Amino acid dipepetide frequency for Methylocystis parvus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.075AlaAla: 19.075 ± 0.23	1.247AlaCys: 1.247 ± 0.035	6.47AlaAsp: 6.47 ± 0.088	7.891AlaGlu: 7.891 ± 0.097	5.185AlaPhe: 5.185 ± 0.072	10.238AlaGly: 10.238 ± 0.103	2.652AlaHis: 2.652 ± 0.048	6.438AlaIle: 6.438 ± 0.081	4.884AlaLys: 4.884 ± 0.08	14.966AlaLeu: 14.966 ± 0.158	3.223AlaMet: 3.223 ± 0.051	3.272AlaAsn: 3.272 ± 0.068	7.859AlaPro: 7.859 ± 0.125	4.454AlaGln: 4.454 ± 0.068	10.665AlaArg: 10.665 ± 0.137	7.145AlaSer: 7.145 ± 0.081	6.083AlaThr: 6.083 ± 0.077	7.885AlaVal: 7.885 ± 0.083	1.438AlaTrp: 1.438 ± 0.036	2.852AlaTyr: 2.852 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	1.349CysAla: 1.349 ± 0.036	0.134CysCys: 0.134 ± 0.01	0.593CysAsp: 0.593 ± 0.02	0.545CysGlu: 0.545 ± 0.021	0.359CysPhe: 0.359 ± 0.016	0.978CysGly: 0.978 ± 0.031	0.227CysHis: 0.227 ± 0.017	0.356CysIle: 0.356 ± 0.016	0.238CysLys: 0.238 ± 0.014	0.8CysLeu: 0.8 ± 0.029	0.145CysMet: 0.145 ± 0.011	0.243CysAsn: 0.243 ± 0.014	0.482CysPro: 0.482 ± 0.019	0.206CysGln: 0.206 ± 0.013	0.633CysArg: 0.633 ± 0.025	0.478CysSer: 0.478 ± 0.02	0.313CysThr: 0.313 ± 0.017	0.78CysVal: 0.78 ± 0.025	0.111CysTrp: 0.111 ± 0.009	0.201CysTyr: 0.201 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	7.884AspAla: 7.884 ± 0.095	0.548AspCys: 0.548 ± 0.023	3.12AspAsp: 3.12 ± 0.064	3.621AspGlu: 3.621 ± 0.064	2.423AspPhe: 2.423 ± 0.04	4.819AspGly: 4.819 ± 0.068	1.111AspHis: 1.111 ± 0.034	2.825AspIle: 2.825 ± 0.05	1.929AspLys: 1.929 ± 0.047	5.719AspLeu: 5.719 ± 0.07	1.24AspMet: 1.24 ± 0.032	1.296AspAsn: 1.296 ± 0.032	3.369AspPro: 3.369 ± 0.055	1.486AspGln: 1.486 ± 0.034	3.995AspArg: 3.995 ± 0.062	2.139AspSer: 2.139 ± 0.042	1.88AspThr: 1.88 ± 0.041	4.097AspVal: 4.097 ± 0.059	0.959AspTrp: 0.959 ± 0.033	1.626AspTyr: 1.626 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	8.338GluAla: 8.338 ± 0.108	0.435GluCys: 0.435 ± 0.021	2.738GluAsp: 2.738 ± 0.05	3.617GluGlu: 3.617 ± 0.074	1.868GluPhe: 1.868 ± 0.042	4.383GluGly: 4.383 ± 0.073	1.116GluHis: 1.116 ± 0.028	3.738GluIle: 3.738 ± 0.054	2.954GluLys: 2.954 ± 0.054	5.274GluLeu: 5.274 ± 0.069	1.524GluMet: 1.524 ± 0.039	1.757GluAsn: 1.757 ± 0.036	2.814GluPro: 2.814 ± 0.053	1.907GluGln: 1.907 ± 0.044	5.435GluArg: 5.435 ± 0.083	2.917GluSer: 2.917 ± 0.043	3.856GluThr: 3.856 ± 0.055	3.127GluVal: 3.127 ± 0.05	0.774GluTrp: 0.774 ± 0.023	0.927GluTyr: 0.927 ± 0.025	0.0GluXaa: 0.0 ± 0.0
Phe	5.187PheAla: 5.187 ± 0.075	0.476PheCys: 0.476 ± 0.023	2.832PheAsp: 2.832 ± 0.047	2.466PheGlu: 2.466 ± 0.057	1.726PhePhe: 1.726 ± 0.048	3.77PheGly: 3.77 ± 0.055	0.791PheHis: 0.791 ± 0.026	1.699PheIle: 1.699 ± 0.035	1.126PheLys: 1.126 ± 0.035	3.814PheLeu: 3.814 ± 0.06	0.805PheMet: 0.805 ± 0.025	1.083PheAsn: 1.083 ± 0.035	1.753PhePro: 1.753 ± 0.035	1.008PheGln: 1.008 ± 0.029	2.329PheArg: 2.329 ± 0.044	2.575PheSer: 2.575 ± 0.051	1.845PheThr: 1.845 ± 0.041	3.159PheVal: 3.159 ± 0.056	0.555PheTrp: 0.555 ± 0.025	0.994PheTyr: 0.994 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	11.372GlyAla: 11.372 ± 0.124	0.852GlyCys: 0.852 ± 0.027	4.515GlyAsp: 4.515 ± 0.065	4.836GlyGlu: 4.836 ± 0.071	3.724GlyPhe: 3.724 ± 0.059	7.509GlyGly: 7.509 ± 0.148	1.607GlyHis: 1.607 ± 0.042	2.725GlyIle: 2.725 ± 0.05	3.447GlyLys: 3.447 ± 0.061	8.343GlyLeu: 8.343 ± 0.079	1.849GlyMet: 1.849 ± 0.043	1.767GlyAsn: 1.767 ± 0.047	3.5GlyPro: 3.5 ± 0.059	2.344GlyGln: 2.344 ± 0.047	6.074GlyArg: 6.074 ± 0.084	4.05GlySer: 4.05 ± 0.06	2.956GlyThr: 2.956 ± 0.063	7.287GlyVal: 7.287 ± 0.084	1.332GlyTrp: 1.332 ± 0.042	2.245GlyTyr: 2.245 ± 0.052	0.0GlyXaa: 0.0 ± 0.0
His	2.319HisAla: 2.319 ± 0.043	0.223HisCys: 0.223 ± 0.015	1.196HisAsp: 1.196 ± 0.034	1.113HisGlu: 1.113 ± 0.03	0.894HisPhe: 0.894 ± 0.023	1.855HisGly: 1.855 ± 0.041	0.541HisHis: 0.541 ± 0.023	0.942HisIle: 0.942 ± 0.025	0.557HisLys: 0.557 ± 0.02	1.91HisLeu: 1.91 ± 0.044	0.48HisMet: 0.48 ± 0.019	0.467HisAsn: 0.467 ± 0.019	1.214HisPro: 1.214 ± 0.032	0.468HisGln: 0.468 ± 0.019	1.268HisArg: 1.268 ± 0.035	0.923HisSer: 0.923 ± 0.027	0.667HisThr: 0.667 ± 0.023	1.468HisVal: 1.468 ± 0.033	0.345HisTrp: 0.345 ± 0.018	0.556HisTyr: 0.556 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	6.95IleAla: 6.95 ± 0.078	0.548IleCys: 0.548 ± 0.022	3.679IleAsp: 3.679 ± 0.046	3.709IleGlu: 3.709 ± 0.057	1.884IlePhe: 1.884 ± 0.043	4.693IleGly: 4.693 ± 0.068	0.873IleHis: 0.873 ± 0.029	1.942IleIle: 1.942 ± 0.046	1.384IleLys: 1.384 ± 0.035	4.192IleLeu: 4.192 ± 0.06	0.854IleMet: 0.854 ± 0.027	1.233IleAsn: 1.233 ± 0.032	2.159IlePro: 2.159 ± 0.039	1.059IleGln: 1.059 ± 0.029	2.954IleArg: 2.954 ± 0.051	2.667IleSer: 2.667 ± 0.043	1.837IleThr: 1.837 ± 0.043	4.502IleVal: 4.502 ± 0.069	0.533IleTrp: 0.533 ± 0.021	1.106IleTyr: 1.106 ± 0.026	0.0IleXaa: 0.0 ± 0.0
Lys	4.643LysAla: 4.643 ± 0.068	0.231LysCys: 0.231 ± 0.014	1.909LysAsp: 1.909 ± 0.041	1.999LysGlu: 1.999 ± 0.048	1.103LysPhe: 1.103 ± 0.029	2.997LysGly: 2.997 ± 0.063	0.61LysHis: 0.61 ± 0.022	2.061LysIle: 2.061 ± 0.044	1.684LysLys: 1.684 ± 0.043	3.635LysLeu: 3.635 ± 0.054	0.857LysMet: 0.857 ± 0.025	1.063LysAsn: 1.063 ± 0.03	2.151LysPro: 2.151 ± 0.049	1.022LysGln: 1.022 ± 0.033	2.819LysArg: 2.819 ± 0.05	2.184LysSer: 2.184 ± 0.041	2.03LysThr: 2.03 ± 0.041	2.268LysVal: 2.268 ± 0.05	0.413LysTrp: 0.413 ± 0.017	0.682LysTyr: 0.682 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	14.583LeuAla: 14.583 ± 0.157	0.945LeuCys: 0.945 ± 0.03	6.107LeuAsp: 6.107 ± 0.07	5.343LeuGlu: 5.343 ± 0.074	3.926LeuPhe: 3.926 ± 0.063	7.574LeuGly: 7.574 ± 0.086	1.826LeuHis: 1.826 ± 0.037	4.708LeuIle: 4.708 ± 0.065	3.484LeuLys: 3.484 ± 0.056	9.503LeuLeu: 9.503 ± 0.112	2.031LeuMet: 2.031 ± 0.041	2.45LeuAsn: 2.45 ± 0.044	5.28LeuPro: 5.28 ± 0.071	2.634LeuGln: 2.634 ± 0.053	7.589LeuArg: 7.589 ± 0.094	6.629LeuSer: 6.629 ± 0.071	5.278LeuThr: 5.278 ± 0.073	6.93LeuVal: 6.93 ± 0.088	1.158LeuTrp: 1.158 ± 0.035	2.248LeuTyr: 2.248 ± 0.043	0.0LeuXaa: 0.0 ± 0.0
Met	2.677MetAla: 2.677 ± 0.051	0.147MetCys: 0.147 ± 0.009	0.953MetAsp: 0.953 ± 0.031	1.038MetGlu: 1.038 ± 0.029	0.66MetPhe: 0.66 ± 0.023	1.592MetGly: 1.592 ± 0.038	0.38MetHis: 0.38 ± 0.017	1.174MetIle: 1.174 ± 0.028	0.978MetLys: 0.978 ± 0.027	2.175MetLeu: 2.175 ± 0.043	0.556MetMet: 0.556 ± 0.02	0.734MetAsn: 0.734 ± 0.022	1.2MetPro: 1.2 ± 0.03	0.709MetGln: 0.709 ± 0.027	1.993MetArg: 1.993 ± 0.039	1.741MetSer: 1.741 ± 0.036	1.696MetThr: 1.696 ± 0.036	1.203MetVal: 1.203 ± 0.03	0.206MetTrp: 0.206 ± 0.015	0.242MetTyr: 0.242 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	3.375AsnAla: 3.375 ± 0.063	0.268AsnCys: 0.268 ± 0.015	1.419AsnAsp: 1.419 ± 0.036	1.41AsnGlu: 1.41 ± 0.036	1.119AsnPhe: 1.119 ± 0.038	2.442AsnGly: 2.442 ± 0.064	0.475AsnHis: 0.475 ± 0.021	1.436AsnIle: 1.436 ± 0.034	0.737AsnLys: 0.737 ± 0.025	2.561AsnLeu: 2.561 ± 0.05	0.572AsnMet: 0.572 ± 0.022	0.721AsnAsn: 0.721 ± 0.028	1.709AsnPro: 1.709 ± 0.038	0.694AsnGln: 0.694 ± 0.027	1.702AsnArg: 1.702 ± 0.04	1.236AsnSer: 1.236 ± 0.041	0.978AsnThr: 0.978 ± 0.031	2.034AsnVal: 2.034 ± 0.049	0.475AsnTrp: 0.475 ± 0.024	0.761AsnTyr: 0.761 ± 0.033	0.0AsnXaa: 0.0 ± 0.0
Pro	6.69ProAla: 6.69 ± 0.117	0.364ProCys: 0.364 ± 0.018	3.297ProAsp: 3.297 ± 0.048	3.551ProGlu: 3.551 ± 0.061	2.135ProPhe: 2.135 ± 0.041	4.478ProGly: 4.478 ± 0.061	1.087ProHis: 1.087 ± 0.031	2.493ProIle: 2.493 ± 0.045	1.971ProLys: 1.971 ± 0.041	4.966ProLeu: 4.966 ± 0.069	1.088ProMet: 1.088 ± 0.032	1.416ProAsn: 1.416 ± 0.038	3.274ProPro: 3.274 ± 0.073	1.795ProGln: 1.795 ± 0.039	3.372ProArg: 3.372 ± 0.058	2.98ProSer: 2.98 ± 0.053	2.478ProThr: 2.478 ± 0.046	3.75ProVal: 3.75 ± 0.062	0.701ProTrp: 0.701 ± 0.023	1.184ProTyr: 1.184 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	3.783GlnAla: 3.783 ± 0.055	0.218GlnCys: 0.218 ± 0.015	1.331GlnAsp: 1.331 ± 0.038	1.551GlnGlu: 1.551 ± 0.042	1.105GlnPhe: 1.105 ± 0.032	2.173GlnGly: 2.173 ± 0.048	0.522GlnHis: 0.522 ± 0.019	1.804GlnIle: 1.804 ± 0.04	1.19GlnLys: 1.19 ± 0.028	2.606GlnLeu: 2.606 ± 0.045	0.73GlnMet: 0.73 ± 0.023	0.865GlnAsn: 0.865 ± 0.03	1.592GlnPro: 1.592 ± 0.043	1.018GlnGln: 1.018 ± 0.035	2.299GlnArg: 2.299 ± 0.047	1.794GlnSer: 1.794 ± 0.036	1.684GlnThr: 1.684 ± 0.038	1.641GlnVal: 1.641 ± 0.045	0.395GlnTrp: 0.395 ± 0.019	0.617GlnTyr: 0.617 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	9.533ArgAla: 9.533 ± 0.115	0.573ArgCys: 0.573 ± 0.023	4.338ArgAsp: 4.338 ± 0.065	4.841ArgGlu: 4.841 ± 0.07	3.173ArgPhe: 3.173 ± 0.057	5.085ArgGly: 5.085 ± 0.066	1.607ArgHis: 1.607 ± 0.038	3.95ArgIle: 3.95 ± 0.062	2.724ArgLys: 2.724 ± 0.049	8.619ArgLeu: 8.619 ± 0.104	1.738ArgMet: 1.738 ± 0.035	2.013ArgAsn: 2.013 ± 0.042	3.663ArgPro: 3.663 ± 0.064	2.243ArgGln: 2.243 ± 0.046	6.668ArgArg: 6.668 ± 0.09	3.61ArgSer: 3.61 ± 0.047	2.9ArgThr: 2.9 ± 0.044	4.899ArgVal: 4.899 ± 0.069	1.001ArgTrp: 1.001 ± 0.031	1.808ArgTyr: 1.808 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	6.704SerAla: 6.704 ± 0.072	0.548SerCys: 0.548 ± 0.022	2.979SerAsp: 2.979 ± 0.048	2.941SerGlu: 2.941 ± 0.054	2.509SerPhe: 2.509 ± 0.055	5.174SerGly: 5.174 ± 0.076	1.113SerHis: 1.113 ± 0.034	2.729SerIle: 2.729 ± 0.051	1.844SerLys: 1.844 ± 0.036	5.761SerLeu: 5.761 ± 0.073	1.116SerMet: 1.116 ± 0.03	1.499SerAsn: 1.499 ± 0.041	3.031SerPro: 3.031 ± 0.051	1.665SerGln: 1.665 ± 0.04	3.923SerArg: 3.923 ± 0.056	3.03SerSer: 3.03 ± 0.059	2.482SerThr: 2.482 ± 0.052	3.986SerVal: 3.986 ± 0.054	0.825SerTrp: 0.825 ± 0.027	1.357SerTyr: 1.357 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	5.321ThrAla: 5.321 ± 0.075	0.38ThrCys: 0.38 ± 0.018	2.265ThrAsp: 2.265 ± 0.05	2.242ThrGlu: 2.242 ± 0.053	1.82ThrPhe: 1.82 ± 0.037	4.251ThrGly: 4.251 ± 0.063	0.952ThrHis: 0.952 ± 0.026	2.683ThrIle: 2.683 ± 0.05	1.553ThrLys: 1.553 ± 0.038	5.539ThrLeu: 5.539 ± 0.066	0.95ThrMet: 0.95 ± 0.032	1.196ThrAsn: 1.196 ± 0.037	3.434ThrPro: 3.434 ± 0.052	1.445ThrGln: 1.445 ± 0.042	3.382ThrArg: 3.382 ± 0.048	2.558ThrSer: 2.558 ± 0.05	2.496ThrThr: 2.496 ± 0.062	3.324ThrVal: 3.324 ± 0.054	0.494ThrTrp: 0.494 ± 0.022	1.032ThrTyr: 1.032 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	10.057ValAla: 10.057 ± 0.112	0.661ValCys: 0.661 ± 0.023	4.193ValAsp: 4.193 ± 0.059	4.898ValGlu: 4.898 ± 0.07	2.849ValPhe: 2.849 ± 0.044	5.244ValGly: 5.244 ± 0.071	1.225ValHis: 1.225 ± 0.032	3.533ValIle: 3.533 ± 0.056	2.546ValLys: 2.546 ± 0.048	5.967ValLeu: 5.967 ± 0.076	1.535ValMet: 1.535 ± 0.039	2.009ValAsn: 2.009 ± 0.051	2.822ValPro: 2.822 ± 0.045	1.707ValGln: 1.707 ± 0.038	4.436ValArg: 4.436 ± 0.066	4.44ValSer: 4.44 ± 0.068	4.193ValThr: 4.193 ± 0.065	5.634ValVal: 5.634 ± 0.075	0.886ValTrp: 0.886 ± 0.029	1.608ValTyr: 1.608 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	1.269TrpAla: 1.269 ± 0.037	0.119TrpCys: 0.119 ± 0.011	0.581TrpAsp: 0.581 ± 0.021	0.541TrpGlu: 0.541 ± 0.021	0.519TrpPhe: 0.519 ± 0.019	0.956TrpGly: 0.956 ± 0.037	0.242TrpHis: 0.242 ± 0.014	0.679TrpIle: 0.679 ± 0.023	0.474TrpLys: 0.474 ± 0.019	1.606TrpLeu: 1.606 ± 0.044	0.326TrpMet: 0.326 ± 0.017	0.402TrpAsn: 0.402 ± 0.019	0.69TrpPro: 0.69 ± 0.026	0.368TrpGln: 0.368 ± 0.02	1.658TrpArg: 1.658 ± 0.037	0.883TrpSer: 0.883 ± 0.034	0.77TrpThr: 0.77 ± 0.027	0.686TrpVal: 0.686 ± 0.027	0.223TrpTrp: 0.223 ± 0.012	0.245TrpTyr: 0.245 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.816TyrAla: 2.816 ± 0.053	0.253TyrCys: 0.253 ± 0.017	1.571TyrAsp: 1.571 ± 0.043	1.346TyrGlu: 1.346 ± 0.035	1.015TyrPhe: 1.015 ± 0.03	2.122TyrGly: 2.122 ± 0.047	0.447TyrHis: 0.447 ± 0.019	0.842TyrIle: 0.842 ± 0.025	0.656TyrLys: 0.656 ± 0.023	2.266TyrLeu: 2.266 ± 0.044	0.435TyrMet: 0.435 ± 0.018	0.638TyrAsn: 0.638 ± 0.032	1.074TyrPro: 1.074 ± 0.031	0.686TyrGln: 0.686 ± 0.027	1.794TyrArg: 1.794 ± 0.036	1.24TyrSer: 1.24 ± 0.039	0.894TyrThr: 0.894 ± 0.03	1.782TyrVal: 1.782 ± 0.038	0.414TyrTrp: 0.414 ± 0.019	0.588TyrTyr: 0.588 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4128 proteins (1274671 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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