Amino acid dipepetide frequency for Bacteroides phage Bacuni_F1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.936AlaAla: 12.936 ± 2.139
0.723AlaCys: 0.723 ± 0.26
5.544AlaAsp: 5.544 ± 0.576
9.079AlaGlu: 9.079 ± 0.974
2.33AlaPhe: 2.33 ± 0.367
8.517AlaGly: 8.517 ± 1.049
1.607AlaHis: 1.607 ± 0.367
5.464AlaIle: 5.464 ± 0.859
5.303AlaLys: 5.303 ± 0.58
6.428AlaLeu: 6.428 ± 0.735
2.651AlaMet: 2.651 ± 0.438
5.383AlaAsn: 5.383 ± 0.602
2.491AlaPro: 2.491 ± 0.467
3.535AlaGln: 3.535 ± 0.596
3.375AlaArg: 3.375 ± 0.737
5.865AlaSer: 5.865 ± 0.994
6.588AlaThr: 6.588 ± 1.142
5.544AlaVal: 5.544 ± 0.761
1.366AlaTrp: 1.366 ± 0.387
3.214AlaTyr: 3.214 ± 0.445
0.0AlaXaa: 0.0 ± 0.0
Cys
1.286CysAla: 1.286 ± 0.329
0.482CysCys: 0.482 ± 0.209
1.446CysAsp: 1.446 ± 0.301
1.607CysGlu: 1.607 ± 0.359
0.402CysPhe: 0.402 ± 0.224
1.607CysGly: 1.607 ± 0.321
0.321CysHis: 0.321 ± 0.218
1.045CysIle: 1.045 ± 0.249
1.045CysLys: 1.045 ± 0.257
0.803CysLeu: 0.803 ± 0.268
0.402CysMet: 0.402 ± 0.16
0.402CysAsn: 0.402 ± 0.176
0.402CysPro: 0.402 ± 0.181
0.402CysGln: 0.402 ± 0.161
1.527CysArg: 1.527 ± 0.435
0.964CysSer: 0.964 ± 0.317
0.803CysThr: 0.803 ± 0.221
0.964CysVal: 0.964 ± 0.288
0.321CysTrp: 0.321 ± 0.129
0.643CysTyr: 0.643 ± 0.204
0.0CysXaa: 0.0 ± 0.0
Asp
6.588AspAla: 6.588 ± 1.108
0.964AspCys: 0.964 ± 0.277
3.776AspAsp: 3.776 ± 0.673
4.419AspGlu: 4.419 ± 0.766
2.812AspPhe: 2.812 ± 0.432
5.865AspGly: 5.865 ± 0.649
0.402AspHis: 0.402 ± 0.155
3.214AspIle: 3.214 ± 0.583
4.017AspLys: 4.017 ± 0.567
4.258AspLeu: 4.258 ± 0.447
2.009AspMet: 2.009 ± 0.377
2.732AspAsn: 2.732 ± 0.48
1.928AspPro: 1.928 ± 0.477
0.803AspGln: 0.803 ± 0.216
3.294AspArg: 3.294 ± 0.525
3.535AspSer: 3.535 ± 0.734
4.178AspThr: 4.178 ± 0.737
4.339AspVal: 4.339 ± 0.529
0.884AspTrp: 0.884 ± 0.263
3.134AspTyr: 3.134 ± 0.592
0.0AspXaa: 0.0 ± 0.0
Glu
7.151GluAla: 7.151 ± 1.016
0.402GluCys: 0.402 ± 0.187
3.776GluAsp: 3.776 ± 0.488
2.973GluGlu: 2.973 ± 0.515
2.651GluPhe: 2.651 ± 0.473
3.857GluGly: 3.857 ± 0.583
0.964GluHis: 0.964 ± 0.309
3.857GluIle: 3.857 ± 0.549
4.66GluLys: 4.66 ± 0.593
6.669GluLeu: 6.669 ± 0.68
1.928GluMet: 1.928 ± 0.31
3.535GluAsn: 3.535 ± 0.812
2.33GluPro: 2.33 ± 0.469
2.973GluGln: 2.973 ± 0.6
3.455GluArg: 3.455 ± 0.635
2.732GluSer: 2.732 ± 0.526
4.419GluThr: 4.419 ± 0.651
4.901GluVal: 4.901 ± 0.583
0.643GluTrp: 0.643 ± 0.216
3.776GluTyr: 3.776 ± 0.475
0.0GluXaa: 0.0 ± 0.0
Phe
2.973PheAla: 2.973 ± 0.454
0.803PheCys: 0.803 ± 0.279
1.607PheAsp: 1.607 ± 0.386
1.848PheGlu: 1.848 ± 0.388
0.562PhePhe: 0.562 ± 0.266
1.848PheGly: 1.848 ± 0.415
0.803PheHis: 0.803 ± 0.3
1.366PheIle: 1.366 ± 0.264
1.928PheLys: 1.928 ± 0.316
2.25PheLeu: 2.25 ± 0.398
0.562PheMet: 0.562 ± 0.218
1.366PheAsn: 1.366 ± 0.311
0.803PhePro: 0.803 ± 0.251
0.884PheGln: 0.884 ± 0.267
1.446PheArg: 1.446 ± 0.33
2.571PheSer: 2.571 ± 0.415
1.848PheThr: 1.848 ± 0.317
2.089PheVal: 2.089 ± 0.411
0.402PheTrp: 0.402 ± 0.161
1.366PheTyr: 1.366 ± 0.397
0.0PheXaa: 0.0 ± 0.0
Gly
5.383GlyAla: 5.383 ± 0.699
1.366GlyCys: 1.366 ± 0.349
4.58GlyAsp: 4.58 ± 0.661
4.74GlyGlu: 4.74 ± 0.456
1.687GlyPhe: 1.687 ± 0.43
5.303GlyGly: 5.303 ± 0.817
1.366GlyHis: 1.366 ± 0.35
5.624GlyIle: 5.624 ± 0.721
6.669GlyLys: 6.669 ± 0.69
5.624GlyLeu: 5.624 ± 0.882
1.125GlyMet: 1.125 ± 0.249
3.455GlyAsn: 3.455 ± 0.629
1.045GlyPro: 1.045 ± 0.193
2.41GlyGln: 2.41 ± 0.412
3.616GlyArg: 3.616 ± 0.477
3.616GlySer: 3.616 ± 0.554
4.419GlyThr: 4.419 ± 0.787
4.339GlyVal: 4.339 ± 0.392
1.286GlyTrp: 1.286 ± 0.302
3.776GlyTyr: 3.776 ± 0.708
0.0GlyXaa: 0.0 ± 0.0
His
1.125HisAla: 1.125 ± 0.297
0.562HisCys: 0.562 ± 0.2
0.643HisAsp: 0.643 ± 0.24
0.562HisGlu: 0.562 ± 0.28
0.161HisPhe: 0.161 ± 0.124
0.884HisGly: 0.884 ± 0.262
0.241HisHis: 0.241 ± 0.14
0.964HisIle: 0.964 ± 0.355
0.964HisLys: 0.964 ± 0.289
1.446HisLeu: 1.446 ± 0.379
0.161HisMet: 0.161 ± 0.119
0.643HisAsn: 0.643 ± 0.217
1.286HisPro: 1.286 ± 0.309
0.161HisGln: 0.161 ± 0.117
0.884HisArg: 0.884 ± 0.235
0.482HisSer: 0.482 ± 0.27
1.366HisThr: 1.366 ± 0.283
1.205HisVal: 1.205 ± 0.339
0.241HisTrp: 0.241 ± 0.123
0.884HisTyr: 0.884 ± 0.276
0.0HisXaa: 0.0 ± 0.0
Ile
4.339IleAla: 4.339 ± 0.619
1.527IleCys: 1.527 ± 0.373
4.258IleAsp: 4.258 ± 0.497
4.098IleGlu: 4.098 ± 0.606
1.366IlePhe: 1.366 ± 0.462
3.696IleGly: 3.696 ± 0.623
0.884IleHis: 0.884 ± 0.298
3.053IleIle: 3.053 ± 0.498
3.455IleLys: 3.455 ± 0.662
4.339IleLeu: 4.339 ± 0.507
1.527IleMet: 1.527 ± 0.296
4.017IleAsn: 4.017 ± 0.64
1.366IlePro: 1.366 ± 0.346
1.687IleGln: 1.687 ± 0.39
3.455IleArg: 3.455 ± 0.565
3.134IleSer: 3.134 ± 0.448
4.821IleThr: 4.821 ± 0.572
3.696IleVal: 3.696 ± 0.413
0.08IleTrp: 0.08 ± 0.086
2.25IleTyr: 2.25 ± 0.366
0.0IleXaa: 0.0 ± 0.0
Lys
5.785LysAla: 5.785 ± 0.721
0.803LysCys: 0.803 ± 0.217
4.499LysAsp: 4.499 ± 0.575
4.178LysGlu: 4.178 ± 0.683
1.848LysPhe: 1.848 ± 0.374
5.062LysGly: 5.062 ± 0.671
0.803LysHis: 0.803 ± 0.301
3.455LysIle: 3.455 ± 0.523
4.821LysLys: 4.821 ± 0.831
4.74LysLeu: 4.74 ± 0.604
1.527LysMet: 1.527 ± 0.44
2.33LysAsn: 2.33 ± 0.407
2.973LysPro: 2.973 ± 0.59
2.491LysGln: 2.491 ± 0.452
2.651LysArg: 2.651 ± 0.458
2.892LysSer: 2.892 ± 0.409
4.098LysThr: 4.098 ± 0.481
4.178LysVal: 4.178 ± 0.749
1.446LysTrp: 1.446 ± 0.358
3.053LysTyr: 3.053 ± 0.541
0.0LysXaa: 0.0 ± 0.0
Leu
7.874LeuAla: 7.874 ± 1.286
1.446LeuCys: 1.446 ± 0.518
5.383LeuAsp: 5.383 ± 0.721
4.74LeuGlu: 4.74 ± 0.619
2.009LeuPhe: 2.009 ± 0.448
4.178LeuGly: 4.178 ± 0.629
1.286LeuHis: 1.286 ± 0.342
4.339LeuIle: 4.339 ± 0.62
4.339LeuLys: 4.339 ± 0.579
5.946LeuLeu: 5.946 ± 0.729
1.848LeuMet: 1.848 ± 0.314
3.776LeuAsn: 3.776 ± 0.534
3.776LeuPro: 3.776 ± 0.549
3.937LeuGln: 3.937 ± 0.646
5.464LeuArg: 5.464 ± 0.79
4.74LeuSer: 4.74 ± 0.584
5.383LeuThr: 5.383 ± 0.798
4.499LeuVal: 4.499 ± 0.714
0.884LeuTrp: 0.884 ± 0.228
4.017LeuTyr: 4.017 ± 0.785
0.0LeuXaa: 0.0 ± 0.0
Met
3.214MetAla: 3.214 ± 0.481
0.402MetCys: 0.402 ± 0.176
1.928MetAsp: 1.928 ± 0.35
1.446MetGlu: 1.446 ± 0.352
0.482MetPhe: 0.482 ± 0.241
2.491MetGly: 2.491 ± 0.378
0.482MetHis: 0.482 ± 0.229
0.643MetIle: 0.643 ± 0.193
1.205MetLys: 1.205 ± 0.276
2.169MetLeu: 2.169 ± 0.374
0.402MetMet: 0.402 ± 0.172
0.723MetAsn: 0.723 ± 0.277
0.482MetPro: 0.482 ± 0.185
1.366MetGln: 1.366 ± 0.373
1.607MetArg: 1.607 ± 0.358
1.286MetSer: 1.286 ± 0.332
0.884MetThr: 0.884 ± 0.256
1.527MetVal: 1.527 ± 0.418
0.161MetTrp: 0.161 ± 0.162
0.803MetTyr: 0.803 ± 0.309
0.0MetXaa: 0.0 ± 0.0
Asn
4.901AsnAla: 4.901 ± 0.791
0.964AsnCys: 0.964 ± 0.237
2.169AsnAsp: 2.169 ± 0.467
1.928AsnGlu: 1.928 ± 0.458
1.125AsnPhe: 1.125 ± 0.338
3.937AsnGly: 3.937 ± 0.594
0.321AsnHis: 0.321 ± 0.155
1.928AsnIle: 1.928 ± 0.364
2.25AsnLys: 2.25 ± 0.433
3.214AsnLeu: 3.214 ± 0.475
1.125AsnMet: 1.125 ± 0.265
2.571AsnAsn: 2.571 ± 0.673
2.25AsnPro: 2.25 ± 0.408
1.446AsnGln: 1.446 ± 0.328
2.089AsnArg: 2.089 ± 0.388
2.812AsnSer: 2.812 ± 0.582
2.41AsnThr: 2.41 ± 0.455
3.455AsnVal: 3.455 ± 0.52
0.723AsnTrp: 0.723 ± 0.221
2.892AsnTyr: 2.892 ± 0.673
0.0AsnXaa: 0.0 ± 0.0
Pro
4.339ProAla: 4.339 ± 0.639
0.402ProCys: 0.402 ± 0.189
2.651ProAsp: 2.651 ± 0.42
1.446ProGlu: 1.446 ± 0.421
0.964ProPhe: 0.964 ± 0.234
1.768ProGly: 1.768 ± 0.33
0.482ProHis: 0.482 ± 0.178
1.768ProIle: 1.768 ± 0.502
2.491ProLys: 2.491 ± 0.423
2.33ProLeu: 2.33 ± 0.467
0.643ProMet: 0.643 ± 0.213
1.607ProAsn: 1.607 ± 0.3
0.321ProPro: 0.321 ± 0.146
1.527ProGln: 1.527 ± 0.427
1.446ProArg: 1.446 ± 0.514
1.366ProSer: 1.366 ± 0.329
2.25ProThr: 2.25 ± 0.461
2.651ProVal: 2.651 ± 0.521
0.321ProTrp: 0.321 ± 0.146
1.286ProTyr: 1.286 ± 0.387
0.0ProXaa: 0.0 ± 0.0
Gln
3.375GlnAla: 3.375 ± 0.465
0.964GlnCys: 0.964 ± 0.314
1.848GlnAsp: 1.848 ± 0.338
2.33GlnGlu: 2.33 ± 0.448
1.607GlnPhe: 1.607 ± 0.385
2.25GlnGly: 2.25 ± 0.476
0.482GlnHis: 0.482 ± 0.18
2.732GlnIle: 2.732 ± 0.547
0.964GlnLys: 0.964 ± 0.269
3.616GlnLeu: 3.616 ± 0.461
1.205GlnMet: 1.205 ± 0.361
0.964GlnAsn: 0.964 ± 0.313
1.527GlnPro: 1.527 ± 0.342
2.892GlnGln: 2.892 ± 0.696
2.973GlnArg: 2.973 ± 0.391
1.205GlnSer: 1.205 ± 0.313
2.491GlnThr: 2.491 ± 0.653
1.848GlnVal: 1.848 ± 0.421
0.723GlnTrp: 0.723 ± 0.295
1.848GlnTyr: 1.848 ± 0.427
0.0GlnXaa: 0.0 ± 0.0
Arg
3.696ArgAla: 3.696 ± 0.554
1.125ArgCys: 1.125 ± 0.34
3.696ArgAsp: 3.696 ± 0.793
4.258ArgGlu: 4.258 ± 0.711
2.009ArgPhe: 2.009 ± 0.441
2.892ArgGly: 2.892 ± 0.545
0.803ArgHis: 0.803 ± 0.315
3.294ArgIle: 3.294 ± 0.439
4.098ArgLys: 4.098 ± 0.732
4.419ArgLeu: 4.419 ± 0.756
1.527ArgMet: 1.527 ± 0.396
1.607ArgAsn: 1.607 ± 0.462
1.366ArgPro: 1.366 ± 0.258
2.571ArgGln: 2.571 ± 0.52
2.892ArgArg: 2.892 ± 0.768
2.009ArgSer: 2.009 ± 0.436
3.696ArgThr: 3.696 ± 0.562
4.66ArgVal: 4.66 ± 0.722
1.045ArgTrp: 1.045 ± 0.27
2.571ArgTyr: 2.571 ± 0.489
0.0ArgXaa: 0.0 ± 0.0
Ser
4.982SerAla: 4.982 ± 0.722
1.045SerCys: 1.045 ± 0.261
3.857SerAsp: 3.857 ± 0.678
3.535SerGlu: 3.535 ± 0.558
2.089SerPhe: 2.089 ± 0.406
4.58SerGly: 4.58 ± 0.908
0.562SerHis: 0.562 ± 0.169
3.134SerIle: 3.134 ± 0.475
3.375SerLys: 3.375 ± 0.456
4.017SerLeu: 4.017 ± 0.685
1.045SerMet: 1.045 ± 0.256
1.928SerAsn: 1.928 ± 0.539
1.286SerPro: 1.286 ± 0.338
1.527SerGln: 1.527 ± 0.283
2.41SerArg: 2.41 ± 0.415
3.053SerSer: 3.053 ± 0.476
3.937SerThr: 3.937 ± 0.636
3.696SerVal: 3.696 ± 0.507
0.562SerTrp: 0.562 ± 0.174
2.491SerTyr: 2.491 ± 0.47
0.0SerXaa: 0.0 ± 0.0
Thr
7.954ThrAla: 7.954 ± 0.76
0.482ThrCys: 0.482 ± 0.202
3.053ThrAsp: 3.053 ± 0.618
4.901ThrGlu: 4.901 ± 0.702
1.205ThrPhe: 1.205 ± 0.281
5.624ThrGly: 5.624 ± 0.682
0.884ThrHis: 0.884 ± 0.262
4.178ThrIle: 4.178 ± 0.645
4.74ThrLys: 4.74 ± 0.697
6.749ThrLeu: 6.749 ± 0.748
0.884ThrMet: 0.884 ± 0.226
2.892ThrAsn: 2.892 ± 0.488
2.571ThrPro: 2.571 ± 0.416
1.768ThrGln: 1.768 ± 0.332
3.053ThrArg: 3.053 ± 0.552
3.053ThrSer: 3.053 ± 0.641
4.901ThrThr: 4.901 ± 0.736
5.785ThrVal: 5.785 ± 0.894
0.803ThrTrp: 0.803 ± 0.274
2.25ThrTyr: 2.25 ± 0.328
0.0ThrXaa: 0.0 ± 0.0
Val
4.901ValAla: 4.901 ± 0.627
1.366ValCys: 1.366 ± 0.344
3.857ValAsp: 3.857 ± 0.527
4.982ValGlu: 4.982 ± 0.679
2.33ValPhe: 2.33 ± 0.433
3.214ValGly: 3.214 ± 0.685
1.205ValHis: 1.205 ± 0.334
4.258ValIle: 4.258 ± 0.529
3.455ValLys: 3.455 ± 0.506
5.865ValLeu: 5.865 ± 0.783
1.366ValMet: 1.366 ± 0.263
2.169ValAsn: 2.169 ± 0.469
1.848ValPro: 1.848 ± 0.416
3.053ValGln: 3.053 ± 0.349
5.062ValArg: 5.062 ± 0.799
4.901ValSer: 4.901 ± 0.791
5.062ValThr: 5.062 ± 0.904
3.375ValVal: 3.375 ± 0.693
1.286ValTrp: 1.286 ± 0.297
2.33ValTyr: 2.33 ± 0.439
0.0ValXaa: 0.0 ± 0.0
Trp
1.125TrpAla: 1.125 ± 0.361
0.321TrpCys: 0.321 ± 0.117
1.045TrpAsp: 1.045 ± 0.347
1.366TrpGlu: 1.366 ± 0.343
0.321TrpPhe: 0.321 ± 0.131
0.402TrpGly: 0.402 ± 0.151
0.321TrpHis: 0.321 ± 0.145
0.482TrpIle: 0.482 ± 0.159
1.205TrpLys: 1.205 ± 0.369
1.446TrpLeu: 1.446 ± 0.303
0.161TrpMet: 0.161 ± 0.112
0.562TrpAsn: 0.562 ± 0.263
0.562TrpPro: 0.562 ± 0.223
1.125TrpGln: 1.125 ± 0.319
0.803TrpArg: 0.803 ± 0.242
0.562TrpSer: 0.562 ± 0.226
0.643TrpThr: 0.643 ± 0.215
0.723TrpVal: 0.723 ± 0.207
0.08TrpTrp: 0.08 ± 0.091
0.884TrpTyr: 0.884 ± 0.34
0.0TrpXaa: 0.0 ± 0.0
Tyr
4.017TyrAla: 4.017 ± 0.571
0.723TyrCys: 0.723 ± 0.203
3.535TyrAsp: 3.535 ± 0.609
3.214TyrGlu: 3.214 ± 0.509
1.366TyrPhe: 1.366 ± 0.448
3.455TyrGly: 3.455 ± 0.474
0.643TyrHis: 0.643 ± 0.234
2.25TyrIle: 2.25 ± 0.443
2.651TyrLys: 2.651 ± 0.462
3.535TyrLeu: 3.535 ± 0.685
1.527TyrMet: 1.527 ± 0.371
1.848TyrAsn: 1.848 ± 0.457
1.446TyrPro: 1.446 ± 0.399
1.286TyrGln: 1.286 ± 0.408
2.732TyrArg: 2.732 ± 0.525
2.33TyrSer: 2.33 ± 0.624
3.535TyrThr: 3.535 ± 0.447
2.491TyrVal: 2.491 ± 0.445
0.884TyrTrp: 0.884 ± 0.236
1.527TyrTyr: 1.527 ± 0.451
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 51 proteins (12447 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski