Amino acid dipepetide frequency for Anaeromassilibacillus sp. An250

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.142AlaAla: 10.142 ± 0.134	1.407AlaCys: 1.407 ± 0.047	5.285AlaAsp: 5.285 ± 0.071	6.602AlaGlu: 6.602 ± 0.09	3.545AlaPhe: 3.545 ± 0.065	6.712AlaGly: 6.712 ± 0.079	1.482AlaHis: 1.482 ± 0.042	5.226AlaIle: 5.226 ± 0.069	4.663AlaLys: 4.663 ± 0.075	8.868AlaLeu: 8.868 ± 0.109	2.586AlaMet: 2.586 ± 0.059	2.94AlaAsn: 2.94 ± 0.068	3.119AlaPro: 3.119 ± 0.057	3.623AlaGln: 3.623 ± 0.064	4.044AlaArg: 4.044 ± 0.078	4.588AlaSer: 4.588 ± 0.079	3.984AlaThr: 3.984 ± 0.094	7.194AlaVal: 7.194 ± 0.091	0.871AlaTrp: 0.871 ± 0.032	3.106AlaTyr: 3.106 ± 0.067	0.0AlaXaa: 0.0 ± 0.0
Cys	1.378CysAla: 1.378 ± 0.037	0.328CysCys: 0.328 ± 0.02	0.839CysAsp: 0.839 ± 0.029	0.905CysGlu: 0.905 ± 0.029	0.653CysPhe: 0.653 ± 0.023	1.641CysGly: 1.641 ± 0.047	0.282CysHis: 0.282 ± 0.018	0.946CysIle: 0.946 ± 0.036	0.719CysLys: 0.719 ± 0.029	1.206CysLeu: 1.206 ± 0.038	0.434CysMet: 0.434 ± 0.021	0.527CysAsn: 0.527 ± 0.022	0.788CysPro: 0.788 ± 0.035	0.438CysGln: 0.438 ± 0.022	0.888CysArg: 0.888 ± 0.03	0.953CysSer: 0.953 ± 0.031	0.852CysThr: 0.852 ± 0.032	1.055CysVal: 1.055 ± 0.035	0.124CysTrp: 0.124 ± 0.011	0.581CysTyr: 0.581 ± 0.025	0.0CysXaa: 0.0 ± 0.0
Asp	5.381AspAla: 5.381 ± 0.082	0.878AspCys: 0.878 ± 0.031	3.008AspAsp: 3.008 ± 0.074	4.32AspGlu: 4.32 ± 0.078	2.674AspPhe: 2.674 ± 0.053	5.125AspGly: 5.125 ± 0.095	0.968AspHis: 0.968 ± 0.03	3.569AspIle: 3.569 ± 0.07	2.617AspLys: 2.617 ± 0.053	5.036AspLeu: 5.036 ± 0.075	1.621AspMet: 1.621 ± 0.04	1.883AspAsn: 1.883 ± 0.056	2.43AspPro: 2.43 ± 0.05	1.507AspGln: 1.507 ± 0.04	2.891AspArg: 2.891 ± 0.056	2.868AspSer: 2.868 ± 0.055	3.178AspThr: 3.178 ± 0.071	4.004AspVal: 4.004 ± 0.076	0.71AspTrp: 0.71 ± 0.029	2.485AspTyr: 2.485 ± 0.051	0.0AspXaa: 0.0 ± 0.0
Glu	6.634GluAla: 6.634 ± 0.107	0.775GluCys: 0.775 ± 0.029	4.157GluAsp: 4.157 ± 0.078	6.322GluGlu: 6.322 ± 0.102	2.178GluPhe: 2.178 ± 0.051	4.612GluGly: 4.612 ± 0.075	1.368GluHis: 1.368 ± 0.04	4.653GluIle: 4.653 ± 0.076	4.861GluLys: 4.861 ± 0.076	6.548GluLeu: 6.548 ± 0.082	2.112GluMet: 2.112 ± 0.049	3.456GluAsn: 3.456 ± 0.059	2.564GluPro: 2.564 ± 0.058	3.596GluGln: 3.596 ± 0.062	4.009GluArg: 4.009 ± 0.073	3.338GluSer: 3.338 ± 0.058	3.797GluThr: 3.797 ± 0.075	4.218GluVal: 4.218 ± 0.069	0.765GluTrp: 0.765 ± 0.029	2.609GluTyr: 2.609 ± 0.062	0.0GluXaa: 0.0 ± 0.0
Phe	3.301PheAla: 3.301 ± 0.058	0.796PheCys: 0.796 ± 0.029	2.49PheAsp: 2.49 ± 0.048	2.405PheGlu: 2.405 ± 0.05	1.738PhePhe: 1.738 ± 0.051	2.908PheGly: 2.908 ± 0.063	0.853PheHis: 0.853 ± 0.028	2.154PheIle: 2.154 ± 0.056	1.575PheLys: 1.575 ± 0.042	3.871PheLeu: 3.871 ± 0.083	0.88PheMet: 0.88 ± 0.03	1.244PheAsn: 1.244 ± 0.042	1.486PhePro: 1.486 ± 0.034	1.503PheGln: 1.503 ± 0.039	1.802PheArg: 1.802 ± 0.045	2.93PheSer: 2.93 ± 0.064	2.534PheThr: 2.534 ± 0.058	2.717PheVal: 2.717 ± 0.051	0.438PheTrp: 0.438 ± 0.022	1.559PheTyr: 1.559 ± 0.038	0.0PheXaa: 0.0 ± 0.0
Gly	5.785GlyAla: 5.785 ± 0.088	1.248GlyCys: 1.248 ± 0.04	4.0GlyAsp: 4.0 ± 0.071	5.197GlyGlu: 5.197 ± 0.079	2.947GlyPhe: 2.947 ± 0.057	5.51GlyGly: 5.51 ± 0.092	1.249GlyHis: 1.249 ± 0.037	5.064GlyIle: 5.064 ± 0.085	4.817GlyLys: 4.817 ± 0.079	6.251GlyLeu: 6.251 ± 0.093	2.331GlyMet: 2.331 ± 0.05	3.083GlyAsn: 3.083 ± 0.06	1.721GlyPro: 1.721 ± 0.067	2.516GlyGln: 2.516 ± 0.051	3.669GlyArg: 3.669 ± 0.067	4.214GlySer: 4.214 ± 0.077	4.561GlyThr: 4.561 ± 0.088	5.276GlyVal: 5.276 ± 0.075	0.9GlyTrp: 0.9 ± 0.032	3.01GlyTyr: 3.01 ± 0.061	0.0GlyXaa: 0.0 ± 0.0
His	1.487HisAla: 1.487 ± 0.036	0.408HisCys: 0.408 ± 0.019	0.894HisAsp: 0.894 ± 0.028	0.979HisGlu: 0.979 ± 0.033	0.923HisPhe: 0.923 ± 0.031	1.46HisGly: 1.46 ± 0.04	0.382HisHis: 0.382 ± 0.019	1.243HisIle: 1.243 ± 0.042	0.794HisLys: 0.794 ± 0.028	1.673HisLeu: 1.673 ± 0.044	0.482HisMet: 0.482 ± 0.022	0.727HisAsn: 0.727 ± 0.029	1.08HisPro: 1.08 ± 0.033	0.551HisGln: 0.551 ± 0.023	1.072HisArg: 1.072 ± 0.033	1.026HisSer: 1.026 ± 0.032	1.065HisThr: 1.065 ± 0.035	1.13HisVal: 1.13 ± 0.036	0.207HisTrp: 0.207 ± 0.015	0.761HisTyr: 0.761 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	5.586IleAla: 5.586 ± 0.072	1.071IleCys: 1.071 ± 0.036	3.772IleAsp: 3.772 ± 0.064	3.884IleGlu: 3.884 ± 0.068	2.19IlePhe: 2.19 ± 0.053	4.338IleGly: 4.338 ± 0.079	1.184IleHis: 1.184 ± 0.033	3.146IleIle: 3.146 ± 0.067	2.565IleLys: 2.565 ± 0.061	5.93IleLeu: 5.93 ± 0.111	1.314IleMet: 1.314 ± 0.04	2.12IleAsn: 2.12 ± 0.054	3.035IlePro: 3.035 ± 0.055	2.319IleGln: 2.319 ± 0.052	3.404IleArg: 3.404 ± 0.055	3.983IleSer: 3.983 ± 0.068	3.434IleThr: 3.434 ± 0.062	4.143IleVal: 4.143 ± 0.066	0.519IleTrp: 0.519 ± 0.022	2.07IleTyr: 2.07 ± 0.049	0.0IleXaa: 0.0 ± 0.0
Lys	4.799LysAla: 4.799 ± 0.065	0.594LysCys: 0.594 ± 0.025	2.868LysAsp: 2.868 ± 0.053	4.347LysGlu: 4.347 ± 0.075	1.404LysPhe: 1.404 ± 0.046	3.465LysGly: 3.465 ± 0.061	0.926LysHis: 0.926 ± 0.034	3.404LysIle: 3.404 ± 0.059	3.897LysLys: 3.897 ± 0.083	4.537LysLeu: 4.537 ± 0.075	1.545LysMet: 1.545 ± 0.039	2.344LysAsn: 2.344 ± 0.05	2.139LysPro: 2.139 ± 0.05	2.174LysGln: 2.174 ± 0.056	3.225LysArg: 3.225 ± 0.063	2.812LysSer: 2.812 ± 0.046	3.153LysThr: 3.153 ± 0.056	3.218LysVal: 3.218 ± 0.066	0.555LysTrp: 0.555 ± 0.024	1.95LysTyr: 1.95 ± 0.05	0.0LysXaa: 0.0 ± 0.0
Leu	8.039LeuAla: 8.039 ± 0.121	1.836LeuCys: 1.836 ± 0.047	5.472LeuAsp: 5.472 ± 0.067	6.434LeuGlu: 6.434 ± 0.084	3.974LeuPhe: 3.974 ± 0.072	5.82LeuGly: 5.82 ± 0.089	1.854LeuHis: 1.854 ± 0.049	4.855LeuIle: 4.855 ± 0.09	4.781LeuLys: 4.781 ± 0.071	9.8LeuLeu: 9.8 ± 0.152	2.254LeuMet: 2.254 ± 0.048	3.46LeuAsn: 3.46 ± 0.066	4.447LeuPro: 4.447 ± 0.069	3.37LeuGln: 3.37 ± 0.06	5.194LeuArg: 5.194 ± 0.089	6.565LeuSer: 6.565 ± 0.079	5.352LeuThr: 5.352 ± 0.076	5.888LeuVal: 5.888 ± 0.084	0.892LeuTrp: 0.892 ± 0.032	3.205LeuTyr: 3.205 ± 0.063	0.0LeuXaa: 0.0 ± 0.0
Met	2.513MetAla: 2.513 ± 0.051	0.304MetCys: 0.304 ± 0.018	1.716MetAsp: 1.716 ± 0.041	2.342MetGlu: 2.342 ± 0.049	0.852MetPhe: 0.852 ± 0.032	1.959MetGly: 1.959 ± 0.045	0.451MetHis: 0.451 ± 0.018	1.373MetIle: 1.373 ± 0.039	1.859MetLys: 1.859 ± 0.049	2.637MetLeu: 2.637 ± 0.057	0.789MetMet: 0.789 ± 0.034	1.16MetAsn: 1.16 ± 0.031	1.178MetPro: 1.178 ± 0.041	1.123MetGln: 1.123 ± 0.036	1.452MetArg: 1.452 ± 0.04	1.451MetSer: 1.451 ± 0.036	1.556MetThr: 1.556 ± 0.042	1.685MetVal: 1.685 ± 0.047	0.194MetTrp: 0.194 ± 0.014	0.659MetTyr: 0.659 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	3.508AsnAla: 3.508 ± 0.067	0.58AsnCys: 0.58 ± 0.025	1.895AsnAsp: 1.895 ± 0.052	2.232AsnGlu: 2.232 ± 0.05	1.402AsnPhe: 1.402 ± 0.038	3.606AsnGly: 3.606 ± 0.081	0.754AsnHis: 0.754 ± 0.03	2.443AsnIle: 2.443 ± 0.053	1.644AsnLys: 1.644 ± 0.041	3.663AsnLeu: 3.663 ± 0.068	0.973AsnMet: 0.973 ± 0.028	1.422AsnAsn: 1.422 ± 0.04	2.101AsnPro: 2.101 ± 0.052	1.325AsnGln: 1.325 ± 0.041	2.181AsnArg: 2.181 ± 0.055	2.038AsnSer: 2.038 ± 0.051	2.188AsnThr: 2.188 ± 0.057	2.496AsnVal: 2.496 ± 0.056	0.432AsnTrp: 0.432 ± 0.021	1.426AsnTyr: 1.426 ± 0.045	0.0AsnXaa: 0.0 ± 0.0
Pro	3.751ProAla: 3.751 ± 0.073	0.543ProCys: 0.543 ± 0.022	2.847ProAsp: 2.847 ± 0.058	4.082ProGlu: 4.082 ± 0.067	1.758ProPhe: 1.758 ± 0.044	2.849ProGly: 2.849 ± 0.056	0.785ProHis: 0.785 ± 0.03	2.104ProIle: 2.104 ± 0.047	1.957ProLys: 1.957 ± 0.054	3.284ProLeu: 3.284 ± 0.06	0.99ProMet: 0.99 ± 0.031	1.465ProAsn: 1.465 ± 0.04	1.428ProPro: 1.428 ± 0.045	1.576ProGln: 1.576 ± 0.043	1.491ProArg: 1.491 ± 0.042	2.381ProSer: 2.381 ± 0.055	1.998ProThr: 1.998 ± 0.059	3.419ProVal: 3.419 ± 0.066	0.365ProTrp: 0.365 ± 0.019	1.557ProTyr: 1.557 ± 0.043	0.0ProXaa: 0.0 ± 0.0
Gln	3.516GlnAla: 3.516 ± 0.069	0.404GlnCys: 0.404 ± 0.022	1.875GlnAsp: 1.875 ± 0.042	3.09GlnGlu: 3.09 ± 0.061	1.237GlnPhe: 1.237 ± 0.039	2.276GlnGly: 2.276 ± 0.048	0.585GlnHis: 0.585 ± 0.023	2.435GlnIle: 2.435 ± 0.057	2.646GlnLys: 2.646 ± 0.064	3.215GlnLeu: 3.215 ± 0.065	1.149GlnMet: 1.149 ± 0.033	1.779GlnAsn: 1.779 ± 0.042	1.41GlnPro: 1.41 ± 0.043	1.696GlnGln: 1.696 ± 0.045	2.109GlnArg: 2.109 ± 0.054	2.014GlnSer: 2.014 ± 0.043	2.003GlnThr: 2.003 ± 0.047	2.402GlnVal: 2.402 ± 0.044	0.359GlnTrp: 0.359 ± 0.019	1.513GlnTyr: 1.513 ± 0.044	0.0GlnXaa: 0.0 ± 0.0
Arg	4.314ArgAla: 4.314 ± 0.072	0.739ArgCys: 0.739 ± 0.027	2.573ArgAsp: 2.573 ± 0.056	4.064ArgGlu: 4.064 ± 0.081	2.175ArgPhe: 2.175 ± 0.048	3.079ArgGly: 3.079 ± 0.055	0.998ArgHis: 0.998 ± 0.033	3.443ArgIle: 3.443 ± 0.063	3.247ArgLys: 3.247 ± 0.067	5.09ArgLeu: 5.09 ± 0.084	1.788ArgMet: 1.788 ± 0.046	1.971ArgAsn: 1.971 ± 0.047	1.936ArgPro: 1.936 ± 0.046	2.139ArgGln: 2.139 ± 0.052	3.474ArgArg: 3.474 ± 0.074	2.729ArgSer: 2.729 ± 0.05	2.749ArgThr: 2.749 ± 0.054	3.386ArgVal: 3.386 ± 0.063	0.557ArgTrp: 0.557 ± 0.022	2.027ArgTyr: 2.027 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	4.924SerAla: 4.924 ± 0.072	0.8SerCys: 0.8 ± 0.029	3.221SerAsp: 3.221 ± 0.061	3.646SerGlu: 3.646 ± 0.062	2.573SerPhe: 2.573 ± 0.054	5.242SerGly: 5.242 ± 0.077	1.078SerHis: 1.078 ± 0.035	3.68SerIle: 3.68 ± 0.065	2.669SerLys: 2.669 ± 0.047	5.335SerLeu: 5.335 ± 0.075	1.664SerMet: 1.664 ± 0.044	2.076SerAsn: 2.076 ± 0.051	2.218SerPro: 2.218 ± 0.045	1.922SerGln: 1.922 ± 0.041	2.913SerArg: 2.913 ± 0.059	3.653SerSer: 3.653 ± 0.082	3.076SerThr: 3.076 ± 0.07	4.322SerVal: 4.322 ± 0.064	0.58SerTrp: 0.58 ± 0.028	2.174SerTyr: 2.174 ± 0.051	0.0SerXaa: 0.0 ± 0.0
Thr	5.363ThrAla: 5.363 ± 0.097	0.665ThrCys: 0.665 ± 0.031	3.095ThrAsp: 3.095 ± 0.064	3.683ThrGlu: 3.683 ± 0.08	2.259ThrPhe: 2.259 ± 0.048	4.786ThrGly: 4.786 ± 0.088	0.931ThrHis: 0.931 ± 0.03	3.608ThrIle: 3.608 ± 0.069	2.352ThrLys: 2.352 ± 0.041	5.21ThrLeu: 5.21 ± 0.071	1.399ThrMet: 1.399 ± 0.038	1.869ThrAsn: 1.869 ± 0.048	2.816ThrPro: 2.816 ± 0.062	1.797ThrGln: 1.797 ± 0.045	2.321ThrArg: 2.321 ± 0.05	2.964ThrSer: 2.964 ± 0.066	3.025ThrThr: 3.025 ± 0.075	5.086ThrVal: 5.086 ± 0.101	0.522ThrTrp: 0.522 ± 0.024	1.985ThrTyr: 1.985 ± 0.047	0.0ThrXaa: 0.0 ± 0.0
Val	5.689ValAla: 5.689 ± 0.091	1.331ValCys: 1.331 ± 0.041	4.144ValAsp: 4.144 ± 0.069	4.826ValGlu: 4.826 ± 0.079	2.731ValPhe: 2.731 ± 0.061	4.424ValGly: 4.424 ± 0.076	1.208ValHis: 1.208 ± 0.037	3.955ValIle: 3.955 ± 0.075	3.527ValLys: 3.527 ± 0.062	7.009ValLeu: 7.009 ± 0.101	1.782ValMet: 1.782 ± 0.044	2.678ValAsn: 2.678 ± 0.059	2.969ValPro: 2.969 ± 0.054	2.564ValGln: 2.564 ± 0.048	3.513ValArg: 3.513 ± 0.064	4.577ValSer: 4.577 ± 0.063	4.287ValThr: 4.287 ± 0.081	4.992ValVal: 4.992 ± 0.083	0.76ValTrp: 0.76 ± 0.03	2.625ValTyr: 2.625 ± 0.058	0.0ValXaa: 0.0 ± 0.0
Trp	0.805TrpAla: 0.805 ± 0.027	0.165TrpCys: 0.165 ± 0.012	0.624TrpAsp: 0.624 ± 0.029	0.718TrpGlu: 0.718 ± 0.028	0.446TrpPhe: 0.446 ± 0.021	0.709TrpGly: 0.709 ± 0.027	0.187TrpHis: 0.187 ± 0.013	0.588TrpIle: 0.588 ± 0.023	0.642TrpLys: 0.642 ± 0.024	0.952TrpLeu: 0.952 ± 0.037	0.312TrpMet: 0.312 ± 0.017	0.538TrpAsn: 0.538 ± 0.028	0.246TrpPro: 0.246 ± 0.018	0.472TrpGln: 0.472 ± 0.02	0.574TrpArg: 0.574 ± 0.022	0.572TrpSer: 0.572 ± 0.026	0.55TrpThr: 0.55 ± 0.027	0.636TrpVal: 0.636 ± 0.029	0.137TrpTrp: 0.137 ± 0.015	0.385TrpTyr: 0.385 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.072TyrAla: 3.072 ± 0.064	0.667TyrCys: 0.667 ± 0.026	2.375TyrAsp: 2.375 ± 0.049	2.491TyrGlu: 2.491 ± 0.056	1.525TyrPhe: 1.525 ± 0.044	2.83TyrGly: 2.83 ± 0.054	0.82TyrHis: 0.82 ± 0.025	2.119TyrIle: 2.119 ± 0.044	1.526TyrLys: 1.526 ± 0.037	3.373TyrLeu: 3.373 ± 0.068	0.847TyrMet: 0.847 ± 0.025	1.567TyrAsn: 1.567 ± 0.044	1.516TyrPro: 1.516 ± 0.037	1.503TyrGln: 1.503 ± 0.036	2.253TyrArg: 2.253 ± 0.053	2.111TyrSer: 2.111 ± 0.05	2.393TyrThr: 2.393 ± 0.055	2.327TyrVal: 2.327 ± 0.049	0.372TyrTrp: 0.372 ± 0.02	1.593TyrTyr: 1.593 ± 0.044	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3281 proteins (1017378 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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