Amino acid dipepetide frequency for Mycolicibacterium doricum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
20.136AlaAla: 20.136 ± 0.234
0.954AlaCys: 0.954 ± 0.029
8.525AlaAsp: 8.525 ± 0.094
8.007AlaGlu: 8.007 ± 0.112
3.315AlaPhe: 3.315 ± 0.075
11.791AlaGly: 11.791 ± 0.129
2.601AlaHis: 2.601 ± 0.051
4.94AlaIle: 4.94 ± 0.072
3.022AlaLys: 3.022 ± 0.068
13.194AlaLeu: 13.194 ± 0.145
2.915AlaMet: 2.915 ± 0.055
2.428AlaAsn: 2.428 ± 0.043
6.285AlaPro: 6.285 ± 0.098
3.985AlaGln: 3.985 ± 0.064
8.792AlaArg: 8.792 ± 0.103
5.818AlaSer: 5.818 ± 0.076
7.143AlaThr: 7.143 ± 0.08
12.467AlaVal: 12.467 ± 0.141
1.545AlaTrp: 1.545 ± 0.039
2.322AlaTyr: 2.322 ± 0.055
0.0AlaXaa: 0.0 ± 0.0
Cys
1.084CysAla: 1.084 ± 0.033
0.094CysCys: 0.094 ± 0.01
0.497CysAsp: 0.497 ± 0.024
0.378CysGlu: 0.378 ± 0.017
0.209CysPhe: 0.209 ± 0.013
0.951CysGly: 0.951 ± 0.03
0.194CysHis: 0.194 ± 0.013
0.257CysIle: 0.257 ± 0.017
0.124CysLys: 0.124 ± 0.011
0.622CysLeu: 0.622 ± 0.022
0.129CysMet: 0.129 ± 0.011
0.161CysAsn: 0.161 ± 0.012
0.521CysPro: 0.521 ± 0.023
0.208CysGln: 0.208 ± 0.014
0.618CysArg: 0.618 ± 0.024
0.47CysSer: 0.47 ± 0.022
0.451CysThr: 0.451 ± 0.019
0.669CysVal: 0.669 ± 0.025
0.118CysTrp: 0.118 ± 0.011
0.164CysTyr: 0.164 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
7.924AspAla: 7.924 ± 0.088
0.446AspCys: 0.446 ± 0.02
4.51AspAsp: 4.51 ± 0.091
4.16AspGlu: 4.16 ± 0.069
1.739AspPhe: 1.739 ± 0.043
6.168AspGly: 6.168 ± 0.074
1.454AspHis: 1.454 ± 0.044
2.565AspIle: 2.565 ± 0.051
1.349AspLys: 1.349 ± 0.038
6.139AspLeu: 6.139 ± 0.072
1.031AspMet: 1.031 ± 0.029
1.252AspAsn: 1.252 ± 0.033
4.484AspPro: 4.484 ± 0.07
1.762AspGln: 1.762 ± 0.037
4.776AspArg: 4.776 ± 0.068
2.778AspSer: 2.778 ± 0.047
3.422AspThr: 3.422 ± 0.055
5.6AspVal: 5.6 ± 0.077
0.931AspTrp: 0.931 ± 0.029
1.404AspTyr: 1.404 ± 0.043
0.0AspXaa: 0.0 ± 0.0
Glu
6.298GluAla: 6.298 ± 0.085
0.398GluCys: 0.398 ± 0.021
2.59GluAsp: 2.59 ± 0.059
2.728GluGlu: 2.728 ± 0.059
1.756GluPhe: 1.756 ± 0.041
3.597GluGly: 3.597 ± 0.069
1.529GluHis: 1.529 ± 0.043
2.521GluIle: 2.521 ± 0.047
1.47GluLys: 1.47 ± 0.042
6.596GluLeu: 6.596 ± 0.09
1.1GluMet: 1.1 ± 0.034
1.146GluAsn: 1.146 ± 0.035
3.151GluPro: 3.151 ± 0.059
2.338GluGln: 2.338 ± 0.046
4.693GluArg: 4.693 ± 0.069
2.755GluSer: 2.755 ± 0.048
2.631GluThr: 2.631 ± 0.05
4.789GluVal: 4.789 ± 0.063
0.743GluTrp: 0.743 ± 0.027
1.053GluTyr: 1.053 ± 0.03
0.0GluXaa: 0.0 ± 0.0
Phe
3.89PheAla: 3.89 ± 0.062
0.298PheCys: 0.298 ± 0.014
2.477PheAsp: 2.477 ± 0.046
1.517PheGlu: 1.517 ± 0.044
0.931PhePhe: 0.931 ± 0.035
3.308PheGly: 3.308 ± 0.056
0.623PheHis: 0.623 ± 0.022
1.03PheIle: 1.03 ± 0.032
0.514PheLys: 0.514 ± 0.021
2.49PheLeu: 2.49 ± 0.055
0.463PheMet: 0.463 ± 0.024
0.673PheAsn: 0.673 ± 0.029
1.332PhePro: 1.332 ± 0.035
0.643PheGln: 0.643 ± 0.027
1.611PheArg: 1.611 ± 0.039
1.632PheSer: 1.632 ± 0.037
2.009PheThr: 2.009 ± 0.043
2.553PheVal: 2.553 ± 0.048
0.394PheTrp: 0.394 ± 0.022
0.666PheTyr: 0.666 ± 0.03
0.0PheXaa: 0.0 ± 0.0
Gly
10.435GlyAla: 10.435 ± 0.105
0.801GlyCys: 0.801 ± 0.028
5.302GlyAsp: 5.302 ± 0.072
4.639GlyGlu: 4.639 ± 0.073
2.99GlyPhe: 2.99 ± 0.051
7.899GlyGly: 7.899 ± 0.131
2.091GlyHis: 2.091 ± 0.043
3.919GlyIle: 3.919 ± 0.06
2.215GlyLys: 2.215 ± 0.049
8.567GlyLeu: 8.567 ± 0.099
2.154GlyMet: 2.154 ± 0.044
1.899GlyAsn: 1.899 ± 0.043
4.437GlyPro: 4.437 ± 0.077
2.872GlyGln: 2.872 ± 0.059
6.632GlyArg: 6.632 ± 0.081
5.043GlySer: 5.043 ± 0.069
5.128GlyThr: 5.128 ± 0.066
7.967GlyVal: 7.967 ± 0.096
1.58GlyTrp: 1.58 ± 0.037
2.351GlyTyr: 2.351 ± 0.055
0.0GlyXaa: 0.0 ± 0.0
His
2.5HisAla: 2.5 ± 0.054
0.223HisCys: 0.223 ± 0.015
1.428HisAsp: 1.428 ± 0.036
1.056HisGlu: 1.056 ± 0.032
0.647HisPhe: 0.647 ± 0.022
2.166HisGly: 2.166 ± 0.047
0.661HisHis: 0.661 ± 0.026
0.792HisIle: 0.792 ± 0.03
0.368HisLys: 0.368 ± 0.019
2.16HisLeu: 2.16 ± 0.046
0.341HisMet: 0.341 ± 0.02
0.475HisAsn: 0.475 ± 0.022
1.615HisPro: 1.615 ± 0.042
0.622HisGln: 0.622 ± 0.023
1.977HisArg: 1.977 ± 0.045
1.104HisSer: 1.104 ± 0.031
1.261HisThr: 1.261 ± 0.036
1.727HisVal: 1.727 ± 0.036
0.343HisTrp: 0.343 ± 0.02
0.536HisTyr: 0.536 ± 0.024
0.0HisXaa: 0.0 ± 0.0
Ile
6.007IleAla: 6.007 ± 0.092
0.371IleCys: 0.371 ± 0.019
3.365IleAsp: 3.365 ± 0.056
2.552IleGlu: 2.552 ± 0.051
0.964IlePhe: 0.964 ± 0.028
4.312IleGly: 4.312 ± 0.074
0.76IleHis: 0.76 ± 0.027
1.297IleIle: 1.297 ± 0.039
0.854IleLys: 0.854 ± 0.031
2.936IleLeu: 2.936 ± 0.057
0.595IleMet: 0.595 ± 0.023
0.991IleAsn: 0.991 ± 0.032
2.287IlePro: 2.287 ± 0.046
0.897IleGln: 0.897 ± 0.027
2.612IleArg: 2.612 ± 0.046
2.101IleSer: 2.101 ± 0.042
2.64IleThr: 2.64 ± 0.046
3.686IleVal: 3.686 ± 0.063
0.408IleTrp: 0.408 ± 0.02
0.716IleTyr: 0.716 ± 0.028
0.0IleXaa: 0.0 ± 0.0
Lys
2.671LysAla: 2.671 ± 0.063
0.111LysCys: 0.111 ± 0.01
1.116LysAsp: 1.116 ± 0.033
1.005LysGlu: 1.005 ± 0.033
0.582LysPhe: 0.582 ± 0.022
1.549LysGly: 1.549 ± 0.04
0.438LysHis: 0.438 ± 0.019
0.991LysIle: 0.991 ± 0.034
0.677LysLys: 0.677 ± 0.03
2.204LysLeu: 2.204 ± 0.047
0.501LysMet: 0.501 ± 0.022
0.549LysAsn: 0.549 ± 0.024
1.388LysPro: 1.388 ± 0.038
0.742LysGln: 0.742 ± 0.026
1.664LysArg: 1.664 ± 0.037
1.234LysSer: 1.234 ± 0.036
1.428LysThr: 1.428 ± 0.04
1.949LysVal: 1.949 ± 0.044
0.316LysTrp: 0.316 ± 0.018
0.465LysTyr: 0.465 ± 0.02
0.0LysXaa: 0.0 ± 0.0
Leu
13.986LeuAla: 13.986 ± 0.138
0.793LeuCys: 0.793 ± 0.032
6.654LeuAsp: 6.654 ± 0.087
4.507LeuGlu: 4.507 ± 0.072
2.658LeuPhe: 2.658 ± 0.054
8.681LeuGly: 8.681 ± 0.099
2.091LeuHis: 2.091 ± 0.049
3.978LeuIle: 3.978 ± 0.071
1.762LeuLys: 1.762 ± 0.046
9.898LeuLeu: 9.898 ± 0.118
1.707LeuMet: 1.707 ± 0.039
1.958LeuAsn: 1.958 ± 0.046
5.758LeuPro: 5.758 ± 0.073
2.674LeuGln: 2.674 ± 0.05
7.996LeuArg: 7.996 ± 0.104
5.533LeuSer: 5.533 ± 0.066
6.401LeuThr: 6.401 ± 0.08
8.652LeuVal: 8.652 ± 0.076
1.236LeuTrp: 1.236 ± 0.034
1.65LeuTyr: 1.65 ± 0.04
0.0LeuXaa: 0.0 ± 0.0
Met
2.662MetAla: 2.662 ± 0.05
0.188MetCys: 0.188 ± 0.014
0.862MetAsp: 0.862 ± 0.032
0.754MetGlu: 0.754 ± 0.026
0.609MetPhe: 0.609 ± 0.024
1.47MetGly: 1.47 ± 0.035
0.394MetHis: 0.394 ± 0.021
0.818MetIle: 0.818 ± 0.031
0.411MetLys: 0.411 ± 0.021
2.057MetLeu: 2.057 ± 0.04
0.403MetMet: 0.403 ± 0.019
0.497MetAsn: 0.497 ± 0.02
1.25MetPro: 1.25 ± 0.038
0.533MetGln: 0.533 ± 0.023
1.653MetArg: 1.653 ± 0.038
1.58MetSer: 1.58 ± 0.034
1.788MetThr: 1.788 ± 0.038
1.708MetVal: 1.708 ± 0.045
0.261MetTrp: 0.261 ± 0.017
0.323MetTyr: 0.323 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
2.581AsnAla: 2.581 ± 0.051
0.165AsnCys: 0.165 ± 0.012
1.217AsnAsp: 1.217 ± 0.034
0.96AsnGlu: 0.96 ± 0.032
0.624AsnPhe: 0.624 ± 0.025
2.01AsnGly: 2.01 ± 0.045
0.437AsnHis: 0.437 ± 0.021
0.871AsnIle: 0.871 ± 0.032
0.45AsnLys: 0.45 ± 0.021
2.016AsnLeu: 2.016 ± 0.047
0.384AsnMet: 0.384 ± 0.021
0.521AsnAsn: 0.521 ± 0.023
1.664AsnPro: 1.664 ± 0.043
0.653AsnGln: 0.653 ± 0.025
1.661AsnArg: 1.661 ± 0.038
1.096AsnSer: 1.096 ± 0.032
1.216AsnThr: 1.216 ± 0.036
1.748AsnVal: 1.748 ± 0.034
0.376AsnTrp: 0.376 ± 0.016
0.535AsnTyr: 0.535 ± 0.023
0.0AsnXaa: 0.0 ± 0.0
Pro
7.283ProAla: 7.283 ± 0.1
0.331ProCys: 0.331 ± 0.021
4.372ProAsp: 4.372 ± 0.067
3.684ProGlu: 3.684 ± 0.062
1.557ProPhe: 1.557 ± 0.037
5.687ProGly: 5.687 ± 0.096
1.245ProHis: 1.245 ± 0.036
2.014ProIle: 2.014 ± 0.048
1.283ProLys: 1.283 ± 0.036
4.835ProLeu: 4.835 ± 0.062
1.194ProMet: 1.194 ± 0.032
1.224ProAsn: 1.224 ± 0.038
3.909ProPro: 3.909 ± 0.103
1.87ProGln: 1.87 ± 0.037
3.595ProArg: 3.595 ± 0.061
3.13ProSer: 3.13 ± 0.055
3.498ProThr: 3.498 ± 0.06
5.31ProVal: 5.31 ± 0.078
0.874ProTrp: 0.874 ± 0.03
1.15ProTyr: 1.15 ± 0.035
0.0ProXaa: 0.0 ± 0.0
Gln
3.626GlnAla: 3.626 ± 0.058
0.199GlnCys: 0.199 ± 0.013
1.21GlnAsp: 1.21 ± 0.036
1.199GlnGlu: 1.199 ± 0.033
1.006GlnPhe: 1.006 ± 0.027
1.968GlnGly: 1.968 ± 0.048
0.77GlnHis: 0.77 ± 0.023
1.465GlnIle: 1.465 ± 0.034
0.626GlnLys: 0.626 ± 0.022
3.461GlnLeu: 3.461 ± 0.062
0.742GlnMet: 0.742 ± 0.026
0.634GlnAsn: 0.634 ± 0.027
1.926GlnPro: 1.926 ± 0.042
1.314GlnGln: 1.314 ± 0.038
2.912GlnArg: 2.912 ± 0.048
1.518GlnSer: 1.518 ± 0.04
1.605GlnThr: 1.605 ± 0.044
2.576GlnVal: 2.576 ± 0.051
0.564GlnTrp: 0.564 ± 0.023
0.643GlnTyr: 0.643 ± 0.026
0.0GlnXaa: 0.0 ± 0.0
Arg
8.364ArgAla: 8.364 ± 0.102
0.611ArgCys: 0.611 ± 0.026
4.463ArgAsp: 4.463 ± 0.065
4.022ArgGlu: 4.022 ± 0.068
2.457ArgPhe: 2.457 ± 0.047
5.48ArgGly: 5.48 ± 0.077
1.879ArgHis: 1.879 ± 0.043
3.564ArgIle: 3.564 ± 0.059
1.63ArgLys: 1.63 ± 0.044
7.845ArgLeu: 7.845 ± 0.103
1.766ArgMet: 1.766 ± 0.043
1.714ArgAsn: 1.714 ± 0.04
4.196ArgPro: 4.196 ± 0.07
2.469ArgGln: 2.469 ± 0.048
7.364ArgArg: 7.364 ± 0.102
4.155ArgSer: 4.155 ± 0.065
4.379ArgThr: 4.379 ± 0.068
5.883ArgVal: 5.883 ± 0.079
1.431ArgTrp: 1.431 ± 0.039
1.92ArgTyr: 1.92 ± 0.048
0.0ArgXaa: 0.0 ± 0.0
Ser
6.98SerAla: 6.98 ± 0.095
0.389SerCys: 0.389 ± 0.021
3.151SerAsp: 3.151 ± 0.054
2.672SerGlu: 2.672 ± 0.054
1.522SerPhe: 1.522 ± 0.038
5.653SerGly: 5.653 ± 0.078
1.039SerHis: 1.039 ± 0.031
1.943SerIle: 1.943 ± 0.042
1.123SerLys: 1.123 ± 0.03
4.619SerLeu: 4.619 ± 0.06
1.377SerMet: 1.377 ± 0.042
1.069SerAsn: 1.069 ± 0.033
3.161SerPro: 3.161 ± 0.064
1.46SerGln: 1.46 ± 0.036
3.827SerArg: 3.827 ± 0.057
2.977SerSer: 2.977 ± 0.064
3.299SerThr: 3.299 ± 0.063
4.609SerVal: 4.609 ± 0.061
0.879SerTrp: 0.879 ± 0.031
1.18SerTyr: 1.18 ± 0.032
0.0SerXaa: 0.0 ± 0.0
Thr
8.069ThrAla: 8.069 ± 0.099
0.422ThrCys: 0.422 ± 0.02
3.822ThrAsp: 3.822 ± 0.063
3.251ThrGlu: 3.251 ± 0.054
1.766ThrPhe: 1.766 ± 0.041
5.797ThrGly: 5.797 ± 0.071
1.122ThrHis: 1.122 ± 0.037
2.252ThrIle: 2.252 ± 0.046
1.255ThrLys: 1.255 ± 0.033
5.578ThrLeu: 5.578 ± 0.067
1.19ThrMet: 1.19 ± 0.031
1.197ThrAsn: 1.197 ± 0.037
3.78ThrPro: 3.78 ± 0.072
1.47ThrGln: 1.47 ± 0.037
3.777ThrArg: 3.777 ± 0.059
3.156ThrSer: 3.156 ± 0.055
3.978ThrThr: 3.978 ± 0.084
6.278ThrVal: 6.278 ± 0.089
0.833ThrTrp: 0.833 ± 0.027
1.247ThrTyr: 1.247 ± 0.039
0.0ThrXaa: 0.0 ± 0.0
Val
11.848ValAla: 11.848 ± 0.129
0.765ValCys: 0.765 ± 0.031
6.12ValAsp: 6.12 ± 0.082
5.026ValGlu: 5.026 ± 0.065
2.562ValPhe: 2.562 ± 0.048
7.429ValGly: 7.429 ± 0.081
1.938ValHis: 1.938 ± 0.039
3.872ValIle: 3.872 ± 0.055
1.777ValLys: 1.777 ± 0.046
9.283ValLeu: 9.283 ± 0.094
1.637ValMet: 1.637 ± 0.04
1.989ValAsn: 1.989 ± 0.039
4.843ValPro: 4.843 ± 0.073
2.165ValGln: 2.165 ± 0.043
6.291ValArg: 6.291 ± 0.086
4.811ValSer: 4.811 ± 0.062
5.861ValThr: 5.861 ± 0.07
9.149ValVal: 9.149 ± 0.108
1.074ValTrp: 1.074 ± 0.04
1.646ValTyr: 1.646 ± 0.039
0.0ValXaa: 0.0 ± 0.0
Trp
1.51TrpAla: 1.51 ± 0.042
0.161TrpCys: 0.161 ± 0.013
0.788TrpAsp: 0.788 ± 0.03
0.697TrpGlu: 0.697 ± 0.025
0.471TrpPhe: 0.471 ± 0.022
0.987TrpGly: 0.987 ± 0.033
0.323TrpHis: 0.323 ± 0.017
0.603TrpIle: 0.603 ± 0.026
0.296TrpLys: 0.296 ± 0.018
1.735TrpLeu: 1.735 ± 0.043
0.31TrpMet: 0.31 ± 0.015
0.385TrpAsn: 0.385 ± 0.022
0.845TrpPro: 0.845 ± 0.027
0.604TrpGln: 0.604 ± 0.022
1.296TrpArg: 1.296 ± 0.036
0.91TrpSer: 0.91 ± 0.03
0.879TrpThr: 0.879 ± 0.03
1.117TrpVal: 1.117 ± 0.034
0.365TrpTrp: 0.365 ± 0.02
0.325TrpTyr: 0.325 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.331TyrAla: 2.331 ± 0.051
0.202TyrCys: 0.202 ± 0.013
1.425TyrAsp: 1.425 ± 0.044
1.068TyrGlu: 1.068 ± 0.03
0.686TyrPhe: 0.686 ± 0.025
2.021TyrGly: 2.021 ± 0.045
0.416TyrHis: 0.416 ± 0.018
0.659TyrIle: 0.659 ± 0.027
0.375TyrLys: 0.375 ± 0.02
2.337TyrLeu: 2.337 ± 0.045
0.277TyrMet: 0.277 ± 0.018
0.425TyrAsn: 0.425 ± 0.02
1.213TyrPro: 1.213 ± 0.04
0.686TyrGln: 0.686 ± 0.025
1.845TyrArg: 1.845 ± 0.039
1.128TyrSer: 1.128 ± 0.031
1.222TyrThr: 1.222 ± 0.038
1.649TyrVal: 1.649 ± 0.037
0.335TyrTrp: 0.335 ± 0.019
0.47TyrTyr: 0.47 ± 0.023
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3539 proteins (1113055 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski