Amino acid dipepetide frequency for Sphingopyxis sp. LPB0140

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.056AlaAla: 13.056 ± 0.19
0.867AlaCys: 0.867 ± 0.039
6.267AlaAsp: 6.267 ± 0.102
6.256AlaGlu: 6.256 ± 0.112
3.719AlaPhe: 3.719 ± 0.08
8.271AlaGly: 8.271 ± 0.136
2.106AlaHis: 2.106 ± 0.053
7.776AlaIle: 7.776 ± 0.121
5.862AlaLys: 5.862 ± 0.109
9.798AlaLeu: 9.798 ± 0.14
3.755AlaMet: 3.755 ± 0.063
4.268AlaAsn: 4.268 ± 0.083
4.453AlaPro: 4.453 ± 0.089
4.658AlaGln: 4.658 ± 0.099
5.485AlaArg: 5.485 ± 0.105
5.911AlaSer: 5.911 ± 0.125
4.602AlaThr: 4.602 ± 0.123
6.094AlaVal: 6.094 ± 0.116
1.01AlaTrp: 1.01 ± 0.039
2.432AlaTyr: 2.432 ± 0.057
0.0AlaXaa: 0.0 ± 0.0
Cys
1.051CysAla: 1.051 ± 0.044
0.097CysCys: 0.097 ± 0.012
0.688CysAsp: 0.688 ± 0.031
0.48CysGlu: 0.48 ± 0.04
0.362CysPhe: 0.362 ± 0.021
0.914CysGly: 0.914 ± 0.041
0.217CysHis: 0.217 ± 0.016
0.48CysIle: 0.48 ± 0.025
0.31CysLys: 0.31 ± 0.022
0.667CysLeu: 0.667 ± 0.031
0.166CysMet: 0.166 ± 0.017
0.326CysAsn: 0.326 ± 0.023
0.462CysPro: 0.462 ± 0.024
0.251CysGln: 0.251 ± 0.021
0.433CysArg: 0.433 ± 0.025
0.57CysSer: 0.57 ± 0.027
0.433CysThr: 0.433 ± 0.027
0.497CysVal: 0.497 ± 0.03
0.109CysTrp: 0.109 ± 0.011
0.226CysTyr: 0.226 ± 0.017
0.0CysXaa: 0.0 ± 0.0
Asp
6.475AspAla: 6.475 ± 0.104
0.432AspCys: 0.432 ± 0.023
3.955AspAsp: 3.955 ± 0.081
4.237AspGlu: 4.237 ± 0.076
2.309AspPhe: 2.309 ± 0.064
5.264AspGly: 5.264 ± 0.1
1.267AspHis: 1.267 ± 0.042
4.962AspIle: 4.962 ± 0.077
3.402AspLys: 3.402 ± 0.077
5.116AspLeu: 5.116 ± 0.091
1.997AspMet: 1.997 ± 0.05
2.726AspAsn: 2.726 ± 0.059
2.629AspPro: 2.629 ± 0.058
1.893AspGln: 1.893 ± 0.055
3.11AspArg: 3.11 ± 0.076
2.672AspSer: 2.672 ± 0.073
2.005AspThr: 2.005 ± 0.056
3.772AspVal: 3.772 ± 0.072
0.864AspTrp: 0.864 ± 0.035
1.825AspTyr: 1.825 ± 0.048
0.0AspXaa: 0.0 ± 0.0
Glu
5.825GluAla: 5.825 ± 0.112
0.345GluCys: 0.345 ± 0.024
2.903GluAsp: 2.903 ± 0.07
3.372GluGlu: 3.372 ± 0.095
2.039GluPhe: 2.039 ± 0.057
3.719GluGly: 3.719 ± 0.076
1.151GluHis: 1.151 ± 0.036
4.522GluIle: 4.522 ± 0.081
3.826GluLys: 3.826 ± 0.082
4.46GluLeu: 4.46 ± 0.083
1.935GluMet: 1.935 ± 0.053
3.185GluAsn: 3.185 ± 0.069
1.822GluPro: 1.822 ± 0.041
2.567GluGln: 2.567 ± 0.057
3.305GluArg: 3.305 ± 0.078
2.406GluSer: 2.406 ± 0.055
2.74GluThr: 2.74 ± 0.061
2.989GluVal: 2.989 ± 0.08
0.633GluTrp: 0.633 ± 0.03
1.637GluTyr: 1.637 ± 0.047
0.0GluXaa: 0.0 ± 0.0
Phe
4.544PheAla: 4.544 ± 0.08
0.401PheCys: 0.401 ± 0.024
3.034PheAsp: 3.034 ± 0.072
2.196PheGlu: 2.196 ± 0.054
1.654PhePhe: 1.654 ± 0.058
3.888PheGly: 3.888 ± 0.08
0.754PheHis: 0.754 ± 0.03
2.721PheIle: 2.721 ± 0.069
1.391PheLys: 1.391 ± 0.051
3.403PheLeu: 3.403 ± 0.078
1.067PheMet: 1.067 ± 0.034
1.721PheAsn: 1.721 ± 0.05
1.447PhePro: 1.447 ± 0.044
1.012PheGln: 1.012 ± 0.039
1.643PheArg: 1.643 ± 0.044
2.514PheSer: 2.514 ± 0.058
2.34PheThr: 2.34 ± 0.062
2.239PheVal: 2.239 ± 0.061
0.593PheTrp: 0.593 ± 0.03
1.151PheTyr: 1.151 ± 0.037
0.0PheXaa: 0.0 ± 0.0
Gly
7.988GlyAla: 7.988 ± 0.137
0.78GlyCys: 0.78 ± 0.033
4.941GlyAsp: 4.941 ± 0.084
4.473GlyGlu: 4.473 ± 0.087
3.599GlyPhe: 3.599 ± 0.072
7.083GlyGly: 7.083 ± 0.134
1.852GlyHis: 1.852 ± 0.057
4.848GlyIle: 4.848 ± 0.082
4.545GlyLys: 4.545 ± 0.081
7.213GlyLeu: 7.213 ± 0.096
2.369GlyMet: 2.369 ± 0.06
3.142GlyAsn: 3.142 ± 0.081
2.976GlyPro: 2.976 ± 0.065
3.357GlyGln: 3.357 ± 0.078
4.551GlyArg: 4.551 ± 0.081
4.457GlySer: 4.457 ± 0.096
3.932GlyThr: 3.932 ± 0.097
5.177GlyVal: 5.177 ± 0.105
1.314GlyTrp: 1.314 ± 0.046
2.472GlyTyr: 2.472 ± 0.064
0.0GlyXaa: 0.0 ± 0.0
His
1.894HisAla: 1.894 ± 0.055
0.229HisCys: 0.229 ± 0.019
1.405HisAsp: 1.405 ± 0.044
1.127HisGlu: 1.127 ± 0.041
0.922HisPhe: 0.922 ± 0.036
1.773HisGly: 1.773 ± 0.056
0.766HisHis: 0.766 ± 0.037
1.847HisIle: 1.847 ± 0.05
0.904HisLys: 0.904 ± 0.03
1.883HisLeu: 1.883 ± 0.049
0.578HisMet: 0.578 ± 0.03
0.784HisAsn: 0.784 ± 0.035
1.148HisPro: 1.148 ± 0.047
0.739HisGln: 0.739 ± 0.034
1.035HisArg: 1.035 ± 0.037
1.089HisSer: 1.089 ± 0.038
0.453HisThr: 0.453 ± 0.023
1.242HisVal: 1.242 ± 0.048
0.321HisTrp: 0.321 ± 0.02
0.688HisTyr: 0.688 ± 0.033
0.0HisXaa: 0.0 ± 0.0
Ile
8.189IleAla: 8.189 ± 0.13
0.955IleCys: 0.955 ± 0.049
4.618IleAsp: 4.618 ± 0.077
4.119IleGlu: 4.119 ± 0.084
3.465IlePhe: 3.465 ± 0.086
6.16IleGly: 6.16 ± 0.109
1.027IleHis: 1.027 ± 0.036
6.017IleIle: 6.017 ± 0.118
3.323IleLys: 3.323 ± 0.075
7.466IleLeu: 7.466 ± 0.118
1.935IleMet: 1.935 ± 0.058
3.0IleAsn: 3.0 ± 0.067
2.66IlePro: 2.66 ± 0.059
1.498IleGln: 1.498 ± 0.043
3.026IleArg: 3.026 ± 0.067
5.441IleSer: 5.441 ± 0.093
3.28IleThr: 3.28 ± 0.068
4.076IleVal: 4.076 ± 0.082
1.181IleTrp: 1.181 ± 0.046
2.035IleTyr: 2.035 ± 0.052
0.0IleXaa: 0.0 ± 0.0
Lys
4.991LysAla: 4.991 ± 0.098
0.325LysCys: 0.325 ± 0.02
2.543LysAsp: 2.543 ± 0.057
2.61LysGlu: 2.61 ± 0.064
1.927LysPhe: 1.927 ± 0.054
3.63LysGly: 3.63 ± 0.078
0.843LysHis: 0.843 ± 0.031
4.328LysIle: 4.328 ± 0.077
3.185LysLys: 3.185 ± 0.088
5.158LysLeu: 5.158 ± 0.097
1.942LysMet: 1.942 ± 0.051
2.702LysAsn: 2.702 ± 0.075
2.248LysPro: 2.248 ± 0.06
1.808LysGln: 1.808 ± 0.045
2.434LysArg: 2.434 ± 0.063
3.339LysSer: 3.339 ± 0.067
2.2LysThr: 2.2 ± 0.057
2.636LysVal: 2.636 ± 0.066
0.877LysTrp: 0.877 ± 0.038
1.588LysTyr: 1.588 ± 0.051
0.0LysXaa: 0.0 ± 0.0
Leu
9.733LeuAla: 9.733 ± 0.125
0.925LeuCys: 0.925 ± 0.039
5.22LeuAsp: 5.22 ± 0.1
4.26LeuGlu: 4.26 ± 0.1
3.759LeuPhe: 3.759 ± 0.076
6.978LeuGly: 6.978 ± 0.112
1.731LeuHis: 1.731 ± 0.052
5.881LeuIle: 5.881 ± 0.108
4.039LeuLys: 4.039 ± 0.06
8.342LeuLeu: 8.342 ± 0.148
2.364LeuMet: 2.364 ± 0.061
3.943LeuAsn: 3.943 ± 0.089
4.768LeuPro: 4.768 ± 0.09
2.75LeuGln: 2.75 ± 0.063
4.94LeuArg: 4.94 ± 0.087
7.279LeuSer: 7.279 ± 0.107
4.862LeuThr: 4.862 ± 0.089
5.239LeuVal: 5.239 ± 0.083
1.058LeuTrp: 1.058 ± 0.043
2.3LeuTyr: 2.3 ± 0.062
0.0LeuXaa: 0.0 ± 0.0
Met
3.861MetAla: 3.861 ± 0.073
0.166MetCys: 0.166 ± 0.013
1.748MetAsp: 1.748 ± 0.048
1.512MetGlu: 1.512 ± 0.051
0.776MetPhe: 0.776 ± 0.03
2.589MetGly: 2.589 ± 0.059
0.57MetHis: 0.57 ± 0.024
1.883MetIle: 1.883 ± 0.054
1.438MetLys: 1.438 ± 0.042
2.755MetLeu: 2.755 ± 0.065
1.033MetMet: 1.033 ± 0.046
1.185MetAsn: 1.185 ± 0.042
1.608MetPro: 1.608 ± 0.049
1.108MetGln: 1.108 ± 0.037
1.755MetArg: 1.755 ± 0.043
1.781MetSer: 1.781 ± 0.05
1.829MetThr: 1.829 ± 0.054
1.975MetVal: 1.975 ± 0.046
0.242MetTrp: 0.242 ± 0.019
0.271MetTyr: 0.271 ± 0.021
0.0MetXaa: 0.0 ± 0.0
Asn
4.343AsnAla: 4.343 ± 0.081
0.468AsnCys: 0.468 ± 0.044
2.781AsnAsp: 2.781 ± 0.064
2.175AsnGlu: 2.175 ± 0.055
1.822AsnPhe: 1.822 ± 0.06
4.185AsnGly: 4.185 ± 0.119
0.739AsnHis: 0.739 ± 0.032
4.226AsnIle: 4.226 ± 0.081
2.05AsnLys: 2.05 ± 0.056
3.965AsnLeu: 3.965 ± 0.075
1.363AsnMet: 1.363 ± 0.046
2.186AsnAsn: 2.186 ± 0.07
2.3AsnPro: 2.3 ± 0.077
1.32AsnGln: 1.32 ± 0.05
2.092AsnArg: 2.092 ± 0.055
2.426AsnSer: 2.426 ± 0.058
1.112AsnThr: 1.112 ± 0.047
2.777AsnVal: 2.777 ± 0.085
0.734AsnTrp: 0.734 ± 0.038
1.197AsnTyr: 1.197 ± 0.041
0.0AsnXaa: 0.0 ± 0.0
Pro
4.533ProAla: 4.533 ± 0.13
0.318ProCys: 0.318 ± 0.025
2.909ProAsp: 2.909 ± 0.062
2.784ProGlu: 2.784 ± 0.063
1.815ProPhe: 1.815 ± 0.051
2.694ProGly: 2.694 ± 0.053
1.097ProHis: 1.097 ± 0.04
3.374ProIle: 3.374 ± 0.064
2.43ProLys: 2.43 ± 0.059
3.886ProLeu: 3.886 ± 0.071
1.241ProMet: 1.241 ± 0.037
2.086ProAsn: 2.086 ± 0.063
1.901ProPro: 1.901 ± 0.075
1.856ProGln: 1.856 ± 0.062
1.846ProArg: 1.846 ± 0.056
2.618ProSer: 2.618 ± 0.061
2.076ProThr: 2.076 ± 0.072
3.123ProVal: 3.123 ± 0.068
0.543ProTrp: 0.543 ± 0.028
1.32ProTyr: 1.32 ± 0.044
0.0ProXaa: 0.0 ± 0.0
Gln
3.457GlnAla: 3.457 ± 0.073
0.324GlnCys: 0.324 ± 0.02
1.694GlnAsp: 1.694 ± 0.054
1.672GlnGlu: 1.672 ± 0.045
1.519GlnPhe: 1.519 ± 0.045
2.377GlnGly: 2.377 ± 0.057
0.824GlnHis: 0.824 ± 0.032
3.159GlnIle: 3.159 ± 0.073
2.151GlnLys: 2.151 ± 0.061
3.368GlnLeu: 3.368 ± 0.068
1.202GlnMet: 1.202 ± 0.043
2.077GlnAsn: 2.077 ± 0.062
1.421GlnPro: 1.421 ± 0.048
1.51GlnGln: 1.51 ± 0.047
1.923GlnArg: 1.923 ± 0.051
2.542GlnSer: 2.542 ± 0.061
1.406GlnThr: 1.406 ± 0.05
1.779GlnVal: 1.779 ± 0.055
0.422GlnTrp: 0.422 ± 0.023
1.239GlnTyr: 1.239 ± 0.039
0.0GlnXaa: 0.0 ± 0.0
Arg
5.406ArgAla: 5.406 ± 0.092
0.338ArgCys: 0.338 ± 0.02
3.217ArgAsp: 3.217 ± 0.069
2.951ArgGlu: 2.951 ± 0.078
2.188ArgPhe: 2.188 ± 0.052
3.714ArgGly: 3.714 ± 0.082
1.393ArgHis: 1.393 ± 0.043
3.452ArgIle: 3.452 ± 0.064
2.564ArgLys: 2.564 ± 0.067
5.141ArgLeu: 5.141 ± 0.095
1.484ArgMet: 1.484 ± 0.044
1.984ArgAsn: 1.984 ± 0.055
2.571ArgPro: 2.571 ± 0.063
2.126ArgGln: 2.126 ± 0.056
3.022ArgArg: 3.022 ± 0.073
2.76ArgSer: 2.76 ± 0.062
2.279ArgThr: 2.279 ± 0.063
3.076ArgVal: 3.076 ± 0.068
0.691ArgTrp: 0.691 ± 0.028
1.417ArgTyr: 1.417 ± 0.045
0.0ArgXaa: 0.0 ± 0.0
Ser
6.392SerAla: 6.392 ± 0.094
0.572SerCys: 0.572 ± 0.03
3.597SerAsp: 3.597 ± 0.075
3.027SerGlu: 3.027 ± 0.067
2.65SerPhe: 2.65 ± 0.058
5.765SerGly: 5.765 ± 0.111
1.235SerHis: 1.235 ± 0.039
4.234SerIle: 4.234 ± 0.08
2.748SerLys: 2.748 ± 0.06
5.49SerLeu: 5.49 ± 0.104
1.759SerMet: 1.759 ± 0.049
2.497SerAsn: 2.497 ± 0.078
2.78SerPro: 2.78 ± 0.064
2.079SerGln: 2.079 ± 0.058
2.975SerArg: 2.975 ± 0.065
3.634SerSer: 3.634 ± 0.081
2.721SerThr: 2.721 ± 0.06
3.522SerVal: 3.522 ± 0.113
0.883SerTrp: 0.883 ± 0.039
1.739SerTyr: 1.739 ± 0.053
0.0SerXaa: 0.0 ± 0.0
Thr
4.889ThrAla: 4.889 ± 0.088
0.345ThrCys: 0.345 ± 0.022
2.586ThrAsp: 2.586 ± 0.066
2.067ThrGlu: 2.067 ± 0.056
1.584ThrPhe: 1.584 ± 0.053
4.257ThrGly: 4.257 ± 0.088
0.958ThrHis: 0.958 ± 0.035
3.217ThrIle: 3.217 ± 0.072
2.205ThrLys: 2.205 ± 0.064
4.43ThrLeu: 4.43 ± 0.082
1.145ThrMet: 1.145 ± 0.041
1.968ThrAsn: 1.968 ± 0.072
2.785ThrPro: 2.785 ± 0.086
1.654ThrGln: 1.654 ± 0.049
2.202ThrArg: 2.202 ± 0.053
2.859ThrSer: 2.859 ± 0.068
2.119ThrThr: 2.119 ± 0.074
2.732ThrVal: 2.732 ± 0.073
0.418ThrTrp: 0.418 ± 0.024
1.133ThrTyr: 1.133 ± 0.044
0.0ThrXaa: 0.0 ± 0.0
Val
6.246ValAla: 6.246 ± 0.113
0.405ValCys: 0.405 ± 0.025
4.12ValAsp: 4.12 ± 0.079
4.115ValGlu: 4.115 ± 0.076
1.781ValPhe: 1.781 ± 0.05
4.494ValGly: 4.494 ± 0.085
1.235ValHis: 1.235 ± 0.034
4.095ValIle: 4.095 ± 0.077
3.281ValLys: 3.281 ± 0.07
3.956ValLeu: 3.956 ± 0.081
1.692ValMet: 1.692 ± 0.054
2.867ValAsn: 2.867 ± 0.1
2.73ValPro: 2.73 ± 0.071
2.117ValGln: 2.117 ± 0.051
3.422ValArg: 3.422 ± 0.07
3.511ValSer: 3.511 ± 0.068
3.476ValThr: 3.476 ± 0.083
3.699ValVal: 3.699 ± 0.099
0.467ValTrp: 0.467 ± 0.025
1.251ValTyr: 1.251 ± 0.047
0.0ValXaa: 0.0 ± 0.0
Trp
1.166TrpAla: 1.166 ± 0.036
0.112TrpCys: 0.112 ± 0.011
0.725TrpAsp: 0.725 ± 0.034
0.543TrpGlu: 0.543 ± 0.03
0.53TrpPhe: 0.53 ± 0.028
0.87TrpGly: 0.87 ± 0.036
0.375TrpHis: 0.375 ± 0.022
0.71TrpIle: 0.71 ± 0.033
0.553TrpLys: 0.553 ± 0.024
1.464TrpLeu: 1.464 ± 0.052
0.42TrpMet: 0.42 ± 0.02
0.535TrpAsn: 0.535 ± 0.03
0.61TrpPro: 0.61 ± 0.031
0.728TrpGln: 0.728 ± 0.032
0.945TrpArg: 0.945 ± 0.033
0.776TrpSer: 0.776 ± 0.036
0.658TrpThr: 0.658 ± 0.031
0.814TrpVal: 0.814 ± 0.034
0.2TrpTrp: 0.2 ± 0.015
0.284TrpTyr: 0.284 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.606TyrAla: 2.606 ± 0.061
0.337TyrCys: 0.337 ± 0.02
1.959TyrAsp: 1.959 ± 0.062
1.405TyrGlu: 1.405 ± 0.039
1.291TyrPhe: 1.291 ± 0.046
2.447TyrGly: 2.447 ± 0.058
0.687TyrHis: 0.687 ± 0.033
1.741TyrIle: 1.741 ± 0.056
1.109TyrLys: 1.109 ± 0.038
2.406TyrLeu: 2.406 ± 0.054
0.637TyrMet: 0.637 ± 0.031
1.077TyrAsn: 1.077 ± 0.042
1.134TyrPro: 1.134 ± 0.04
1.038TyrGln: 1.038 ± 0.048
1.631TyrArg: 1.631 ± 0.044
1.712TyrSer: 1.712 ± 0.051
1.03TyrThr: 1.03 ± 0.044
1.504TyrVal: 1.504 ± 0.049
0.455TyrTrp: 0.455 ± 0.024
0.889TyrTyr: 0.889 ± 0.036
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2350 proteins (760127 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski