Amino acid dipepetide frequency for Treponema saccharophilum DSM 2985

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.274AlaAla: 8.274 ± 0.138	0.986AlaCys: 0.986 ± 0.035	5.412AlaAsp: 5.412 ± 0.09	6.99AlaGlu: 6.99 ± 0.098	4.458AlaPhe: 4.458 ± 0.091	6.747AlaGly: 6.747 ± 0.105	1.238AlaHis: 1.238 ± 0.035	4.821AlaIle: 4.821 ± 0.074	5.166AlaLys: 5.166 ± 0.094	8.189AlaLeu: 8.189 ± 0.109	2.108AlaMet: 2.108 ± 0.049	2.813AlaAsn: 2.813 ± 0.063	2.292AlaPro: 2.292 ± 0.058	2.408AlaGln: 2.408 ± 0.057	4.319AlaArg: 4.319 ± 0.087	5.758AlaSer: 5.758 ± 0.099	3.627AlaThr: 3.627 ± 0.092	6.634AlaVal: 6.634 ± 0.095	0.697AlaTrp: 0.697 ± 0.028	2.351AlaTyr: 2.351 ± 0.057	0.0AlaXaa: 0.0 ± 0.0
Cys	1.599CysAla: 1.599 ± 0.043	0.228CysCys: 0.228 ± 0.017	0.887CysAsp: 0.887 ± 0.031	0.874CysGlu: 0.874 ± 0.034	0.61CysPhe: 0.61 ± 0.026	1.461CysGly: 1.461 ± 0.041	0.224CysHis: 0.224 ± 0.014	0.771CysIle: 0.771 ± 0.029	0.633CysLys: 0.633 ± 0.033	0.976CysLeu: 0.976 ± 0.032	0.284CysMet: 0.284 ± 0.019	0.445CysAsn: 0.445 ± 0.024	0.547CysPro: 0.547 ± 0.025	0.239CysGln: 0.239 ± 0.015	0.809CysArg: 0.809 ± 0.031	1.029CysSer: 1.029 ± 0.037	0.815CysThr: 0.815 ± 0.035	1.013CysVal: 1.013 ± 0.033	0.116CysTrp: 0.116 ± 0.01	0.42CysTyr: 0.42 ± 0.022	0.0CysXaa: 0.0 ± 0.0
Asp	5.285AspAla: 5.285 ± 0.087	0.824AspCys: 0.824 ± 0.032	4.203AspAsp: 4.203 ± 0.092	5.524AspGlu: 5.524 ± 0.102	3.692AspPhe: 3.692 ± 0.064	6.007AspGly: 6.007 ± 0.103	0.501AspHis: 0.501 ± 0.022	4.005AspIle: 4.005 ± 0.071	3.525AspLys: 3.525 ± 0.073	3.75AspLeu: 3.75 ± 0.068	1.443AspMet: 1.443 ± 0.039	2.018AspAsn: 2.018 ± 0.05	1.478AspPro: 1.478 ± 0.042	0.75AspGln: 0.75 ± 0.031	2.056AspArg: 2.056 ± 0.047	4.827AspSer: 4.827 ± 0.085	2.662AspThr: 2.662 ± 0.056	4.168AspVal: 4.168 ± 0.074	0.76AspTrp: 0.76 ± 0.029	2.195AspTyr: 2.195 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	4.794GluAla: 4.794 ± 0.082	0.915GluCys: 0.915 ± 0.035	3.443GluAsp: 3.443 ± 0.069	5.289GluGlu: 5.289 ± 0.105	3.435GluPhe: 3.435 ± 0.061	3.985GluGly: 3.985 ± 0.067	0.999GluHis: 0.999 ± 0.035	6.197GluIle: 6.197 ± 0.091	7.008GluLys: 7.008 ± 0.111	5.628GluLeu: 5.628 ± 0.074	1.918GluMet: 1.918 ± 0.05	4.355GluAsn: 4.355 ± 0.074	1.901GluPro: 1.901 ± 0.045	2.214GluGln: 2.214 ± 0.063	3.93GluArg: 3.93 ± 0.087	5.261GluSer: 5.261 ± 0.087	3.633GluThr: 3.633 ± 0.068	3.425GluVal: 3.425 ± 0.071	0.739GluTrp: 0.739 ± 0.031	2.28GluTyr: 2.28 ± 0.053	0.0GluXaa: 0.0 ± 0.0
Phe	4.324PheAla: 4.324 ± 0.075	0.948PheCys: 0.948 ± 0.028	3.372PheAsp: 3.372 ± 0.059	3.006PheGlu: 3.006 ± 0.066	2.802PhePhe: 2.802 ± 0.068	4.011PheGly: 4.011 ± 0.067	0.699PheHis: 0.699 ± 0.025	2.978PheIle: 2.978 ± 0.055	2.284PheLys: 2.284 ± 0.056	4.039PheLeu: 4.039 ± 0.067	1.185PheMet: 1.185 ± 0.036	1.79PheAsn: 1.79 ± 0.044	1.92PhePro: 1.92 ± 0.049	1.003PheGln: 1.003 ± 0.029	2.63PheArg: 2.63 ± 0.059	4.916PheSer: 4.916 ± 0.089	2.565PheThr: 2.565 ± 0.056	3.752PheVal: 3.752 ± 0.066	0.48PheTrp: 0.48 ± 0.023	1.785PheTyr: 1.785 ± 0.046	0.0PheXaa: 0.0 ± 0.0
Gly	6.036GlyAla: 6.036 ± 0.107	1.266GlyCys: 1.266 ± 0.052	4.282GlyAsp: 4.282 ± 0.072	5.031GlyGlu: 5.031 ± 0.08	3.853GlyPhe: 3.853 ± 0.061	6.016GlyGly: 6.016 ± 0.133	0.977GlyHis: 0.977 ± 0.035	5.992GlyIle: 5.992 ± 0.095	6.205GlyLys: 6.205 ± 0.081	5.132GlyLeu: 5.132 ± 0.079	2.0GlyMet: 2.0 ± 0.047	3.44GlyAsn: 3.44 ± 0.073	1.108GlyPro: 1.108 ± 0.036	1.499GlyGln: 1.499 ± 0.039	3.451GlyArg: 3.451 ± 0.068	4.895GlySer: 4.895 ± 0.078	4.897GlyThr: 4.897 ± 0.134	4.69GlyVal: 4.69 ± 0.091	0.918GlyTrp: 0.918 ± 0.031	2.296GlyTyr: 2.296 ± 0.051	0.0GlyXaa: 0.0 ± 0.0
His	1.047HisAla: 1.047 ± 0.029	0.244HisCys: 0.244 ± 0.017	0.822HisAsp: 0.822 ± 0.03	0.93HisGlu: 0.93 ± 0.03	0.814HisPhe: 0.814 ± 0.028	1.041HisGly: 1.041 ± 0.038	0.287HisHis: 0.287 ± 0.016	1.004HisIle: 1.004 ± 0.033	0.788HisLys: 0.788 ± 0.03	1.297HisLeu: 1.297 ± 0.037	0.246HisMet: 0.246 ± 0.016	0.578HisAsn: 0.578 ± 0.026	0.698HisPro: 0.698 ± 0.026	0.32HisGln: 0.32 ± 0.019	0.639HisArg: 0.639 ± 0.029	1.007HisSer: 1.007 ± 0.031	0.698HisThr: 0.698 ± 0.03	0.859HisVal: 0.859 ± 0.027	0.145HisTrp: 0.145 ± 0.012	0.494HisTyr: 0.494 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	6.27IleAla: 6.27 ± 0.097	1.011IleCys: 1.011 ± 0.033	4.279IleAsp: 4.279 ± 0.067	4.846IleGlu: 4.846 ± 0.092	2.918IlePhe: 2.918 ± 0.064	4.745IleGly: 4.745 ± 0.09	1.0IleHis: 1.0 ± 0.037	3.976IleIle: 3.976 ± 0.079	3.903IleLys: 3.903 ± 0.07	5.761IleLeu: 5.761 ± 0.084	1.292IleMet: 1.292 ± 0.04	2.29IleAsn: 2.29 ± 0.05	3.435IlePro: 3.435 ± 0.083	1.813IleGln: 1.813 ± 0.048	3.495IleArg: 3.495 ± 0.062	5.503IleSer: 5.503 ± 0.076	3.62IleThr: 3.62 ± 0.084	4.608IleVal: 4.608 ± 0.087	0.529IleTrp: 0.529 ± 0.023	1.967IleTyr: 1.967 ± 0.047	0.0IleXaa: 0.0 ± 0.0
Lys	5.277LysAla: 5.277 ± 0.087	0.8LysCys: 0.8 ± 0.034	3.764LysAsp: 3.764 ± 0.083	4.823LysGlu: 4.823 ± 0.082	2.703LysPhe: 2.703 ± 0.047	3.803LysGly: 3.803 ± 0.062	0.746LysHis: 0.746 ± 0.03	5.888LysIle: 5.888 ± 0.1	6.055LysLys: 6.055 ± 0.11	4.966LysLeu: 4.966 ± 0.086	2.031LysMet: 2.031 ± 0.047	4.089LysAsn: 4.089 ± 0.077	1.989LysPro: 1.989 ± 0.046	1.688LysGln: 1.688 ± 0.046	2.876LysArg: 2.876 ± 0.057	5.075LysSer: 5.075 ± 0.08	4.1LysThr: 4.1 ± 0.079	3.631LysVal: 3.631 ± 0.072	0.702LysTrp: 0.702 ± 0.026	2.201LysTyr: 2.201 ± 0.059	0.0LysXaa: 0.0 ± 0.0
Leu	6.833LeuAla: 6.833 ± 0.091	1.359LeuCys: 1.359 ± 0.037	4.933LeuAsp: 4.933 ± 0.076	5.124LeuGlu: 5.124 ± 0.073	4.254LeuPhe: 4.254 ± 0.086	5.83LeuGly: 5.83 ± 0.093	1.231LeuHis: 1.231 ± 0.034	4.54LeuIle: 4.54 ± 0.085	5.201LeuLys: 5.201 ± 0.083	7.127LeuLeu: 7.127 ± 0.103	1.982LeuMet: 1.982 ± 0.049	3.257LeuAsn: 3.257 ± 0.071	3.587LeuPro: 3.587 ± 0.058	2.043LeuGln: 2.043 ± 0.052	4.259LeuArg: 4.259 ± 0.073	8.304LeuSer: 8.304 ± 0.12	4.039LeuThr: 4.039 ± 0.063	5.737LeuVal: 5.737 ± 0.086	0.671LeuTrp: 0.671 ± 0.025	2.621LeuTyr: 2.621 ± 0.055	0.0LeuXaa: 0.0 ± 0.0
Met	2.074MetAla: 2.074 ± 0.049	0.27MetCys: 0.27 ± 0.018	1.33MetAsp: 1.33 ± 0.035	1.788MetGlu: 1.788 ± 0.042	0.987MetPhe: 0.987 ± 0.031	1.538MetGly: 1.538 ± 0.044	0.353MetHis: 0.353 ± 0.019	1.483MetIle: 1.483 ± 0.043	2.167MetLys: 2.167 ± 0.046	2.029MetLeu: 2.029 ± 0.051	0.791MetMet: 0.791 ± 0.031	1.447MetAsn: 1.447 ± 0.038	0.919MetPro: 0.919 ± 0.028	0.787MetGln: 0.787 ± 0.033	1.405MetArg: 1.405 ± 0.039	1.688MetSer: 1.688 ± 0.044	1.424MetThr: 1.424 ± 0.04	1.345MetVal: 1.345 ± 0.037	0.17MetTrp: 0.17 ± 0.013	0.713MetTyr: 0.713 ± 0.029	0.0MetXaa: 0.0 ± 0.0
Asn	3.995AsnAla: 3.995 ± 0.072	0.591AsnCys: 0.591 ± 0.031	2.371AsnAsp: 2.371 ± 0.056	2.843AsnGlu: 2.843 ± 0.064	1.911AsnPhe: 1.911 ± 0.048	3.835AsnGly: 3.835 ± 0.073	0.68AsnHis: 0.68 ± 0.026	2.95AsnIle: 2.95 ± 0.06	2.288AsnLys: 2.288 ± 0.065	3.604AsnLeu: 3.604 ± 0.073	1.112AsnMet: 1.112 ± 0.038	1.497AsnAsn: 1.497 ± 0.051	2.368AsnPro: 2.368 ± 0.055	1.012AsnGln: 1.012 ± 0.036	1.874AsnArg: 1.874 ± 0.046	2.78AsnSer: 2.78 ± 0.056	1.932AsnThr: 1.932 ± 0.052	2.892AsnVal: 2.892 ± 0.06	0.456AsnTrp: 0.456 ± 0.025	1.452AsnTyr: 1.452 ± 0.043	0.0AsnXaa: 0.0 ± 0.0
Pro	2.935ProAla: 2.935 ± 0.067	0.413ProCys: 0.413 ± 0.024	2.324ProAsp: 2.324 ± 0.05	3.055ProGlu: 3.055 ± 0.064	1.815ProPhe: 1.815 ± 0.049	2.148ProGly: 2.148 ± 0.054	0.609ProHis: 0.609 ± 0.025	1.691ProIle: 1.691 ± 0.042	1.989ProLys: 1.989 ± 0.045	3.144ProLeu: 3.144 ± 0.064	0.722ProMet: 0.722 ± 0.027	1.324ProAsn: 1.324 ± 0.042	1.053ProPro: 1.053 ± 0.04	0.899ProGln: 0.899 ± 0.029	1.32ProArg: 1.32 ± 0.037	2.698ProSer: 2.698 ± 0.06	1.441ProThr: 1.441 ± 0.044	2.984ProVal: 2.984 ± 0.066	0.33ProTrp: 0.33 ± 0.019	1.21ProTyr: 1.21 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	1.874GlnAla: 1.874 ± 0.051	0.261GlnCys: 0.261 ± 0.015	1.193GlnAsp: 1.193 ± 0.038	1.614GlnGlu: 1.614 ± 0.042	1.21GlnPhe: 1.21 ± 0.033	1.415GlnGly: 1.415 ± 0.04	0.322GlnHis: 0.322 ± 0.02	2.041GlnIle: 2.041 ± 0.05	2.362GlnLys: 2.362 ± 0.054	1.932GlnLeu: 1.932 ± 0.046	0.756GlnMet: 0.756 ± 0.025	1.53GlnAsn: 1.53 ± 0.046	0.733GlnPro: 0.733 ± 0.026	0.832GlnGln: 0.832 ± 0.032	1.134GlnArg: 1.134 ± 0.036	1.813GlnSer: 1.813 ± 0.043	1.323GlnThr: 1.323 ± 0.036	1.443GlnVal: 1.443 ± 0.036	0.244GlnTrp: 0.244 ± 0.017	0.818GlnTyr: 0.818 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	3.923ArgAla: 3.923 ± 0.083	0.582ArgCys: 0.582 ± 0.025	2.752ArgAsp: 2.752 ± 0.049	3.332ArgGlu: 3.332 ± 0.063	2.346ArgPhe: 2.346 ± 0.056	3.027ArgGly: 3.027 ± 0.064	0.715ArgHis: 0.715 ± 0.022	3.945ArgIle: 3.945 ± 0.072	3.84ArgLys: 3.84 ± 0.084	4.134ArgLeu: 4.134 ± 0.082	1.459ArgMet: 1.459 ± 0.041	2.505ArgAsn: 2.505 ± 0.055	1.395ArgPro: 1.395 ± 0.04	1.26ArgGln: 1.26 ± 0.039	2.795ArgArg: 2.795 ± 0.068	2.969ArgSer: 2.969 ± 0.053	2.758ArgThr: 2.758 ± 0.052	2.773ArgVal: 2.773 ± 0.049	0.459ArgTrp: 0.459 ± 0.024	1.518ArgTyr: 1.518 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	7.331SerAla: 7.331 ± 0.115	1.109SerCys: 1.109 ± 0.035	4.716SerAsp: 4.716 ± 0.083	5.317SerGlu: 5.317 ± 0.086	4.24SerPhe: 4.24 ± 0.076	6.901SerGly: 6.901 ± 0.128	1.011SerHis: 1.011 ± 0.032	4.484SerIle: 4.484 ± 0.081	3.996SerLys: 3.996 ± 0.061	7.11SerLeu: 7.11 ± 0.118	1.63SerMet: 1.63 ± 0.042	2.346SerAsn: 2.346 ± 0.052	2.341SerPro: 2.341 ± 0.05	1.825SerGln: 1.825 ± 0.047	3.612SerArg: 3.612 ± 0.074	6.195SerSer: 6.195 ± 0.121	3.163SerThr: 3.163 ± 0.074	6.734SerVal: 6.734 ± 0.129	0.74SerTrp: 0.74 ± 0.031	2.393SerTyr: 2.393 ± 0.054	0.0SerXaa: 0.0 ± 0.0
Thr	4.573ThrAla: 4.573 ± 0.107	0.509ThrCys: 0.509 ± 0.023	3.092ThrAsp: 3.092 ± 0.066	3.688ThrGlu: 3.688 ± 0.054	2.441ThrPhe: 2.441 ± 0.061	4.261ThrGly: 4.261 ± 0.079	0.713ThrHis: 0.713 ± 0.028	3.652ThrIle: 3.652 ± 0.076	3.178ThrLys: 3.178 ± 0.059	4.556ThrLeu: 4.556 ± 0.076	1.221ThrMet: 1.221 ± 0.038	2.013ThrAsn: 2.013 ± 0.054	1.923ThrPro: 1.923 ± 0.05	1.349ThrGln: 1.349 ± 0.041	2.003ThrArg: 2.003 ± 0.052	3.35ThrSer: 3.35 ± 0.083	2.649ThrThr: 2.649 ± 0.085	4.35ThrVal: 4.35 ± 0.102	0.458ThrTrp: 0.458 ± 0.023	1.58ThrTyr: 1.58 ± 0.051	0.0ThrXaa: 0.0 ± 0.0
Val	5.646ValAla: 5.646 ± 0.082	1.059ValCys: 1.059 ± 0.033	3.663ValAsp: 3.663 ± 0.073	4.482ValGlu: 4.482 ± 0.076	3.774ValPhe: 3.774 ± 0.07	4.157ValGly: 4.157 ± 0.082	0.985ValHis: 0.985 ± 0.032	4.136ValIle: 4.136 ± 0.073	3.855ValLys: 3.855 ± 0.077	6.17ValLeu: 6.17 ± 0.096	1.611ValMet: 1.611 ± 0.045	2.587ValAsn: 2.587 ± 0.053	3.107ValPro: 3.107 ± 0.069	1.797ValGln: 1.797 ± 0.039	3.746ValArg: 3.746 ± 0.069	6.022ValSer: 6.022 ± 0.107	3.92ValThr: 3.92 ± 0.095	5.309ValVal: 5.309 ± 0.097	0.622ValTrp: 0.622 ± 0.027	2.117ValTyr: 2.117 ± 0.056	0.0ValXaa: 0.0 ± 0.0
Trp	0.677TrpAla: 0.677 ± 0.024	0.149TrpCys: 0.149 ± 0.012	0.593TrpAsp: 0.593 ± 0.025	0.622TrpGlu: 0.622 ± 0.026	0.533TrpPhe: 0.533 ± 0.024	0.626TrpGly: 0.626 ± 0.024	0.21TrpHis: 0.21 ± 0.014	0.634TrpIle: 0.634 ± 0.025	0.756TrpLys: 0.756 ± 0.03	0.834TrpLeu: 0.834 ± 0.03	0.232TrpMet: 0.232 ± 0.016	0.655TrpAsn: 0.655 ± 0.024	0.159TrpPro: 0.159 ± 0.011	0.351TrpGln: 0.351 ± 0.017	0.509TrpArg: 0.509 ± 0.025	0.63TrpSer: 0.63 ± 0.025	0.543TrpThr: 0.543 ± 0.03	0.479TrpVal: 0.479 ± 0.022	0.136TrpTrp: 0.136 ± 0.012	0.401TrpTyr: 0.401 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.519TyrAla: 2.519 ± 0.05	0.455TyrCys: 0.455 ± 0.022	2.239TyrAsp: 2.239 ± 0.053	2.169TyrGlu: 2.169 ± 0.052	1.695TyrPhe: 1.695 ± 0.042	2.431TyrGly: 2.431 ± 0.049	0.458TyrHis: 0.458 ± 0.02	2.073TyrIle: 2.073 ± 0.05	2.011TyrLys: 2.011 ± 0.045	2.553TyrLeu: 2.553 ± 0.06	0.685TyrMet: 0.685 ± 0.028	1.463TyrAsn: 1.463 ± 0.045	1.152TyrPro: 1.152 ± 0.036	0.762TyrGln: 0.762 ± 0.03	1.623TyrArg: 1.623 ± 0.046	2.474TyrSer: 2.474 ± 0.053	1.753TyrThr: 1.753 ± 0.042	1.936TyrVal: 1.936 ± 0.046	0.357TyrTrp: 0.357 ± 0.019	1.242TyrTyr: 1.242 ± 0.042	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2828 proteins (1013328 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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