Amino acid dipepetide frequency for Apis mellifera associated microvirus 32

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.235AlaAla: 13.235 ± 2.844
0.735AlaCys: 0.735 ± 0.663
4.412AlaAsp: 4.412 ± 1.213
6.618AlaGlu: 6.618 ± 1.855
2.206AlaPhe: 2.206 ± 1.568
5.147AlaGly: 5.147 ± 1.68
1.471AlaHis: 1.471 ± 0.894
2.941AlaIle: 2.941 ± 0.969
2.941AlaLys: 2.941 ± 1.596
8.824AlaLeu: 8.824 ± 1.708
1.471AlaMet: 1.471 ± 0.894
4.412AlaAsn: 4.412 ± 2.405
4.412AlaPro: 4.412 ± 1.609
3.676AlaGln: 3.676 ± 1.083
8.088AlaArg: 8.088 ± 0.807
8.088AlaSer: 8.088 ± 2.508
5.882AlaThr: 5.882 ± 1.836
6.618AlaVal: 6.618 ± 2.857
0.735AlaTrp: 0.735 ± 0.8
2.206AlaTyr: 2.206 ± 0.702
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
0.0CysAsp: 0.0 ± 0.0
0.735CysGlu: 0.735 ± 0.663
0.0CysPhe: 0.0 ± 0.0
0.735CysGly: 0.735 ± 0.663
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
0.0CysLys: 0.0 ± 0.0
3.676CysLeu: 3.676 ± 0.907
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
0.735CysArg: 0.735 ± 0.663
0.0CysSer: 0.0 ± 0.0
0.735CysThr: 0.735 ± 0.663
0.735CysVal: 0.735 ± 0.663
0.0CysTrp: 0.0 ± 0.0
0.735CysTyr: 0.735 ± 0.663
0.0CysXaa: 0.0 ± 0.0
Asp
7.353AspAla: 7.353 ± 1.215
0.0AspCys: 0.0 ± 0.0
2.941AspAsp: 2.941 ± 0.969
2.941AspGlu: 2.941 ± 0.936
3.676AspPhe: 3.676 ± 1.463
1.471AspGly: 1.471 ± 0.844
1.471AspHis: 1.471 ± 0.892
2.941AspIle: 2.941 ± 1.42
1.471AspLys: 1.471 ± 0.894
2.206AspLeu: 2.206 ± 1.202
1.471AspMet: 1.471 ± 0.749
3.676AspAsn: 3.676 ± 1.814
3.676AspPro: 3.676 ± 0.907
1.471AspGln: 1.471 ± 0.844
3.676AspArg: 3.676 ± 0.907
4.412AspSer: 4.412 ± 1.213
4.412AspThr: 4.412 ± 2.033
2.206AspVal: 2.206 ± 1.12
0.0AspTrp: 0.0 ± 0.0
3.676AspTyr: 3.676 ± 2.423
0.0AspXaa: 0.0 ± 0.0
Glu
5.882GluAla: 5.882 ± 1.318
0.0GluCys: 0.0 ± 0.0
2.206GluAsp: 2.206 ± 1.398
2.206GluGlu: 2.206 ± 1.409
5.147GluPhe: 5.147 ± 1.644
2.206GluGly: 2.206 ± 0.702
1.471GluHis: 1.471 ± 0.654
2.206GluIle: 2.206 ± 0.616
1.471GluLys: 1.471 ± 0.926
5.882GluLeu: 5.882 ± 1.399
0.0GluMet: 0.0 ± 0.0
2.941GluAsn: 2.941 ± 1.814
2.941GluPro: 2.941 ± 1.505
2.941GluGln: 2.941 ± 1.308
4.412GluArg: 4.412 ± 1.28
5.147GluSer: 5.147 ± 2.295
2.941GluThr: 2.941 ± 0.936
5.147GluVal: 5.147 ± 1.814
0.735GluTrp: 0.735 ± 0.485
1.471GluTyr: 1.471 ± 0.489
0.0GluXaa: 0.0 ± 0.0
Phe
5.147PheAla: 5.147 ± 2.871
0.0PheCys: 0.0 ± 0.0
2.941PheAsp: 2.941 ± 0.969
5.147PheGlu: 5.147 ± 3.209
1.471PhePhe: 1.471 ± 0.948
4.412PheGly: 4.412 ± 1.489
1.471PheHis: 1.471 ± 1.327
0.735PheIle: 0.735 ± 0.485
1.471PheLys: 1.471 ± 0.926
4.412PheLeu: 4.412 ± 1.042
0.0PheMet: 0.0 ± 0.0
0.735PheAsn: 0.735 ± 0.485
1.471PhePro: 1.471 ± 0.948
2.941PheGln: 2.941 ± 0.612
4.412PheArg: 4.412 ± 2.386
2.206PheSer: 2.206 ± 0.713
2.206PheThr: 2.206 ± 1.119
2.206PheVal: 2.206 ± 0.713
1.471PheTrp: 1.471 ± 0.489
0.0PheTyr: 0.0 ± 0.0
0.0PheXaa: 0.0 ± 0.0
Gly
5.882GlyAla: 5.882 ± 3.022
0.735GlyCys: 0.735 ± 0.663
2.941GlyAsp: 2.941 ± 1.289
4.412GlyGlu: 4.412 ± 1.945
3.676GlyPhe: 3.676 ± 1.837
5.882GlyGly: 5.882 ± 1.406
0.0GlyHis: 0.0 ± 0.0
3.676GlyIle: 3.676 ± 0.511
2.941GlyLys: 2.941 ± 2.053
10.294GlyLeu: 10.294 ± 2.071
1.471GlyMet: 1.471 ± 0.844
2.206GlyAsn: 2.206 ± 0.804
3.676GlyPro: 3.676 ± 0.511
2.941GlyGln: 2.941 ± 0.774
2.941GlyArg: 2.941 ± 1.699
8.824GlySer: 8.824 ± 1.723
2.941GlyThr: 2.941 ± 0.774
2.941GlyVal: 2.941 ± 1.243
0.0GlyTrp: 0.0 ± 0.0
1.471GlyTyr: 1.471 ± 0.489
0.0GlyXaa: 0.0 ± 0.0
His
0.735HisAla: 0.735 ± 0.485
0.735HisCys: 0.735 ± 0.8
2.206HisAsp: 2.206 ± 1.398
0.0HisGlu: 0.0 ± 0.0
1.471HisPhe: 1.471 ± 0.969
1.471HisGly: 1.471 ± 0.489
1.471HisHis: 1.471 ± 1.327
0.0HisIle: 0.0 ± 0.0
1.471HisLys: 1.471 ± 0.489
2.206HisLeu: 2.206 ± 0.616
0.735HisMet: 0.735 ± 0.663
0.0HisAsn: 0.0 ± 0.0
1.471HisPro: 1.471 ± 1.321
0.735HisGln: 0.735 ± 0.642
2.206HisArg: 2.206 ± 1.283
2.206HisSer: 2.206 ± 0.9
0.0HisThr: 0.0 ± 0.0
0.735HisVal: 0.735 ± 0.485
2.206HisTrp: 2.206 ± 1.454
0.735HisTyr: 0.735 ± 0.663
0.0HisXaa: 0.0 ± 0.0
Ile
2.941IleAla: 2.941 ± 0.654
0.0IleCys: 0.0 ± 0.0
3.676IleAsp: 3.676 ± 1.564
0.735IleGlu: 0.735 ± 0.485
2.206IlePhe: 2.206 ± 1.454
2.206IleGly: 2.206 ± 1.202
0.0IleHis: 0.0 ± 0.0
1.471IleIle: 1.471 ± 0.844
2.941IleLys: 2.941 ± 2.504
2.206IleLeu: 2.206 ± 0.616
1.471IleMet: 1.471 ± 1.069
3.676IleAsn: 3.676 ± 1.922
2.206IlePro: 2.206 ± 0.713
0.735IleGln: 0.735 ± 0.663
2.206IleArg: 2.206 ± 0.702
2.206IleSer: 2.206 ± 0.979
0.735IleThr: 0.735 ± 0.485
2.206IleVal: 2.206 ± 1.454
0.735IleTrp: 0.735 ± 0.485
1.471IleTyr: 1.471 ± 0.489
0.0IleXaa: 0.0 ± 0.0
Lys
2.206LysAla: 2.206 ± 1.598
0.0LysCys: 0.0 ± 0.0
1.471LysAsp: 1.471 ± 0.948
4.412LysGlu: 4.412 ± 1.572
1.471LysPhe: 1.471 ± 0.654
5.882LysGly: 5.882 ± 1.909
0.735LysHis: 0.735 ± 0.663
2.206LysIle: 2.206 ± 0.804
4.412LysLys: 4.412 ± 2.179
2.941LysLeu: 2.941 ± 2.306
1.471LysMet: 1.471 ± 1.285
2.206LysAsn: 2.206 ± 0.979
2.206LysPro: 2.206 ± 1.06
2.206LysGln: 2.206 ± 1.571
3.676LysArg: 3.676 ± 1.641
5.882LysSer: 5.882 ± 2.753
1.471LysThr: 1.471 ± 0.654
2.206LysVal: 2.206 ± 1.733
0.0LysTrp: 0.0 ± 0.0
2.206LysTyr: 2.206 ± 1.409
0.0LysXaa: 0.0 ± 0.0
Leu
6.618LeuAla: 6.618 ± 2.525
0.0LeuCys: 0.0 ± 0.0
6.618LeuAsp: 6.618 ± 1.833
5.882LeuGlu: 5.882 ± 2.321
4.412LeuPhe: 4.412 ± 2.976
3.676LeuGly: 3.676 ± 1.564
2.941LeuHis: 2.941 ± 2.307
2.206LeuIle: 2.206 ± 0.616
9.559LeuLys: 9.559 ± 4.042
5.882LeuLeu: 5.882 ± 0.861
1.471LeuMet: 1.471 ± 0.696
2.941LeuAsn: 2.941 ± 0.972
10.294LeuPro: 10.294 ± 2.311
1.471LeuGln: 1.471 ± 0.969
7.353LeuArg: 7.353 ± 2.454
2.206LeuSer: 2.206 ± 0.955
8.088LeuThr: 8.088 ± 2.065
4.412LeuVal: 4.412 ± 1.213
0.735LeuTrp: 0.735 ± 0.663
1.471LeuTyr: 1.471 ± 0.969
0.0LeuXaa: 0.0 ± 0.0
Met
2.206MetAla: 2.206 ± 1.927
0.0MetCys: 0.0 ± 0.0
1.471MetAsp: 1.471 ± 0.948
1.471MetGlu: 1.471 ± 1.285
0.0MetPhe: 0.0 ± 0.0
1.471MetGly: 1.471 ± 0.969
0.0MetHis: 0.0 ± 0.0
0.735MetIle: 0.735 ± 0.663
2.941MetLys: 2.941 ± 1.377
2.206MetLeu: 2.206 ± 0.9
0.0MetMet: 0.0 ± 0.0
1.471MetAsn: 1.471 ± 0.654
2.206MetPro: 2.206 ± 0.702
0.735MetGln: 0.735 ± 0.642
0.0MetArg: 0.0 ± 0.0
2.941MetSer: 2.941 ± 0.612
1.471MetThr: 1.471 ± 0.844
1.471MetVal: 1.471 ± 0.489
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
2.206AsnAla: 2.206 ± 0.955
1.471AsnCys: 1.471 ± 0.489
2.206AsnAsp: 2.206 ± 1.202
2.941AsnGlu: 2.941 ± 0.972
0.735AsnPhe: 0.735 ± 0.8
1.471AsnGly: 1.471 ± 0.926
0.735AsnHis: 0.735 ± 0.485
2.206AsnIle: 2.206 ± 1.333
1.471AsnLys: 1.471 ± 0.844
4.412AsnLeu: 4.412 ± 1.24
1.471AsnMet: 1.471 ± 0.654
0.0AsnAsn: 0.0 ± 0.0
2.941AsnPro: 2.941 ± 0.972
0.735AsnGln: 0.735 ± 0.485
2.941AsnArg: 2.941 ± 0.984
2.941AsnSer: 2.941 ± 1.116
2.941AsnThr: 2.941 ± 0.984
4.412AsnVal: 4.412 ± 1.962
0.0AsnTrp: 0.0 ± 0.0
0.0AsnTyr: 0.0 ± 0.0
0.0AsnXaa: 0.0 ± 0.0
Pro
5.882ProAla: 5.882 ± 2.847
1.471ProCys: 1.471 ± 1.327
5.882ProAsp: 5.882 ± 1.957
2.941ProGlu: 2.941 ± 0.978
2.206ProPhe: 2.206 ± 1.12
4.412ProGly: 4.412 ± 1.716
2.206ProHis: 2.206 ± 1.06
7.353ProIle: 7.353 ± 3.253
1.471ProLys: 1.471 ± 0.926
2.941ProLeu: 2.941 ± 0.774
0.0ProMet: 0.0 ± 0.0
2.206ProAsn: 2.206 ± 0.713
5.882ProPro: 5.882 ± 2.847
2.206ProGln: 2.206 ± 0.955
3.676ProArg: 3.676 ± 2.2
5.882ProSer: 5.882 ± 0.703
2.941ProThr: 2.941 ± 0.774
3.676ProVal: 3.676 ± 1.83
0.735ProTrp: 0.735 ± 0.485
0.735ProTyr: 0.735 ± 0.485
0.0ProXaa: 0.0 ± 0.0
Gln
4.412GlnAla: 4.412 ± 1.45
0.735GlnCys: 0.735 ± 0.663
2.941GlnAsp: 2.941 ± 0.984
2.206GlnGlu: 2.206 ± 0.804
2.206GlnPhe: 2.206 ± 1.009
2.206GlnGly: 2.206 ± 1.454
0.0GlnHis: 0.0 ± 0.0
0.0GlnIle: 0.0 ± 0.0
0.735GlnLys: 0.735 ± 0.485
2.941GlnLeu: 2.941 ± 0.654
2.206GlnMet: 2.206 ± 0.791
1.471GlnAsn: 1.471 ± 0.654
0.0GlnPro: 0.0 ± 0.0
1.471GlnGln: 1.471 ± 0.969
2.206GlnArg: 2.206 ± 1.202
2.941GlnSer: 2.941 ± 1.793
4.412GlnThr: 4.412 ± 1.738
1.471GlnVal: 1.471 ± 0.844
0.735GlnTrp: 0.735 ± 0.663
0.0GlnTyr: 0.0 ± 0.0
0.0GlnXaa: 0.0 ± 0.0
Arg
5.147ArgAla: 5.147 ± 1.796
0.735ArgCys: 0.735 ± 0.663
2.206ArgAsp: 2.206 ± 0.616
4.412ArgGlu: 4.412 ± 1.617
3.676ArgPhe: 3.676 ± 1.463
5.147ArgGly: 5.147 ± 0.994
2.206ArgHis: 2.206 ± 0.955
0.735ArgIle: 0.735 ± 0.485
4.412ArgLys: 4.412 ± 0.658
7.353ArgLeu: 7.353 ± 2.304
2.206ArgMet: 2.206 ± 1.333
2.206ArgAsn: 2.206 ± 0.702
2.941ArgPro: 2.941 ± 1.699
3.676ArgGln: 3.676 ± 1.594
2.941ArgArg: 2.941 ± 0.774
8.088ArgSer: 8.088 ± 2.985
2.206ArgThr: 2.206 ± 1.212
5.882ArgVal: 5.882 ± 1.784
0.735ArgTrp: 0.735 ± 0.485
5.882ArgTyr: 5.882 ± 0.984
0.0ArgXaa: 0.0 ± 0.0
Ser
8.824SerAla: 8.824 ± 3.576
0.735SerCys: 0.735 ± 0.485
2.206SerAsp: 2.206 ± 1.06
2.206SerGlu: 2.206 ± 1.06
3.676SerPhe: 3.676 ± 1.122
10.294SerGly: 10.294 ± 1.876
2.206SerHis: 2.206 ± 1.454
2.206SerIle: 2.206 ± 0.955
4.412SerLys: 4.412 ± 2.675
8.824SerLeu: 8.824 ± 2.319
1.471SerMet: 1.471 ± 1.069
0.735SerAsn: 0.735 ± 0.485
8.824SerPro: 8.824 ± 2.815
5.882SerGln: 5.882 ± 2.715
5.882SerArg: 5.882 ± 3.122
6.618SerSer: 6.618 ± 1.988
2.206SerThr: 2.206 ± 1.06
5.882SerVal: 5.882 ± 1.591
1.471SerTrp: 1.471 ± 0.654
1.471SerTyr: 1.471 ± 0.654
0.0SerXaa: 0.0 ± 0.0
Thr
5.882ThrAla: 5.882 ± 2.487
0.0ThrCys: 0.0 ± 0.0
3.676ThrAsp: 3.676 ± 1.566
0.735ThrGlu: 0.735 ± 0.485
1.471ThrPhe: 1.471 ± 0.969
5.882ThrGly: 5.882 ± 0.992
1.471ThrHis: 1.471 ± 0.489
2.941ThrIle: 2.941 ± 0.774
0.735ThrLys: 0.735 ± 0.485
4.412ThrLeu: 4.412 ± 1.425
1.471ThrMet: 1.471 ± 0.489
1.471ThrAsn: 1.471 ± 0.654
3.676ThrPro: 3.676 ± 1.403
0.0ThrGln: 0.0 ± 0.0
6.618ThrArg: 6.618 ± 1.063
5.882ThrSer: 5.882 ± 1.493
2.206ThrThr: 2.206 ± 0.955
2.206ThrVal: 2.206 ± 0.713
0.735ThrTrp: 0.735 ± 0.485
2.206ThrTyr: 2.206 ± 0.616
0.0ThrXaa: 0.0 ± 0.0
Val
7.353ValAla: 7.353 ± 1.338
0.0ValCys: 0.0 ± 0.0
2.206ValAsp: 2.206 ± 0.713
3.676ValGlu: 3.676 ± 1.083
0.735ValPhe: 0.735 ± 0.485
2.941ValGly: 2.941 ± 1.373
2.206ValHis: 2.206 ± 1.212
1.471ValIle: 1.471 ± 0.948
2.206ValLys: 2.206 ± 0.702
5.882ValLeu: 5.882 ± 1.187
0.735ValMet: 0.735 ± 0.603
4.412ValAsn: 4.412 ± 2.424
3.676ValPro: 3.676 ± 1.566
0.0ValGln: 0.0 ± 0.0
5.882ValArg: 5.882 ± 1.662
5.882ValSer: 5.882 ± 1.22
5.147ValThr: 5.147 ± 1.981
3.676ValVal: 3.676 ± 0.511
0.735ValTrp: 0.735 ± 0.485
1.471ValTyr: 1.471 ± 0.969
0.0ValXaa: 0.0 ± 0.0
Trp
1.471TrpAla: 1.471 ± 0.489
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
1.471TrpGlu: 1.471 ± 0.969
0.735TrpPhe: 0.735 ± 0.485
0.735TrpGly: 0.735 ± 0.663
0.735TrpHis: 0.735 ± 0.485
0.0TrpIle: 0.0 ± 0.0
0.735TrpLys: 0.735 ± 0.642
0.0TrpLeu: 0.0 ± 0.0
0.735TrpMet: 0.735 ± 0.8
1.471TrpAsn: 1.471 ± 0.969
0.735TrpPro: 0.735 ± 0.485
0.0TrpGln: 0.0 ± 0.0
0.0TrpArg: 0.0 ± 0.0
1.471TrpSer: 1.471 ± 0.489
0.735TrpThr: 0.735 ± 0.485
0.0TrpVal: 0.0 ± 0.0
0.0TrpTrp: 0.0 ± 0.0
0.735TrpTyr: 0.735 ± 0.485
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.735TyrAla: 0.735 ± 0.663
0.735TyrCys: 0.735 ± 0.663
2.941TyrAsp: 2.941 ± 0.654
2.206TyrGlu: 2.206 ± 0.955
3.676TyrPhe: 3.676 ± 1.511
2.206TyrGly: 2.206 ± 0.979
0.0TyrHis: 0.0 ± 0.0
0.0TyrIle: 0.0 ± 0.0
1.471TyrLys: 1.471 ± 0.489
1.471TyrLeu: 1.471 ± 0.654
2.206TyrMet: 2.206 ± 0.921
0.0TyrAsn: 0.0 ± 0.0
1.471TyrPro: 1.471 ± 0.489
1.471TyrGln: 1.471 ± 0.969
2.941TyrArg: 2.941 ± 1.116
2.206TyrSer: 2.206 ± 1.119
0.0TyrThr: 0.0 ± 0.0
2.206TyrVal: 2.206 ± 0.713
0.0TyrTrp: 0.0 ± 0.0
0.735TyrTyr: 0.735 ± 0.485
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5 proteins (1361 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski