Amino acid dipepetide frequency for Bacteroides heparinolyticus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.599AlaAla: 6.599 ± 0.098	1.15AlaCys: 1.15 ± 0.038	4.728AlaAsp: 4.728 ± 0.067	5.25AlaGlu: 5.25 ± 0.091	3.307AlaPhe: 3.307 ± 0.057	5.774AlaGly: 5.774 ± 0.076	1.322AlaHis: 1.322 ± 0.038	4.535AlaIle: 4.535 ± 0.08	4.161AlaLys: 4.161 ± 0.09	7.286AlaLeu: 7.286 ± 0.097	1.995AlaMet: 1.995 ± 0.049	3.104AlaAsn: 3.104 ± 0.065	2.512AlaPro: 2.512 ± 0.061	2.693AlaGln: 2.693 ± 0.059	3.517AlaArg: 3.517 ± 0.064	4.562AlaSer: 4.562 ± 0.069	4.095AlaThr: 4.095 ± 0.071	5.249AlaVal: 5.249 ± 0.079	0.879AlaTrp: 0.879 ± 0.03	3.183AlaTyr: 3.183 ± 0.062	0.0AlaXaa: 0.0 ± 0.0
Cys	0.838CysAla: 0.838 ± 0.03	0.223CysCys: 0.223 ± 0.015	0.667CysAsp: 0.667 ± 0.027	0.669CysGlu: 0.669 ± 0.025	0.626CysPhe: 0.626 ± 0.027	1.088CysGly: 1.088 ± 0.037	0.303CysHis: 0.303 ± 0.018	0.921CysIle: 0.921 ± 0.03	0.653CysLys: 0.653 ± 0.023	1.185CysLeu: 1.185 ± 0.039	0.355CysMet: 0.355 ± 0.019	0.598CysAsn: 0.598 ± 0.024	0.557CysPro: 0.557 ± 0.028	0.296CysGln: 0.296 ± 0.018	0.778CysArg: 0.778 ± 0.027	0.789CysSer: 0.789 ± 0.027	0.654CysThr: 0.654 ± 0.026	0.72CysVal: 0.72 ± 0.027	0.141CysTrp: 0.141 ± 0.011	0.551CysTyr: 0.551 ± 0.023	0.0CysXaa: 0.0 ± 0.0
Asp	4.193AspAla: 4.193 ± 0.065	0.615AspCys: 0.615 ± 0.023	2.548AspAsp: 2.548 ± 0.055	3.855AspGlu: 3.855 ± 0.068	3.041AspPhe: 3.041 ± 0.052	4.166AspGly: 4.166 ± 0.083	0.795AspHis: 0.795 ± 0.033	3.883AspIle: 3.883 ± 0.057	3.867AspLys: 3.867 ± 0.056	4.418AspLeu: 4.418 ± 0.062	1.599AspMet: 1.599 ± 0.043	2.577AspAsn: 2.577 ± 0.052	1.73AspPro: 1.73 ± 0.045	0.951AspGln: 0.951 ± 0.031	2.549AspArg: 2.549 ± 0.045	2.938AspSer: 2.938 ± 0.053	2.704AspThr: 2.704 ± 0.052	3.621AspVal: 3.621 ± 0.061	0.834AspTrp: 0.834 ± 0.032	2.791AspTyr: 2.791 ± 0.06	0.0AspXaa: 0.0 ± 0.0
Glu	5.329GluAla: 5.329 ± 0.084	0.641GluCys: 0.641 ± 0.028	3.127GluAsp: 3.127 ± 0.063	5.423GluGlu: 5.423 ± 0.097	2.37GluPhe: 2.37 ± 0.051	4.258GluGly: 4.258 ± 0.064	1.375GluHis: 1.375 ± 0.037	4.266GluIle: 4.266 ± 0.074	5.248GluLys: 5.248 ± 0.086	6.271GluLeu: 6.271 ± 0.091	2.076GluMet: 2.076 ± 0.054	3.321GluAsn: 3.321 ± 0.061	1.747GluPro: 1.747 ± 0.043	2.719GluGln: 2.719 ± 0.058	3.607GluArg: 3.607 ± 0.072	3.068GluSer: 3.068 ± 0.057	3.484GluThr: 3.484 ± 0.055	4.418GluVal: 4.418 ± 0.068	0.826GluTrp: 0.826 ± 0.034	2.697GluTyr: 2.697 ± 0.046	0.0GluXaa: 0.0 ± 0.0
Phe	3.232PheAla: 3.232 ± 0.06	0.678PheCys: 0.678 ± 0.025	2.693PheAsp: 2.693 ± 0.058	2.368PheGlu: 2.368 ± 0.048	2.291PhePhe: 2.291 ± 0.056	3.245PheGly: 3.245 ± 0.073	0.896PheHis: 0.896 ± 0.028	3.053PheIle: 3.053 ± 0.059	2.361PheLys: 2.361 ± 0.054	4.125PheLeu: 4.125 ± 0.079	1.246PheMet: 1.246 ± 0.033	2.213PheAsn: 2.213 ± 0.05	1.771PhePro: 1.771 ± 0.038	1.13PheGln: 1.13 ± 0.036	2.419PheArg: 2.419 ± 0.053	3.373PheSer: 3.373 ± 0.058	2.627PheThr: 2.627 ± 0.05	2.92PheVal: 2.92 ± 0.059	0.556PheTrp: 0.556 ± 0.026	1.946PheTyr: 1.946 ± 0.047	0.0PheXaa: 0.0 ± 0.0
Gly	4.656GlyAla: 4.656 ± 0.072	0.947GlyCys: 0.947 ± 0.033	3.395GlyAsp: 3.395 ± 0.062	4.381GlyGlu: 4.381 ± 0.071	3.195GlyPhe: 3.195 ± 0.065	5.201GlyGly: 5.201 ± 0.085	1.375GlyHis: 1.375 ± 0.037	5.302GlyIle: 5.302 ± 0.089	5.578GlyLys: 5.578 ± 0.088	5.914GlyLeu: 5.914 ± 0.084	2.373GlyMet: 2.373 ± 0.052	3.584GlyAsn: 3.584 ± 0.075	1.278GlyPro: 1.278 ± 0.037	2.059GlyGln: 2.059 ± 0.051	3.438GlyArg: 3.438 ± 0.061	4.082GlySer: 4.082 ± 0.073	4.298GlyThr: 4.298 ± 0.08	4.939GlyVal: 4.939 ± 0.087	1.06GlyTrp: 1.06 ± 0.037	3.38GlyTyr: 3.38 ± 0.082	0.0GlyXaa: 0.0 ± 0.0
His	1.399HisAla: 1.399 ± 0.04	0.33HisCys: 0.33 ± 0.018	0.968HisAsp: 0.968 ± 0.032	1.047HisGlu: 1.047 ± 0.035	1.05HisPhe: 1.05 ± 0.034	1.337HisGly: 1.337 ± 0.039	0.512HisHis: 0.512 ± 0.026	1.438HisIle: 1.438 ± 0.037	1.027HisLys: 1.027 ± 0.038	1.909HisLeu: 1.909 ± 0.043	0.363HisMet: 0.363 ± 0.02	0.898HisAsn: 0.898 ± 0.028	1.18HisPro: 1.18 ± 0.036	0.583HisGln: 0.583 ± 0.028	1.08HisArg: 1.08 ± 0.034	1.152HisSer: 1.152 ± 0.032	1.187HisThr: 1.187 ± 0.037	1.13HisVal: 1.13 ± 0.032	0.269HisTrp: 0.269 ± 0.015	0.871HisTyr: 0.871 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	5.252IleAla: 5.252 ± 0.091	0.917IleCys: 0.917 ± 0.029	4.006IleAsp: 4.006 ± 0.062	4.263IleGlu: 4.263 ± 0.067	2.586IlePhe: 2.586 ± 0.057	4.771IleGly: 4.771 ± 0.072	1.324IleHis: 1.324 ± 0.033	4.082IleIle: 4.082 ± 0.073	3.712IleLys: 3.712 ± 0.071	5.576IleLeu: 5.576 ± 0.081	1.373IleMet: 1.373 ± 0.039	3.106IleAsn: 3.106 ± 0.06	3.115IlePro: 3.115 ± 0.057	1.83IleGln: 1.83 ± 0.039	3.564IleArg: 3.564 ± 0.07	4.233IleSer: 4.233 ± 0.069	3.663IleThr: 3.663 ± 0.059	4.256IleVal: 4.256 ± 0.067	0.656IleTrp: 0.656 ± 0.025	2.58IleTyr: 2.58 ± 0.047	0.0IleXaa: 0.0 ± 0.0
Lys	5.03LysAla: 5.03 ± 0.083	0.533LysCys: 0.533 ± 0.025	3.693LysAsp: 3.693 ± 0.065	5.896LysGlu: 5.896 ± 0.086	2.02LysPhe: 2.02 ± 0.049	4.509LysGly: 4.509 ± 0.074	1.319LysHis: 1.319 ± 0.036	3.804LysIle: 3.804 ± 0.065	4.851LysLys: 4.851 ± 0.079	5.188LysLeu: 5.188 ± 0.066	1.967LysMet: 1.967 ± 0.04	3.36LysAsn: 3.36 ± 0.065	2.193LysPro: 2.193 ± 0.047	2.631LysGln: 2.631 ± 0.053	3.426LysArg: 3.426 ± 0.057	3.242LysSer: 3.242 ± 0.058	3.525LysThr: 3.525 ± 0.061	4.14LysVal: 4.14 ± 0.07	0.754LysTrp: 0.754 ± 0.03	2.72LysTyr: 2.72 ± 0.058	0.0LysXaa: 0.0 ± 0.0
Leu	6.7LeuAla: 6.7 ± 0.091	1.409LeuCys: 1.409 ± 0.046	4.291LeuAsp: 4.291 ± 0.064	5.114LeuGlu: 5.114 ± 0.079	4.642LeuPhe: 4.642 ± 0.078	5.682LeuGly: 5.682 ± 0.097	1.978LeuHis: 1.978 ± 0.038	5.292LeuIle: 5.292 ± 0.089	6.32LeuLys: 6.32 ± 0.071	9.246LeuLeu: 9.246 ± 0.133	2.544LeuMet: 2.544 ± 0.049	4.536LeuAsn: 4.536 ± 0.072	4.303LeuPro: 4.303 ± 0.07	3.472LeuGln: 3.472 ± 0.068	4.573LeuArg: 4.573 ± 0.085	6.715LeuSer: 6.715 ± 0.092	5.309LeuThr: 5.309 ± 0.077	5.067LeuVal: 5.067 ± 0.077	1.148LeuTrp: 1.148 ± 0.034	3.68LeuTyr: 3.68 ± 0.064	0.0LeuXaa: 0.0 ± 0.0
Met	2.175MetAla: 2.175 ± 0.048	0.251MetCys: 0.251 ± 0.015	1.46MetAsp: 1.46 ± 0.039	1.948MetGlu: 1.948 ± 0.04	0.983MetPhe: 0.983 ± 0.027	1.996MetGly: 1.996 ± 0.039	0.478MetHis: 0.478 ± 0.022	1.507MetIle: 1.507 ± 0.044	2.553MetLys: 2.553 ± 0.048	2.617MetLeu: 2.617 ± 0.055	0.826MetMet: 0.826 ± 0.031	1.586MetAsn: 1.586 ± 0.042	1.195MetPro: 1.195 ± 0.035	1.115MetGln: 1.115 ± 0.035	1.502MetArg: 1.502 ± 0.038	1.527MetSer: 1.527 ± 0.042	1.484MetThr: 1.484 ± 0.04	1.571MetVal: 1.571 ± 0.037	0.234MetTrp: 0.234 ± 0.014	0.837MetTyr: 0.837 ± 0.03	0.0MetXaa: 0.0 ± 0.0
Asn	3.529AsnAla: 3.529 ± 0.064	0.493AsnCys: 0.493 ± 0.025	2.465AsnAsp: 2.465 ± 0.051	2.959AsnGlu: 2.959 ± 0.052	2.162AsnPhe: 2.162 ± 0.053	3.782AsnGly: 3.782 ± 0.072	0.956AsnHis: 0.956 ± 0.033	3.451AsnIle: 3.451 ± 0.07	2.921AsnLys: 2.921 ± 0.062	4.319AsnLeu: 4.319 ± 0.064	1.266AsnMet: 1.266 ± 0.035	2.508AsnAsn: 2.508 ± 0.061	2.507AsnPro: 2.507 ± 0.05	1.464AsnGln: 1.464 ± 0.042	2.676AsnArg: 2.676 ± 0.05	2.675AsnSer: 2.675 ± 0.058	2.58AsnThr: 2.58 ± 0.055	3.077AsnVal: 3.077 ± 0.06	0.607AsnTrp: 0.607 ± 0.027	2.219AsnTyr: 2.219 ± 0.052	0.0AsnXaa: 0.0 ± 0.0
Pro	3.171ProAla: 3.171 ± 0.063	0.391ProCys: 0.391 ± 0.021	2.635ProAsp: 2.635 ± 0.058	3.33ProGlu: 3.33 ± 0.057	1.887ProPhe: 1.887 ± 0.047	2.607ProGly: 2.607 ± 0.055	0.814ProHis: 0.814 ± 0.03	2.278ProIle: 2.278 ± 0.045	1.97ProLys: 1.97 ± 0.048	3.367ProLeu: 3.367 ± 0.064	1.037ProMet: 1.037 ± 0.029	1.572ProAsn: 1.572 ± 0.045	0.869ProPro: 0.869 ± 0.035	1.446ProGln: 1.446 ± 0.041	1.468ProArg: 1.468 ± 0.036	2.177ProSer: 2.177 ± 0.049	2.032ProThr: 2.032 ± 0.044	2.878ProVal: 2.878 ± 0.056	0.475ProTrp: 0.475 ± 0.024	1.674ProTyr: 1.674 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	2.558GlnAla: 2.558 ± 0.049	0.289GlnCys: 0.289 ± 0.016	1.52GlnAsp: 1.52 ± 0.036	2.414GlnGlu: 2.414 ± 0.05	1.177GlnPhe: 1.177 ± 0.038	2.073GlnGly: 2.073 ± 0.05	0.619GlnHis: 0.619 ± 0.026	2.144GlnIle: 2.144 ± 0.049	2.31GlnLys: 2.31 ± 0.049	3.147GlnLeu: 3.147 ± 0.059	1.041GlnMet: 1.041 ± 0.035	1.596GlnAsn: 1.596 ± 0.04	1.255GlnPro: 1.255 ± 0.04	1.452GlnGln: 1.452 ± 0.038	1.68GlnArg: 1.68 ± 0.04	1.892GlnSer: 1.892 ± 0.042	2.024GlnThr: 2.024 ± 0.044	2.184GlnVal: 2.184 ± 0.054	0.451GlnTrp: 0.451 ± 0.023	1.287GlnTyr: 1.287 ± 0.039	0.0GlnXaa: 0.0 ± 0.0
Arg	3.142ArgAla: 3.142 ± 0.064	0.541ArgCys: 0.541 ± 0.021	2.205ArgAsp: 2.205 ± 0.045	3.241ArgGlu: 3.241 ± 0.075	2.611ArgPhe: 2.611 ± 0.051	2.743ArgGly: 2.743 ± 0.055	1.189ArgHis: 1.189 ± 0.032	3.974ArgIle: 3.974 ± 0.067	3.719ArgLys: 3.719 ± 0.063	5.103ArgLeu: 5.103 ± 0.087	1.823ArgMet: 1.823 ± 0.044	2.594ArgAsn: 2.594 ± 0.049	1.86ArgPro: 1.86 ± 0.048	1.992ArgGln: 1.992 ± 0.045	2.784ArgArg: 2.784 ± 0.066	2.62ArgSer: 2.62 ± 0.06	2.796ArgThr: 2.796 ± 0.05	2.741ArgVal: 2.741 ± 0.057	0.72ArgTrp: 0.72 ± 0.028	2.365ArgTyr: 2.365 ± 0.056	0.0ArgXaa: 0.0 ± 0.0
Ser	4.509SerAla: 4.509 ± 0.072	0.85SerCys: 0.85 ± 0.029	3.143SerAsp: 3.143 ± 0.061	3.339SerGlu: 3.339 ± 0.055	3.235SerPhe: 3.235 ± 0.059	4.598SerGly: 4.598 ± 0.074	1.167SerHis: 1.167 ± 0.035	4.012SerIle: 4.012 ± 0.064	3.134SerLys: 3.134 ± 0.054	5.979SerLeu: 5.979 ± 0.095	1.491SerMet: 1.491 ± 0.045	2.645SerAsn: 2.645 ± 0.06	2.33SerPro: 2.33 ± 0.048	1.727SerGln: 1.727 ± 0.042	2.794SerArg: 2.794 ± 0.062	3.681SerSer: 3.681 ± 0.07	3.167SerThr: 3.167 ± 0.058	4.298SerVal: 4.298 ± 0.072	0.766SerTrp: 0.766 ± 0.029	2.734SerTyr: 2.734 ± 0.061	0.0SerXaa: 0.0 ± 0.0
Thr	4.616ThrAla: 4.616 ± 0.088	0.611ThrCys: 0.611 ± 0.027	3.533ThrAsp: 3.533 ± 0.061	3.349ThrGlu: 3.349 ± 0.06	2.58ThrPhe: 2.58 ± 0.047	4.503ThrGly: 4.503 ± 0.068	1.013ThrHis: 1.013 ± 0.034	3.43ThrIle: 3.43 ± 0.061	2.754ThrLys: 2.754 ± 0.055	5.449ThrLeu: 5.449 ± 0.082	1.216ThrMet: 1.216 ± 0.035	2.379ThrAsn: 2.379 ± 0.052	2.859ThrPro: 2.859 ± 0.055	1.642ThrGln: 1.642 ± 0.042	2.349ThrArg: 2.349 ± 0.046	3.142ThrSer: 3.142 ± 0.061	3.032ThrThr: 3.032 ± 0.063	4.111ThrVal: 4.111 ± 0.067	0.635ThrTrp: 0.635 ± 0.025	2.416ThrTyr: 2.416 ± 0.049	0.0ThrXaa: 0.0 ± 0.0
Val	4.996ValAla: 4.996 ± 0.075	1.002ValCys: 1.002 ± 0.032	3.496ValAsp: 3.496 ± 0.067	4.104ValGlu: 4.104 ± 0.063	2.818ValPhe: 2.818 ± 0.054	4.154ValGly: 4.154 ± 0.067	1.118ValHis: 1.118 ± 0.037	4.073ValIle: 4.073 ± 0.061	4.161ValLys: 4.161 ± 0.072	5.907ValLeu: 5.907 ± 0.083	1.715ValMet: 1.715 ± 0.041	3.307ValAsn: 3.307 ± 0.066	2.621ValPro: 2.621 ± 0.052	1.985ValGln: 1.985 ± 0.035	3.415ValArg: 3.415 ± 0.058	4.459ValSer: 4.459 ± 0.069	3.683ValThr: 3.683 ± 0.068	4.641ValVal: 4.641 ± 0.076	0.781ValTrp: 0.781 ± 0.031	2.715ValTyr: 2.715 ± 0.056	0.0ValXaa: 0.0 ± 0.0
Trp	0.815TrpAla: 0.815 ± 0.031	0.164TrpCys: 0.164 ± 0.011	0.658TrpAsp: 0.658 ± 0.031	0.843TrpGlu: 0.843 ± 0.027	0.53TrpPhe: 0.53 ± 0.027	0.957TrpGly: 0.957 ± 0.029	0.278TrpHis: 0.278 ± 0.016	0.75TrpIle: 0.75 ± 0.025	0.912TrpLys: 0.912 ± 0.034	1.159TrpLeu: 1.159 ± 0.039	0.447TrpMet: 0.447 ± 0.02	0.775TrpAsn: 0.775 ± 0.028	0.295TrpPro: 0.295 ± 0.017	0.557TrpGln: 0.557 ± 0.023	0.595TrpArg: 0.595 ± 0.026	0.696TrpSer: 0.696 ± 0.03	0.691TrpThr: 0.691 ± 0.029	0.733TrpVal: 0.733 ± 0.03	0.199TrpTrp: 0.199 ± 0.016	0.524TrpTyr: 0.524 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.164TyrAla: 3.164 ± 0.062	0.578TyrCys: 0.578 ± 0.027	2.446TyrAsp: 2.446 ± 0.053	2.479TyrGlu: 2.479 ± 0.049	2.032TyrPhe: 2.032 ± 0.049	2.992TyrGly: 2.992 ± 0.056	0.9TyrHis: 0.9 ± 0.026	2.671TyrIle: 2.671 ± 0.054	2.587TyrLys: 2.587 ± 0.047	3.856TyrLeu: 3.856 ± 0.069	1.091TyrMet: 1.091 ± 0.033	2.359TyrAsn: 2.359 ± 0.06	1.901TyrPro: 1.901 ± 0.045	1.368TyrGln: 1.368 ± 0.038	2.55TyrArg: 2.55 ± 0.053	2.576TyrSer: 2.576 ± 0.051	2.581TyrThr: 2.581 ± 0.062	2.455TyrVal: 2.455 ± 0.054	0.584TyrTrp: 0.584 ± 0.027	2.017TyrTyr: 2.017 ± 0.048	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2705 proteins (1004298 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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