Amino acid dipepetide frequency for Desulfococcus oleovorans (strain DSM 6200 / JCM 39069 / Hxd3)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.277AlaAla: 11.277 ± 0.135	1.528AlaCys: 1.528 ± 0.047	6.389AlaAsp: 6.389 ± 0.096	5.648AlaGlu: 5.648 ± 0.078	4.162AlaPhe: 4.162 ± 0.069	9.348AlaGly: 9.348 ± 0.17	1.836AlaHis: 1.836 ± 0.047	5.36AlaIle: 5.36 ± 0.073	3.769AlaLys: 3.769 ± 0.07	9.622AlaLeu: 9.622 ± 0.113	2.958AlaMet: 2.958 ± 0.052	2.578AlaAsn: 2.578 ± 0.047	3.949AlaPro: 3.949 ± 0.072	2.529AlaGln: 2.529 ± 0.046	6.033AlaArg: 6.033 ± 0.093	4.47AlaSer: 4.47 ± 0.084	4.499AlaThr: 4.499 ± 0.084	8.122AlaVal: 8.122 ± 0.126	1.173AlaTrp: 1.173 ± 0.039	2.831AlaTyr: 2.831 ± 0.058	0.0AlaXaa: 0.0 ± 0.0
Cys	1.171CysAla: 1.171 ± 0.034	0.287CysCys: 0.287 ± 0.02	0.78CysAsp: 0.78 ± 0.033	0.632CysGlu: 0.632 ± 0.024	0.636CysPhe: 0.636 ± 0.026	1.344CysGly: 1.344 ± 0.037	0.405CysHis: 0.405 ± 0.028	0.678CysIle: 0.678 ± 0.032	0.446CysLys: 0.446 ± 0.022	1.301CysLeu: 1.301 ± 0.042	0.349CysMet: 0.349 ± 0.021	0.418CysAsn: 0.418 ± 0.021	0.815CysPro: 0.815 ± 0.036	0.335CysGln: 0.335 ± 0.02	1.032CysArg: 1.032 ± 0.036	0.648CysSer: 0.648 ± 0.025	0.612CysThr: 0.612 ± 0.026	0.889CysVal: 0.889 ± 0.031	0.152CysTrp: 0.152 ± 0.012	0.372CysTyr: 0.372 ± 0.021	0.0CysXaa: 0.0 ± 0.0
Asp	5.317AspAla: 5.317 ± 0.082	0.696AspCys: 0.696 ± 0.027	3.266AspAsp: 3.266 ± 0.089	3.264AspGlu: 3.264 ± 0.075	2.713AspPhe: 2.713 ± 0.052	4.634AspGly: 4.634 ± 0.159	1.294AspHis: 1.294 ± 0.043	4.15AspIle: 4.15 ± 0.07	2.502AspLys: 2.502 ± 0.05	5.985AspLeu: 5.985 ± 0.074	1.716AspMet: 1.716 ± 0.042	2.026AspAsn: 2.026 ± 0.068	3.201AspPro: 3.201 ± 0.066	1.77AspGln: 1.77 ± 0.038	4.241AspArg: 4.241 ± 0.074	2.426AspSer: 2.426 ± 0.065	3.673AspThr: 3.673 ± 0.108	3.771AspVal: 3.771 ± 0.087	0.659AspTrp: 0.659 ± 0.028	1.955AspTyr: 1.955 ± 0.048	0.0AspXaa: 0.0 ± 0.0
Glu	6.125GluAla: 6.125 ± 0.086	0.524GluCys: 0.524 ± 0.026	2.988GluAsp: 2.988 ± 0.067	3.805GluGlu: 3.805 ± 0.085	1.878GluPhe: 1.878 ± 0.044	3.641GluGly: 3.641 ± 0.057	1.106GluHis: 1.106 ± 0.033	4.186GluIle: 4.186 ± 0.074	5.157GluLys: 5.157 ± 0.088	4.923GluLeu: 4.923 ± 0.075	1.912GluMet: 1.912 ± 0.047	2.808GluAsn: 2.808 ± 0.053	2.201GluPro: 2.201 ± 0.048	2.274GluGln: 2.274 ± 0.052	3.248GluArg: 3.248 ± 0.056	2.91GluSer: 2.91 ± 0.049	4.113GluThr: 4.113 ± 0.064	3.634GluVal: 3.634 ± 0.059	0.624GluTrp: 0.624 ± 0.025	1.569GluTyr: 1.569 ± 0.043	0.0GluXaa: 0.0 ± 0.0
Phe	3.877PheAla: 3.877 ± 0.064	0.709PheCys: 0.709 ± 0.029	2.83PheAsp: 2.83 ± 0.058	2.559PheGlu: 2.559 ± 0.049	2.554PhePhe: 2.554 ± 0.061	3.211PheGly: 3.211 ± 0.061	0.906PheHis: 0.906 ± 0.028	2.405PheIle: 2.405 ± 0.056	1.81PheLys: 1.81 ± 0.052	4.352PheLeu: 4.352 ± 0.083	1.036PheMet: 1.036 ± 0.033	1.405PheAsn: 1.405 ± 0.037	1.829PhePro: 1.829 ± 0.044	1.183PheGln: 1.183 ± 0.032	2.091PheArg: 2.091 ± 0.049	3.161PheSer: 3.161 ± 0.053	2.312PheThr: 2.312 ± 0.048	3.072PheVal: 3.072 ± 0.064	0.55PheTrp: 0.55 ± 0.024	1.516PheTyr: 1.516 ± 0.038	0.0PheXaa: 0.0 ± 0.0
Gly	6.913GlyAla: 6.913 ± 0.132	1.221GlyCys: 1.221 ± 0.037	4.297GlyAsp: 4.297 ± 0.18	4.01GlyGlu: 4.01 ± 0.072	3.624GlyPhe: 3.624 ± 0.067	6.065GlyGly: 6.065 ± 0.193	1.736GlyHis: 1.736 ± 0.042	5.35GlyIle: 5.35 ± 0.076	4.178GlyLys: 4.178 ± 0.065	7.663GlyLeu: 7.663 ± 0.094	2.458GlyMet: 2.458 ± 0.046	2.589GlyAsn: 2.589 ± 0.076	2.829GlyPro: 2.829 ± 0.047	2.324GlyGln: 2.324 ± 0.044	5.124GlyArg: 5.124 ± 0.078	3.926GlySer: 3.926 ± 0.124	4.742GlyThr: 4.742 ± 0.15	5.665GlyVal: 5.665 ± 0.105	0.963GlyTrp: 0.963 ± 0.035	2.615GlyTyr: 2.615 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	1.776HisAla: 1.776 ± 0.044	0.284HisCys: 0.284 ± 0.017	1.121HisAsp: 1.121 ± 0.03	1.077HisGlu: 1.077 ± 0.035	0.927HisPhe: 0.927 ± 0.03	1.574HisGly: 1.574 ± 0.039	0.59HisHis: 0.59 ± 0.022	1.333HisIle: 1.333 ± 0.036	0.841HisLys: 0.841 ± 0.03	2.183HisLeu: 2.183 ± 0.052	0.529HisMet: 0.529 ± 0.025	0.713HisAsn: 0.713 ± 0.023	1.27HisPro: 1.27 ± 0.03	0.686HisGln: 0.686 ± 0.024	1.321HisArg: 1.321 ± 0.039	0.982HisSer: 0.982 ± 0.031	1.18HisThr: 1.18 ± 0.03	1.401HisVal: 1.401 ± 0.035	0.265HisTrp: 0.265 ± 0.02	0.745HisTyr: 0.745 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	5.443IleAla: 5.443 ± 0.077	0.834IleCys: 0.834 ± 0.031	4.182IleAsp: 4.182 ± 0.074	3.758IleGlu: 3.758 ± 0.06	2.399IlePhe: 2.399 ± 0.05	4.441IleGly: 4.441 ± 0.073	1.367IleHis: 1.367 ± 0.036	3.368IleIle: 3.368 ± 0.067	2.951IleLys: 2.951 ± 0.066	5.409IleLeu: 5.409 ± 0.085	1.318IleMet: 1.318 ± 0.039	2.359IleAsn: 2.359 ± 0.051	2.874IlePro: 2.874 ± 0.054	1.95IleGln: 1.95 ± 0.04	3.59IleArg: 3.59 ± 0.062	3.714IleSer: 3.714 ± 0.071	3.769IleThr: 3.769 ± 0.098	4.181IleVal: 4.181 ± 0.064	0.529IleTrp: 0.529 ± 0.023	1.717IleTyr: 1.717 ± 0.046	0.0IleXaa: 0.0 ± 0.0
Lys	4.842LysAla: 4.842 ± 0.087	0.408LysCys: 0.408 ± 0.024	2.752LysAsp: 2.752 ± 0.05	3.589LysGlu: 3.589 ± 0.074	1.262LysPhe: 1.262 ± 0.033	3.578LysGly: 3.578 ± 0.069	0.9LysHis: 0.9 ± 0.03	3.274LysIle: 3.274 ± 0.075	4.36LysLys: 4.36 ± 0.106	3.548LysLeu: 3.548 ± 0.075	1.455LysMet: 1.455 ± 0.043	2.366LysAsn: 2.366 ± 0.053	2.196LysPro: 2.196 ± 0.045	1.894LysGln: 1.894 ± 0.052	2.706LysArg: 2.706 ± 0.07	2.468LysSer: 2.468 ± 0.052	3.638LysThr: 3.638 ± 0.061	2.914LysVal: 2.914 ± 0.065	0.478LysTrp: 0.478 ± 0.022	1.249LysTyr: 1.249 ± 0.037	0.0LysXaa: 0.0 ± 0.0
Leu	10.405LeuAla: 10.405 ± 0.125	1.358LeuCys: 1.358 ± 0.04	5.325LeuAsp: 5.325 ± 0.077	5.85LeuGlu: 5.85 ± 0.083	4.69LeuPhe: 4.69 ± 0.083	6.51LeuGly: 6.51 ± 0.09	1.785LeuHis: 1.785 ± 0.044	5.025LeuIle: 5.025 ± 0.088	5.09LeuLys: 5.09 ± 0.098	9.325LeuLeu: 9.325 ± 0.143	2.418LeuMet: 2.418 ± 0.057	3.164LeuAsn: 3.164 ± 0.052	4.655LeuPro: 4.655 ± 0.071	2.462LeuGln: 2.462 ± 0.054	4.677LeuArg: 4.677 ± 0.079	6.363LeuSer: 6.363 ± 0.083	5.075LeuThr: 5.075 ± 0.082	7.012LeuVal: 7.012 ± 0.097	1.026LeuTrp: 1.026 ± 0.035	2.717LeuTyr: 2.717 ± 0.066	0.0LeuXaa: 0.0 ± 0.0
Met	3.432MetAla: 3.432 ± 0.066	0.23MetCys: 0.23 ± 0.014	1.733MetAsp: 1.733 ± 0.042	1.892MetGlu: 1.892 ± 0.046	0.848MetPhe: 0.848 ± 0.027	2.338MetGly: 2.338 ± 0.046	0.451MetHis: 0.451 ± 0.02	1.534MetIle: 1.534 ± 0.043	1.575MetLys: 1.575 ± 0.044	2.37MetLeu: 2.37 ± 0.05	0.702MetMet: 0.702 ± 0.026	0.988MetAsn: 0.988 ± 0.031	1.314MetPro: 1.314 ± 0.038	0.756MetGln: 0.756 ± 0.026	1.345MetArg: 1.345 ± 0.035	1.376MetSer: 1.376 ± 0.035	1.736MetThr: 1.736 ± 0.04	2.271MetVal: 2.271 ± 0.049	0.186MetTrp: 0.186 ± 0.012	0.494MetTyr: 0.494 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	2.935AsnAla: 2.935 ± 0.054	0.509AsnCys: 0.509 ± 0.031	1.824AsnAsp: 1.824 ± 0.053	1.619AsnGlu: 1.619 ± 0.045	1.344AsnPhe: 1.344 ± 0.034	2.717AsnGly: 2.717 ± 0.086	0.755AsnHis: 0.755 ± 0.026	2.478AsnIle: 2.478 ± 0.047	1.366AsnLys: 1.366 ± 0.047	3.221AsnLeu: 3.221 ± 0.054	0.946AsnMet: 0.946 ± 0.03	1.326AsnAsn: 1.326 ± 0.045	2.132AsnPro: 2.132 ± 0.048	1.048AsnGln: 1.048 ± 0.028	2.63AsnArg: 2.63 ± 0.054	1.659AsnSer: 1.659 ± 0.043	2.045AsnThr: 2.045 ± 0.06	2.196AsnVal: 2.196 ± 0.056	0.407AsnTrp: 0.407 ± 0.018	0.98AsnTyr: 0.98 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	5.014ProAla: 5.014 ± 0.08	0.564ProCys: 0.564 ± 0.028	3.897ProAsp: 3.897 ± 0.072	3.985ProGlu: 3.985 ± 0.069	2.204ProPhe: 2.204 ± 0.046	4.103ProGly: 4.103 ± 0.073	0.892ProHis: 0.892 ± 0.03	1.914ProIle: 1.914 ± 0.048	1.621ProLys: 1.621 ± 0.048	4.116ProLeu: 4.116 ± 0.063	1.125ProMet: 1.125 ± 0.033	1.156ProAsn: 1.156 ± 0.041	2.239ProPro: 2.239 ± 0.057	1.093ProGln: 1.093 ± 0.031	2.119ProArg: 2.119 ± 0.045	2.298ProSer: 2.298 ± 0.046	1.836ProThr: 1.836 ± 0.046	4.669ProVal: 4.669 ± 0.067	0.616ProTrp: 0.616 ± 0.025	1.265ProTyr: 1.265 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	3.556GlnAla: 3.556 ± 0.056	0.363GlnCys: 0.363 ± 0.018	1.376GlnAsp: 1.376 ± 0.032	1.928GlnGlu: 1.928 ± 0.046	0.99GlnPhe: 0.99 ± 0.031	2.15GlnGly: 2.15 ± 0.046	0.552GlnHis: 0.552 ± 0.023	1.78GlnIle: 1.78 ± 0.04	1.985GlnLys: 1.985 ± 0.053	2.39GlnLeu: 2.39 ± 0.055	0.944GlnMet: 0.944 ± 0.027	1.108GlnAsn: 1.108 ± 0.031	1.279GlnPro: 1.279 ± 0.036	1.279GlnGln: 1.279 ± 0.039	1.803GlnArg: 1.803 ± 0.046	1.437GlnSer: 1.437 ± 0.031	1.864GlnThr: 1.864 ± 0.042	2.361GlnVal: 2.361 ± 0.05	0.527GlnTrp: 0.527 ± 0.024	0.882GlnTyr: 0.882 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	4.693ArgAla: 4.693 ± 0.08	0.706ArgCys: 0.706 ± 0.028	2.85ArgAsp: 2.85 ± 0.057	3.631ArgGlu: 3.631 ± 0.072	3.018ArgPhe: 3.018 ± 0.047	3.331ArgGly: 3.331 ± 0.069	1.633ArgHis: 1.633 ± 0.047	4.064ArgIle: 4.064 ± 0.072	3.245ArgLys: 3.245 ± 0.068	6.41ArgLeu: 6.41 ± 0.103	1.787ArgMet: 1.787 ± 0.043	1.861ArgAsn: 1.861 ± 0.044	2.73ArgPro: 2.73 ± 0.057	2.698ArgGln: 2.698 ± 0.065	3.819ArgArg: 3.819 ± 0.091	2.824ArgSer: 2.824 ± 0.042	2.844ArgThr: 2.844 ± 0.052	4.271ArgVal: 4.271 ± 0.062	0.693ArgTrp: 0.693 ± 0.029	1.98ArgTyr: 1.98 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	5.008SerAla: 5.008 ± 0.098	0.632SerCys: 0.632 ± 0.026	3.166SerAsp: 3.166 ± 0.056	2.797SerGlu: 2.797 ± 0.061	2.367SerPhe: 2.367 ± 0.05	5.398SerGly: 5.398 ± 0.104	1.109SerHis: 1.109 ± 0.036	3.021SerIle: 3.021 ± 0.056	1.962SerLys: 1.962 ± 0.052	5.241SerLeu: 5.241 ± 0.076	1.557SerMet: 1.557 ± 0.033	1.473SerAsn: 1.473 ± 0.04	2.768SerPro: 2.768 ± 0.054	1.473SerGln: 1.473 ± 0.035	3.515SerArg: 3.515 ± 0.066	2.826SerSer: 2.826 ± 0.06	2.541SerThr: 2.541 ± 0.074	3.9SerVal: 3.9 ± 0.08	0.629SerTrp: 0.629 ± 0.029	1.426SerTyr: 1.426 ± 0.043	0.0SerXaa: 0.0 ± 0.0
Thr	5.644ThrAla: 5.644 ± 0.131	0.692ThrCys: 0.692 ± 0.025	3.511ThrAsp: 3.511 ± 0.082	2.925ThrGlu: 2.925 ± 0.057	2.152ThrPhe: 2.152 ± 0.047	6.1ThrGly: 6.1 ± 0.137	1.118ThrHis: 1.118 ± 0.031	3.572ThrIle: 3.572 ± 0.092	1.78ThrLys: 1.78 ± 0.046	5.494ThrLeu: 5.494 ± 0.087	1.229ThrMet: 1.229 ± 0.034	1.488ThrAsn: 1.488 ± 0.054	3.184ThrPro: 3.184 ± 0.068	1.367ThrGln: 1.367 ± 0.032	3.175ThrArg: 3.175 ± 0.059	2.595ThrSer: 2.595 ± 0.063	3.171ThrThr: 3.171 ± 0.109	4.832ThrVal: 4.832 ± 0.147	0.699ThrTrp: 0.699 ± 0.024	1.669ThrTyr: 1.669 ± 0.053	0.0ThrXaa: 0.0 ± 0.0
Val	7.248ValAla: 7.248 ± 0.111	1.181ValCys: 1.181 ± 0.035	4.413ValAsp: 4.413 ± 0.084	4.295ValGlu: 4.295 ± 0.059	3.611ValPhe: 3.611 ± 0.065	4.613ValGly: 4.613 ± 0.083	1.337ValHis: 1.337 ± 0.036	4.4ValIle: 4.4 ± 0.081	3.394ValLys: 3.394 ± 0.058	7.337ValLeu: 7.337 ± 0.105	2.059ValMet: 2.059 ± 0.045	2.669ValAsn: 2.669 ± 0.067	3.362ValPro: 3.362 ± 0.063	1.896ValGln: 1.896 ± 0.042	3.95ValArg: 3.95 ± 0.064	4.596ValSer: 4.596 ± 0.096	4.434ValThr: 4.434 ± 0.124	6.057ValVal: 6.057 ± 0.099	0.792ValTrp: 0.792 ± 0.026	2.173ValTyr: 2.173 ± 0.05	0.0ValXaa: 0.0 ± 0.0
Trp	0.884TrpAla: 0.884 ± 0.035	0.147TrpCys: 0.147 ± 0.01	0.618TrpAsp: 0.618 ± 0.027	0.737TrpGlu: 0.737 ± 0.027	0.592TrpPhe: 0.592 ± 0.027	0.81TrpGly: 0.81 ± 0.029	0.315TrpHis: 0.315 ± 0.017	0.72TrpIle: 0.72 ± 0.026	0.618TrpLys: 0.618 ± 0.024	1.15TrpLeu: 1.15 ± 0.039	0.379TrpMet: 0.379 ± 0.023	0.451TrpAsn: 0.451 ± 0.028	0.536TrpPro: 0.536 ± 0.028	0.53TrpGln: 0.53 ± 0.023	0.665TrpArg: 0.665 ± 0.028	0.568TrpSer: 0.568 ± 0.023	0.527TrpThr: 0.527 ± 0.024	0.764TrpVal: 0.764 ± 0.022	0.173TrpTrp: 0.173 ± 0.012	0.361TrpTyr: 0.361 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.521TyrAla: 2.521 ± 0.044	0.429TyrCys: 0.429 ± 0.019	1.942TyrAsp: 1.942 ± 0.059	1.626TyrGlu: 1.626 ± 0.04	1.394TyrPhe: 1.394 ± 0.045	2.386TyrGly: 2.386 ± 0.053	0.711TyrHis: 0.711 ± 0.027	1.542TyrIle: 1.542 ± 0.035	1.227TyrLys: 1.227 ± 0.034	2.895TyrLeu: 2.895 ± 0.059	0.691TyrMet: 0.691 ± 0.029	1.188TyrAsn: 1.188 ± 0.041	1.364TyrPro: 1.364 ± 0.041	1.007TyrGln: 1.007 ± 0.031	2.004TyrArg: 2.004 ± 0.048	1.563TyrSer: 1.563 ± 0.036	1.785TyrThr: 1.785 ± 0.049	1.836TyrVal: 1.836 ± 0.041	0.404TyrTrp: 0.404 ± 0.019	1.149TyrTyr: 1.149 ± 0.038	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3255 proteins (1152799 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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