Amino acid dipepetide frequency for Serratia symbiotica str. Cinara cedri

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.203AlaAla: 6.203 ± 0.201
0.989AlaCys: 0.989 ± 0.072
3.363AlaAsp: 3.363 ± 0.145
4.216AlaGlu: 4.216 ± 0.164
2.365AlaPhe: 2.365 ± 0.106
5.315AlaGly: 5.315 ± 0.165
1.675AlaHis: 1.675 ± 0.083
6.564AlaIle: 6.564 ± 0.166
4.458AlaLys: 4.458 ± 0.151
9.202AlaLeu: 9.202 ± 0.192
1.965AlaMet: 1.965 ± 0.107
3.223AlaAsn: 3.223 ± 0.113
2.414AlaPro: 2.414 ± 0.106
3.258AlaGln: 3.258 ± 0.134
4.199AlaArg: 4.199 ± 0.136
4.291AlaSer: 4.291 ± 0.138
3.878AlaThr: 3.878 ± 0.141
4.884AlaVal: 4.884 ± 0.17
0.822AlaTrp: 0.822 ± 0.059
2.273AlaTyr: 2.273 ± 0.1
0.0AlaXaa: 0.0 ± 0.0
Cys
0.963CysAla: 0.963 ± 0.067
0.215CysCys: 0.215 ± 0.029
0.734CysAsp: 0.734 ± 0.06
0.598CysGlu: 0.598 ± 0.057
0.545CysPhe: 0.545 ± 0.056
1.024CysGly: 1.024 ± 0.075
0.413CysHis: 0.413 ± 0.051
1.134CysIle: 1.134 ± 0.072
0.681CysLys: 0.681 ± 0.053
1.134CysLeu: 1.134 ± 0.061
0.317CysMet: 0.317 ± 0.036
0.637CysAsn: 0.637 ± 0.055
0.422CysPro: 0.422 ± 0.049
0.528CysGln: 0.528 ± 0.046
0.62CysArg: 0.62 ± 0.057
0.879CysSer: 0.879 ± 0.065
0.624CysThr: 0.624 ± 0.049
0.743CysVal: 0.743 ± 0.055
0.18CysTrp: 0.18 ± 0.026
0.51CysTyr: 0.51 ± 0.049
0.0CysXaa: 0.0 ± 0.0
Asp
3.596AspAla: 3.596 ± 0.12
0.536AspCys: 0.536 ± 0.053
1.86AspAsp: 1.86 ± 0.092
2.458AspGlu: 2.458 ± 0.114
2.049AspPhe: 2.049 ± 0.093
2.932AspGly: 2.932 ± 0.115
1.147AspHis: 1.147 ± 0.067
5.082AspIle: 5.082 ± 0.149
2.629AspLys: 2.629 ± 0.101
4.599AspLeu: 4.599 ± 0.136
1.253AspMet: 1.253 ± 0.08
2.528AspAsn: 2.528 ± 0.128
1.741AspPro: 1.741 ± 0.084
1.675AspGln: 1.675 ± 0.094
2.348AspArg: 2.348 ± 0.106
2.677AspSer: 2.677 ± 0.106
2.73AspThr: 2.73 ± 0.12
3.077AspVal: 3.077 ± 0.131
0.611AspTrp: 0.611 ± 0.048
1.745AspTyr: 1.745 ± 0.096
0.0AspXaa: 0.0 ± 0.0
Glu
4.067GluAla: 4.067 ± 0.169
0.629GluCys: 0.629 ± 0.059
2.304GluAsp: 2.304 ± 0.116
2.976GluGlu: 2.976 ± 0.135
1.649GluPhe: 1.649 ± 0.094
2.866GluGly: 2.866 ± 0.122
1.539GluHis: 1.539 ± 0.086
4.26GluIle: 4.26 ± 0.132
3.135GluLys: 3.135 ± 0.12
6.005GluLeu: 6.005 ± 0.158
1.512GluMet: 1.512 ± 0.085
2.15GluAsn: 2.15 ± 0.11
1.574GluPro: 1.574 ± 0.094
2.717GluGln: 2.717 ± 0.119
3.478GluArg: 3.478 ± 0.152
2.418GluSer: 2.418 ± 0.103
2.282GluThr: 2.282 ± 0.103
4.062GluVal: 4.062 ± 0.148
0.545GluTrp: 0.545 ± 0.054
1.64GluTyr: 1.64 ± 0.078
0.0GluXaa: 0.0 ± 0.0
Phe
2.44PheAla: 2.44 ± 0.115
0.655PheCys: 0.655 ± 0.051
1.974PheAsp: 1.974 ± 0.089
1.653PheGlu: 1.653 ± 0.097
1.561PhePhe: 1.561 ± 0.096
2.831PheGly: 2.831 ± 0.118
0.769PheHis: 0.769 ± 0.057
3.596PheIle: 3.596 ± 0.147
1.798PheLys: 1.798 ± 0.093
3.451PheLeu: 3.451 ± 0.134
0.954PheMet: 0.954 ± 0.069
2.286PheAsn: 2.286 ± 0.111
1.227PhePro: 1.227 ± 0.08
1.218PheGln: 1.218 ± 0.078
1.679PheArg: 1.679 ± 0.082
3.288PheSer: 3.288 ± 0.118
2.194PheThr: 2.194 ± 0.092
2.079PheVal: 2.079 ± 0.1
0.426PheTrp: 0.426 ± 0.049
1.231PheTyr: 1.231 ± 0.078
0.0PheXaa: 0.0 ± 0.0
Gly
4.634GlyAla: 4.634 ± 0.154
1.081GlyCys: 1.081 ± 0.062
3.201GlyAsp: 3.201 ± 0.135
3.456GlyGlu: 3.456 ± 0.142
2.792GlyPhe: 2.792 ± 0.124
4.471GlyGly: 4.471 ± 0.177
1.732GlyHis: 1.732 ± 0.083
6.353GlyIle: 6.353 ± 0.194
4.392GlyLys: 4.392 ± 0.148
6.463GlyLeu: 6.463 ± 0.182
1.93GlyMet: 1.93 ± 0.108
2.765GlyAsn: 2.765 ± 0.108
1.635GlyPro: 1.635 ± 0.086
2.374GlyGln: 2.374 ± 0.106
3.565GlyArg: 3.565 ± 0.135
3.93GlySer: 3.93 ± 0.128
3.464GlyThr: 3.464 ± 0.123
4.858GlyVal: 4.858 ± 0.179
0.734GlyTrp: 0.734 ± 0.057
2.598GlyTyr: 2.598 ± 0.115
0.0GlyXaa: 0.0 ± 0.0
His
1.97HisAla: 1.97 ± 0.093
0.36HisCys: 0.36 ± 0.038
1.095HisAsp: 1.095 ± 0.069
1.055HisGlu: 1.055 ± 0.074
1.09HisPhe: 1.09 ± 0.069
1.956HisGly: 1.956 ± 0.092
0.791HisHis: 0.791 ± 0.072
2.167HisIle: 2.167 ± 0.103
1.143HisLys: 1.143 ± 0.07
2.506HisLeu: 2.506 ± 0.108
0.637HisMet: 0.637 ± 0.048
1.394HisAsn: 1.394 ± 0.075
1.293HisPro: 1.293 ± 0.079
1.205HisGln: 1.205 ± 0.075
1.174HisArg: 1.174 ± 0.081
1.534HisSer: 1.534 ± 0.086
1.2HisThr: 1.2 ± 0.07
1.341HisVal: 1.341 ± 0.081
0.378HisTrp: 0.378 ± 0.039
1.187HisTyr: 1.187 ± 0.072
0.0HisXaa: 0.0 ± 0.0
Ile
7.25IleAla: 7.25 ± 0.163
1.112IleCys: 1.112 ± 0.071
4.827IleAsp: 4.827 ± 0.126
4.735IleGlu: 4.735 ± 0.17
3.253IlePhe: 3.253 ± 0.142
6.401IleGly: 6.401 ± 0.207
1.961IleHis: 1.961 ± 0.097
7.522IleIle: 7.522 ± 0.234
4.779IleLys: 4.779 ± 0.183
8.208IleLeu: 8.208 ± 0.215
2.075IleMet: 2.075 ± 0.099
5.1IleAsn: 5.1 ± 0.169
3.394IlePro: 3.394 ± 0.12
2.748IleGln: 2.748 ± 0.106
4.08IleArg: 4.08 ± 0.137
6.133IleSer: 6.133 ± 0.175
5.465IleThr: 5.465 ± 0.148
4.779IleVal: 4.779 ± 0.165
0.769IleTrp: 0.769 ± 0.067
2.625IleTyr: 2.625 ± 0.122
0.0IleXaa: 0.0 ± 0.0
Lys
3.724LysAla: 3.724 ± 0.154
0.594LysCys: 0.594 ± 0.053
2.673LysAsp: 2.673 ± 0.127
3.091LysGlu: 3.091 ± 0.131
1.613LysPhe: 1.613 ± 0.083
3.227LysGly: 3.227 ± 0.121
1.372LysHis: 1.372 ± 0.072
4.862LysIle: 4.862 ± 0.18
3.715LysLys: 3.715 ± 0.144
6.01LysLeu: 6.01 ± 0.16
1.534LysMet: 1.534 ± 0.085
3.108LysAsn: 3.108 ± 0.113
2.005LysPro: 2.005 ± 0.101
2.519LysGln: 2.519 ± 0.124
3.091LysArg: 3.091 ± 0.124
3.069LysSer: 3.069 ± 0.131
2.796LysThr: 2.796 ± 0.112
3.992LysVal: 3.992 ± 0.138
0.475LysTrp: 0.475 ± 0.048
1.912LysTyr: 1.912 ± 0.108
0.0LysXaa: 0.0 ± 0.0
Leu
8.898LeuAla: 8.898 ± 0.208
1.358LeuCys: 1.358 ± 0.07
5.267LeuAsp: 5.267 ± 0.167
5.72LeuGlu: 5.72 ± 0.169
3.886LeuPhe: 3.886 ± 0.156
6.863LeuGly: 6.863 ± 0.172
2.778LeuHis: 2.778 ± 0.1
8.309LeuIle: 8.309 ± 0.219
5.658LeuLys: 5.658 ± 0.16
11.703LeuLeu: 11.703 ± 0.338
2.902LeuMet: 2.902 ± 0.13
4.845LeuAsn: 4.845 ± 0.144
4.849LeuPro: 4.849 ± 0.158
4.462LeuGln: 4.462 ± 0.149
5.988LeuArg: 5.988 ± 0.173
7.588LeuSer: 7.588 ± 0.212
5.531LeuThr: 5.531 ± 0.156
7.32LeuVal: 7.32 ± 0.213
1.09LeuTrp: 1.09 ± 0.082
3.306LeuTyr: 3.306 ± 0.131
0.0LeuXaa: 0.0 ± 0.0
Met
2.167MetAla: 2.167 ± 0.102
0.286MetCys: 0.286 ± 0.035
0.998MetAsp: 0.998 ± 0.065
1.156MetGlu: 1.156 ± 0.077
0.884MetPhe: 0.884 ± 0.063
1.508MetGly: 1.508 ± 0.09
0.708MetHis: 0.708 ± 0.06
2.33MetIle: 2.33 ± 0.113
1.345MetLys: 1.345 ± 0.064
3.091MetLeu: 3.091 ± 0.12
0.822MetMet: 0.822 ± 0.061
1.147MetAsn: 1.147 ± 0.065
1.297MetPro: 1.297 ± 0.077
1.191MetGln: 1.191 ± 0.069
1.591MetArg: 1.591 ± 0.084
1.794MetSer: 1.794 ± 0.105
1.442MetThr: 1.442 ± 0.086
1.824MetVal: 1.824 ± 0.096
0.167MetTrp: 0.167 ± 0.025
0.673MetTyr: 0.673 ± 0.045
0.0MetXaa: 0.0 ± 0.0
Asn
3.302AsnAla: 3.302 ± 0.098
0.62AsnCys: 0.62 ± 0.056
2.29AsnAsp: 2.29 ± 0.119
2.326AsnGlu: 2.326 ± 0.098
1.833AsnPhe: 1.833 ± 0.089
3.007AsnGly: 3.007 ± 0.124
1.336AsnHis: 1.336 ± 0.071
5.056AsnIle: 5.056 ± 0.169
3.258AsnLys: 3.258 ± 0.129
4.81AsnLeu: 4.81 ± 0.165
1.095AsnMet: 1.095 ± 0.071
3.104AsnAsn: 3.104 ± 0.133
1.996AsnPro: 1.996 ± 0.104
2.049AsnGln: 2.049 ± 0.097
2.247AsnArg: 2.247 ± 0.113
2.84AsnSer: 2.84 ± 0.105
2.866AsnThr: 2.866 ± 0.112
2.669AsnVal: 2.669 ± 0.101
0.695AsnTrp: 0.695 ± 0.054
1.719AsnTyr: 1.719 ± 0.109
0.0AsnXaa: 0.0 ± 0.0
Pro
2.431ProAla: 2.431 ± 0.098
0.475ProCys: 0.475 ± 0.046
1.701ProAsp: 1.701 ± 0.093
2.37ProGlu: 2.37 ± 0.106
1.416ProPhe: 1.416 ± 0.072
2.484ProGly: 2.484 ± 0.113
1.002ProHis: 1.002 ± 0.073
3.003ProIle: 3.003 ± 0.124
1.89ProLys: 1.89 ± 0.097
4.339ProLeu: 4.339 ± 0.142
0.972ProMet: 0.972 ± 0.07
1.693ProAsn: 1.693 ± 0.08
1.165ProPro: 1.165 ± 0.074
1.556ProGln: 1.556 ± 0.085
1.539ProArg: 1.539 ± 0.086
2.326ProSer: 2.326 ± 0.096
1.842ProThr: 1.842 ± 0.093
2.748ProVal: 2.748 ± 0.112
0.528ProTrp: 0.528 ± 0.06
1.495ProTyr: 1.495 ± 0.083
0.0ProXaa: 0.0 ± 0.0
Gln
3.328GlnAla: 3.328 ± 0.14
0.532GlnCys: 0.532 ± 0.048
1.706GlnAsp: 1.706 ± 0.09
2.352GlnGlu: 2.352 ± 0.1
1.534GlnPhe: 1.534 ± 0.08
2.55GlnGly: 2.55 ± 0.116
1.077GlnHis: 1.077 ± 0.072
3.205GlnIle: 3.205 ± 0.102
2.093GlnLys: 2.093 ± 0.109
5.043GlnLeu: 5.043 ± 0.175
0.994GlnMet: 0.994 ± 0.073
1.622GlnAsn: 1.622 ± 0.084
1.627GlnPro: 1.627 ± 0.087
2.814GlnGln: 2.814 ± 0.128
2.537GlnArg: 2.537 ± 0.127
2.216GlnSer: 2.216 ± 0.089
1.609GlnThr: 1.609 ± 0.073
3.011GlnVal: 3.011 ± 0.101
0.55GlnTrp: 0.55 ± 0.05
1.75GlnTyr: 1.75 ± 0.077
0.0GlnXaa: 0.0 ± 0.0
Arg
3.957ArgAla: 3.957 ± 0.148
0.576ArgCys: 0.576 ± 0.056
2.607ArgAsp: 2.607 ± 0.113
3.029ArgGlu: 3.029 ± 0.125
2.225ArgPhe: 2.225 ± 0.098
3.214ArgGly: 3.214 ± 0.126
1.442ArgHis: 1.442 ± 0.078
4.445ArgIle: 4.445 ± 0.144
2.822ArgLys: 2.822 ± 0.123
5.662ArgLeu: 5.662 ± 0.181
1.354ArgMet: 1.354 ± 0.076
2.607ArgAsn: 2.607 ± 0.122
1.952ArgPro: 1.952 ± 0.094
2.572ArgGln: 2.572 ± 0.107
3.113ArgArg: 3.113 ± 0.134
2.822ArgSer: 2.822 ± 0.135
2.26ArgThr: 2.26 ± 0.095
3.416ArgVal: 3.416 ± 0.134
0.703ArgTrp: 0.703 ± 0.061
2.159ArgTyr: 2.159 ± 0.094
0.0ArgXaa: 0.0 ± 0.0
Ser
4.735SerAla: 4.735 ± 0.151
0.725SerCys: 0.725 ± 0.06
2.866SerAsp: 2.866 ± 0.105
2.95SerGlu: 2.95 ± 0.121
2.449SerPhe: 2.449 ± 0.11
4.814SerGly: 4.814 ± 0.171
1.504SerHis: 1.504 ± 0.089
5.328SerIle: 5.328 ± 0.134
3.236SerLys: 3.236 ± 0.119
6.674SerLeu: 6.674 ± 0.19
1.745SerMet: 1.745 ± 0.095
3.165SerAsn: 3.165 ± 0.126
1.948SerPro: 1.948 ± 0.095
2.497SerGln: 2.497 ± 0.098
2.994SerArg: 2.994 ± 0.12
4.251SerSer: 4.251 ± 0.144
3.328SerThr: 3.328 ± 0.138
3.908SerVal: 3.908 ± 0.121
0.743SerTrp: 0.743 ± 0.061
2.233SerTyr: 2.233 ± 0.121
0.0SerXaa: 0.0 ± 0.0
Thr
3.86ThrAla: 3.86 ± 0.128
0.721ThrCys: 0.721 ± 0.062
2.44ThrAsp: 2.44 ± 0.107
2.528ThrGlu: 2.528 ± 0.112
1.89ThrPhe: 1.89 ± 0.076
3.957ThrGly: 3.957 ± 0.129
1.222ThrHis: 1.222 ± 0.066
4.475ThrIle: 4.475 ± 0.143
2.765ThrLys: 2.765 ± 0.12
6.704ThrLeu: 6.704 ± 0.18
1.183ThrMet: 1.183 ± 0.069
2.559ThrAsn: 2.559 ± 0.103
2.339ThrPro: 2.339 ± 0.108
1.996ThrGln: 1.996 ± 0.105
2.576ThrArg: 2.576 ± 0.117
3.064ThrSer: 3.064 ± 0.128
3.157ThrThr: 3.157 ± 0.122
3.28ThrVal: 3.28 ± 0.117
0.558ThrTrp: 0.558 ± 0.049
1.38ThrTyr: 1.38 ± 0.079
0.0ThrXaa: 0.0 ± 0.0
Val
4.99ValAla: 4.99 ± 0.16
0.686ValCys: 0.686 ± 0.061
3.293ValAsp: 3.293 ± 0.13
3.464ValGlu: 3.464 ± 0.151
2.378ValPhe: 2.378 ± 0.098
4.146ValGly: 4.146 ± 0.156
1.464ValHis: 1.464 ± 0.07
6.058ValIle: 6.058 ± 0.196
3.482ValLys: 3.482 ± 0.133
7.118ValLeu: 7.118 ± 0.183
1.965ValMet: 1.965 ± 0.115
3.073ValAsn: 3.073 ± 0.114
2.339ValPro: 2.339 ± 0.104
2.079ValGln: 2.079 ± 0.089
3.486ValArg: 3.486 ± 0.14
4.37ValSer: 4.37 ± 0.149
3.9ValThr: 3.9 ± 0.138
4.673ValVal: 4.673 ± 0.174
0.536ValTrp: 0.536 ± 0.053
1.644ValTyr: 1.644 ± 0.093
0.0ValXaa: 0.0 ± 0.0
Trp
0.659TrpAla: 0.659 ± 0.055
0.176TrpCys: 0.176 ± 0.032
0.4TrpAsp: 0.4 ± 0.048
0.426TrpGlu: 0.426 ± 0.044
0.501TrpPhe: 0.501 ± 0.054
0.594TrpGly: 0.594 ± 0.052
0.391TrpHis: 0.391 ± 0.04
0.848TrpIle: 0.848 ± 0.065
0.435TrpLys: 0.435 ± 0.046
1.824TrpLeu: 1.824 ± 0.112
0.312TrpMet: 0.312 ± 0.037
0.497TrpAsn: 0.497 ± 0.04
0.462TrpPro: 0.462 ± 0.05
0.87TrpGln: 0.87 ± 0.07
0.708TrpArg: 0.708 ± 0.059
0.497TrpSer: 0.497 ± 0.053
0.343TrpThr: 0.343 ± 0.034
0.686TrpVal: 0.686 ± 0.054
0.141TrpTrp: 0.141 ± 0.026
0.382TrpTyr: 0.382 ± 0.049
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.383TyrAla: 2.383 ± 0.111
0.576TyrCys: 0.576 ± 0.051
1.675TyrAsp: 1.675 ± 0.088
1.249TyrGlu: 1.249 ± 0.075
1.398TyrPhe: 1.398 ± 0.087
2.269TyrGly: 2.269 ± 0.1
1.152TyrHis: 1.152 ± 0.067
2.616TyrIle: 2.616 ± 0.099
1.666TyrLys: 1.666 ± 0.089
3.781TyrLeu: 3.781 ± 0.128
0.897TyrMet: 0.897 ± 0.065
1.613TyrAsn: 1.613 ± 0.094
1.297TyrPro: 1.297 ± 0.072
1.82TyrGln: 1.82 ± 0.098
1.926TyrArg: 1.926 ± 0.102
2.106TyrSer: 2.106 ± 0.112
1.745TyrThr: 1.745 ± 0.092
1.794TyrVal: 1.794 ± 0.086
0.501TyrTrp: 0.501 ± 0.055
1.222TyrTyr: 1.222 ± 0.083
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 672 proteins (227463 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski