Amino acid dipepetide frequency for Sediminicola luteus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.38AlaAla: 5.38 ± 0.112	0.648AlaCys: 0.648 ± 0.026	4.19AlaAsp: 4.19 ± 0.089	4.665AlaGlu: 4.665 ± 0.08	3.659AlaPhe: 3.659 ± 0.056	4.843AlaGly: 4.843 ± 0.085	1.734AlaHis: 1.734 ± 0.039	4.92AlaIle: 4.92 ± 0.071	4.646AlaLys: 4.646 ± 0.081	8.108AlaLeu: 8.108 ± 0.099	1.903AlaMet: 1.903 ± 0.038	3.542AlaAsn: 3.542 ± 0.094	2.65AlaPro: 2.65 ± 0.063	4.23AlaGln: 4.23 ± 0.062	2.531AlaArg: 2.531 ± 0.047	4.25AlaSer: 4.25 ± 0.066	4.204AlaThr: 4.204 ± 0.104	4.484AlaVal: 4.484 ± 0.07	0.848AlaTrp: 0.848 ± 0.029	2.98AlaTyr: 2.98 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	0.509CysAla: 0.509 ± 0.022	0.102CysCys: 0.102 ± 0.009	0.457CysAsp: 0.457 ± 0.032	0.445CysGlu: 0.445 ± 0.027	0.384CysPhe: 0.384 ± 0.019	0.628CysGly: 0.628 ± 0.029	0.247CysHis: 0.247 ± 0.016	0.527CysIle: 0.527 ± 0.022	0.398CysLys: 0.398 ± 0.016	0.687CysLeu: 0.687 ± 0.025	0.179CysMet: 0.179 ± 0.012	0.333CysAsn: 0.333 ± 0.023	0.363CysPro: 0.363 ± 0.025	0.276CysGln: 0.276 ± 0.015	0.246CysArg: 0.246 ± 0.013	0.519CysSer: 0.519 ± 0.027	0.483CysThr: 0.483 ± 0.029	0.412CysVal: 0.412 ± 0.02	0.081CysTrp: 0.081 ± 0.007	0.289CysTyr: 0.289 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	4.446AspAla: 4.446 ± 0.082	0.454AspCys: 0.454 ± 0.039	2.99AspAsp: 2.99 ± 0.109	2.997AspGlu: 2.997 ± 0.061	3.634AspPhe: 3.634 ± 0.064	4.709AspGly: 4.709 ± 0.119	1.218AspHis: 1.218 ± 0.033	3.916AspIle: 3.916 ± 0.06	3.41AspLys: 3.41 ± 0.06	5.609AspLeu: 5.609 ± 0.081	1.32AspMet: 1.32 ± 0.033	2.797AspAsn: 2.797 ± 0.086	2.516AspPro: 2.516 ± 0.061	2.167AspGln: 2.167 ± 0.05	2.508AspArg: 2.508 ± 0.046	3.293AspSer: 3.293 ± 0.068	3.407AspThr: 3.407 ± 0.087	3.334AspVal: 3.334 ± 0.061	0.912AspTrp: 0.912 ± 0.027	2.867AspTyr: 2.867 ± 0.05	0.0AspXaa: 0.0 ± 0.0
Glu	5.395GluAla: 5.395 ± 0.08	0.308GluCys: 0.308 ± 0.016	3.212GluAsp: 3.212 ± 0.066	3.95GluGlu: 3.95 ± 0.077	2.528GluPhe: 2.528 ± 0.04	4.184GluGly: 4.184 ± 0.059	1.234GluHis: 1.234 ± 0.028	4.356GluIle: 4.356 ± 0.067	5.062GluLys: 5.062 ± 0.075	6.166GluLeu: 6.166 ± 0.076	1.668GluMet: 1.668 ± 0.038	3.671GluAsn: 3.671 ± 0.057	1.789GluPro: 1.789 ± 0.039	2.425GluGln: 2.425 ± 0.044	2.818GluArg: 2.818 ± 0.049	3.157GluSer: 3.157 ± 0.054	3.71GluThr: 3.71 ± 0.055	4.405GluVal: 4.405 ± 0.065	0.665GluTrp: 0.665 ± 0.022	2.158GluTyr: 2.158 ± 0.045	0.0GluXaa: 0.0 ± 0.0
Phe	3.165PheAla: 3.165 ± 0.053	0.416PheCys: 0.416 ± 0.017	3.281PheAsp: 3.281 ± 0.044	3.336PheGlu: 3.336 ± 0.05	2.496PhePhe: 2.496 ± 0.056	3.748PheGly: 3.748 ± 0.058	0.923PheHis: 0.923 ± 0.026	2.855PheIle: 2.855 ± 0.047	3.0PheLys: 3.0 ± 0.054	4.585PheLeu: 4.585 ± 0.084	1.21PheMet: 1.21 ± 0.035	2.59PheAsn: 2.59 ± 0.048	1.849PhePro: 1.849 ± 0.04	1.559PheGln: 1.559 ± 0.035	1.789PheArg: 1.789 ± 0.036	3.579PheSer: 3.579 ± 0.059	2.941PheThr: 2.941 ± 0.055	3.086PheVal: 3.086 ± 0.051	0.664PheTrp: 0.664 ± 0.027	1.978PheTyr: 1.978 ± 0.041	0.0PheXaa: 0.0 ± 0.0
Gly	5.021GlyAla: 5.021 ± 0.077	0.729GlyCys: 0.729 ± 0.044	3.85GlyAsp: 3.85 ± 0.074	3.79GlyGlu: 3.79 ± 0.061	4.042GlyPhe: 4.042 ± 0.07	5.117GlyGly: 5.117 ± 0.095	1.545GlyHis: 1.545 ± 0.035	5.293GlyIle: 5.293 ± 0.081	5.083GlyLys: 5.083 ± 0.078	7.001GlyLeu: 7.001 ± 0.073	1.988GlyMet: 1.988 ± 0.041	3.924GlyAsn: 3.924 ± 0.095	2.044GlyPro: 2.044 ± 0.044	2.875GlyGln: 2.875 ± 0.051	2.683GlyArg: 2.683 ± 0.049	4.528GlySer: 4.528 ± 0.084	4.508GlyThr: 4.508 ± 0.104	4.786GlyVal: 4.786 ± 0.066	0.938GlyTrp: 0.938 ± 0.025	3.309GlyTyr: 3.309 ± 0.055	0.0GlyXaa: 0.0 ± 0.0
His	1.315HisAla: 1.315 ± 0.037	0.216HisCys: 0.216 ± 0.015	0.979HisAsp: 0.979 ± 0.027	1.067HisGlu: 1.067 ± 0.028	1.295HisPhe: 1.295 ± 0.035	1.511HisGly: 1.511 ± 0.038	0.544HisHis: 0.544 ± 0.023	1.553HisIle: 1.553 ± 0.034	1.257HisLys: 1.257 ± 0.032	2.11HisLeu: 2.11 ± 0.043	0.479HisMet: 0.479 ± 0.017	0.958HisAsn: 0.958 ± 0.027	1.069HisPro: 1.069 ± 0.033	0.869HisGln: 0.869 ± 0.025	0.928HisArg: 0.928 ± 0.027	1.161HisSer: 1.161 ± 0.032	1.219HisThr: 1.219 ± 0.031	1.06HisVal: 1.06 ± 0.029	0.347HisTrp: 0.347 ± 0.017	0.988HisTyr: 0.988 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	4.982IleAla: 4.982 ± 0.078	0.539IleCys: 0.539 ± 0.022	4.245IleAsp: 4.245 ± 0.067	4.133IleGlu: 4.133 ± 0.06	2.706IlePhe: 2.706 ± 0.05	5.043IleGly: 5.043 ± 0.073	1.3IleHis: 1.3 ± 0.035	3.779IleIle: 3.779 ± 0.067	3.995IleLys: 3.995 ± 0.07	5.758IleLeu: 5.758 ± 0.078	1.279IleMet: 1.279 ± 0.032	3.207IleAsn: 3.207 ± 0.057	3.151IlePro: 3.151 ± 0.056	2.492IleGln: 2.492 ± 0.045	2.814IleArg: 2.814 ± 0.05	4.47IleSer: 4.47 ± 0.06	3.894IleThr: 3.894 ± 0.082	3.786IleVal: 3.786 ± 0.064	0.679IleTrp: 0.679 ± 0.026	2.159IleTyr: 2.159 ± 0.041	0.0IleXaa: 0.0 ± 0.0
Lys	5.243LysAla: 5.243 ± 0.086	0.249LysCys: 0.249 ± 0.014	3.626LysAsp: 3.626 ± 0.067	4.816LysGlu: 4.816 ± 0.07	2.077LysPhe: 2.077 ± 0.044	4.704LysGly: 4.704 ± 0.067	1.334LysHis: 1.334 ± 0.034	4.178LysIle: 4.178 ± 0.071	5.585LysLys: 5.585 ± 0.095	5.414LysLeu: 5.414 ± 0.086	1.742LysMet: 1.742 ± 0.04	3.617LysAsn: 3.617 ± 0.059	2.437LysPro: 2.437 ± 0.043	2.427LysGln: 2.427 ± 0.043	2.972LysArg: 2.972 ± 0.059	3.568LysSer: 3.568 ± 0.055	4.01LysThr: 4.01 ± 0.064	4.222LysVal: 4.222 ± 0.061	0.78LysTrp: 0.78 ± 0.024	2.224LysTyr: 2.224 ± 0.043	0.0LysXaa: 0.0 ± 0.0
Leu	7.615LeuAla: 7.615 ± 0.097	0.785LeuCys: 0.785 ± 0.028	6.068LeuAsp: 6.068 ± 0.077	6.743LeuGlu: 6.743 ± 0.091	4.804LeuPhe: 4.804 ± 0.08	7.121LeuGly: 7.121 ± 0.08	1.784LeuHis: 1.784 ± 0.04	5.721LeuIle: 5.721 ± 0.093	6.367LeuLys: 6.367 ± 0.089	9.301LeuLeu: 9.301 ± 0.131	2.258LeuMet: 2.258 ± 0.053	4.731LeuAsn: 4.731 ± 0.074	4.156LeuPro: 4.156 ± 0.058	3.565LeuGln: 3.565 ± 0.058	3.799LeuArg: 3.799 ± 0.06	6.395LeuSer: 6.395 ± 0.085	5.292LeuThr: 5.292 ± 0.086	6.131LeuVal: 6.131 ± 0.08	1.164LeuTrp: 1.164 ± 0.032	3.314LeuTyr: 3.314 ± 0.053	0.0LeuXaa: 0.0 ± 0.0
Met	2.498MetAla: 2.498 ± 0.047	0.122MetCys: 0.122 ± 0.009	1.556MetAsp: 1.556 ± 0.036	1.846MetGlu: 1.846 ± 0.041	0.881MetPhe: 0.881 ± 0.034	2.061MetGly: 2.061 ± 0.04	0.468MetHis: 0.468 ± 0.018	1.251MetIle: 1.251 ± 0.034	1.655MetLys: 1.655 ± 0.041	1.98MetLeu: 1.98 ± 0.044	0.543MetMet: 0.543 ± 0.022	0.994MetAsn: 0.994 ± 0.03	1.081MetPro: 1.081 ± 0.029	0.928MetGln: 0.928 ± 0.027	1.057MetArg: 1.057 ± 0.031	1.167MetSer: 1.167 ± 0.034	1.123MetThr: 1.123 ± 0.031	1.795MetVal: 1.795 ± 0.039	0.214MetTrp: 0.214 ± 0.014	0.654MetTyr: 0.654 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.772AsnAla: 3.772 ± 0.072	0.386AsnCys: 0.386 ± 0.026	2.971AsnAsp: 2.971 ± 0.079	2.853AsnGlu: 2.853 ± 0.059	2.204AsnPhe: 2.204 ± 0.049	4.433AsnGly: 4.433 ± 0.112	1.072AsnHis: 1.072 ± 0.029	3.154AsnIle: 3.154 ± 0.058	2.652AsnLys: 2.652 ± 0.049	4.774AsnLeu: 4.774 ± 0.074	1.095AsnMet: 1.095 ± 0.034	2.533AsnAsn: 2.533 ± 0.067	2.791AsnPro: 2.791 ± 0.052	2.225AsnGln: 2.225 ± 0.044	2.252AsnArg: 2.252 ± 0.051	2.767AsnSer: 2.767 ± 0.051	3.347AsnThr: 3.347 ± 0.075	2.748AsnVal: 2.748 ± 0.057	0.684AsnTrp: 0.684 ± 0.028	2.111AsnTyr: 2.111 ± 0.046	0.0AsnXaa: 0.0 ± 0.0
Pro	2.509ProAla: 2.509 ± 0.063	0.236ProCys: 0.236 ± 0.015	2.586ProAsp: 2.586 ± 0.069	3.336ProGlu: 3.336 ± 0.06	2.036ProPhe: 2.036 ± 0.043	2.507ProGly: 2.507 ± 0.052	0.856ProHis: 0.856 ± 0.025	2.731ProIle: 2.731 ± 0.043	2.957ProLys: 2.957 ± 0.061	3.616ProLeu: 3.616 ± 0.065	1.013ProMet: 1.013 ± 0.029	2.393ProAsn: 2.393 ± 0.058	1.066ProPro: 1.066 ± 0.035	1.534ProGln: 1.534 ± 0.035	1.17ProArg: 1.17 ± 0.034	2.329ProSer: 2.329 ± 0.039	2.312ProThr: 2.312 ± 0.051	2.492ProVal: 2.492 ± 0.046	0.504ProTrp: 0.504 ± 0.021	1.594ProTyr: 1.594 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	3.062GlnAla: 3.062 ± 0.06	0.229GlnCys: 0.229 ± 0.014	2.033GlnAsp: 2.033 ± 0.04	2.809GlnGlu: 2.809 ± 0.052	1.61GlnPhe: 1.61 ± 0.035	2.839GlnGly: 2.839 ± 0.048	0.818GlnHis: 0.818 ± 0.025	2.585GlnIle: 2.585 ± 0.049	2.803GlnLys: 2.803 ± 0.051	4.224GlnLeu: 4.224 ± 0.064	1.107GlnMet: 1.107 ± 0.027	2.059GlnAsn: 2.059 ± 0.042	1.388GlnPro: 1.388 ± 0.031	1.757GlnGln: 1.757 ± 0.048	1.644GlnArg: 1.644 ± 0.042	2.042GlnSer: 2.042 ± 0.041	2.14GlnThr: 2.14 ± 0.048	2.551GlnVal: 2.551 ± 0.046	0.673GlnTrp: 0.673 ± 0.023	1.406GlnTyr: 1.406 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	2.553ArgAla: 2.553 ± 0.045	0.215ArgCys: 0.215 ± 0.013	2.015ArgAsp: 2.015 ± 0.043	2.345ArgGlu: 2.345 ± 0.046	2.429ArgPhe: 2.429 ± 0.04	2.212ArgGly: 2.212 ± 0.044	0.819ArgHis: 0.819 ± 0.027	3.154ArgIle: 3.154 ± 0.05	2.97ArgLys: 2.97 ± 0.053	4.144ArgLeu: 4.144 ± 0.073	1.136ArgMet: 1.136 ± 0.03	2.167ArgAsn: 2.167 ± 0.041	1.544ArgPro: 1.544 ± 0.035	1.391ArgGln: 1.391 ± 0.035	1.5ArgArg: 1.5 ± 0.035	2.236ArgSer: 2.236 ± 0.049	2.142ArgThr: 2.142 ± 0.044	2.45ArgVal: 2.45 ± 0.048	0.536ArgTrp: 0.536 ± 0.021	1.849ArgTyr: 1.849 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	3.949SerAla: 3.949 ± 0.064	0.669SerCys: 0.669 ± 0.03	3.467SerAsp: 3.467 ± 0.064	3.595SerGlu: 3.595 ± 0.051	3.374SerPhe: 3.374 ± 0.053	5.003SerGly: 5.003 ± 0.087	1.14SerHis: 1.14 ± 0.029	3.947SerIle: 3.947 ± 0.062	3.642SerLys: 3.642 ± 0.064	6.029SerLeu: 6.029 ± 0.073	1.323SerMet: 1.323 ± 0.033	2.803SerAsn: 2.803 ± 0.062	2.534SerPro: 2.534 ± 0.056	2.151SerGln: 2.151 ± 0.04	2.251SerArg: 2.251 ± 0.046	3.36SerSer: 3.36 ± 0.064	3.205SerThr: 3.205 ± 0.061	3.87SerVal: 3.87 ± 0.059	0.81SerTrp: 0.81 ± 0.032	2.4SerTyr: 2.4 ± 0.045	0.0SerXaa: 0.0 ± 0.0
Thr	4.345ThrAla: 4.345 ± 0.092	0.296ThrCys: 0.296 ± 0.019	4.024ThrAsp: 4.024 ± 0.103	3.697ThrGlu: 3.697 ± 0.058	2.688ThrPhe: 2.688 ± 0.054	4.294ThrGly: 4.294 ± 0.091	1.391ThrHis: 1.391 ± 0.029	3.852ThrIle: 3.852 ± 0.077	3.0ThrLys: 3.0 ± 0.056	5.94ThrLeu: 5.94 ± 0.076	1.038ThrMet: 1.038 ± 0.029	2.704ThrAsn: 2.704 ± 0.076	2.765ThrPro: 2.765 ± 0.064	2.696ThrGln: 2.696 ± 0.05	1.811ThrArg: 1.811 ± 0.042	3.141ThrSer: 3.141 ± 0.06	3.437ThrThr: 3.437 ± 0.093	3.91ThrVal: 3.91 ± 0.095	0.643ThrTrp: 0.643 ± 0.027	2.465ThrTyr: 2.465 ± 0.056	0.0ThrXaa: 0.0 ± 0.0
Val	5.002ValAla: 5.002 ± 0.073	0.549ValCys: 0.549 ± 0.022	3.818ValAsp: 3.818 ± 0.066	3.404ValGlu: 3.404 ± 0.053	3.374ValPhe: 3.374 ± 0.062	4.241ValGly: 4.241 ± 0.059	1.227ValHis: 1.227 ± 0.034	3.727ValIle: 3.727 ± 0.065	3.634ValLys: 3.634 ± 0.064	6.562ValLeu: 6.562 ± 0.076	1.454ValMet: 1.454 ± 0.03	3.169ValAsn: 3.169 ± 0.06	2.572ValPro: 2.572 ± 0.053	2.002ValGln: 2.002 ± 0.043	2.479ValArg: 2.479 ± 0.046	4.569ValSer: 4.569 ± 0.066	3.626ValThr: 3.626 ± 0.095	4.503ValVal: 4.503 ± 0.064	0.75ValTrp: 0.75 ± 0.028	2.474ValTyr: 2.474 ± 0.047	0.0ValXaa: 0.0 ± 0.0
Trp	0.909TrpAla: 0.909 ± 0.028	0.103TrpCys: 0.103 ± 0.008	0.773TrpAsp: 0.773 ± 0.031	0.864TrpGlu: 0.864 ± 0.027	0.626TrpPhe: 0.626 ± 0.022	0.92TrpGly: 0.92 ± 0.027	0.321TrpHis: 0.321 ± 0.016	0.695TrpIle: 0.695 ± 0.022	0.785TrpLys: 0.785 ± 0.026	1.192TrpLeu: 1.192 ± 0.027	0.334TrpMet: 0.334 ± 0.016	0.7TrpAsn: 0.7 ± 0.031	0.388TrpPro: 0.388 ± 0.019	0.608TrpGln: 0.608 ± 0.021	0.525TrpArg: 0.525 ± 0.021	0.698TrpSer: 0.698 ± 0.026	0.598TrpThr: 0.598 ± 0.025	0.895TrpVal: 0.895 ± 0.026	0.19TrpTrp: 0.19 ± 0.014	0.481TrpTyr: 0.481 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.743TyrAla: 2.743 ± 0.042	0.311TyrCys: 0.311 ± 0.016	2.362TyrAsp: 2.362 ± 0.042	2.171TyrGlu: 2.171 ± 0.041	2.205TyrPhe: 2.205 ± 0.044	2.937TyrGly: 2.937 ± 0.046	0.95TyrHis: 0.95 ± 0.029	2.217TyrIle: 2.217 ± 0.044	2.323TyrLys: 2.323 ± 0.043	3.914TyrLeu: 3.914 ± 0.057	0.804TyrMet: 0.804 ± 0.026	1.935TyrAsn: 1.935 ± 0.041	1.624TyrPro: 1.624 ± 0.034	1.603TyrGln: 1.603 ± 0.04	2.033TyrArg: 2.033 ± 0.041	2.294TyrSer: 2.294 ± 0.044	2.538TyrThr: 2.538 ± 0.051	2.211TyrVal: 2.211 ± 0.043	0.525TyrTrp: 0.525 ± 0.019	1.713TyrTyr: 1.713 ± 0.043	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3771 proteins (1364760 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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