Amino acid dipepetide frequency for Orientia tsutsugamushi (strain Boryong) (Rickettsia tsutsugamushi)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.3AlaAla: 4.3 ± 0.158
0.837AlaCys: 0.837 ± 0.052
2.782AlaAsp: 2.782 ± 0.101
3.496AlaGlu: 3.496 ± 0.137
2.381AlaPhe: 2.381 ± 0.081
3.089AlaGly: 3.089 ± 0.126
0.92AlaHis: 0.92 ± 0.056
6.751AlaIle: 6.751 ± 0.165
5.332AlaLys: 5.332 ± 0.141
6.073AlaLeu: 6.073 ± 0.16
1.518AlaMet: 1.518 ± 0.076
3.642AlaAsn: 3.642 ± 0.125
1.313AlaPro: 1.313 ± 0.072
2.342AlaGln: 2.342 ± 0.099
2.127AlaArg: 2.127 ± 0.089
4.072AlaSer: 4.072 ± 0.133
3.063AlaThr: 3.063 ± 0.104
4.039AlaVal: 4.039 ± 0.118
0.483AlaTrp: 0.483 ± 0.049
1.971AlaTyr: 1.971 ± 0.084
0.0AlaXaa: 0.0 ± 0.0
Cys
0.671CysAla: 0.671 ± 0.052
0.281CysCys: 0.281 ± 0.032
0.635CysAsp: 0.635 ± 0.037
0.605CysGlu: 0.605 ± 0.046
0.678CysPhe: 0.678 ± 0.047
0.784CysGly: 0.784 ± 0.055
0.301CysHis: 0.301 ± 0.035
1.409CysIle: 1.409 ± 0.069
1.105CysLys: 1.105 ± 0.064
1.234CysLeu: 1.234 ± 0.074
0.417CysMet: 0.417 ± 0.041
1.297CysAsn: 1.297 ± 0.064
0.404CysPro: 0.404 ± 0.04
0.612CysGln: 0.612 ± 0.045
0.549CysArg: 0.549 ± 0.042
1.244CysSer: 1.244 ± 0.07
0.8CysThr: 0.8 ± 0.054
0.622CysVal: 0.622 ± 0.051
0.129CysTrp: 0.129 ± 0.02
0.86CysTyr: 0.86 ± 0.057
0.0CysXaa: 0.0 ± 0.0
Asp
2.342AspAla: 2.342 ± 0.098
0.738AspCys: 0.738 ± 0.052
2.524AspAsp: 2.524 ± 0.124
2.811AspGlu: 2.811 ± 0.106
2.57AspPhe: 2.57 ± 0.111
1.978AspGly: 1.978 ± 0.11
1.029AspHis: 1.029 ± 0.064
5.841AspIle: 5.841 ± 0.139
3.916AspLys: 3.916 ± 0.139
5.031AspLeu: 5.031 ± 0.137
0.873AspMet: 0.873 ± 0.068
3.665AspAsn: 3.665 ± 0.12
1.3AspPro: 1.3 ± 0.071
1.915AspGln: 1.915 ± 0.081
1.505AspArg: 1.505 ± 0.073
3.489AspSer: 3.489 ± 0.112
2.358AspThr: 2.358 ± 0.107
2.778AspVal: 2.778 ± 0.107
0.324AspTrp: 0.324 ± 0.035
2.262AspTyr: 2.262 ± 0.084
0.0AspXaa: 0.0 ± 0.0
Glu
3.341GluAla: 3.341 ± 0.152
0.774GluCys: 0.774 ± 0.048
2.56GluAsp: 2.56 ± 0.113
3.274GluGlu: 3.274 ± 0.132
2.325GluPhe: 2.325 ± 0.084
2.12GluGly: 2.12 ± 0.107
1.26GluHis: 1.26 ± 0.072
5.279GluIle: 5.279 ± 0.141
4.234GluLys: 4.234 ± 0.141
6.188GluLeu: 6.188 ± 0.169
1.197GluMet: 1.197 ± 0.051
3.509GluAsn: 3.509 ± 0.138
1.184GluPro: 1.184 ± 0.074
2.689GluGln: 2.689 ± 0.105
1.856GluArg: 1.856 ± 0.087
3.473GluSer: 3.473 ± 0.119
2.276GluThr: 2.276 ± 0.098
3.36GluVal: 3.36 ± 0.129
0.503GluTrp: 0.503 ± 0.04
2.418GluTyr: 2.418 ± 0.102
0.0GluXaa: 0.0 ± 0.0
Phe
2.385PheAla: 2.385 ± 0.105
0.751PheCys: 0.751 ± 0.055
2.527PheAsp: 2.527 ± 0.1
2.031PheGlu: 2.031 ± 0.093
2.415PhePhe: 2.415 ± 0.112
2.266PheGly: 2.266 ± 0.104
0.863PheHis: 0.863 ± 0.054
4.65PheIle: 4.65 ± 0.141
3.112PheLys: 3.112 ± 0.112
4.164PheLeu: 4.164 ± 0.151
0.946PheMet: 0.946 ± 0.054
3.241PheAsn: 3.241 ± 0.109
1.171PhePro: 1.171 ± 0.067
1.445PheGln: 1.445 ± 0.081
1.386PheArg: 1.386 ± 0.069
3.876PheSer: 3.876 ± 0.123
2.19PheThr: 2.19 ± 0.095
2.196PheVal: 2.196 ± 0.09
0.334PheTrp: 0.334 ± 0.036
1.875PheTyr: 1.875 ± 0.081
0.0PheXaa: 0.0 ± 0.0
Gly
3.139GlyAla: 3.139 ± 0.142
0.708GlyCys: 0.708 ± 0.049
2.14GlyAsp: 2.14 ± 0.102
2.421GlyGlu: 2.421 ± 0.106
1.899GlyPhe: 1.899 ± 0.078
3.013GlyGly: 3.013 ± 0.124
0.877GlyHis: 0.877 ± 0.051
5.54GlyIle: 5.54 ± 0.169
3.797GlyLys: 3.797 ± 0.134
4.254GlyLeu: 4.254 ± 0.128
1.062GlyMet: 1.062 ± 0.071
2.755GlyAsn: 2.755 ± 0.092
1.072GlyPro: 1.072 ± 0.057
1.779GlyGln: 1.779 ± 0.085
1.803GlyArg: 1.803 ± 0.09
3.136GlySer: 3.136 ± 0.11
2.398GlyThr: 2.398 ± 0.079
3.059GlyVal: 3.059 ± 0.116
0.486GlyTrp: 0.486 ± 0.043
2.087GlyTyr: 2.087 ± 0.079
0.0GlyXaa: 0.0 ± 0.0
His
1.158HisAla: 1.158 ± 0.063
0.377HisCys: 0.377 ± 0.038
1.115HisAsp: 1.115 ± 0.066
1.025HisGlu: 1.025 ± 0.062
0.877HisPhe: 0.877 ± 0.054
1.227HisGly: 1.227 ± 0.068
0.595HisHis: 0.595 ± 0.045
2.223HisIle: 2.223 ± 0.09
1.571HisLys: 1.571 ± 0.07
2.067HisLeu: 2.067 ± 0.084
0.37HisMet: 0.37 ± 0.045
1.624HisAsn: 1.624 ± 0.086
0.609HisPro: 0.609 ± 0.04
0.926HisGln: 0.926 ± 0.052
0.797HisArg: 0.797 ± 0.051
1.528HisSer: 1.528 ± 0.071
1.088HisThr: 1.088 ± 0.07
0.92HisVal: 0.92 ± 0.054
0.218HisTrp: 0.218 ± 0.027
0.982HisTyr: 0.982 ± 0.054
0.0HisXaa: 0.0 ± 0.0
Ile
7.181IleAla: 7.181 ± 0.197
1.459IleCys: 1.459 ± 0.079
5.755IleAsp: 5.755 ± 0.155
5.653IleGlu: 5.653 ± 0.151
4.164IlePhe: 4.164 ± 0.173
5.113IleGly: 5.113 ± 0.164
1.869IleHis: 1.869 ± 0.09
10.068IleIle: 10.068 ± 0.285
8.494IleLys: 8.494 ± 0.168
9.698IleLeu: 9.698 ± 0.256
2.037IleMet: 2.037 ± 0.087
7.26IleAsn: 7.26 ± 0.188
3.265IlePro: 3.265 ± 0.11
3.437IleGln: 3.437 ± 0.105
3.04IleArg: 3.04 ± 0.103
7.892IleSer: 7.892 ± 0.221
6.099IleThr: 6.099 ± 0.152
5.735IleVal: 5.735 ± 0.171
0.714IleTrp: 0.714 ± 0.055
3.367IleTyr: 3.367 ± 0.093
0.0IleXaa: 0.0 ± 0.0
Lys
4.631LysAla: 4.631 ± 0.139
1.035LysCys: 1.035 ± 0.068
3.919LysAsp: 3.919 ± 0.127
4.541LysGlu: 4.541 ± 0.158
3.612LysPhe: 3.612 ± 0.117
2.851LysGly: 2.851 ± 0.112
1.928LysHis: 1.928 ± 0.081
8.328LysIle: 8.328 ± 0.179
5.947LysLys: 5.947 ± 0.154
9.41LysLeu: 9.41 ± 0.201
1.746LysMet: 1.746 ± 0.074
5.391LysAsn: 5.391 ± 0.131
1.892LysPro: 1.892 ± 0.077
3.079LysGln: 3.079 ± 0.092
2.329LysArg: 2.329 ± 0.097
5.18LysSer: 5.18 ± 0.149
3.661LysThr: 3.661 ± 0.107
4.908LysVal: 4.908 ± 0.148
0.546LysTrp: 0.546 ± 0.043
3.695LysTyr: 3.695 ± 0.143
0.0LysXaa: 0.0 ± 0.0
Leu
6.556LeuAla: 6.556 ± 0.149
1.392LeuCys: 1.392 ± 0.072
4.488LeuAsp: 4.488 ± 0.116
5.365LeuGlu: 5.365 ± 0.139
4.24LeuPhe: 4.24 ± 0.161
4.809LeuGly: 4.809 ± 0.165
2.544LeuHis: 2.544 ± 0.121
9.129LeuIle: 9.129 ± 0.207
7.564LeuLys: 7.564 ± 0.168
11.014LeuLeu: 11.014 ± 0.255
2.276LeuMet: 2.276 ± 0.09
6.569LeuAsn: 6.569 ± 0.15
3.767LeuPro: 3.767 ± 0.12
4.442LeuGln: 4.442 ± 0.134
3.437LeuArg: 3.437 ± 0.117
8.527LeuSer: 8.527 ± 0.173
5.527LeuThr: 5.527 ± 0.14
5.742LeuVal: 5.742 ± 0.153
0.748LeuTrp: 0.748 ± 0.056
3.632LeuTyr: 3.632 ± 0.101
0.0LeuXaa: 0.0 ± 0.0
Met
1.204MetAla: 1.204 ± 0.066
0.294MetCys: 0.294 ± 0.03
0.797MetAsp: 0.797 ± 0.052
0.982MetGlu: 0.982 ± 0.06
0.903MetPhe: 0.903 ± 0.068
0.761MetGly: 0.761 ± 0.063
0.698MetHis: 0.698 ± 0.045
2.054MetIle: 2.054 ± 0.078
1.442MetLys: 1.442 ± 0.072
3.02MetLeu: 3.02 ± 0.11
0.46MetMet: 0.46 ± 0.045
1.33MetAsn: 1.33 ± 0.068
0.863MetPro: 0.863 ± 0.048
1.065MetGln: 1.065 ± 0.062
0.857MetArg: 0.857 ± 0.053
1.72MetSer: 1.72 ± 0.068
0.923MetThr: 0.923 ± 0.066
1.23MetVal: 1.23 ± 0.063
0.169MetTrp: 0.169 ± 0.024
0.609MetTyr: 0.609 ± 0.04
0.0MetXaa: 0.0 ± 0.0
Asn
3.526AsnAla: 3.526 ± 0.121
0.989AsnCys: 0.989 ± 0.054
3.327AsnAsp: 3.327 ± 0.105
3.126AsnGlu: 3.126 ± 0.115
3.205AsnPhe: 3.205 ± 0.125
2.62AsnGly: 2.62 ± 0.1
1.435AsnHis: 1.435 ± 0.073
8.223AsnIle: 8.223 ± 0.19
5.795AsnLys: 5.795 ± 0.157
6.774AsnLeu: 6.774 ± 0.154
1.353AsnMet: 1.353 ± 0.064
6.453AsnAsn: 6.453 ± 0.174
1.991AsnPro: 1.991 ± 0.083
2.861AsnGln: 2.861 ± 0.106
2.054AsnArg: 2.054 ± 0.091
5.603AsnSer: 5.603 ± 0.152
3.744AsnThr: 3.744 ± 0.138
3.774AsnVal: 3.774 ± 0.118
0.45AsnTrp: 0.45 ± 0.04
3.294AsnTyr: 3.294 ± 0.126
0.0AsnXaa: 0.0 ± 0.0
Pro
1.617ProAla: 1.617 ± 0.069
0.341ProCys: 0.341 ± 0.038
1.419ProAsp: 1.419 ± 0.075
1.912ProGlu: 1.912 ± 0.079
1.31ProPhe: 1.31 ± 0.069
1.445ProGly: 1.445 ± 0.072
0.533ProHis: 0.533 ± 0.046
2.901ProIle: 2.901 ± 0.119
2.074ProLys: 2.074 ± 0.085
2.706ProLeu: 2.706 ± 0.103
0.546ProMet: 0.546 ± 0.052
2.021ProAsn: 2.021 ± 0.087
0.85ProPro: 0.85 ± 0.072
1.039ProGln: 1.039 ± 0.06
0.8ProArg: 0.8 ± 0.055
2.094ProSer: 2.094 ± 0.081
1.512ProThr: 1.512 ± 0.079
1.879ProVal: 1.879 ± 0.087
0.251ProTrp: 0.251 ± 0.029
1.174ProTyr: 1.174 ± 0.067
0.0ProXaa: 0.0 ± 0.0
Gln
2.355GlnAla: 2.355 ± 0.085
0.513GlnCys: 0.513 ± 0.039
1.958GlnAsp: 1.958 ± 0.094
2.742GlnGlu: 2.742 ± 0.099
1.594GlnPhe: 1.594 ± 0.082
1.607GlnGly: 1.607 ± 0.083
0.996GlnHis: 0.996 ± 0.061
3.132GlnIle: 3.132 ± 0.117
3.463GlnLys: 3.463 ± 0.127
4.452GlnLeu: 4.452 ± 0.121
0.794GlnMet: 0.794 ± 0.05
2.977GlnAsn: 2.977 ± 0.103
1.009GlnPro: 1.009 ± 0.072
2.59GlnGln: 2.59 ± 0.119
1.273GlnArg: 1.273 ± 0.064
2.947GlnSer: 2.947 ± 0.104
1.703GlnThr: 1.703 ± 0.07
2.236GlnVal: 2.236 ± 0.078
0.298GlnTrp: 0.298 ± 0.034
1.796GlnTyr: 1.796 ± 0.072
0.0GlnXaa: 0.0 ± 0.0
Arg
2.044ArgAla: 2.044 ± 0.091
0.559ArgCys: 0.559 ± 0.043
1.531ArgAsp: 1.531 ± 0.086
1.736ArgGlu: 1.736 ± 0.082
1.637ArgPhe: 1.637 ± 0.079
1.614ArgGly: 1.614 ± 0.088
0.734ArgHis: 0.734 ± 0.05
3.337ArgIle: 3.337 ± 0.106
2.646ArgLys: 2.646 ± 0.11
3.549ArgLeu: 3.549 ± 0.114
0.82ArgMet: 0.82 ± 0.05
1.935ArgAsn: 1.935 ± 0.082
0.847ArgPro: 0.847 ± 0.056
1.376ArgGln: 1.376 ± 0.062
1.323ArgArg: 1.323 ± 0.076
2.256ArgSer: 2.256 ± 0.083
1.518ArgThr: 1.518 ± 0.076
1.842ArgVal: 1.842 ± 0.094
0.232ArgTrp: 0.232 ± 0.026
1.561ArgTyr: 1.561 ± 0.076
0.0ArgXaa: 0.0 ± 0.0
Ser
4.138SerAla: 4.138 ± 0.11
1.191SerCys: 1.191 ± 0.064
3.959SerAsp: 3.959 ± 0.131
4.065SerGlu: 4.065 ± 0.126
3.298SerPhe: 3.298 ± 0.103
3.966SerGly: 3.966 ± 0.143
1.34SerHis: 1.34 ± 0.07
7.588SerIle: 7.588 ± 0.172
6.198SerLys: 6.198 ± 0.158
6.837SerLeu: 6.837 ± 0.158
1.713SerMet: 1.713 ± 0.08
5.884SerAsn: 5.884 ± 0.152
2.037SerPro: 2.037 ± 0.083
2.659SerGln: 2.659 ± 0.118
2.52SerArg: 2.52 ± 0.092
6.268SerSer: 6.268 ± 0.172
4.28SerThr: 4.28 ± 0.114
3.82SerVal: 3.82 ± 0.1
0.542SerTrp: 0.542 ± 0.046
2.97SerTyr: 2.97 ± 0.097
0.0SerXaa: 0.0 ± 0.0
Thr
3.592ThrAla: 3.592 ± 0.109
0.605ThrCys: 0.605 ± 0.047
2.424ThrAsp: 2.424 ± 0.112
2.808ThrGlu: 2.808 ± 0.097
2.014ThrPhe: 2.014 ± 0.076
2.778ThrGly: 2.778 ± 0.123
0.949ThrHis: 0.949 ± 0.055
5.441ThrIle: 5.441 ± 0.161
4.032ThrLys: 4.032 ± 0.104
4.846ThrLeu: 4.846 ± 0.154
1.002ThrMet: 1.002 ± 0.056
3.483ThrAsn: 3.483 ± 0.12
1.803ThrPro: 1.803 ± 0.087
1.882ThrGln: 1.882 ± 0.079
1.634ThrArg: 1.634 ± 0.07
3.903ThrSer: 3.903 ± 0.126
3.149ThrThr: 3.149 ± 0.11
3.251ThrVal: 3.251 ± 0.107
0.294ThrTrp: 0.294 ± 0.031
1.717ThrTyr: 1.717 ± 0.082
0.0ThrXaa: 0.0 ± 0.0
Val
3.781ValAla: 3.781 ± 0.126
0.734ValCys: 0.734 ± 0.05
2.891ValAsp: 2.891 ± 0.103
3.212ValGlu: 3.212 ± 0.097
2.358ValPhe: 2.358 ± 0.097
2.957ValGly: 2.957 ± 0.108
1.091ValHis: 1.091 ± 0.056
5.911ValIle: 5.911 ± 0.176
4.521ValLys: 4.521 ± 0.132
5.494ValLeu: 5.494 ± 0.153
1.353ValMet: 1.353 ± 0.078
3.764ValAsn: 3.764 ± 0.108
1.743ValPro: 1.743 ± 0.07
2.021ValGln: 2.021 ± 0.106
2.067ValArg: 2.067 ± 0.089
4.224ValSer: 4.224 ± 0.13
3.043ValThr: 3.043 ± 0.097
3.929ValVal: 3.929 ± 0.133
0.413ValTrp: 0.413 ± 0.039
1.922ValTyr: 1.922 ± 0.091
0.0ValXaa: 0.0 ± 0.0
Trp
0.361TrpAla: 0.361 ± 0.038
0.149TrpCys: 0.149 ± 0.027
0.255TrpAsp: 0.255 ± 0.024
0.261TrpGlu: 0.261 ± 0.031
0.466TrpPhe: 0.466 ± 0.043
0.417TrpGly: 0.417 ± 0.038
0.248TrpHis: 0.248 ± 0.026
0.771TrpIle: 0.771 ± 0.062
0.496TrpLys: 0.496 ± 0.043
0.916TrpLeu: 0.916 ± 0.061
0.129TrpMet: 0.129 ± 0.019
0.493TrpAsn: 0.493 ± 0.039
0.245TrpPro: 0.245 ± 0.03
0.546TrpGln: 0.546 ± 0.046
0.304TrpArg: 0.304 ± 0.027
0.486TrpSer: 0.486 ± 0.044
0.265TrpThr: 0.265 ± 0.03
0.324TrpVal: 0.324 ± 0.032
0.083TrpTrp: 0.083 ± 0.016
0.377TrpTyr: 0.377 ± 0.032
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.209TyrAla: 2.209 ± 0.094
0.91TyrCys: 0.91 ± 0.063
2.243TyrAsp: 2.243 ± 0.099
1.753TyrGlu: 1.753 ± 0.078
1.882TyrPhe: 1.882 ± 0.087
2.008TyrGly: 2.008 ± 0.086
1.088TyrHis: 1.088 ± 0.075
3.724TyrIle: 3.724 ± 0.129
2.891TyrLys: 2.891 ± 0.095
4.042TyrLeu: 4.042 ± 0.131
0.764TyrMet: 0.764 ± 0.048
3.304TyrAsn: 3.304 ± 0.126
1.058TyrPro: 1.058 ± 0.068
1.73TyrGln: 1.73 ± 0.078
1.439TyrArg: 1.439 ± 0.064
3.357TyrSer: 3.357 ± 0.111
2.011TyrThr: 2.011 ± 0.079
1.783TyrVal: 1.783 ± 0.073
0.374TyrTrp: 0.374 ± 0.037
2.12TyrTyr: 2.12 ± 0.091
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 966 proteins (302339 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski