Amino acid dipepetide frequency for Stenotrophomonas phage vB_SmaS_BUCT548

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.829AlaAla: 9.829 ± 1.175
0.784AlaCys: 0.784 ± 0.209
5.437AlaAsp: 5.437 ± 0.442
5.96AlaGlu: 5.96 ± 0.63
3.241AlaPhe: 3.241 ± 0.317
6.274AlaGly: 6.274 ± 0.704
1.412AlaHis: 1.412 ± 0.379
4.757AlaIle: 4.757 ± 0.462
5.855AlaLys: 5.855 ± 0.718
7.476AlaLeu: 7.476 ± 0.727
3.712AlaMet: 3.712 ± 0.461
5.489AlaAsn: 5.489 ± 0.872
4.914AlaPro: 4.914 ± 1.161
4.235AlaGln: 4.235 ± 0.793
5.594AlaArg: 5.594 ± 0.774
4.496AlaSer: 4.496 ± 0.792
5.908AlaThr: 5.908 ± 0.551
6.117AlaVal: 6.117 ± 0.504
1.307AlaTrp: 1.307 ± 0.236
3.137AlaTyr: 3.137 ± 0.389
0.0AlaXaa: 0.0 ± 0.0
Cys
0.366CysAla: 0.366 ± 0.117
0.0CysCys: 0.0 ± 0.0
0.732CysAsp: 0.732 ± 0.2
0.784CysGlu: 0.784 ± 0.255
0.523CysPhe: 0.523 ± 0.169
0.941CysGly: 0.941 ± 0.217
0.314CysHis: 0.314 ± 0.157
0.575CysIle: 0.575 ± 0.207
0.784CysLys: 0.784 ± 0.225
1.046CysLeu: 1.046 ± 0.269
0.314CysMet: 0.314 ± 0.128
0.471CysAsn: 0.471 ± 0.122
0.68CysPro: 0.68 ± 0.307
0.366CysGln: 0.366 ± 0.153
0.889CysArg: 0.889 ± 0.237
0.209CysSer: 0.209 ± 0.094
0.523CysThr: 0.523 ± 0.185
0.68CysVal: 0.68 ± 0.245
0.261CysTrp: 0.261 ± 0.116
0.261CysTyr: 0.261 ± 0.12
0.0CysXaa: 0.0 ± 0.0
Asp
5.594AspAla: 5.594 ± 0.645
0.366AspCys: 0.366 ± 0.136
4.026AspAsp: 4.026 ± 0.569
3.607AspGlu: 3.607 ± 0.455
3.137AspPhe: 3.137 ± 0.462
6.169AspGly: 6.169 ± 0.512
1.464AspHis: 1.464 ± 0.277
3.66AspIle: 3.66 ± 0.339
3.032AspLys: 3.032 ± 0.347
4.914AspLeu: 4.914 ± 0.48
2.562AspMet: 2.562 ± 0.475
1.83AspAsn: 1.83 ± 0.316
2.562AspPro: 2.562 ± 0.394
1.621AspGln: 1.621 ± 0.301
3.294AspArg: 3.294 ± 0.457
3.189AspSer: 3.189 ± 0.408
2.875AspThr: 2.875 ± 0.349
3.66AspVal: 3.66 ± 0.457
0.941AspTrp: 0.941 ± 0.277
2.143AspTyr: 2.143 ± 0.345
0.0AspXaa: 0.0 ± 0.0
Glu
8.26GluAla: 8.26 ± 0.961
0.732GluCys: 0.732 ± 0.224
3.241GluAsp: 3.241 ± 0.417
4.81GluGlu: 4.81 ± 0.704
2.3GluPhe: 2.3 ± 0.34
4.548GluGly: 4.548 ± 0.443
1.202GluHis: 1.202 ± 0.239
3.712GluIle: 3.712 ± 0.436
2.875GluLys: 2.875 ± 0.4
5.332GluLeu: 5.332 ± 0.564
1.621GluMet: 1.621 ± 0.407
2.562GluAsn: 2.562 ± 0.256
2.039GluPro: 2.039 ± 0.36
2.719GluGln: 2.719 ± 0.423
4.444GluArg: 4.444 ± 0.742
2.98GluSer: 2.98 ± 0.451
3.032GluThr: 3.032 ± 0.372
5.019GluVal: 5.019 ± 0.504
0.993GluTrp: 0.993 ± 0.282
2.091GluTyr: 2.091 ± 0.358
0.0GluXaa: 0.0 ± 0.0
Phe
3.032PheAla: 3.032 ± 0.428
0.471PheCys: 0.471 ± 0.169
3.398PheAsp: 3.398 ± 0.399
2.091PheGlu: 2.091 ± 0.305
1.046PhePhe: 1.046 ± 0.283
3.084PheGly: 3.084 ± 0.305
0.68PheHis: 0.68 ± 0.179
2.353PheIle: 2.353 ± 0.379
1.777PheLys: 1.777 ± 0.382
2.248PheLeu: 2.248 ± 0.279
1.098PheMet: 1.098 ± 0.26
2.248PheAsn: 2.248 ± 0.295
1.777PhePro: 1.777 ± 0.252
1.621PheGln: 1.621 ± 0.275
2.457PheArg: 2.457 ± 0.45
2.353PheSer: 2.353 ± 0.306
2.248PheThr: 2.248 ± 0.33
2.509PheVal: 2.509 ± 0.489
0.209PheTrp: 0.209 ± 0.106
1.098PheTyr: 1.098 ± 0.287
0.0PheXaa: 0.0 ± 0.0
Gly
6.274GlyAla: 6.274 ± 0.62
0.732GlyCys: 0.732 ± 0.224
3.764GlyAsp: 3.764 ± 0.723
4.496GlyGlu: 4.496 ± 0.363
2.719GlyPhe: 2.719 ± 0.456
6.535GlyGly: 6.535 ± 0.824
1.098GlyHis: 1.098 ± 0.282
3.816GlyIle: 3.816 ± 0.477
4.862GlyLys: 4.862 ± 0.499
4.862GlyLeu: 4.862 ± 0.474
3.032GlyMet: 3.032 ± 0.414
3.921GlyAsn: 3.921 ± 0.626
2.562GlyPro: 2.562 ± 0.407
3.66GlyGln: 3.66 ± 0.554
4.182GlyArg: 4.182 ± 0.375
4.757GlySer: 4.757 ± 0.418
4.653GlyThr: 4.653 ± 0.645
6.43GlyVal: 6.43 ± 0.976
1.359GlyTrp: 1.359 ± 0.274
2.98GlyTyr: 2.98 ± 0.49
0.0GlyXaa: 0.0 ± 0.0
His
1.83HisAla: 1.83 ± 0.331
0.314HisCys: 0.314 ± 0.136
0.993HisAsp: 0.993 ± 0.28
0.627HisGlu: 0.627 ± 0.19
0.732HisPhe: 0.732 ± 0.219
1.777HisGly: 1.777 ± 0.371
0.157HisHis: 0.157 ± 0.08
1.307HisIle: 1.307 ± 0.3
0.993HisLys: 0.993 ± 0.229
1.046HisLeu: 1.046 ± 0.215
1.046HisMet: 1.046 ± 0.245
0.68HisAsn: 0.68 ± 0.165
0.732HisPro: 0.732 ± 0.194
0.732HisGln: 0.732 ± 0.234
1.202HisArg: 1.202 ± 0.247
1.098HisSer: 1.098 ± 0.206
0.889HisThr: 0.889 ± 0.233
1.202HisVal: 1.202 ± 0.235
0.366HisTrp: 0.366 ± 0.128
0.732HisTyr: 0.732 ± 0.237
0.0HisXaa: 0.0 ± 0.0
Ile
5.751IleAla: 5.751 ± 0.503
0.366IleCys: 0.366 ± 0.139
4.287IleAsp: 4.287 ± 0.471
5.019IleGlu: 5.019 ± 0.48
1.255IlePhe: 1.255 ± 0.24
4.391IleGly: 4.391 ± 0.502
0.732IleHis: 0.732 ± 0.227
2.509IleIle: 2.509 ± 0.443
2.928IleLys: 2.928 ± 0.485
3.084IleLeu: 3.084 ± 0.398
1.255IleMet: 1.255 ± 0.256
2.719IleAsn: 2.719 ± 0.413
2.614IlePro: 2.614 ± 0.432
1.673IleGln: 1.673 ± 0.262
4.287IleArg: 4.287 ± 0.509
2.509IleSer: 2.509 ± 0.589
3.607IleThr: 3.607 ± 0.534
3.555IleVal: 3.555 ± 0.469
0.471IleTrp: 0.471 ± 0.132
1.621IleTyr: 1.621 ± 0.344
0.0IleXaa: 0.0 ± 0.0
Lys
4.914LysAla: 4.914 ± 0.493
0.523LysCys: 0.523 ± 0.203
2.666LysAsp: 2.666 ± 0.409
3.398LysGlu: 3.398 ± 0.603
1.673LysPhe: 1.673 ± 0.328
3.555LysGly: 3.555 ± 0.449
1.307LysHis: 1.307 ± 0.312
2.771LysIle: 2.771 ± 0.423
2.143LysLys: 2.143 ± 0.399
4.391LysLeu: 4.391 ± 0.634
1.725LysMet: 1.725 ± 0.285
2.666LysAsn: 2.666 ± 0.399
2.928LysPro: 2.928 ± 0.453
1.464LysGln: 1.464 ± 0.334
2.719LysArg: 2.719 ± 0.427
2.771LysSer: 2.771 ± 0.363
3.503LysThr: 3.503 ± 0.369
4.026LysVal: 4.026 ± 0.443
0.993LysTrp: 0.993 ± 0.203
1.621LysTyr: 1.621 ± 0.344
0.0LysXaa: 0.0 ± 0.0
Leu
6.901LeuAla: 6.901 ± 0.848
1.202LeuCys: 1.202 ± 0.325
5.489LeuAsp: 5.489 ± 0.664
4.81LeuGlu: 4.81 ± 0.651
3.084LeuPhe: 3.084 ± 0.448
5.28LeuGly: 5.28 ± 0.639
1.464LeuHis: 1.464 ± 0.271
3.607LeuIle: 3.607 ± 0.468
3.294LeuLys: 3.294 ± 0.492
4.757LeuLeu: 4.757 ± 0.61
2.457LeuMet: 2.457 ± 0.372
3.137LeuAsn: 3.137 ± 0.426
3.555LeuPro: 3.555 ± 0.577
2.196LeuGln: 2.196 ± 0.277
5.385LeuArg: 5.385 ± 0.478
4.287LeuSer: 4.287 ± 0.457
5.751LeuThr: 5.751 ± 0.781
3.45LeuVal: 3.45 ± 0.516
0.889LeuTrp: 0.889 ± 0.223
2.091LeuTyr: 2.091 ± 0.291
0.0LeuXaa: 0.0 ± 0.0
Met
2.928MetAla: 2.928 ± 0.317
0.261MetCys: 0.261 ± 0.118
1.725MetAsp: 1.725 ± 0.252
2.771MetGlu: 2.771 ± 0.463
1.412MetPhe: 1.412 ± 0.207
3.137MetGly: 3.137 ± 0.41
0.732MetHis: 0.732 ± 0.22
1.725MetIle: 1.725 ± 0.243
1.934MetLys: 1.934 ± 0.406
2.457MetLeu: 2.457 ± 0.365
1.046MetMet: 1.046 ± 0.255
2.353MetAsn: 2.353 ± 0.411
1.412MetPro: 1.412 ± 0.199
1.202MetGln: 1.202 ± 0.256
1.882MetArg: 1.882 ± 0.27
2.196MetSer: 2.196 ± 0.34
1.882MetThr: 1.882 ± 0.348
1.83MetVal: 1.83 ± 0.296
0.471MetTrp: 0.471 ± 0.185
0.627MetTyr: 0.627 ± 0.166
0.0MetXaa: 0.0 ± 0.0
Asn
4.705AsnAla: 4.705 ± 0.882
0.523AsnCys: 0.523 ± 0.194
2.196AsnAsp: 2.196 ± 0.366
3.607AsnGlu: 3.607 ± 0.526
1.412AsnPhe: 1.412 ± 0.296
5.176AsnGly: 5.176 ± 0.593
1.046AsnHis: 1.046 ± 0.272
2.091AsnIle: 2.091 ± 0.361
1.987AsnLys: 1.987 ± 0.343
4.026AsnLeu: 4.026 ± 0.511
1.568AsnMet: 1.568 ± 0.28
2.509AsnAsn: 2.509 ± 0.521
2.457AsnPro: 2.457 ± 0.315
1.673AsnGln: 1.673 ± 0.322
2.928AsnArg: 2.928 ± 0.466
2.719AsnSer: 2.719 ± 0.485
3.241AsnThr: 3.241 ± 0.65
2.719AsnVal: 2.719 ± 0.447
0.941AsnTrp: 0.941 ± 0.191
1.568AsnTyr: 1.568 ± 0.308
0.0AsnXaa: 0.0 ± 0.0
Pro
3.973ProAla: 3.973 ± 0.78
0.366ProCys: 0.366 ± 0.134
2.823ProAsp: 2.823 ± 0.397
2.614ProGlu: 2.614 ± 0.305
2.143ProPhe: 2.143 ± 0.361
2.823ProGly: 2.823 ± 0.489
0.732ProHis: 0.732 ± 0.226
1.777ProIle: 1.777 ± 0.296
2.196ProLys: 2.196 ± 0.412
2.98ProLeu: 2.98 ± 0.409
1.307ProMet: 1.307 ± 0.252
2.457ProAsn: 2.457 ± 0.362
2.091ProPro: 2.091 ± 0.432
1.516ProGln: 1.516 ± 0.328
1.621ProArg: 1.621 ± 0.296
2.457ProSer: 2.457 ± 0.402
3.398ProThr: 3.398 ± 0.528
3.555ProVal: 3.555 ± 0.382
0.889ProTrp: 0.889 ± 0.2
1.202ProTyr: 1.202 ± 0.234
0.0ProXaa: 0.0 ± 0.0
Gln
5.437GlnAla: 5.437 ± 0.66
0.157GlnCys: 0.157 ± 0.09
2.039GlnAsp: 2.039 ± 0.311
2.353GlnGlu: 2.353 ± 0.279
1.15GlnPhe: 1.15 ± 0.209
2.196GlnGly: 2.196 ± 0.334
0.627GlnHis: 0.627 ± 0.157
1.882GlnIle: 1.882 ± 0.263
1.621GlnLys: 1.621 ± 0.418
3.189GlnLeu: 3.189 ± 0.422
1.307GlnMet: 1.307 ± 0.225
1.621GlnAsn: 1.621 ± 0.283
1.098GlnPro: 1.098 ± 0.233
2.091GlnGln: 2.091 ± 0.43
2.3GlnArg: 2.3 ± 0.294
2.091GlnSer: 2.091 ± 0.4
2.3GlnThr: 2.3 ± 0.342
1.882GlnVal: 1.882 ± 0.293
0.627GlnTrp: 0.627 ± 0.174
1.307GlnTyr: 1.307 ± 0.266
0.0GlnXaa: 0.0 ± 0.0
Arg
4.705ArgAla: 4.705 ± 0.464
0.471ArgCys: 0.471 ± 0.143
3.555ArgAsp: 3.555 ± 0.474
3.66ArgGlu: 3.66 ± 0.509
3.084ArgPhe: 3.084 ± 0.326
3.137ArgGly: 3.137 ± 0.406
0.836ArgHis: 0.836 ± 0.189
4.914ArgIle: 4.914 ± 0.459
3.294ArgLys: 3.294 ± 0.517
4.601ArgLeu: 4.601 ± 0.522
3.084ArgMet: 3.084 ± 0.393
3.032ArgAsn: 3.032 ± 0.375
2.196ArgPro: 2.196 ± 0.494
2.196ArgGln: 2.196 ± 0.44
3.66ArgArg: 3.66 ± 0.399
3.503ArgSer: 3.503 ± 0.388
2.928ArgThr: 2.928 ± 0.366
5.332ArgVal: 5.332 ± 0.595
1.202ArgTrp: 1.202 ± 0.22
2.196ArgTyr: 2.196 ± 0.288
0.0ArgXaa: 0.0 ± 0.0
Ser
5.489SerAla: 5.489 ± 0.56
0.784SerCys: 0.784 ± 0.244
4.287SerAsp: 4.287 ± 0.515
2.3SerGlu: 2.3 ± 0.305
1.777SerPhe: 1.777 ± 0.283
4.705SerGly: 4.705 ± 0.798
0.836SerHis: 0.836 ± 0.162
3.084SerIle: 3.084 ± 0.422
2.3SerLys: 2.3 ± 0.434
4.078SerLeu: 4.078 ± 0.524
1.777SerMet: 1.777 ± 0.398
2.823SerAsn: 2.823 ± 0.544
1.359SerPro: 1.359 ± 0.294
2.353SerGln: 2.353 ± 0.366
3.294SerArg: 3.294 ± 0.34
3.032SerSer: 3.032 ± 0.45
2.928SerThr: 2.928 ± 0.386
3.503SerVal: 3.503 ± 0.627
1.046SerTrp: 1.046 ± 0.212
1.464SerTyr: 1.464 ± 0.236
0.0SerXaa: 0.0 ± 0.0
Thr
6.274ThrAla: 6.274 ± 0.716
0.68ThrCys: 0.68 ± 0.22
3.503ThrAsp: 3.503 ± 0.41
4.13ThrGlu: 4.13 ± 0.492
2.823ThrPhe: 2.823 ± 0.448
4.967ThrGly: 4.967 ± 0.614
1.464ThrHis: 1.464 ± 0.261
3.555ThrIle: 3.555 ± 0.548
3.137ThrLys: 3.137 ± 0.428
4.078ThrLeu: 4.078 ± 0.448
1.359ThrMet: 1.359 ± 0.229
3.241ThrAsn: 3.241 ± 0.356
2.614ThrPro: 2.614 ± 0.512
1.987ThrGln: 1.987 ± 0.324
3.241ThrArg: 3.241 ± 0.483
2.771ThrSer: 2.771 ± 0.758
4.078ThrThr: 4.078 ± 1.055
4.235ThrVal: 4.235 ± 0.571
0.941ThrTrp: 0.941 ± 0.245
1.882ThrTyr: 1.882 ± 0.363
0.0ThrXaa: 0.0 ± 0.0
Val
5.489ValAla: 5.489 ± 0.594
1.15ValCys: 1.15 ± 0.266
3.607ValAsp: 3.607 ± 0.466
4.182ValGlu: 4.182 ± 0.483
2.091ValPhe: 2.091 ± 0.325
4.757ValGly: 4.757 ± 0.412
1.255ValHis: 1.255 ± 0.252
3.712ValIle: 3.712 ± 0.465
5.019ValLys: 5.019 ± 0.468
3.816ValLeu: 3.816 ± 0.483
1.934ValMet: 1.934 ± 0.362
3.241ValAsn: 3.241 ± 0.591
3.66ValPro: 3.66 ± 0.435
2.405ValGln: 2.405 ± 0.501
4.548ValArg: 4.548 ± 0.348
3.66ValSer: 3.66 ± 0.366
4.548ValThr: 4.548 ± 0.491
4.757ValVal: 4.757 ± 0.508
1.307ValTrp: 1.307 ± 0.304
2.875ValTyr: 2.875 ± 0.39
0.0ValXaa: 0.0 ± 0.0
Trp
1.255TrpAla: 1.255 ± 0.271
0.418TrpCys: 0.418 ± 0.156
0.836TrpAsp: 0.836 ± 0.25
1.15TrpGlu: 1.15 ± 0.185
0.627TrpPhe: 0.627 ± 0.161
0.889TrpGly: 0.889 ± 0.174
0.471TrpHis: 0.471 ± 0.145
0.784TrpIle: 0.784 ± 0.193
0.261TrpLys: 0.261 ± 0.101
1.725TrpLeu: 1.725 ± 0.314
0.68TrpMet: 0.68 ± 0.158
0.941TrpAsn: 0.941 ± 0.234
0.366TrpPro: 0.366 ± 0.134
0.418TrpGln: 0.418 ± 0.15
1.307TrpArg: 1.307 ± 0.268
0.627TrpSer: 0.627 ± 0.148
0.993TrpThr: 0.993 ± 0.279
1.255TrpVal: 1.255 ± 0.253
0.523TrpTrp: 0.523 ± 0.191
0.68TrpTyr: 0.68 ± 0.159
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.928TyrAla: 2.928 ± 0.495
0.418TyrCys: 0.418 ± 0.156
2.039TyrAsp: 2.039 ± 0.308
2.143TyrGlu: 2.143 ± 0.344
1.568TyrPhe: 1.568 ± 0.301
2.353TyrGly: 2.353 ± 0.377
0.627TyrHis: 0.627 ± 0.15
2.039TyrIle: 2.039 ± 0.321
1.464TyrLys: 1.464 ± 0.309
2.98TyrLeu: 2.98 ± 0.439
1.046TyrMet: 1.046 ± 0.215
1.15TyrAsn: 1.15 ± 0.269
1.307TyrPro: 1.307 ± 0.177
1.15TyrGln: 1.15 ± 0.241
2.405TyrArg: 2.405 ± 0.333
1.516TyrSer: 1.516 ± 0.282
1.673TyrThr: 1.673 ± 0.311
2.3TyrVal: 2.3 ± 0.328
0.471TyrTrp: 0.471 ± 0.126
0.941TyrTyr: 0.941 ± 0.23
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 102 proteins (19129 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski