Amino acid dipepetide frequency for Alteromonas aestuariivivens

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.265AlaAla: 8.265 ± 0.122
1.021AlaCys: 1.021 ± 0.029
4.928AlaAsp: 4.928 ± 0.067
5.929AlaGlu: 5.929 ± 0.085
3.523AlaPhe: 3.523 ± 0.064
6.82AlaGly: 6.82 ± 0.096
1.866AlaHis: 1.866 ± 0.04
5.405AlaIle: 5.405 ± 0.074
3.941AlaLys: 3.941 ± 0.072
10.312AlaLeu: 10.312 ± 0.097
2.678AlaMet: 2.678 ± 0.049
3.561AlaAsn: 3.561 ± 0.055
3.31AlaPro: 3.31 ± 0.062
4.286AlaGln: 4.286 ± 0.065
4.843AlaArg: 4.843 ± 0.069
5.842AlaSer: 5.842 ± 0.079
4.573AlaThr: 4.573 ± 0.076
6.287AlaVal: 6.287 ± 0.082
1.037AlaTrp: 1.037 ± 0.034
2.563AlaTyr: 2.563 ± 0.044
0.0AlaXaa: 0.0 ± 0.0
Cys
0.857CysAla: 0.857 ± 0.029
0.161CysCys: 0.161 ± 0.013
0.574CysAsp: 0.574 ± 0.02
0.578CysGlu: 0.578 ± 0.021
0.447CysPhe: 0.447 ± 0.021
0.851CysGly: 0.851 ± 0.029
0.342CysHis: 0.342 ± 0.021
0.556CysIle: 0.556 ± 0.025
0.361CysLys: 0.361 ± 0.019
1.041CysLeu: 1.041 ± 0.034
0.231CysMet: 0.231 ± 0.014
0.363CysAsn: 0.363 ± 0.016
0.456CysPro: 0.456 ± 0.023
0.519CysGln: 0.519 ± 0.021
0.576CysArg: 0.576 ± 0.026
0.713CysSer: 0.713 ± 0.026
0.46CysThr: 0.46 ± 0.021
0.675CysVal: 0.675 ± 0.03
0.14CysTrp: 0.14 ± 0.012
0.312CysTyr: 0.312 ± 0.017
0.0CysXaa: 0.0 ± 0.0
Asp
4.923AspAla: 4.923 ± 0.08
0.578AspCys: 0.578 ± 0.022
3.314AspAsp: 3.314 ± 0.056
3.739AspGlu: 3.739 ± 0.066
2.539AspPhe: 2.539 ± 0.051
4.1AspGly: 4.1 ± 0.071
1.134AspHis: 1.134 ± 0.034
3.652AspIle: 3.652 ± 0.057
2.747AspLys: 2.747 ± 0.048
4.959AspLeu: 4.959 ± 0.076
1.452AspMet: 1.452 ± 0.035
2.366AspAsn: 2.366 ± 0.051
2.444AspPro: 2.444 ± 0.049
1.835AspGln: 1.835 ± 0.039
2.393AspArg: 2.393 ± 0.053
3.5AspSer: 3.5 ± 0.057
2.926AspThr: 2.926 ± 0.058
3.887AspVal: 3.887 ± 0.054
1.036AspTrp: 1.036 ± 0.034
2.216AspTyr: 2.216 ± 0.048
0.0AspXaa: 0.0 ± 0.0
Glu
5.388GluAla: 5.388 ± 0.078
0.484GluCys: 0.484 ± 0.021
2.967GluAsp: 2.967 ± 0.053
3.519GluGlu: 3.519 ± 0.08
2.665GluPhe: 2.665 ± 0.049
3.681GluGly: 3.681 ± 0.062
1.597GluHis: 1.597 ± 0.04
3.388GluIle: 3.388 ± 0.061
3.083GluLys: 3.083 ± 0.056
6.822GluLeu: 6.822 ± 0.085
1.554GluMet: 1.554 ± 0.04
2.497GluAsn: 2.497 ± 0.047
2.354GluPro: 2.354 ± 0.052
4.206GluGln: 4.206 ± 0.077
3.515GluArg: 3.515 ± 0.062
3.716GluSer: 3.716 ± 0.058
2.9GluThr: 2.9 ± 0.055
4.225GluVal: 4.225 ± 0.067
0.787GluTrp: 0.787 ± 0.028
1.852GluTyr: 1.852 ± 0.042
0.0GluXaa: 0.0 ± 0.0
Phe
3.78PheAla: 3.78 ± 0.071
0.515PheCys: 0.515 ± 0.024
2.863PheAsp: 2.863 ± 0.042
2.703PheGlu: 2.703 ± 0.055
1.714PhePhe: 1.714 ± 0.05
3.215PheGly: 3.215 ± 0.058
0.875PheHis: 0.875 ± 0.025
2.435PheIle: 2.435 ± 0.048
1.63PheLys: 1.63 ± 0.038
3.436PheLeu: 3.436 ± 0.068
0.977PheMet: 0.977 ± 0.032
1.897PheAsn: 1.897 ± 0.044
1.461PhePro: 1.461 ± 0.034
1.276PheGln: 1.276 ± 0.034
1.976PheArg: 1.976 ± 0.047
3.374PheSer: 3.374 ± 0.06
2.287PheThr: 2.287 ± 0.048
2.934PheVal: 2.934 ± 0.051
0.563PheTrp: 0.563 ± 0.023
1.463PheTyr: 1.463 ± 0.039
0.0PheXaa: 0.0 ± 0.0
Gly
5.607GlyAla: 5.607 ± 0.075
0.892GlyCys: 0.892 ± 0.029
3.868GlyAsp: 3.868 ± 0.06
4.454GlyGlu: 4.454 ± 0.069
3.472GlyPhe: 3.472 ± 0.055
4.868GlyGly: 4.868 ± 0.08
1.658GlyHis: 1.658 ± 0.041
4.491GlyIle: 4.491 ± 0.069
3.789GlyLys: 3.789 ± 0.07
7.304GlyLeu: 7.304 ± 0.092
2.091GlyMet: 2.091 ± 0.052
2.875GlyAsn: 2.875 ± 0.05
2.084GlyPro: 2.084 ± 0.044
3.166GlyGln: 3.166 ± 0.053
3.459GlyArg: 3.459 ± 0.063
4.194GlySer: 4.194 ± 0.07
3.593GlyThr: 3.593 ± 0.062
5.231GlyVal: 5.231 ± 0.079
1.123GlyTrp: 1.123 ± 0.03
2.68GlyTyr: 2.68 ± 0.056
0.0GlyXaa: 0.0 ± 0.0
His
1.702HisAla: 1.702 ± 0.037
0.34HisCys: 0.34 ± 0.02
1.02HisAsp: 1.02 ± 0.03
1.142HisGlu: 1.142 ± 0.033
1.131HisPhe: 1.131 ± 0.035
1.647HisGly: 1.647 ± 0.035
0.722HisHis: 0.722 ± 0.027
1.336HisIle: 1.336 ± 0.034
0.965HisLys: 0.965 ± 0.033
2.265HisLeu: 2.265 ± 0.047
0.522HisMet: 0.522 ± 0.021
0.987HisAsn: 0.987 ± 0.031
1.336HisPro: 1.336 ± 0.033
1.278HisGln: 1.278 ± 0.03
1.291HisArg: 1.291 ± 0.034
1.559HisSer: 1.559 ± 0.037
1.215HisThr: 1.215 ± 0.036
1.287HisVal: 1.287 ± 0.034
0.442HisTrp: 0.442 ± 0.02
1.001HisTyr: 1.001 ± 0.034
0.0HisXaa: 0.0 ± 0.0
Ile
5.604IleAla: 5.604 ± 0.082
0.596IleCys: 0.596 ± 0.024
3.717IleAsp: 3.717 ± 0.06
4.104IleGlu: 4.104 ± 0.059
1.899IlePhe: 1.899 ± 0.045
4.341IleGly: 4.341 ± 0.062
1.226IleHis: 1.226 ± 0.036
2.828IleIle: 2.828 ± 0.063
2.437IleLys: 2.437 ± 0.049
4.814IleLeu: 4.814 ± 0.071
1.153IleMet: 1.153 ± 0.036
2.55IleAsn: 2.55 ± 0.05
2.493IlePro: 2.493 ± 0.05
2.226IleGln: 2.226 ± 0.046
3.107IleArg: 3.107 ± 0.051
3.948IleSer: 3.948 ± 0.056
3.219IleThr: 3.219 ± 0.055
3.763IleVal: 3.763 ± 0.061
0.647IleTrp: 0.647 ± 0.025
1.568IleTyr: 1.568 ± 0.04
0.0IleXaa: 0.0 ± 0.0
Lys
4.324LysAla: 4.324 ± 0.073
0.315LysCys: 0.315 ± 0.02
2.173LysAsp: 2.173 ± 0.047
2.391LysGlu: 2.391 ± 0.056
1.37LysPhe: 1.37 ± 0.039
2.907LysGly: 2.907 ± 0.055
1.076LysHis: 1.076 ± 0.029
2.385LysIle: 2.385 ± 0.055
2.039LysLys: 2.039 ± 0.049
4.645LysLeu: 4.645 ± 0.066
1.098LysMet: 1.098 ± 0.036
1.755LysAsn: 1.755 ± 0.043
2.144LysPro: 2.144 ± 0.041
2.468LysGln: 2.468 ± 0.053
2.55LysArg: 2.55 ± 0.047
2.69LysSer: 2.69 ± 0.051
2.369LysThr: 2.369 ± 0.048
3.287LysVal: 3.287 ± 0.052
0.539LysTrp: 0.539 ± 0.02
1.235LysTyr: 1.235 ± 0.034
0.0LysXaa: 0.0 ± 0.0
Leu
10.538LeuAla: 10.538 ± 0.114
1.101LeuCys: 1.101 ± 0.034
5.786LeuAsp: 5.786 ± 0.082
5.962LeuGlu: 5.962 ± 0.079
4.183LeuPhe: 4.183 ± 0.074
6.984LeuGly: 6.984 ± 0.082
2.18LeuHis: 2.18 ± 0.045
5.522LeuIle: 5.522 ± 0.075
4.759LeuLys: 4.759 ± 0.075
10.463LeuLeu: 10.463 ± 0.148
2.654LeuMet: 2.654 ± 0.055
4.587LeuAsn: 4.587 ± 0.065
5.23LeuPro: 5.23 ± 0.077
4.324LeuGln: 4.324 ± 0.077
4.901LeuArg: 4.901 ± 0.075
7.649LeuSer: 7.649 ± 0.092
5.855LeuThr: 5.855 ± 0.079
7.112LeuVal: 7.112 ± 0.097
1.147LeuTrp: 1.147 ± 0.036
2.883LeuTyr: 2.883 ± 0.059
0.0LeuXaa: 0.0 ± 0.0
Met
2.658MetAla: 2.658 ± 0.057
0.19MetCys: 0.19 ± 0.014
1.27MetAsp: 1.27 ± 0.038
1.276MetGlu: 1.276 ± 0.035
0.827MetPhe: 0.827 ± 0.027
1.781MetGly: 1.781 ± 0.043
0.545MetHis: 0.545 ± 0.023
1.22MetIle: 1.22 ± 0.036
1.191MetLys: 1.191 ± 0.032
2.791MetLeu: 2.791 ± 0.047
0.712MetMet: 0.712 ± 0.025
0.98MetAsn: 0.98 ± 0.033
1.259MetPro: 1.259 ± 0.033
1.343MetGln: 1.343 ± 0.037
1.266MetArg: 1.266 ± 0.031
1.746MetSer: 1.746 ± 0.041
1.508MetThr: 1.508 ± 0.03
1.74MetVal: 1.74 ± 0.041
0.238MetTrp: 0.238 ± 0.014
0.524MetTyr: 0.524 ± 0.021
0.0MetXaa: 0.0 ± 0.0
Asn
3.52AsnAla: 3.52 ± 0.057
0.383AsnCys: 0.383 ± 0.02
2.205AsnAsp: 2.205 ± 0.048
2.225AsnGlu: 2.225 ± 0.048
1.556AsnPhe: 1.556 ± 0.04
3.116AsnGly: 3.116 ± 0.06
0.965AsnHis: 0.965 ± 0.026
2.291AsnIle: 2.291 ± 0.049
1.691AsnLys: 1.691 ± 0.045
3.991AsnLeu: 3.991 ± 0.056
0.927AsnMet: 0.927 ± 0.03
1.696AsnAsn: 1.696 ± 0.051
2.2AsnPro: 2.2 ± 0.048
2.14AsnGln: 2.14 ± 0.046
2.409AsnArg: 2.409 ± 0.047
2.385AsnSer: 2.385 ± 0.052
2.236AsnThr: 2.236 ± 0.042
2.581AsnVal: 2.581 ± 0.048
0.696AsnTrp: 0.696 ± 0.025
1.298AsnTyr: 1.298 ± 0.035
0.0AsnXaa: 0.0 ± 0.0
Pro
3.887ProAla: 3.887 ± 0.066
0.338ProCys: 0.338 ± 0.017
2.884ProAsp: 2.884 ± 0.051
3.437ProGlu: 3.437 ± 0.053
1.827ProPhe: 1.827 ± 0.039
3.21ProGly: 3.21 ± 0.061
0.978ProHis: 0.978 ± 0.031
2.227ProIle: 2.227 ± 0.053
1.772ProLys: 1.772 ± 0.044
4.338ProLeu: 4.338 ± 0.071
1.071ProMet: 1.071 ± 0.029
1.644ProAsn: 1.644 ± 0.039
1.487ProPro: 1.487 ± 0.043
2.06ProGln: 2.06 ± 0.05
1.658ProArg: 1.658 ± 0.042
2.544ProSer: 2.544 ± 0.049
1.964ProThr: 1.964 ± 0.041
3.662ProVal: 3.662 ± 0.06
0.607ProTrp: 0.607 ± 0.022
1.387ProTyr: 1.387 ± 0.033
0.0ProXaa: 0.0 ± 0.0
Gln
4.966GlnAla: 4.966 ± 0.085
0.414GlnCys: 0.414 ± 0.022
2.192GlnAsp: 2.192 ± 0.048
2.467GlnGlu: 2.467 ± 0.044
1.892GlnPhe: 1.892 ± 0.042
3.215GlnGly: 3.215 ± 0.051
1.339GlnHis: 1.339 ± 0.037
2.549GlnIle: 2.549 ± 0.045
2.015GlnLys: 2.015 ± 0.042
5.228GlnLeu: 5.228 ± 0.074
1.102GlnMet: 1.102 ± 0.031
1.743GlnAsn: 1.743 ± 0.04
2.195GlnPro: 2.195 ± 0.046
3.563GlnGln: 3.563 ± 0.081
2.803GlnArg: 2.803 ± 0.062
3.137GlnSer: 3.137 ± 0.056
2.474GlnThr: 2.474 ± 0.046
3.281GlnVal: 3.281 ± 0.064
0.763GlnTrp: 0.763 ± 0.027
1.409GlnTyr: 1.409 ± 0.034
0.0GlnXaa: 0.0 ± 0.0
Arg
4.135ArgAla: 4.135 ± 0.065
0.497ArgCys: 0.497 ± 0.022
2.656ArgAsp: 2.656 ± 0.054
3.307ArgGlu: 3.307 ± 0.065
2.557ArgPhe: 2.557 ± 0.054
2.942ArgGly: 2.942 ± 0.056
1.383ArgHis: 1.383 ± 0.037
3.243ArgIle: 3.243 ± 0.056
2.311ArgLys: 2.311 ± 0.045
5.691ArgLeu: 5.691 ± 0.079
1.382ArgMet: 1.382 ± 0.04
2.098ArgAsn: 2.098 ± 0.044
2.039ArgPro: 2.039 ± 0.043
2.953ArgGln: 2.953 ± 0.059
2.851ArgArg: 2.851 ± 0.055
2.967ArgSer: 2.967 ± 0.05
2.298ArgThr: 2.298 ± 0.046
3.665ArgVal: 3.665 ± 0.057
0.797ArgTrp: 0.797 ± 0.023
2.086ArgTyr: 2.086 ± 0.047
0.0ArgXaa: 0.0 ± 0.0
Ser
6.153SerAla: 6.153 ± 0.072
0.612SerCys: 0.612 ± 0.025
3.817SerAsp: 3.817 ± 0.059
4.113SerGlu: 4.113 ± 0.067
2.617SerPhe: 2.617 ± 0.057
5.342SerGly: 5.342 ± 0.068
1.47SerHis: 1.47 ± 0.033
3.424SerIle: 3.424 ± 0.061
2.642SerLys: 2.642 ± 0.049
6.937SerLeu: 6.937 ± 0.092
1.623SerMet: 1.623 ± 0.037
2.379SerAsn: 2.379 ± 0.056
2.745SerPro: 2.745 ± 0.053
3.209SerGln: 3.209 ± 0.057
3.343SerArg: 3.343 ± 0.061
4.148SerSer: 4.148 ± 0.081
3.052SerThr: 3.052 ± 0.055
4.994SerVal: 4.994 ± 0.069
0.881SerTrp: 0.881 ± 0.034
1.914SerTyr: 1.914 ± 0.043
0.0SerXaa: 0.0 ± 0.0
Thr
4.527ThrAla: 4.527 ± 0.068
0.435ThrCys: 0.435 ± 0.019
2.978ThrAsp: 2.978 ± 0.061
3.13ThrGlu: 3.13 ± 0.043
2.06ThrPhe: 2.06 ± 0.043
4.23ThrGly: 4.23 ± 0.058
1.251ThrHis: 1.251 ± 0.035
2.874ThrIle: 2.874 ± 0.058
1.636ThrLys: 1.636 ± 0.038
6.351ThrLeu: 6.351 ± 0.079
1.055ThrMet: 1.055 ± 0.032
1.794ThrAsn: 1.794 ± 0.043
2.703ThrPro: 2.703 ± 0.052
2.373ThrGln: 2.373 ± 0.054
2.658ThrArg: 2.658 ± 0.05
3.205ThrSer: 3.205 ± 0.058
2.613ThrThr: 2.613 ± 0.053
3.955ThrVal: 3.955 ± 0.063
0.598ThrTrp: 0.598 ± 0.027
1.476ThrTyr: 1.476 ± 0.039
0.0ThrXaa: 0.0 ± 0.0
Val
6.652ValAla: 6.652 ± 0.094
0.795ValCys: 0.795 ± 0.029
4.112ValAsp: 4.112 ± 0.059
4.388ValGlu: 4.388 ± 0.066
2.947ValPhe: 2.947 ± 0.057
4.651ValGly: 4.651 ± 0.073
1.364ValHis: 1.364 ± 0.034
4.302ValIle: 4.302 ± 0.076
3.178ValLys: 3.178 ± 0.053
6.92ValLeu: 6.92 ± 0.083
1.857ValMet: 1.857 ± 0.044
3.073ValAsn: 3.073 ± 0.052
2.974ValPro: 2.974 ± 0.052
2.401ValGln: 2.401 ± 0.042
3.391ValArg: 3.391 ± 0.065
5.238ValSer: 5.238 ± 0.076
4.278ValThr: 4.278 ± 0.067
5.444ValVal: 5.444 ± 0.082
0.845ValTrp: 0.845 ± 0.031
2.079ValTyr: 2.079 ± 0.041
0.0ValXaa: 0.0 ± 0.0
Trp
0.957TrpAla: 0.957 ± 0.033
0.163TrpCys: 0.163 ± 0.012
0.654TrpAsp: 0.654 ± 0.028
0.631TrpGlu: 0.631 ± 0.025
0.647TrpPhe: 0.647 ± 0.025
0.831TrpGly: 0.831 ± 0.027
0.39TrpHis: 0.39 ± 0.02
0.657TrpIle: 0.657 ± 0.022
0.475TrpLys: 0.475 ± 0.02
1.882TrpLeu: 1.882 ± 0.047
0.357TrpMet: 0.357 ± 0.019
0.52TrpAsn: 0.52 ± 0.022
0.566TrpPro: 0.566 ± 0.025
1.166TrpGln: 1.166 ± 0.035
0.777TrpArg: 0.777 ± 0.026
0.774TrpSer: 0.774 ± 0.033
0.506TrpThr: 0.506 ± 0.022
0.966TrpVal: 0.966 ± 0.027
0.227TrpTrp: 0.227 ± 0.016
0.478TrpTyr: 0.478 ± 0.022
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.546TyrAla: 2.546 ± 0.051
0.383TyrCys: 0.383 ± 0.019
1.761TyrAsp: 1.761 ± 0.037
1.708TyrGlu: 1.708 ± 0.04
1.499TyrPhe: 1.499 ± 0.034
2.169TyrGly: 2.169 ± 0.048
0.831TyrHis: 0.831 ± 0.032
1.457TyrIle: 1.457 ± 0.04
1.096TyrLys: 1.096 ± 0.033
3.628TyrLeu: 3.628 ± 0.068
0.569TyrMet: 0.569 ± 0.026
1.146TyrAsn: 1.146 ± 0.032
1.504TyrPro: 1.504 ± 0.038
1.955TyrGln: 1.955 ± 0.049
2.092TyrArg: 2.092 ± 0.043
2.088TyrSer: 2.088 ± 0.044
1.574TyrThr: 1.574 ± 0.04
1.911TyrVal: 1.911 ± 0.042
0.509TyrTrp: 0.509 ± 0.02
1.148TyrTyr: 1.148 ± 0.035
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3306 proteins (1141386 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski