Amino acid dipepetide frequency for Enterococcus florum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.721AlaAla: 6.721 ± 0.097	0.702AlaCys: 0.702 ± 0.027	3.897AlaAsp: 3.897 ± 0.062	5.436AlaGlu: 5.436 ± 0.087	3.414AlaPhe: 3.414 ± 0.06	5.464AlaGly: 5.464 ± 0.071	1.22AlaHis: 1.22 ± 0.037	5.839AlaIle: 5.839 ± 0.084	4.945AlaLys: 4.945 ± 0.067	7.307AlaLeu: 7.307 ± 0.089	2.183AlaMet: 2.183 ± 0.047	2.891AlaAsn: 2.891 ± 0.053	2.249AlaPro: 2.249 ± 0.052	2.75AlaGln: 2.75 ± 0.051	2.495AlaArg: 2.495 ± 0.05	3.999AlaSer: 3.999 ± 0.059	3.79AlaThr: 3.79 ± 0.067	5.713AlaVal: 5.713 ± 0.073	0.593AlaTrp: 0.593 ± 0.025	2.48AlaTyr: 2.48 ± 0.04	0.0AlaXaa: 0.0 ± 0.0
Cys	0.485CysAla: 0.485 ± 0.018	0.119CysCys: 0.119 ± 0.011	0.414CysAsp: 0.414 ± 0.022	0.455CysGlu: 0.455 ± 0.02	0.39CysPhe: 0.39 ± 0.019	0.762CysGly: 0.762 ± 0.028	0.176CysHis: 0.176 ± 0.014	0.551CysIle: 0.551 ± 0.024	0.31CysLys: 0.31 ± 0.016	0.901CysLeu: 0.901 ± 0.027	0.186CysMet: 0.186 ± 0.012	0.268CysAsn: 0.268 ± 0.015	0.343CysPro: 0.343 ± 0.019	0.33CysGln: 0.33 ± 0.018	0.333CysArg: 0.333 ± 0.016	0.518CysSer: 0.518 ± 0.024	0.415CysThr: 0.415 ± 0.018	0.51CysVal: 0.51 ± 0.026	0.084CysTrp: 0.084 ± 0.008	0.315CysTyr: 0.315 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	3.464AspAla: 3.464 ± 0.067	0.455AspCys: 0.455 ± 0.02	2.396AspAsp: 2.396 ± 0.058	4.171AspGlu: 4.171 ± 0.084	2.796AspPhe: 2.796 ± 0.052	3.512AspGly: 3.512 ± 0.063	1.164AspHis: 1.164 ± 0.034	3.617AspIle: 3.617 ± 0.063	2.834AspLys: 2.834 ± 0.054	5.213AspLeu: 5.213 ± 0.066	1.326AspMet: 1.326 ± 0.03	1.819AspAsn: 1.819 ± 0.044	2.215AspPro: 2.215 ± 0.049	2.763AspGln: 2.763 ± 0.054	2.338AspArg: 2.338 ± 0.049	2.895AspSer: 2.895 ± 0.049	2.689AspThr: 2.689 ± 0.053	3.469AspVal: 3.469 ± 0.065	0.615AspTrp: 0.615 ± 0.023	2.535AspTyr: 2.535 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	5.943GluAla: 5.943 ± 0.079	0.438GluCys: 0.438 ± 0.024	3.701GluAsp: 3.701 ± 0.058	6.967GluGlu: 6.967 ± 0.105	2.447GluPhe: 2.447 ± 0.045	4.038GluGly: 4.038 ± 0.068	1.289GluHis: 1.289 ± 0.04	5.472GluIle: 5.472 ± 0.083	6.463GluLys: 6.463 ± 0.082	7.55GluLeu: 7.55 ± 0.095	2.344GluMet: 2.344 ± 0.052	3.763GluAsn: 3.763 ± 0.054	2.032GluPro: 2.032 ± 0.044	3.554GluGln: 3.554 ± 0.066	3.294GluArg: 3.294 ± 0.067	3.267GluSer: 3.267 ± 0.053	4.338GluThr: 4.338 ± 0.074	4.911GluVal: 4.911 ± 0.073	0.678GluTrp: 0.678 ± 0.028	2.293GluTyr: 2.293 ± 0.049	0.0GluXaa: 0.0 ± 0.0
Phe	3.209PheAla: 3.209 ± 0.063	0.415PheCys: 0.415 ± 0.02	2.71PheAsp: 2.71 ± 0.059	2.967PheGlu: 2.967 ± 0.051	2.521PhePhe: 2.521 ± 0.06	3.297PheGly: 3.297 ± 0.054	0.869PheHis: 0.869 ± 0.028	3.177PheIle: 3.177 ± 0.055	2.119PheLys: 2.119 ± 0.049	4.871PheLeu: 4.871 ± 0.076	1.148PheMet: 1.148 ± 0.034	1.806PheAsn: 1.806 ± 0.04	1.663PhePro: 1.663 ± 0.037	1.74PheGln: 1.74 ± 0.042	1.529PheArg: 1.529 ± 0.038	3.469PheSer: 3.469 ± 0.067	2.62PheThr: 2.62 ± 0.055	3.298PheVal: 3.298 ± 0.075	0.419PheTrp: 0.419 ± 0.018	1.806PheTyr: 1.806 ± 0.041	0.0PheXaa: 0.0 ± 0.0
Gly	4.775GlyAla: 4.775 ± 0.082	0.626GlyCys: 0.626 ± 0.025	3.154GlyAsp: 3.154 ± 0.054	4.314GlyGlu: 4.314 ± 0.061	3.337GlyPhe: 3.337 ± 0.075	4.794GlyGly: 4.794 ± 0.084	1.148GlyHis: 1.148 ± 0.032	6.114GlyIle: 6.114 ± 0.084	4.699GlyLys: 4.699 ± 0.066	6.535GlyLeu: 6.535 ± 0.093	2.126GlyMet: 2.126 ± 0.038	2.769GlyAsn: 2.769 ± 0.048	1.624GlyPro: 1.624 ± 0.037	2.36GlyGln: 2.36 ± 0.051	2.537GlyArg: 2.537 ± 0.046	3.947GlySer: 3.947 ± 0.058	4.179GlyThr: 4.179 ± 0.056	4.831GlyVal: 4.831 ± 0.074	0.736GlyTrp: 0.736 ± 0.031	2.784GlyTyr: 2.784 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	1.263HisAla: 1.263 ± 0.036	0.206HisCys: 0.206 ± 0.013	0.908HisAsp: 0.908 ± 0.026	1.196HisGlu: 1.196 ± 0.028	1.105HisPhe: 1.105 ± 0.031	1.27HisGly: 1.27 ± 0.033	0.49HisHis: 0.49 ± 0.021	1.113HisIle: 1.113 ± 0.035	0.815HisLys: 0.815 ± 0.027	2.069HisLeu: 2.069 ± 0.045	0.454HisMet: 0.454 ± 0.021	0.594HisAsn: 0.594 ± 0.022	0.984HisPro: 0.984 ± 0.029	0.984HisGln: 0.984 ± 0.03	0.87HisArg: 0.87 ± 0.032	1.114HisSer: 1.114 ± 0.032	1.001HisThr: 1.001 ± 0.027	1.204HisVal: 1.204 ± 0.036	0.203HisTrp: 0.203 ± 0.012	0.942HisTyr: 0.942 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	5.961IleAla: 5.961 ± 0.078	0.72IleCys: 0.72 ± 0.025	4.548IleAsp: 4.548 ± 0.07	5.379IleGlu: 5.379 ± 0.075	3.252IlePhe: 3.252 ± 0.06	5.736IleGly: 5.736 ± 0.085	1.552IleHis: 1.552 ± 0.037	4.774IleIle: 4.774 ± 0.075	4.113IleLys: 4.113 ± 0.062	6.815IleLeu: 6.815 ± 0.096	1.659IleMet: 1.659 ± 0.044	3.211IleAsn: 3.211 ± 0.054	3.21IlePro: 3.21 ± 0.051	3.129IleGln: 3.129 ± 0.05	3.026IleArg: 3.026 ± 0.048	4.647IleSer: 4.647 ± 0.07	4.078IleThr: 4.078 ± 0.059	5.391IleVal: 5.391 ± 0.072	0.547IleTrp: 0.547 ± 0.024	2.379IleTyr: 2.379 ± 0.052	0.0IleXaa: 0.0 ± 0.0
Lys	4.646LysAla: 4.646 ± 0.065	0.271LysCys: 0.271 ± 0.016	3.572LysAsp: 3.572 ± 0.061	6.568LysGlu: 6.568 ± 0.086	1.743LysPhe: 1.743 ± 0.039	3.778LysGly: 3.778 ± 0.061	1.176LysHis: 1.176 ± 0.033	4.811LysIle: 4.811 ± 0.067	5.952LysLys: 5.952 ± 0.078	5.299LysLeu: 5.299 ± 0.073	1.956LysMet: 1.956 ± 0.04	3.423LysAsn: 3.423 ± 0.052	1.833LysPro: 1.833 ± 0.038	3.277LysGln: 3.277 ± 0.053	3.26LysArg: 3.26 ± 0.06	3.021LysSer: 3.021 ± 0.056	3.662LysThr: 3.662 ± 0.057	4.24LysVal: 4.24 ± 0.059	0.571LysTrp: 0.571 ± 0.023	1.978LysTyr: 1.978 ± 0.047	0.0LysXaa: 0.0 ± 0.0
Leu	8.021LeuAla: 8.021 ± 0.091	0.79LeuCys: 0.79 ± 0.027	5.054LeuAsp: 5.054 ± 0.077	6.711LeuGlu: 6.711 ± 0.088	4.814LeuPhe: 4.814 ± 0.086	6.542LeuGly: 6.542 ± 0.116	1.669LeuHis: 1.669 ± 0.036	7.157LeuIle: 7.157 ± 0.11	6.234LeuLys: 6.234 ± 0.078	10.805LeuLeu: 10.805 ± 0.209	2.699LeuMet: 2.699 ± 0.053	4.259LeuAsn: 4.259 ± 0.061	4.183LeuPro: 4.183 ± 0.06	3.607LeuGln: 3.607 ± 0.06	3.749LeuArg: 3.749 ± 0.06	7.135LeuSer: 7.135 ± 0.1	6.154LeuThr: 6.154 ± 0.075	6.582LeuVal: 6.582 ± 0.091	0.764LeuTrp: 0.764 ± 0.03	2.975LeuTyr: 2.975 ± 0.056	0.0LeuXaa: 0.0 ± 0.0
Met	2.04MetAla: 2.04 ± 0.039	0.159MetCys: 0.159 ± 0.01	1.501MetAsp: 1.501 ± 0.033	1.891MetGlu: 1.891 ± 0.04	0.951MetPhe: 0.951 ± 0.03	1.89MetGly: 1.89 ± 0.043	0.422MetHis: 0.422 ± 0.017	2.405MetIle: 2.405 ± 0.049	2.288MetLys: 2.288 ± 0.039	2.449MetLeu: 2.449 ± 0.055	0.918MetMet: 0.918 ± 0.028	1.511MetAsn: 1.511 ± 0.035	1.005MetPro: 1.005 ± 0.029	1.008MetGln: 1.008 ± 0.027	1.079MetArg: 1.079 ± 0.035	1.533MetSer: 1.533 ± 0.038	1.816MetThr: 1.816 ± 0.044	1.877MetVal: 1.877 ± 0.042	0.157MetTrp: 0.157 ± 0.013	0.794MetTyr: 0.794 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	2.705AsnAla: 2.705 ± 0.051	0.379AsnCys: 0.379 ± 0.019	2.37AsnAsp: 2.37 ± 0.046	3.047AsnGlu: 3.047 ± 0.053	1.729AsnPhe: 1.729 ± 0.034	3.142AsnGly: 3.142 ± 0.059	1.002AsnHis: 1.002 ± 0.028	2.803AsnIle: 2.803 ± 0.052	2.372AsnLys: 2.372 ± 0.05	3.864AsnLeu: 3.864 ± 0.064	1.125AsnMet: 1.125 ± 0.034	1.81AsnAsn: 1.81 ± 0.05	1.944AsnPro: 1.944 ± 0.046	2.712AsnGln: 2.712 ± 0.061	1.984AsnArg: 1.984 ± 0.041	2.212AsnSer: 2.212 ± 0.049	2.144AsnThr: 2.144 ± 0.042	2.868AsnVal: 2.868 ± 0.053	0.464AsnTrp: 0.464 ± 0.019	1.875AsnTyr: 1.875 ± 0.045	0.0AsnXaa: 0.0 ± 0.0
Pro	2.697ProAla: 2.697 ± 0.052	0.219ProCys: 0.219 ± 0.013	2.006ProAsp: 2.006 ± 0.043	3.395ProGlu: 3.395 ± 0.064	1.848ProPhe: 1.848 ± 0.041	2.046ProGly: 2.046 ± 0.04	0.688ProHis: 0.688 ± 0.025	2.761ProIle: 2.761 ± 0.052	2.168ProLys: 2.168 ± 0.049	3.407ProLeu: 3.407 ± 0.053	0.986ProMet: 0.986 ± 0.029	1.613ProAsn: 1.613 ± 0.035	0.743ProPro: 0.743 ± 0.03	1.376ProGln: 1.376 ± 0.034	1.114ProArg: 1.114 ± 0.033	2.078ProSer: 2.078 ± 0.045	2.175ProThr: 2.175 ± 0.051	2.745ProVal: 2.745 ± 0.051	0.305ProTrp: 0.305 ± 0.016	1.36ProTyr: 1.36 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	3.633GlnAla: 3.633 ± 0.06	0.202GlnCys: 0.202 ± 0.015	1.77GlnAsp: 1.77 ± 0.041	3.529GlnGlu: 3.529 ± 0.066	1.67GlnPhe: 1.67 ± 0.035	2.428GlnGly: 2.428 ± 0.052	0.793GlnHis: 0.793 ± 0.026	2.847GlnIle: 2.847 ± 0.05	3.212GlnLys: 3.212 ± 0.056	5.008GlnLeu: 5.008 ± 0.084	1.247GlnMet: 1.247 ± 0.033	1.635GlnAsn: 1.635 ± 0.044	1.491GlnPro: 1.491 ± 0.034	2.608GlnGln: 2.608 ± 0.065	2.062GlnArg: 2.062 ± 0.048	2.169GlnSer: 2.169 ± 0.048	2.618GlnThr: 2.618 ± 0.048	2.864GlnVal: 2.864 ± 0.045	0.424GlnTrp: 0.424 ± 0.019	1.308GlnTyr: 1.308 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	2.325ArgAla: 2.325 ± 0.048	0.315ArgCys: 0.315 ± 0.018	1.819ArgAsp: 1.819 ± 0.044	3.042ArgGlu: 3.042 ± 0.065	2.131ArgPhe: 2.131 ± 0.044	2.258ArgGly: 2.258 ± 0.045	0.733ArgHis: 0.733 ± 0.029	3.153ArgIle: 3.153 ± 0.055	3.111ArgLys: 3.111 ± 0.053	4.315ArgLeu: 4.315 ± 0.067	1.279ArgMet: 1.279 ± 0.033	1.711ArgAsn: 1.711 ± 0.037	1.342ArgPro: 1.342 ± 0.041	1.861ArgGln: 1.861 ± 0.042	1.905ArgArg: 1.905 ± 0.044	2.296ArgSer: 2.296 ± 0.045	2.089ArgThr: 2.089 ± 0.048	2.661ArgVal: 2.661 ± 0.051	0.382ArgTrp: 0.382 ± 0.018	1.753ArgTyr: 1.753 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	3.897SerAla: 3.897 ± 0.064	0.426SerCys: 0.426 ± 0.02	3.039SerAsp: 3.039 ± 0.05	4.16SerGlu: 4.16 ± 0.058	3.161SerPhe: 3.161 ± 0.061	4.446SerGly: 4.446 ± 0.062	1.065SerHis: 1.065 ± 0.036	4.479SerIle: 4.479 ± 0.068	3.521SerLys: 3.521 ± 0.055	6.078SerLeu: 6.078 ± 0.081	1.636SerMet: 1.636 ± 0.036	2.468SerAsn: 2.468 ± 0.054	1.982SerPro: 1.982 ± 0.042	2.285SerGln: 2.285 ± 0.049	2.262SerArg: 2.262 ± 0.049	3.808SerSer: 3.808 ± 0.072	3.199SerThr: 3.199 ± 0.059	3.943SerVal: 3.943 ± 0.075	0.621SerTrp: 0.621 ± 0.023	2.287SerTyr: 2.287 ± 0.042	0.0SerXaa: 0.0 ± 0.0
Thr	4.336ThrAla: 4.336 ± 0.064	0.378ThrCys: 0.378 ± 0.021	3.058ThrAsp: 3.058 ± 0.061	3.866ThrGlu: 3.866 ± 0.056	2.631ThrPhe: 2.631 ± 0.053	4.257ThrGly: 4.257 ± 0.065	1.083ThrHis: 1.083 ± 0.031	5.008ThrIle: 5.008 ± 0.066	3.501ThrLys: 3.501 ± 0.057	5.309ThrLeu: 5.309 ± 0.073	1.45ThrMet: 1.45 ± 0.037	2.402ThrAsn: 2.402 ± 0.054	2.475ThrPro: 2.475 ± 0.052	1.96ThrGln: 1.96 ± 0.042	1.937ThrArg: 1.937 ± 0.041	3.3ThrSer: 3.3 ± 0.057	3.318ThrThr: 3.318 ± 0.057	4.188ThrVal: 4.188 ± 0.069	0.458ThrTrp: 0.458 ± 0.022	2.021ThrTyr: 2.021 ± 0.041	0.0ThrXaa: 0.0 ± 0.0
Val	5.194ValAla: 5.194 ± 0.073	0.61ValCys: 0.61 ± 0.023	3.865ValAsp: 3.865 ± 0.064	4.822ValGlu: 4.822 ± 0.073	3.29ValPhe: 3.29 ± 0.061	4.616ValGly: 4.616 ± 0.073	1.207ValHis: 1.207 ± 0.035	5.263ValIle: 5.263 ± 0.065	4.154ValLys: 4.154 ± 0.064	7.05ValLeu: 7.05 ± 0.137	1.913ValMet: 1.913 ± 0.044	2.884ValAsn: 2.884 ± 0.057	2.697ValPro: 2.697 ± 0.049	2.399ValGln: 2.399 ± 0.042	2.499ValArg: 2.499 ± 0.043	4.579ValSer: 4.579 ± 0.062	4.198ValThr: 4.198 ± 0.058	5.145ValVal: 5.145 ± 0.071	0.535ValTrp: 0.535 ± 0.021	2.28ValTyr: 2.28 ± 0.052	0.0ValXaa: 0.0 ± 0.0
Trp	0.468TrpAla: 0.468 ± 0.021	0.09TrpCys: 0.09 ± 0.009	0.439TrpAsp: 0.439 ± 0.021	0.553TrpGlu: 0.553 ± 0.021	0.464TrpPhe: 0.464 ± 0.022	0.67TrpGly: 0.67 ± 0.027	0.183TrpHis: 0.183 ± 0.011	0.681TrpIle: 0.681 ± 0.023	0.559TrpLys: 0.559 ± 0.022	1.058TrpLeu: 1.058 ± 0.034	0.283TrpMet: 0.283 ± 0.016	0.445TrpAsn: 0.445 ± 0.024	0.236TrpPro: 0.236 ± 0.014	0.51TrpGln: 0.51 ± 0.022	0.434TrpArg: 0.434 ± 0.019	0.517TrpSer: 0.517 ± 0.023	0.514TrpThr: 0.514 ± 0.02	0.525TrpVal: 0.525 ± 0.024	0.122TrpTrp: 0.122 ± 0.011	0.328TrpTyr: 0.328 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.308TyrAla: 2.308 ± 0.044	0.346TyrCys: 0.346 ± 0.017	2.062TyrAsp: 2.062 ± 0.045	2.316TyrGlu: 2.316 ± 0.049	1.957TyrPhe: 1.957 ± 0.042	2.443TyrGly: 2.443 ± 0.042	0.856TyrHis: 0.856 ± 0.029	2.1TyrIle: 2.1 ± 0.042	1.667TyrLys: 1.667 ± 0.043	4.002TyrLeu: 4.002 ± 0.06	0.777TyrMet: 0.777 ± 0.03	1.27TyrAsn: 1.27 ± 0.035	1.48TyrPro: 1.48 ± 0.04	2.306TyrGln: 2.306 ± 0.048	1.773TyrArg: 1.773 ± 0.049	2.257TyrSer: 2.257 ± 0.054	1.937TyrThr: 1.937 ± 0.045	2.236TyrVal: 2.236 ± 0.041	0.397TyrTrp: 0.397 ± 0.019	1.641TyrTyr: 1.641 ± 0.047	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3833 proteins (1160261 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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