Amino acid dipepetide frequency for Paenibacillus protaetiae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.4AlaAla: 12.4 ± 0.181	0.791AlaCys: 0.791 ± 0.029	5.224AlaAsp: 5.224 ± 0.076	6.378AlaGlu: 6.378 ± 0.1	3.498AlaPhe: 3.498 ± 0.053	8.358AlaGly: 8.358 ± 0.106	1.557AlaHis: 1.557 ± 0.034	5.577AlaIle: 5.577 ± 0.074	4.618AlaLys: 4.618 ± 0.068	8.688AlaLeu: 8.688 ± 0.099	2.419AlaMet: 2.419 ± 0.051	2.785AlaAsn: 2.785 ± 0.057	3.098AlaPro: 3.098 ± 0.071	2.972AlaGln: 2.972 ± 0.055	3.836AlaArg: 3.836 ± 0.055	5.906AlaSer: 5.906 ± 0.08	3.465AlaThr: 3.465 ± 0.085	7.677AlaVal: 7.677 ± 0.106	0.984AlaTrp: 0.984 ± 0.03	2.834AlaTyr: 2.834 ± 0.055	0.0AlaXaa: 0.0 ± 0.0
Cys	0.58CysAla: 0.58 ± 0.024	0.112CysCys: 0.112 ± 0.01	0.361CysAsp: 0.361 ± 0.019	0.433CysGlu: 0.433 ± 0.019	0.31CysPhe: 0.31 ± 0.016	0.771CysGly: 0.771 ± 0.031	0.173CysHis: 0.173 ± 0.013	0.44CysIle: 0.44 ± 0.021	0.301CysLys: 0.301 ± 0.017	0.71CysLeu: 0.71 ± 0.028	0.181CysMet: 0.181 ± 0.011	0.247CysAsn: 0.247 ± 0.015	0.345CysPro: 0.345 ± 0.02	0.183CysGln: 0.183 ± 0.014	0.456CysArg: 0.456 ± 0.022	0.561CysSer: 0.561 ± 0.025	0.403CysThr: 0.403 ± 0.02	0.409CysVal: 0.409 ± 0.019	0.091CysTrp: 0.091 ± 0.009	0.263CysTyr: 0.263 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	4.304AspAla: 4.304 ± 0.071	0.33AspCys: 0.33 ± 0.017	2.447AspAsp: 2.447 ± 0.049	3.85AspGlu: 3.85 ± 0.063	1.94AspPhe: 1.94 ± 0.046	4.311AspGly: 4.311 ± 0.074	1.124AspHis: 1.124 ± 0.032	3.34AspIle: 3.34 ± 0.057	2.862AspLys: 2.862 ± 0.055	4.714AspLeu: 4.714 ± 0.064	1.396AspMet: 1.396 ± 0.032	1.943AspAsn: 1.943 ± 0.045	2.459AspPro: 2.459 ± 0.05	1.834AspGln: 1.834 ± 0.045	2.806AspArg: 2.806 ± 0.061	2.88AspSer: 2.88 ± 0.042	2.584AspThr: 2.584 ± 0.051	3.572AspVal: 3.572 ± 0.063	0.841AspTrp: 0.841 ± 0.031	2.045AspTyr: 2.045 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	6.77GluAla: 6.77 ± 0.087	0.375GluCys: 0.375 ± 0.019	2.868GluAsp: 2.868 ± 0.056	4.979GluGlu: 4.979 ± 0.092	1.796GluPhe: 1.796 ± 0.042	4.426GluGly: 4.426 ± 0.067	1.538GluHis: 1.538 ± 0.04	3.711GluIle: 3.711 ± 0.064	3.438GluLys: 3.438 ± 0.06	7.345GluLeu: 7.345 ± 0.098	1.821GluMet: 1.821 ± 0.045	1.957GluAsn: 1.957 ± 0.041	2.481GluPro: 2.481 ± 0.049	4.308GluGln: 4.308 ± 0.071	4.19GluArg: 4.19 ± 0.074	3.209GluSer: 3.209 ± 0.047	3.421GluThr: 3.421 ± 0.055	4.019GluVal: 4.019 ± 0.069	0.962GluTrp: 0.962 ± 0.031	1.747GluTyr: 1.747 ± 0.041	0.0GluXaa: 0.0 ± 0.0
Phe	3.496PheAla: 3.496 ± 0.061	0.325PheCys: 0.325 ± 0.018	2.183PheAsp: 2.183 ± 0.043	2.349PheGlu: 2.349 ± 0.051	1.602PhePhe: 1.602 ± 0.039	3.25PheGly: 3.25 ± 0.05	0.925PheHis: 0.925 ± 0.028	2.737PheIle: 2.737 ± 0.054	1.834PheLys: 1.834 ± 0.047	3.417PheLeu: 3.417 ± 0.069	1.109PheMet: 1.109 ± 0.028	1.545PheAsn: 1.545 ± 0.041	1.572PhePro: 1.572 ± 0.033	1.416PheGln: 1.416 ± 0.033	2.075PheArg: 2.075 ± 0.045	2.533PheSer: 2.533 ± 0.048	2.334PheThr: 2.334 ± 0.045	2.877PheVal: 2.877 ± 0.049	0.51PheTrp: 0.51 ± 0.022	1.353PheTyr: 1.353 ± 0.036	0.0PheXaa: 0.0 ± 0.0
Gly	6.333GlyAla: 6.333 ± 0.111	0.698GlyCys: 0.698 ± 0.026	3.593GlyAsp: 3.593 ± 0.063	4.74GlyGlu: 4.74 ± 0.07	3.192GlyPhe: 3.192 ± 0.057	6.059GlyGly: 6.059 ± 0.095	1.554GlyHis: 1.554 ± 0.041	5.686GlyIle: 5.686 ± 0.077	4.719GlyLys: 4.719 ± 0.075	7.376GlyLeu: 7.376 ± 0.089	2.362GlyMet: 2.362 ± 0.044	2.649GlyAsn: 2.649 ± 0.058	2.108GlyPro: 2.108 ± 0.059	2.923GlyGln: 2.923 ± 0.058	3.828GlyArg: 3.828 ± 0.068	5.211GlySer: 5.211 ± 0.077	4.583GlyThr: 4.583 ± 0.071	5.241GlyVal: 5.241 ± 0.085	1.107GlyTrp: 1.107 ± 0.039	3.028GlyTyr: 3.028 ± 0.057	0.0GlyXaa: 0.0 ± 0.0
His	1.79HisAla: 1.79 ± 0.035	0.195HisCys: 0.195 ± 0.014	1.019HisAsp: 1.019 ± 0.03	1.228HisGlu: 1.228 ± 0.033	0.958HisPhe: 0.958 ± 0.026	1.482HisGly: 1.482 ± 0.038	0.625HisHis: 0.625 ± 0.027	1.431HisIle: 1.431 ± 0.036	0.889HisLys: 0.889 ± 0.027	2.077HisLeu: 2.077 ± 0.048	0.607HisMet: 0.607 ± 0.025	0.723HisAsn: 0.723 ± 0.027	1.335HisPro: 1.335 ± 0.041	0.747HisGln: 0.747 ± 0.026	1.079HisArg: 1.079 ± 0.034	1.135HisSer: 1.135 ± 0.027	1.1HisThr: 1.1 ± 0.032	1.485HisVal: 1.485 ± 0.034	0.299HisTrp: 0.299 ± 0.015	0.91HisTyr: 0.91 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	6.377IleAla: 6.377 ± 0.082	0.614IleCys: 0.614 ± 0.02	3.575IleAsp: 3.575 ± 0.061	3.979IleGlu: 3.979 ± 0.062	2.024IlePhe: 2.024 ± 0.046	5.569IleGly: 5.569 ± 0.074	1.343IleHis: 1.343 ± 0.038	4.075IleIle: 4.075 ± 0.074	2.719IleLys: 2.719 ± 0.053	4.786IleLeu: 4.786 ± 0.089	1.599IleMet: 1.599 ± 0.037	2.251IleAsn: 2.251 ± 0.04	3.015IlePro: 3.015 ± 0.056	2.317IleGln: 2.317 ± 0.049	3.861IleArg: 3.861 ± 0.07	4.069IleSer: 4.069 ± 0.076	3.688IleThr: 3.688 ± 0.056	5.362IleVal: 5.362 ± 0.075	0.694IleTrp: 0.694 ± 0.026	1.98IleTyr: 1.98 ± 0.044	0.0IleXaa: 0.0 ± 0.0
Lys	4.652LysAla: 4.652 ± 0.074	0.207LysCys: 0.207 ± 0.014	2.614LysAsp: 2.614 ± 0.06	3.858LysGlu: 3.858 ± 0.066	1.453LysPhe: 1.453 ± 0.039	3.502LysGly: 3.502 ± 0.059	1.107LysHis: 1.107 ± 0.029	2.696LysIle: 2.696 ± 0.051	2.846LysLys: 2.846 ± 0.062	5.954LysLeu: 5.954 ± 0.081	1.436LysMet: 1.436 ± 0.04	1.702LysAsn: 1.702 ± 0.041	2.589LysPro: 2.589 ± 0.047	2.843LysGln: 2.843 ± 0.057	3.023LysArg: 3.023 ± 0.054	2.688LysSer: 2.688 ± 0.042	2.695LysThr: 2.695 ± 0.054	3.291LysVal: 3.291 ± 0.06	0.675LysTrp: 0.675 ± 0.028	1.589LysTyr: 1.589 ± 0.039	0.0LysXaa: 0.0 ± 0.0
Leu	9.359LeuAla: 9.359 ± 0.116	0.748LeuCys: 0.748 ± 0.025	5.23LeuAsp: 5.23 ± 0.068	6.153LeuGlu: 6.153 ± 0.097	4.564LeuPhe: 4.564 ± 0.085	6.622LeuGly: 6.622 ± 0.085	2.197LeuHis: 2.197 ± 0.047	6.121LeuIle: 6.121 ± 0.083	5.079LeuLys: 5.079 ± 0.073	11.196LeuLeu: 11.196 ± 0.143	2.614LeuMet: 2.614 ± 0.054	3.624LeuAsn: 3.624 ± 0.053	4.627LeuPro: 4.627 ± 0.071	4.343LeuGln: 4.343 ± 0.074	4.977LeuArg: 4.977 ± 0.075	6.665LeuSer: 6.665 ± 0.084	5.358LeuThr: 5.358 ± 0.07	6.229LeuVal: 6.229 ± 0.09	1.072LeuTrp: 1.072 ± 0.035	3.178LeuTyr: 3.178 ± 0.053	0.0LeuXaa: 0.0 ± 0.0
Met	2.428MetAla: 2.428 ± 0.05	0.145MetCys: 0.145 ± 0.011	1.487MetAsp: 1.487 ± 0.034	1.863MetGlu: 1.863 ± 0.043	0.924MetPhe: 0.924 ± 0.029	1.635MetGly: 1.635 ± 0.043	0.483MetHis: 0.483 ± 0.019	1.743MetIle: 1.743 ± 0.048	1.854MetLys: 1.854 ± 0.039	2.982MetLeu: 2.982 ± 0.059	0.883MetMet: 0.883 ± 0.032	1.439MetAsn: 1.439 ± 0.035	1.247MetPro: 1.247 ± 0.034	1.039MetGln: 1.039 ± 0.029	1.36MetArg: 1.36 ± 0.036	1.739MetSer: 1.739 ± 0.038	1.615MetThr: 1.615 ± 0.036	1.647MetVal: 1.647 ± 0.04	0.226MetTrp: 0.226 ± 0.015	0.734MetTyr: 0.734 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	2.973AsnAla: 2.973 ± 0.057	0.235AsnCys: 0.235 ± 0.017	1.865AsnAsp: 1.865 ± 0.046	2.448AsnGlu: 2.448 ± 0.051	1.203AsnPhe: 1.203 ± 0.035	3.402AsnGly: 3.402 ± 0.07	0.793AsnHis: 0.793 ± 0.027	2.156AsnIle: 2.156 ± 0.049	1.942AsnLys: 1.942 ± 0.045	2.936AsnLeu: 2.936 ± 0.047	0.929AsnMet: 0.929 ± 0.028	1.484AsnAsn: 1.484 ± 0.047	2.0AsnPro: 2.0 ± 0.04	1.287AsnGln: 1.287 ± 0.032	2.139AsnArg: 2.139 ± 0.044	1.996AsnSer: 1.996 ± 0.041	1.858AsnThr: 1.858 ± 0.041	2.619AsnVal: 2.619 ± 0.046	0.55AsnTrp: 0.55 ± 0.025	1.3AsnTyr: 1.3 ± 0.036	0.0AsnXaa: 0.0 ± 0.0
Pro	4.154ProAla: 4.154 ± 0.082	0.272ProCys: 0.272 ± 0.016	2.884ProAsp: 2.884 ± 0.059	3.424ProGlu: 3.424 ± 0.065	2.011ProPhe: 2.011 ± 0.046	3.275ProGly: 3.275 ± 0.063	0.951ProHis: 0.951 ± 0.027	2.368ProIle: 2.368 ± 0.052	1.717ProLys: 1.717 ± 0.038	4.125ProLeu: 4.125 ± 0.06	0.953ProMet: 0.953 ± 0.034	1.476ProAsn: 1.476 ± 0.039	1.379ProPro: 1.379 ± 0.043	1.491ProGln: 1.491 ± 0.035	1.505ProArg: 1.505 ± 0.037	2.786ProSer: 2.786 ± 0.052	1.69ProThr: 1.69 ± 0.048	3.646ProVal: 3.646 ± 0.059	0.504ProTrp: 0.504 ± 0.023	1.595ProTyr: 1.595 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	3.904GlnAla: 3.904 ± 0.072	0.167GlnCys: 0.167 ± 0.012	1.752GlnAsp: 1.752 ± 0.04	2.511GlnGlu: 2.511 ± 0.055	1.593GlnPhe: 1.593 ± 0.038	2.589GlnGly: 2.589 ± 0.048	0.86GlnHis: 0.86 ± 0.024	2.467GlnIle: 2.467 ± 0.046	1.88GlnLys: 1.88 ± 0.042	4.814GlnLeu: 4.814 ± 0.077	1.202GlnMet: 1.202 ± 0.034	1.324GlnAsn: 1.324 ± 0.032	1.818GlnPro: 1.818 ± 0.041	2.204GlnGln: 2.204 ± 0.05	1.887GlnArg: 1.887 ± 0.043	2.387GlnSer: 2.387 ± 0.048	2.192GlnThr: 2.192 ± 0.049	2.554GlnVal: 2.554 ± 0.044	0.513GlnTrp: 0.513 ± 0.022	1.43GlnTyr: 1.43 ± 0.037	0.0GlnXaa: 0.0 ± 0.0
Arg	3.548ArgAla: 3.548 ± 0.063	0.342ArgCys: 0.342 ± 0.018	2.375ArgAsp: 2.375 ± 0.058	3.592ArgGlu: 3.592 ± 0.054	2.375ArgPhe: 2.375 ± 0.051	3.106ArgGly: 3.106 ± 0.066	1.194ArgHis: 1.194 ± 0.039	3.721ArgIle: 3.721 ± 0.06	3.213ArgLys: 3.213 ± 0.063	5.693ArgLeu: 5.693 ± 0.087	1.732ArgMet: 1.732 ± 0.041	2.038ArgAsn: 2.038 ± 0.045	1.872ArgPro: 1.872 ± 0.044	2.209ArgGln: 2.209 ± 0.048	2.891ArgArg: 2.891 ± 0.065	3.357ArgSer: 3.357 ± 0.054	2.867ArgThr: 2.867 ± 0.055	3.078ArgVal: 3.078 ± 0.053	0.659ArgTrp: 0.659 ± 0.025	1.93ArgTyr: 1.93 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	5.56SerAla: 5.56 ± 0.072	0.459SerCys: 0.459 ± 0.023	3.194SerAsp: 3.194 ± 0.058	3.486SerGlu: 3.486 ± 0.057	2.968SerPhe: 2.968 ± 0.064	5.854SerGly: 5.854 ± 0.089	1.204SerHis: 1.204 ± 0.036	4.078SerIle: 4.078 ± 0.068	3.045SerLys: 3.045 ± 0.059	6.17SerLeu: 6.17 ± 0.078	1.659SerMet: 1.659 ± 0.041	2.204SerAsn: 2.204 ± 0.048	2.464SerPro: 2.464 ± 0.046	2.004SerGln: 2.004 ± 0.041	3.318SerArg: 3.318 ± 0.057	4.366SerSer: 4.366 ± 0.073	2.864SerThr: 2.864 ± 0.059	4.381SerVal: 4.381 ± 0.071	0.812SerTrp: 0.812 ± 0.028	2.199SerTyr: 2.199 ± 0.047	0.0SerXaa: 0.0 ± 0.0
Thr	5.314ThrAla: 5.314 ± 0.076	0.315ThrCys: 0.315 ± 0.017	2.907ThrAsp: 2.907 ± 0.056	3.02ThrGlu: 3.02 ± 0.042	2.211ThrPhe: 2.211 ± 0.042	4.861ThrGly: 4.861 ± 0.139	0.937ThrHis: 0.937 ± 0.031	3.733ThrIle: 3.733 ± 0.065	2.305ThrLys: 2.305 ± 0.044	4.953ThrLeu: 4.953 ± 0.063	1.244ThrMet: 1.244 ± 0.035	1.934ThrAsn: 1.934 ± 0.046	2.583ThrPro: 2.583 ± 0.054	1.378ThrGln: 1.378 ± 0.037	2.226ThrArg: 2.226 ± 0.049	3.085ThrSer: 3.085 ± 0.055	2.575ThrThr: 2.575 ± 0.063	4.555ThrVal: 4.555 ± 0.072	0.563ThrTrp: 0.563 ± 0.023	1.775ThrTyr: 1.775 ± 0.043	0.0ThrXaa: 0.0 ± 0.0
Val	5.357ValAla: 5.357 ± 0.077	0.636ValCys: 0.636 ± 0.023	3.436ValAsp: 3.436 ± 0.065	4.041ValGlu: 4.041 ± 0.064	2.786ValPhe: 2.786 ± 0.055	4.387ValGly: 4.387 ± 0.074	1.531ValHis: 1.531 ± 0.038	4.965ValIle: 4.965 ± 0.073	3.817ValLys: 3.817 ± 0.061	7.306ValLeu: 7.306 ± 0.084	2.014ValMet: 2.014 ± 0.036	2.795ValAsn: 2.795 ± 0.051	3.276ValPro: 3.276 ± 0.06	2.981ValGln: 2.981 ± 0.056	3.611ValArg: 3.611 ± 0.057	4.758ValSer: 4.758 ± 0.062	4.557ValThr: 4.557 ± 0.091	4.971ValVal: 4.971 ± 0.087	0.864ValTrp: 0.864 ± 0.028	2.568ValTyr: 2.568 ± 0.051	0.0ValXaa: 0.0 ± 0.0
Trp	0.869TrpAla: 0.869 ± 0.031	0.1TrpCys: 0.1 ± 0.01	0.67TrpAsp: 0.67 ± 0.028	0.663TrpGlu: 0.663 ± 0.025	0.521TrpPhe: 0.521 ± 0.022	0.795TrpGly: 0.795 ± 0.024	0.316TrpHis: 0.316 ± 0.017	0.814TrpIle: 0.814 ± 0.029	0.708TrpLys: 0.708 ± 0.032	1.542TrpLeu: 1.542 ± 0.041	0.441TrpMet: 0.441 ± 0.021	0.645TrpAsn: 0.645 ± 0.023	0.423TrpPro: 0.423 ± 0.019	0.511TrpGln: 0.511 ± 0.021	0.658TrpArg: 0.658 ± 0.022	0.791TrpSer: 0.791 ± 0.032	0.703TrpThr: 0.703 ± 0.026	0.785TrpVal: 0.785 ± 0.024	0.17TrpTrp: 0.17 ± 0.015	0.4TrpTyr: 0.4 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.896TyrAla: 2.896 ± 0.056	0.265TyrCys: 0.265 ± 0.014	1.897TyrAsp: 1.897 ± 0.048	2.367TyrGlu: 2.367 ± 0.051	1.515TyrPhe: 1.515 ± 0.038	2.738TyrGly: 2.738 ± 0.048	0.703TyrHis: 0.703 ± 0.025	2.038TyrIle: 2.038 ± 0.04	1.634TyrLys: 1.634 ± 0.039	3.175TyrLeu: 3.175 ± 0.056	0.87TyrMet: 0.87 ± 0.026	1.347TyrAsn: 1.347 ± 0.034	1.514TyrPro: 1.514 ± 0.043	1.056TyrGln: 1.056 ± 0.03	2.07TyrArg: 2.07 ± 0.043	2.166TyrSer: 2.166 ± 0.044	1.923TyrThr: 1.923 ± 0.051	2.258TyrVal: 2.258 ± 0.047	0.427TyrTrp: 0.427 ± 0.021	1.409TyrTyr: 1.409 ± 0.043	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3615 proteins (1155770 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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