: 2.716 ± 0.052
2.576AspThr: 2.576 ± 0.054
3.59AspVal: 3.59 ± 0.078
0.836AspTrp: 0.836 ± 0.031
1.713AspTyr: 1.713 ± 0.045
0.0AspXaa: 0.0 ± 0.0
Glu
6.56GluAla: 6.56 ± 0.111
0.456GluCys: 0.456 ± 0.02
2.565GluAsp: 2.565 ± 0.053
3.736GluGlu: 3.736 ± 0.081
2.244GluPhe: 2.244 ± 0.051
3.944GluGly: 3.944 ± 0.063
1.538GluHis: 1.538 ± 0.04
4.186GluIle: 4.186 ± 0.084
3.502GluLys: 3.502 ± 0.068
6.391GluLeu: 6.391 ± 0.091
1.917GluMet: 1.917 ± 0.047
2.132GluAsn: 2.132 ± 0.048
2.266GluPro: 2.266 ± 0.051
2.823GluGln: 2.823 ± 0.07
4.167GluArg: 4.167 ± 0.066
3.229GluSer: 3.229 ± 0.059
3.162GluThr: 3.162 ± 0.063
4.395GluVal: 4.395 ± 0.077
0.836GluTrp: 0.836 ± 0.029
1.409GluTyr: 1.409 ± 0.037
0.0GluXaa: 0.0 ± 0.0
Phe
3.714PheAla: 3.714 ± 0.064
0.416PheCys: 0.416 ± 0.024
2.457PheAsp: 2.457 ± 0.056
2.25PheGlu: 2.25 ± 0.056
1.687PhePhe: 1.687 ± 0.048
3.317PheGly: 3.317 ± 0.065
0.855PheHis: 0.855 ± 0.032
2.097PheIle: 2.097 ± 0.048
1.534PheLys: 1.534 ± 0.04
3.641PheLeu: 3.641 ± 0.069
0.967PheMet: 0.967 ± 0.03
1.365PheAsn: 1.365 ± 0.037
1.65PhePro: 1.65 ± 0.039
1.172PheGln: 1.172 ± 0.033
1.975PheArg: 1.975 ± 0.045
2.766PheSer: 2.766 ± 0.055
1.992PheThr: 1.992 ± 0.05
2.555PheVal: 2.555 ± 0.058
0.532PheTrp: 0.532 ± 0.027
1.162PheTyr: 1.162 ± 0.037
0.0PheXaa: 0.0 ± 0.0
Gly
6.871GlyAla: 6.871 ± 0.088
1.013GlyCys: 1.013 ± 0.038
3.776GlyAsp: 3.776 ± 0.074
4.76GlyGlu: 4.76 ± 0.076
3.312GlyPhe: 3.312 ± 0.058
6.144GlyGly: 6.144 ± 0.112
1.827GlyHis: 1.827 ± 0.043
4.673GlyIle: 4.673 ± 0.074
4.468GlyLys: 4.468 ± 0.086
8.23GlyLeu: 8.23 ± 0.097
2.548GlyMet: 2.548 ± 0.068
2.58GlyAsn: 2.58 ± 0.063
2.132GlyPro: 2.132 ± 0.051
2.895GlyGln: 2.895 ± 0.061
4.39GlyArg: 4.39 ± 0.077
4.436GlySer: 4.436 ± 0.081
3.843GlyThr: 3.843 ± 0.079
6.131GlyVal: 6.131 ± 0.093
1.177GlyTrp: 1.177 ± 0.039
2.434GlyTyr: 2.434 ± 0.053
0.0GlyXaa: 0.0 ± 0.0
His
2.48HisAla: 2.48 ± 0.056
0.285HisCys: 0.285 ± 0.018
1.361HisAsp: 1.361 ± 0.039
1.394HisGlu: 1.394 ± 0.04
1.061HisPhe: 1.061 ± 0.035
2.081HisGly: 2.081 ± 0.053
0.743HisHis: 0.743 ± 0.031
1.299HisIle: 1.299 ± 0.039
0.831HisLys: 0.831 ± 0.032
2.49HisLeu: 2.49 ± 0.053
0.492HisMet: 0.492 ± 0.021
0.716HisAsn: 0.716 ± 0.03
1.486HisPro: 1.486 ± 0.044
0.905HisGln: 0.905 ± 0.035
1.286HisArg: 1.286 ± 0.041
1.246HisSer: 1.246 ± 0.038
1.096HisThr: 1.096 ± 0.036
1.451HisVal: 1.451 ± 0.041
0.342HisTrp: 0.342 ± 0.02
0.811HisTyr: 0.811 ± 0.027
0.0HisXaa: 0.0 ± 0.0
Ile
6.202IleAla: 6.202 ± 0.08
0.517IleCys: 0.517 ± 0.024
3.219IleAsp: 3.219 ± 0.06
3.754IleGlu: 3.754 ± 0.066
1.857IlePhe: 1.857 ± 0.048
4.753IleGly: 4.753 ± 0.075
1.186IleHis: 1.186 ± 0.037
2.695IleIle: 2.695 ± 0.059
2.5IleLys: 2.5 ± 0.052
5.294IleLeu: 5.294 ± 0.074
1.19IleMet: 1.19 ± 0.037
1.989IleAsn: 1.989 ± 0.049
2.809IlePro: 2.809 ± 0.055
1.786IleGln: 1.786 ± 0.046
3.181IleArg: 3.181 ± 0.056
3.574IleSer: 3.574 ± 0.063
3.053IleThr: 3.053 ± 0.061
3.892IleVal: 3.892 ± 0.072
0.581IleTrp: 0.581 ± 0.028
1.457IleTyr: 1.457 ± 0.04
0.0IleXaa: 0.0 ± 0.0
Lys
4.425LysAla: 4.425 ± 0.092
0.313LysCys: 0.313 ± 0.022
2.183LysAsp: 2.183 ± 0.054
2.632LysGlu: 2.632 ± 0.059
1.385LysPhe: 1.385 ± 0.042
3.008LysGly: 3.008 ± 0.065
1.03LysHis: 1.03 ± 0.031
2.816LysIle: 2.816 ± 0.057
2.452LysLys: 2.452 ± 0.074
4.924LysLeu: 4.924 ± 0.067
1.393LysMet: 1.393 ± 0.043
1.713LysAsn: 1.713 ± 0.044
2.487LysPro: 2.487 ± 0.064
1.961LysGln: 1.961 ± 0.051
2.69LysArg: 2.69 ± 0.049
2.537LysSer: 2.537 ± 0.047
2.551LysThr: 2.551 ± 0.057
3.243LysVal: 3.243 ± 0.069
0.474LysTrp: 0.474 ± 0.021
0.958LysTyr: 0.958 ± 0.031
0.0LysXaa: 0.0 ± 0.0
Leu
12.58LeuAla: 12.58 ± 0.127
0.985LeuCys: 0.985 ± 0.037
6.033LeuAsp: 6.033 ± 0.085
6.364LeuGlu: 6.364 ± 0.098
4.149LeuPhe: 4.149 ± 0.072
8.218LeuGly: 8.218 ± 0.099
2.453LeuHis: 2.453 ± 0.056
5.577LeuIle: 5.577 ± 0.079
5.067LeuLys: 5.067 ± 0.083
11.975LeuLeu: 11.975 ± 0.153
2.611LeuMet: 2.611 ± 0.055
3.708LeuAsn: 3.708 ± 0.064
5.727LeuPro: 5.727 ± 0.084
3.768LeuGln: 3.768 ± 0.076
6.657LeuArg: 6.657 ± 0.097
6.67LeuSer: 6.67 ± 0.093
5.7LeuThr: 5.7 ± 0.082
7.194LeuVal: 7.194 ± 0.1
1.173LeuTrp: 1.173 ± 0.037
2.439LeuTyr: 2.439 ± 0.047
0.0LeuXaa: 0.0 ± 0.0
Met
2.938MetAla: 2.938 ± 0.054
0.17MetCys: 0.17 ± 0.014
1.36MetAsp: 1.36 ± 0.041
1.59MetGlu: 1.59 ± 0.046
0.757MetPhe: 0.757 ± 0.028
1.913MetGly: 1.913 ± 0.048
0.627MetHis: 0.627 ± 0.028
1.39MetIle: 1.39 ± 0.041
1.426MetLys: 1.426 ± 0.039
2.903MetLeu: 2.903 ± 0.059
0.704MetMet: 0.704 ± 0.031
1.058MetAsn: 1.058 ± 0.032
1.388MetPro: 1.388 ± 0.038
1.211MetGln: 1.211 ± 0.034
1.661MetArg: 1.661 ± 0.04
1.638MetSer: 1.638 ± 0.039
1.478MetThr: 1.478 ± 0.04
1.921MetVal: 1.921 ± 0.045
0.211MetTrp: 0.211 ± 0.015
0.398MetTyr: 0.398 ± 0.017
0.0MetXaa: 0.0 ± 0.0
Asn
3.085AsnAla: 3.085 ± 0.063
0.357AsnCys: 0.357 ± 0.021
1.611AsnAsp: 1.611 ± 0.044
1.701AsnGlu: 1.701 ± 0.043
1.305AsnPhe: 1.305 ± 0.042
2.55AsnGly: 2.55 ± 0.072
0.779AsnHis: 0.779 ± 0.031
1.991AsnIle: 1.991 ± 0.046
1.298AsnLys: 1.298 ± 0.04
3.876AsnLeu: 3.876 ± 0.068
0.807AsnMet: 0.807 ± 0.03
1.179AsnAsn: 1.179 ± 0.046
2.188AsnPro: 2.188 ± 0.047
1.278AsnGln: 1.278 ± 0.039
2.043AsnArg: 2.043 ± 0.049
1.711AsnSer: 1.711 ± 0.041
1.671AsnThr: 1.671 ± 0.052
2.173AsnVal: 2.173 ± 0.051
0.516AsnTrp: 0.516 ± 0.022
0.954AsnTyr: 0.954 ± 0.032
0.0AsnXaa: 0.0 ± 0.0
Pro
4.824ProAla: 4.824 ± 0.076
0.393ProCys: 0.393 ± 0.021
3.097ProAsp: 3.097 ± 0.058
3.649ProGlu: 3.649 ± 0.058
1.78ProPhe: 1.78 ± 0.046
3.668ProGly: 3.668 ± 0.064
1.091ProHis: 1.091 ± 0.038
2.112ProIle: 2.112 ± 0.044
1.854ProLys: 1.854 ± 0.047
4.859ProLeu: 4.859 ± 0.08
1.156ProMet: 1.156 ± 0.034
1.419ProAsn: 1.419 ± 0.044
2.036ProPro: 2.036 ± 0.049
1.892ProGln: 1.892 ± 0.051
2.174ProArg: 2.174 ± 0.058
2.423ProSer: 2.423 ± 0.052
2.134ProThr: 2.134 ± 0.055
4.039ProVal: 4.039 ± 0.068
0.575ProTrp: 0.575 ± 0.028
1.32ProTyr: 1.32 ± 0.035
0.0ProXaa: 0.0 ± 0.0
Gln
4.448GlnAla: 4.448 ± 0.088
0.337GlnCys: 0.337 ± 0.028
1.808GlnAsp: 1.808 ± 0.044
2.257GlnGlu: 2.257 ± 0.049
1.343GlnPhe: 1.343 ± 0.039
2.911GlnGly: 2.911 ± 0.061
1.032GlnHis: 1.032 ± 0.035
2.278GlnIle: 2.278 ± 0.054
1.67GlnLys: 1.67 ± 0.045
3.967GlnLeu: 3.967 ± 0.07
1.086GlnMet: 1.086 ± 0.035
1.213GlnAsn: 1.213 ± 0.034
1.98GlnPro: 1.98 ± 0.045
1.867GlnGln: 1.867 ± 0.059
2.618GlnArg: 2.618 ± 0.063
2.074GlnSer: 2.074 ± 0.051
1.919GlnThr: 1.919 ± 0.046
2.898GlnVal: 2.898 ± 0.061
0.432GlnTrp: 0.432 ± 0.023
0.871GlnTyr: 0.871 ± 0.031
0.0GlnXaa: 0.0 ± 0.0
Arg
5.254ArgAla: 5.254 ± 0.086
0.509ArgCys: 0.509 ± 0.027
3.21ArgAsp: 3.21 ± 0.056
4.225ArgGlu: 4.225 ± 0.073
2.704ArgPhe: 2.704 ± 0.057
3.716ArgGly: 3.716 ± 0.067
1.667ArgHis: 1.667 ± 0.048
3.702ArgIle: 3.702 ± 0.066
2.638ArgLys: 2.638 ± 0.055
7.051ArgLeu: 7.051 ± 0.099
1.707ArgMet: 1.707 ± 0.05
2.132ArgAsn: 2.132 ± 0.046
2.402ArgPro: 2.402 ± 0.053
2.74ArgGln: 2.74 ± 0.061
3.772ArgArg: 3.772 ± 0.062
2.906ArgSer: 2.906 ± 0.055
2.611ArgThr: 2.611 ± 0.056
4.006ArgVal: 4.006 ± 0.071
0.823ArgTrp: 0.823 ± 0.029
1.952ArgTyr: 1.952 ± 0.047
0.0ArgXaa: 0.0 ± 0.0
Ser
5.672SerAla: 5.672 ± 0.085
0.624SerCys: 0.624 ± 0.03
2.83SerAsp: 2.83 ± 0.055
3.084SerGlu: 3.084 ± 0.056
2.16SerPhe: 2.16 ± 0.044
5.557SerGly: 5.557 ± 0.077
1.394SerHis: 1.394 ± 0.042
3.078SerIle: 3.078 ± 0.061
2.182SerLys: 2.182 ± 0.053
6.263SerLeu: 6.263 ± 0.085
1.474SerMet: 1.474 ± 0.041
1.819SerAsn: 1.819 ± 0.047
2.725SerPro: 2.725 ± 0.058
2.153SerGln: 2.153 ± 0.054
3.542SerArg: 3.542 ± 0.065
3.424SerSer: 3.424 ± 0.063
2.892SerThr: 2.892 ± 0.069
3.883SerVal: 3.883 ± 0.065
0.747SerTrp: 0.747 ± 0.029
1.455SerTyr: 1.455 ± 0.044
0.0SerXaa: 0.0 ± 0.0
Thr
5.112ThrAla: 5.112 ± 0.078
0.507ThrCys: 0.507 ± 0.037
2.495ThrAsp: 2.495 ± 0.055
2.762ThrGlu: 2.762 ± 0.055
1.85ThrPhe: 1.85 ± 0.043
4.457ThrGly: 4.457 ± 0.085
1.208ThrHis: 1.208 ± 0.036
2.61ThrIle: 2.61 ± 0.055
1.7ThrLys: 1.7 ± 0.044
6.254ThrLeu: 6.254 ± 0.101
1.099ThrMet: 1.099 ± 0.032
1.404ThrAsn: 1.404 ± 0.041
3.0ThrPro: 3.0 ± 0.053
1.949ThrGln: 1.949 ± 0.042
2.842ThrArg: 2.842 ± 0.063
2.837ThrSer: 2.837 ± 0.061
2.683ThrThr: 2.683 ± 0.067
3.931ThrVal: 3.931 ± 0.066
0.596ThrTrp: 0.596 ± 0.024
1.236ThrTyr: 1.236 ± 0.041
0.0ThrXaa: 0.0 ± 0.0
Val
7.826ValAla: 7.826 ± 0.1
0.722ValCys: 0.722 ± 0.031
3.795ValAsp: 3.795 ± 0.065
4.547ValGlu: 4.547 ± 0.071
2.641ValPhe: 2.641 ± 0.059
4.967ValGly: 4.967 ± 0.085
1.46ValHis: 1.46 ± 0.038
4.149ValIle: 4.149 ± 0.077
3.236ValLys: 3.236 ± 0.064
7.709ValLeu: 7.709 ± 0.094
2.033ValMet: 2.033 ± 0.055
2.39ValAsn: 2.39 ± 0.054
3.271ValPro: 3.271 ± 0.057
2.272ValGln: 2.272 ± 0.048
4.174ValArg: 4.174 ± 0.065
4.415ValSer: 4.415 ± 0.075
3.799ValThr: 3.799 ± 0.069
5.764ValVal: 5.764 ± 0.091
0.873ValTrp: 0.873 ± 0.032
1.72ValTyr: 1.72 ± 0.042
0.0ValXaa: 0.0 ± 0.0
Trp
1.025TrpAla: 1.025 ± 0.035
0.144TrpCys: 0.144 ± 0.013
0.592TrpAsp: 0.592 ± 0.026
0.632TrpGlu: 0.632 ± 0.028
0.511TrpPhe: 0.511 ± 0.025
0.802TrpGly: 0.802 ± 0.03
0.352TrpHis: 0.352 ± 0.019
0.618TrpIle: 0.618 ± 0.029
0.635TrpLys: 0.635 ± 0.024
1.882TrpLeu: 1.882 ± 0.058
0.338TrpMet: 0.338 ± 0.018
0.422TrpAsn: 0.422 ± 0.023
0.508TrpPro: 0.508 ± 0.022
0.745TrpGln: 0.745 ± 0.031
0.965TrpArg: 0.965 ± 0.031
0.63TrpSer: 0.63 ± 0.026
0.516TrpThr: 0.516 ± 0.021
0.974TrpVal: 0.974 ± 0.031
0.182TrpTrp: 0.182 ± 0.014
0.304TrpTyr: 0.304 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.537TyrAla: 2.537 ± 0.054
0.31TyrCys: 0.31 ± 0.02
1.395TyrAsp: 1.395 ± 0.04
1.3TyrGlu: 1.3 ± 0.034
1.183TyrPhe: 1.183 ± 0.036
2.106TyrGly: 2.106 ± 0.044
0.697TyrHis: 0.697 ± 0.029
1.104TyrIle: 1.104 ± 0.037
0.919TyrLys: 0.919 ± 0.035
3.021TyrLeu: 3.021 ± 0.054
0.534TyrMet: 0.534 ± 0.024
0.837TyrAsn: 0.837 ± 0.034
1.352TyrPro: 1.352 ± 0.037
1.224TyrGln: 1.224 ± 0.036
1.919TyrArg: 1.919 ± 0.042
1.566TyrSer: 1.566 ± 0.047
1.352TyrThr: 1.352 ± 0.045
1.664TyrVal: 1.664 ± 0.043
0.408TyrTrp: 0.408 ± 0.02
0.826TyrTyr: 0.826 ± 0.033
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3071 proteins (966249 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski