Amino acid dipepetide frequency for Propionibacterium sp. oral taxon 192 str. F0372

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.311AlaAla: 14.311 ± 0.2
1.183AlaCys: 1.183 ± 0.043
7.159AlaAsp: 7.159 ± 0.097
7.303AlaGlu: 7.303 ± 0.135
2.983AlaPhe: 2.983 ± 0.07
9.783AlaGly: 9.783 ± 0.136
2.563AlaHis: 2.563 ± 0.056
5.428AlaIle: 5.428 ± 0.083
3.271AlaLys: 3.271 ± 0.077
10.811AlaLeu: 10.811 ± 0.143
3.237AlaMet: 3.237 ± 0.067
2.677AlaAsn: 2.677 ± 0.059
5.048AlaPro: 5.048 ± 0.109
4.04AlaGln: 4.04 ± 0.071
7.632AlaArg: 7.632 ± 0.109
6.88AlaSer: 6.88 ± 0.107
6.86AlaThr: 6.86 ± 0.097
9.401AlaVal: 9.401 ± 0.121
1.799AlaTrp: 1.799 ± 0.056
2.018AlaTyr: 2.018 ± 0.055
0.0AlaXaa: 0.0 ± 0.0
Cys
1.059CysAla: 1.059 ± 0.036
0.134CysCys: 0.134 ± 0.012
0.618CysAsp: 0.618 ± 0.029
0.531CysGlu: 0.531 ± 0.028
0.341CysPhe: 0.341 ± 0.021
1.106CysGly: 1.106 ± 0.041
0.268CysHis: 0.268 ± 0.019
0.367CysIle: 0.367 ± 0.023
0.15CysLys: 0.15 ± 0.015
0.914CysLeu: 0.914 ± 0.035
0.166CysMet: 0.166 ± 0.015
0.228CysAsn: 0.228 ± 0.019
0.562CysPro: 0.562 ± 0.031
0.273CysGln: 0.273 ± 0.019
0.576CysArg: 0.576 ± 0.029
0.665CysSer: 0.665 ± 0.031
0.572CysThr: 0.572 ± 0.03
0.703CysVal: 0.703 ± 0.028
0.199CysTrp: 0.199 ± 0.016
0.218CysTyr: 0.218 ± 0.018
0.0CysXaa: 0.0 ± 0.0
Asp
6.891AspAla: 6.891 ± 0.097
0.442AspCys: 0.442 ± 0.026
3.915AspAsp: 3.915 ± 0.075
4.346AspGlu: 4.346 ± 0.072
1.826AspPhe: 1.826 ± 0.052
5.09AspGly: 5.09 ± 0.097
1.444AspHis: 1.444 ± 0.043
2.573AspIle: 2.573 ± 0.064
1.391AspLys: 1.391 ± 0.042
6.407AspLeu: 6.407 ± 0.09
1.23AspMet: 1.23 ± 0.04
1.317AspAsn: 1.317 ± 0.043
4.278AspPro: 4.278 ± 0.078
2.235AspGln: 2.235 ± 0.048
3.917AspArg: 3.917 ± 0.078
2.998AspSer: 2.998 ± 0.06
2.969AspThr: 2.969 ± 0.065
4.616AspVal: 4.616 ± 0.074
0.952AspTrp: 0.952 ± 0.037
1.297AspTyr: 1.297 ± 0.043
0.0AspXaa: 0.0 ± 0.0
Glu
6.43GluAla: 6.43 ± 0.125
0.408GluCys: 0.408 ± 0.022
2.407GluAsp: 2.407 ± 0.053
3.261GluGlu: 3.261 ± 0.075
1.746GluPhe: 1.746 ± 0.052
3.54GluGly: 3.54 ± 0.069
1.357GluHis: 1.357 ± 0.042
3.432GluIle: 3.432 ± 0.083
1.704GluLys: 1.704 ± 0.055
6.691GluLeu: 6.691 ± 0.1
1.416GluMet: 1.416 ± 0.044
1.372GluAsn: 1.372 ± 0.044
2.789GluPro: 2.789 ± 0.062
2.728GluGln: 2.728 ± 0.064
4.127GluArg: 4.127 ± 0.083
2.959GluSer: 2.959 ± 0.069
2.984GluThr: 2.984 ± 0.057
5.167GluVal: 5.167 ± 0.096
0.838GluTrp: 0.838 ± 0.033
1.108GluTyr: 1.108 ± 0.041
0.0GluXaa: 0.0 ± 0.0
Phe
3.485PheAla: 3.485 ± 0.066
0.328PheCys: 0.328 ± 0.02
2.263PheAsp: 2.263 ± 0.071
1.627PheGlu: 1.627 ± 0.054
0.99PhePhe: 0.99 ± 0.041
3.052PheGly: 3.052 ± 0.064
0.662PheHis: 0.662 ± 0.031
1.373PheIle: 1.373 ± 0.049
0.623PheLys: 0.623 ± 0.029
2.608PheLeu: 2.608 ± 0.062
0.618PheMet: 0.618 ± 0.028
0.789PheAsn: 0.789 ± 0.031
1.352PhePro: 1.352 ± 0.041
0.787PheGln: 0.787 ± 0.032
1.627PheArg: 1.627 ± 0.046
1.875PheSer: 1.875 ± 0.051
2.201PheThr: 2.201 ± 0.05
2.332PheVal: 2.332 ± 0.051
0.454PheTrp: 0.454 ± 0.023
0.595PheTyr: 0.595 ± 0.026
0.0PheXaa: 0.0 ± 0.0
Gly
8.821GlyAla: 8.821 ± 0.123
1.008GlyCys: 1.008 ± 0.043
4.519GlyAsp: 4.519 ± 0.079
4.799GlyGlu: 4.799 ± 0.077
3.097GlyPhe: 3.097 ± 0.062
6.645GlyGly: 6.645 ± 0.121
2.075GlyHis: 2.075 ± 0.055
4.796GlyIle: 4.796 ± 0.077
2.592GlyLys: 2.592 ± 0.06
9.03GlyLeu: 9.03 ± 0.115
2.574GlyMet: 2.574 ± 0.062
2.136GlyAsn: 2.136 ± 0.052
3.452GlyPro: 3.452 ± 0.068
2.929GlyGln: 2.929 ± 0.061
5.583GlyArg: 5.583 ± 0.094
5.248GlySer: 5.248 ± 0.097
5.439GlyThr: 5.439 ± 0.095
7.451GlyVal: 7.451 ± 0.103
1.735GlyTrp: 1.735 ± 0.057
2.139GlyTyr: 2.139 ± 0.056
0.0GlyXaa: 0.0 ± 0.0
His
2.079HisAla: 2.079 ± 0.056
0.248HisCys: 0.248 ± 0.017
1.543HisAsp: 1.543 ± 0.046
1.211HisGlu: 1.211 ± 0.044
0.626HisPhe: 0.626 ± 0.031
1.966HisGly: 1.966 ± 0.046
0.719HisHis: 0.719 ± 0.036
0.993HisIle: 0.993 ± 0.033
0.457HisLys: 0.457 ± 0.025
2.417HisLeu: 2.417 ± 0.06
0.456HisMet: 0.456 ± 0.024
0.546HisAsn: 0.546 ± 0.027
1.679HisPro: 1.679 ± 0.051
0.855HisGln: 0.855 ± 0.029
1.874HisArg: 1.874 ± 0.054
1.136HisSer: 1.136 ± 0.039
1.21HisThr: 1.21 ± 0.036
1.661HisVal: 1.661 ± 0.045
0.325HisTrp: 0.325 ± 0.021
0.46HisTyr: 0.46 ± 0.023
0.0HisXaa: 0.0 ± 0.0
Ile
6.344IleAla: 6.344 ± 0.106
0.531IleCys: 0.531 ± 0.024
3.746IleAsp: 3.746 ± 0.078
2.932IleGlu: 2.932 ± 0.071
1.353IlePhe: 1.353 ± 0.048
4.91IleGly: 4.91 ± 0.086
1.043IleHis: 1.043 ± 0.035
2.521IleIle: 2.521 ± 0.06
1.2IleLys: 1.2 ± 0.045
3.688IleLeu: 3.688 ± 0.075
1.002IleMet: 1.002 ± 0.036
1.496IleAsn: 1.496 ± 0.046
2.648IlePro: 2.648 ± 0.061
1.195IleGln: 1.195 ± 0.038
2.845IleArg: 2.845 ± 0.063
2.952IleSer: 2.952 ± 0.061
3.778IleThr: 3.778 ± 0.066
4.113IleVal: 4.113 ± 0.072
0.642IleTrp: 0.642 ± 0.029
0.842IleTyr: 0.842 ± 0.038
0.0IleXaa: 0.0 ± 0.0
Lys
3.137LysAla: 3.137 ± 0.073
0.166LysCys: 0.166 ± 0.013
1.305LysAsp: 1.305 ± 0.044
1.235LysGlu: 1.235 ± 0.044
0.634LysPhe: 0.634 ± 0.034
1.847LysGly: 1.847 ± 0.052
0.505LysHis: 0.505 ± 0.023
1.295LysIle: 1.295 ± 0.044
0.973LysLys: 0.973 ± 0.037
2.388LysLeu: 2.388 ± 0.057
0.678LysMet: 0.678 ± 0.029
0.73LysAsn: 0.73 ± 0.028
1.285LysPro: 1.285 ± 0.044
1.087LysGln: 1.087 ± 0.04
1.645LysArg: 1.645 ± 0.052
1.429LysSer: 1.429 ± 0.037
1.467LysThr: 1.467 ± 0.052
2.562LysVal: 2.562 ± 0.064
0.326LysTrp: 0.326 ± 0.02
0.573LysTyr: 0.573 ± 0.027
0.0LysXaa: 0.0 ± 0.0
Leu
12.461LeuAla: 12.461 ± 0.152
0.914LeuCys: 0.914 ± 0.037
6.469LeuAsp: 6.469 ± 0.098
4.929LeuGlu: 4.929 ± 0.084
2.701LeuPhe: 2.701 ± 0.06
9.245LeuGly: 9.245 ± 0.121
2.001LeuHis: 2.001 ± 0.049
4.457LeuIle: 4.457 ± 0.076
2.095LeuLys: 2.095 ± 0.057
9.631LeuLeu: 9.631 ± 0.147
2.201LeuMet: 2.201 ± 0.06
2.432LeuAsn: 2.432 ± 0.059
5.29LeuPro: 5.29 ± 0.092
2.366LeuGln: 2.366 ± 0.054
6.49LeuArg: 6.49 ± 0.111
6.001LeuSer: 6.001 ± 0.099
6.192LeuThr: 6.192 ± 0.096
9.425LeuVal: 9.425 ± 0.117
1.163LeuTrp: 1.163 ± 0.051
1.467LeuTyr: 1.467 ± 0.049
0.0LeuXaa: 0.0 ± 0.0
Met
3.048MetAla: 3.048 ± 0.062
0.216MetCys: 0.216 ± 0.016
1.28MetAsp: 1.28 ± 0.038
1.045MetGlu: 1.045 ± 0.039
0.637MetPhe: 0.637 ± 0.029
2.021MetGly: 2.021 ± 0.054
0.444MetHis: 0.444 ± 0.022
1.358MetIle: 1.358 ± 0.045
0.67MetLys: 0.67 ± 0.029
2.371MetLeu: 2.371 ± 0.057
0.712MetMet: 0.712 ± 0.031
0.811MetAsn: 0.811 ± 0.034
1.341MetPro: 1.341 ± 0.036
0.68MetGln: 0.68 ± 0.027
1.636MetArg: 1.636 ± 0.045
1.842MetSer: 1.842 ± 0.046
1.981MetThr: 1.981 ± 0.046
2.346MetVal: 2.346 ± 0.062
0.257MetTrp: 0.257 ± 0.018
0.375MetTyr: 0.375 ± 0.023
0.0MetXaa: 0.0 ± 0.0
Asn
2.695AsnAla: 2.695 ± 0.057
0.221AsnCys: 0.221 ± 0.015
1.544AsnAsp: 1.544 ± 0.046
1.302AsnGlu: 1.302 ± 0.041
0.731AsnPhe: 0.731 ± 0.032
2.352AsnGly: 2.352 ± 0.056
0.637AsnHis: 0.637 ± 0.03
1.039AsnIle: 1.039 ± 0.038
0.642AsnLys: 0.642 ± 0.033
2.512AsnLeu: 2.512 ± 0.061
0.547AsnMet: 0.547 ± 0.027
0.779AsnAsn: 0.779 ± 0.036
2.033AsnPro: 2.033 ± 0.055
1.048AsnGln: 1.048 ± 0.04
1.771AsnArg: 1.771 ± 0.042
1.442AsnSer: 1.442 ± 0.048
1.519AsnThr: 1.519 ± 0.044
1.722AsnVal: 1.722 ± 0.046
0.443AsnTrp: 0.443 ± 0.024
0.592AsnTyr: 0.592 ± 0.031
0.0AsnXaa: 0.0 ± 0.0
Pro
5.446ProAla: 5.446 ± 0.093
0.355ProCys: 0.355 ± 0.021
3.78ProAsp: 3.78 ± 0.08
3.516ProGlu: 3.516 ± 0.068
1.334ProPhe: 1.334 ± 0.042
5.284ProGly: 5.284 ± 0.105
1.169ProHis: 1.169 ± 0.035
2.126ProIle: 2.126 ± 0.051
1.314ProLys: 1.314 ± 0.041
4.255ProLeu: 4.255 ± 0.078
1.229ProMet: 1.229 ± 0.038
1.273ProAsn: 1.273 ± 0.045
2.16ProPro: 2.16 ± 0.071
1.823ProGln: 1.823 ± 0.053
3.164ProArg: 3.164 ± 0.069
3.422ProSer: 3.422 ± 0.083
3.649ProThr: 3.649 ± 0.078
4.796ProVal: 4.796 ± 0.077
0.716ProTrp: 0.716 ± 0.026
0.969ProTyr: 0.969 ± 0.039
0.0ProXaa: 0.0 ± 0.0
Gln
4.229GlnAla: 4.229 ± 0.085
0.22GlnCys: 0.22 ± 0.017
1.379GlnAsp: 1.379 ± 0.044
1.684GlnGlu: 1.684 ± 0.05
0.914GlnPhe: 0.914 ± 0.036
2.397GlnGly: 2.397 ± 0.058
0.725GlnHis: 0.725 ± 0.035
1.926GlnIle: 1.926 ± 0.053
0.727GlnLys: 0.727 ± 0.032
3.76GlnLeu: 3.76 ± 0.067
0.998GlnMet: 0.998 ± 0.035
0.781GlnAsn: 0.781 ± 0.035
1.734GlnPro: 1.734 ± 0.058
1.558GlnGln: 1.558 ± 0.048
2.482GlnArg: 2.482 ± 0.066
1.578GlnSer: 1.578 ± 0.045
1.756GlnThr: 1.756 ± 0.045
3.519GlnVal: 3.519 ± 0.064
0.552GlnTrp: 0.552 ± 0.028
0.686GlnTyr: 0.686 ± 0.031
0.0GlnXaa: 0.0 ± 0.0
Arg
6.942ArgAla: 6.942 ± 0.114
0.725ArgCys: 0.725 ± 0.031
3.555ArgAsp: 3.555 ± 0.074
3.768ArgGlu: 3.768 ± 0.075
2.228ArgPhe: 2.228 ± 0.059
4.764ArgGly: 4.764 ± 0.079
1.561ArgHis: 1.561 ± 0.045
3.987ArgIle: 3.987 ± 0.064
1.676ArgLys: 1.676 ± 0.047
6.789ArgLeu: 6.789 ± 0.113
1.959ArgMet: 1.959 ± 0.054
1.82ArgAsn: 1.82 ± 0.049
3.17ArgPro: 3.17 ± 0.064
2.265ArgGln: 2.265 ± 0.057
5.938ArgArg: 5.938 ± 0.107
4.072ArgSer: 4.072 ± 0.085
3.992ArgThr: 3.992 ± 0.07
5.322ArgVal: 5.322 ± 0.077
1.215ArgTrp: 1.215 ± 0.047
1.493ArgTyr: 1.493 ± 0.048
0.0ArgXaa: 0.0 ± 0.0
Ser
6.542SerAla: 6.542 ± 0.11
0.585SerCys: 0.585 ± 0.03
3.247SerAsp: 3.247 ± 0.063
2.87SerGlu: 2.87 ± 0.047
1.976SerPhe: 1.976 ± 0.05
6.3SerGly: 6.3 ± 0.096
1.319SerHis: 1.319 ± 0.04
2.736SerIle: 2.736 ± 0.066
1.486SerLys: 1.486 ± 0.048
5.662SerLeu: 5.662 ± 0.095
1.713SerMet: 1.713 ± 0.045
1.487SerAsn: 1.487 ± 0.038
3.163SerPro: 3.163 ± 0.064
2.122SerGln: 2.122 ± 0.054
4.049SerArg: 4.049 ± 0.071
4.193SerSer: 4.193 ± 0.094
3.93SerThr: 3.93 ± 0.075
4.802SerVal: 4.802 ± 0.093
1.101SerTrp: 1.101 ± 0.042
1.26SerTyr: 1.26 ± 0.037
0.0SerXaa: 0.0 ± 0.0
Thr
6.765ThrAla: 6.765 ± 0.117
0.573ThrCys: 0.573 ± 0.026
3.849ThrAsp: 3.849 ± 0.078
3.349ThrGlu: 3.349 ± 0.067
1.753ThrPhe: 1.753 ± 0.046
5.97ThrGly: 5.97 ± 0.083
1.375ThrHis: 1.375 ± 0.043
3.273ThrIle: 3.273 ± 0.074
1.594ThrLys: 1.594 ± 0.054
5.288ThrLeu: 5.288 ± 0.086
1.437ThrMet: 1.437 ± 0.042
1.656ThrAsn: 1.656 ± 0.056
3.866ThrPro: 3.866 ± 0.085
1.907ThrGln: 1.907 ± 0.048
3.775ThrArg: 3.775 ± 0.07
4.226ThrSer: 4.226 ± 0.08
4.571ThrThr: 4.571 ± 0.096
5.244ThrVal: 5.244 ± 0.097
1.044ThrTrp: 1.044 ± 0.036
1.122ThrTyr: 1.122 ± 0.037
0.0ThrXaa: 0.0 ± 0.0
Val
10.003ValAla: 10.003 ± 0.14
0.976ValCys: 0.976 ± 0.038
5.53ValAsp: 5.53 ± 0.085
4.925ValGlu: 4.925 ± 0.091
2.516ValPhe: 2.516 ± 0.061
6.953ValGly: 6.953 ± 0.104
1.852ValHis: 1.852 ± 0.049
4.62ValIle: 4.62 ± 0.088
1.931ValLys: 1.931 ± 0.047
8.815ValLeu: 8.815 ± 0.129
2.134ValMet: 2.134 ± 0.057
2.31ValAsn: 2.31 ± 0.053
4.206ValPro: 4.206 ± 0.075
2.274ValGln: 2.274 ± 0.049
5.379ValArg: 5.379 ± 0.086
5.494ValSer: 5.494 ± 0.082
5.538ValThr: 5.538 ± 0.092
8.761ValVal: 8.761 ± 0.13
1.184ValTrp: 1.184 ± 0.038
1.367ValTyr: 1.367 ± 0.042
0.0ValXaa: 0.0 ± 0.0
Trp
1.658TrpAla: 1.658 ± 0.047
0.206TrpCys: 0.206 ± 0.016
0.768TrpAsp: 0.768 ± 0.031
0.684TrpGlu: 0.684 ± 0.03
0.582TrpPhe: 0.582 ± 0.028
1.108TrpGly: 1.108 ± 0.038
0.35TrpHis: 0.35 ± 0.022
0.818TrpIle: 0.818 ± 0.033
0.367TrpLys: 0.367 ± 0.024
1.789TrpLeu: 1.789 ± 0.053
0.417TrpMet: 0.417 ± 0.023
0.47TrpAsn: 0.47 ± 0.024
0.662TrpPro: 0.662 ± 0.027
0.684TrpGln: 0.684 ± 0.034
1.187TrpArg: 1.187 ± 0.038
0.987TrpSer: 0.987 ± 0.038
0.906TrpThr: 0.906 ± 0.034
1.307TrpVal: 1.307 ± 0.038
0.367TrpTrp: 0.367 ± 0.023
0.32TrpTyr: 0.32 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.042TyrAla: 2.042 ± 0.049
0.213TyrCys: 0.213 ± 0.015
1.26TyrAsp: 1.26 ± 0.046
1.147TyrGlu: 1.147 ± 0.039
0.674TyrPhe: 0.674 ± 0.032
1.734TyrGly: 1.734 ± 0.051
0.392TyrHis: 0.392 ± 0.021
0.662TyrIle: 0.662 ± 0.034
0.402TyrLys: 0.402 ± 0.024
2.104TyrLeu: 2.104 ± 0.049
0.345TyrMet: 0.345 ± 0.02
0.462TyrAsn: 0.462 ± 0.023
1.065TyrPro: 1.065 ± 0.041
0.748TyrGln: 0.748 ± 0.037
1.544TyrArg: 1.544 ± 0.047
1.144TyrSer: 1.144 ± 0.038
1.121TyrThr: 1.121 ± 0.042
1.518TyrVal: 1.518 ± 0.044
0.325TyrTrp: 0.325 ± 0.018
0.457TyrTyr: 0.457 ± 0.028
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2523 proteins (805660 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski