Amino acid dipepetide frequency for Tardiphaga robiniae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
16.29AlaAla: 16.29 ± 0.134
0.991AlaCys: 0.991 ± 0.027
6.583AlaAsp: 6.583 ± 0.07
6.341AlaGlu: 6.341 ± 0.081
4.46AlaPhe: 4.46 ± 0.055
10.153AlaGly: 10.153 ± 0.12
2.105AlaHis: 2.105 ± 0.033
6.935AlaIle: 6.935 ± 0.069
5.077AlaLys: 5.077 ± 0.077
12.614AlaLeu: 12.614 ± 0.102
3.615AlaMet: 3.615 ± 0.044
3.308AlaAsn: 3.308 ± 0.05
5.675AlaPro: 5.675 ± 0.08
4.128AlaGln: 4.128 ± 0.051
7.582AlaArg: 7.582 ± 0.081
7.062AlaSer: 7.062 ± 0.071
6.66AlaThr: 6.66 ± 0.079
8.707AlaVal: 8.707 ± 0.07
1.362AlaTrp: 1.362 ± 0.03
2.519AlaTyr: 2.519 ± 0.035
0.0AlaXaa: 0.0 ± 0.0
Cys
0.917CysAla: 0.917 ± 0.026
0.103CysCys: 0.103 ± 0.008
0.481CysAsp: 0.481 ± 0.017
0.38CysGlu: 0.38 ± 0.017
0.302CysPhe: 0.302 ± 0.014
0.857CysGly: 0.857 ± 0.024
0.206CysHis: 0.206 ± 0.011
0.41CysIle: 0.41 ± 0.015
0.219CysLys: 0.219 ± 0.012
0.675CysLeu: 0.675 ± 0.021
0.172CysMet: 0.172 ± 0.01
0.219CysAsn: 0.219 ± 0.012
0.369CysPro: 0.369 ± 0.016
0.217CysGln: 0.217 ± 0.012
0.528CysArg: 0.528 ± 0.02
0.43CysSer: 0.43 ± 0.017
0.425CysThr: 0.425 ± 0.015
0.617CysVal: 0.617 ± 0.019
0.094CysTrp: 0.094 ± 0.008
0.18CysTyr: 0.18 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
6.857AspAla: 6.857 ± 0.06
0.428AspCys: 0.428 ± 0.018
3.209AspAsp: 3.209 ± 0.06
3.108AspGlu: 3.108 ± 0.052
2.164AspPhe: 2.164 ± 0.039
5.105AspGly: 5.105 ± 0.067
1.244AspHis: 1.244 ± 0.028
3.357AspIle: 3.357 ± 0.047
2.112AspLys: 2.112 ± 0.036
5.501AspLeu: 5.501 ± 0.062
1.342AspMet: 1.342 ± 0.029
1.504AspAsn: 1.504 ± 0.03
3.105AspPro: 3.105 ± 0.043
1.691AspGln: 1.691 ± 0.033
3.888AspArg: 3.888 ± 0.05
2.346AspSer: 2.346 ± 0.043
2.753AspThr: 2.753 ± 0.048
4.596AspVal: 4.596 ± 0.056
0.818AspTrp: 0.818 ± 0.02
1.529AspTyr: 1.529 ± 0.03
0.0AspXaa: 0.0 ± 0.0
Glu
6.248GluAla: 6.248 ± 0.071
0.316GluCys: 0.316 ± 0.014
2.274GluAsp: 2.274 ± 0.039
2.357GluGlu: 2.357 ± 0.044
1.771GluPhe: 1.771 ± 0.028
3.542GluGly: 3.542 ± 0.056
1.055GluHis: 1.055 ± 0.026
3.344GluIle: 3.344 ± 0.048
2.324GluLys: 2.324 ± 0.048
4.957GluLeu: 4.957 ± 0.056
1.431GluMet: 1.431 ± 0.031
1.47GluAsn: 1.47 ± 0.029
2.321GluPro: 2.321 ± 0.039
2.007GluGln: 2.007 ± 0.034
4.049GluArg: 4.049 ± 0.053
2.252GluSer: 2.252 ± 0.033
3.095GluThr: 3.095 ± 0.047
3.551GluVal: 3.551 ± 0.047
0.614GluTrp: 0.614 ± 0.019
0.908GluTyr: 0.908 ± 0.024
0.0GluXaa: 0.0 ± 0.0
Phe
4.828PheAla: 4.828 ± 0.058
0.375PheCys: 0.375 ± 0.013
2.594PheAsp: 2.594 ± 0.04
1.954PheGlu: 1.954 ± 0.036
1.471PhePhe: 1.471 ± 0.032
3.932PheGly: 3.932 ± 0.056
0.71PheHis: 0.71 ± 0.02
1.841PheIle: 1.841 ± 0.032
1.293PheLys: 1.293 ± 0.028
3.238PheLeu: 3.238 ± 0.049
0.871PheMet: 0.871 ± 0.023
1.227PheAsn: 1.227 ± 0.025
1.621PhePro: 1.621 ± 0.028
1.013PheGln: 1.013 ± 0.026
2.145PheArg: 2.145 ± 0.036
2.296PheSer: 2.296 ± 0.036
2.152PheThr: 2.152 ± 0.04
3.023PheVal: 3.023 ± 0.044
0.516PheTrp: 0.516 ± 0.019
0.902PheTyr: 0.902 ± 0.023
0.0PheXaa: 0.0 ± 0.0
Gly
9.133GlyAla: 9.133 ± 0.102
0.774GlyCys: 0.774 ± 0.023
4.473GlyAsp: 4.473 ± 0.076
4.123GlyGlu: 4.123 ± 0.05
3.71GlyPhe: 3.71 ± 0.045
7.56GlyGly: 7.56 ± 0.129
1.745GlyHis: 1.745 ± 0.031
4.997GlyIle: 4.997 ± 0.061
3.632GlyLys: 3.632 ± 0.053
8.542GlyLeu: 8.542 ± 0.085
2.283GlyMet: 2.283 ± 0.037
2.494GlyAsn: 2.494 ± 0.062
3.319GlyPro: 3.319 ± 0.046
2.802GlyGln: 2.802 ± 0.039
5.281GlyArg: 5.281 ± 0.063
4.947GlySer: 4.947 ± 0.07
4.958GlyThr: 4.958 ± 0.08
6.224GlyVal: 6.224 ± 0.06
1.29GlyTrp: 1.29 ± 0.029
2.382GlyTyr: 2.382 ± 0.037
0.0GlyXaa: 0.0 ± 0.0
His
2.25HisAla: 2.25 ± 0.033
0.199HisCys: 0.199 ± 0.011
1.244HisAsp: 1.244 ± 0.029
0.902HisGlu: 0.902 ± 0.024
0.808HisPhe: 0.808 ± 0.023
1.807HisGly: 1.807 ± 0.034
0.573HisHis: 0.573 ± 0.021
0.968HisIle: 0.968 ± 0.022
0.522HisLys: 0.522 ± 0.019
1.816HisLeu: 1.816 ± 0.033
0.485HisMet: 0.485 ± 0.016
0.466HisAsn: 0.466 ± 0.017
1.254HisPro: 1.254 ± 0.028
0.584HisGln: 0.584 ± 0.019
1.318HisArg: 1.318 ± 0.029
0.925HisSer: 0.925 ± 0.026
0.821HisThr: 0.821 ± 0.024
1.482HisVal: 1.482 ± 0.028
0.279HisTrp: 0.279 ± 0.014
0.537HisTyr: 0.537 ± 0.016
0.0HisXaa: 0.0 ± 0.0
Ile
8.044IleAla: 8.044 ± 0.08
0.552IleCys: 0.552 ± 0.016
3.963IleAsp: 3.963 ± 0.048
3.427IleGlu: 3.427 ± 0.046
1.815IlePhe: 1.815 ± 0.035
5.453IleGly: 5.453 ± 0.06
0.933IleHis: 0.933 ± 0.026
2.63IleIle: 2.63 ± 0.039
2.007IleLys: 2.007 ± 0.041
4.43IleLeu: 4.43 ± 0.05
1.153IleMet: 1.153 ± 0.028
1.759IleAsn: 1.759 ± 0.032
2.433IlePro: 2.433 ± 0.035
1.297IleGln: 1.297 ± 0.027
3.228IleArg: 3.228 ± 0.045
3.441IleSer: 3.441 ± 0.053
3.138IleThr: 3.138 ± 0.043
4.907IleVal: 4.907 ± 0.049
0.642IleTrp: 0.642 ± 0.021
1.326IleTyr: 1.326 ± 0.03
0.0IleXaa: 0.0 ± 0.0
Lys
4.726LysAla: 4.726 ± 0.06
0.184LysCys: 0.184 ± 0.01
2.075LysAsp: 2.075 ± 0.042
1.694LysGlu: 1.694 ± 0.035
1.242LysPhe: 1.242 ± 0.031
2.769LysGly: 2.769 ± 0.041
0.739LysHis: 0.739 ± 0.02
2.229LysIle: 2.229 ± 0.035
1.778LysLys: 1.778 ± 0.047
4.035LysLeu: 4.035 ± 0.051
1.029LysMet: 1.029 ± 0.023
1.076LysAsn: 1.076 ± 0.024
2.557LysPro: 2.557 ± 0.043
1.296LysGln: 1.296 ± 0.024
2.607LysArg: 2.607 ± 0.038
2.278LysSer: 2.278 ± 0.036
2.348LysThr: 2.348 ± 0.037
2.821LysVal: 2.821 ± 0.046
0.422LysTrp: 0.422 ± 0.016
0.815LysTyr: 0.815 ± 0.026
0.0LysXaa: 0.0 ± 0.0
Leu
12.578LeuAla: 12.578 ± 0.096
0.791LeuCys: 0.791 ± 0.022
5.623LeuAsp: 5.623 ± 0.063
4.351LeuGlu: 4.351 ± 0.061
3.538LeuPhe: 3.538 ± 0.054
8.13LeuGly: 8.13 ± 0.075
1.771LeuHis: 1.771 ± 0.035
5.354LeuIle: 5.354 ± 0.061
3.965LeuLys: 3.965 ± 0.055
9.317LeuLeu: 9.317 ± 0.105
2.47LeuMet: 2.47 ± 0.043
2.882LeuAsn: 2.882 ± 0.041
5.265LeuPro: 5.265 ± 0.064
2.889LeuGln: 2.889 ± 0.043
6.231LeuArg: 6.231 ± 0.062
6.283LeuSer: 6.283 ± 0.062
5.901LeuThr: 5.901 ± 0.072
7.299LeuVal: 7.299 ± 0.068
1.104LeuTrp: 1.104 ± 0.027
1.916LeuTyr: 1.916 ± 0.033
0.0LeuXaa: 0.0 ± 0.0
Met
3.041MetAla: 3.041 ± 0.042
0.183MetCys: 0.183 ± 0.011
1.109MetAsp: 1.109 ± 0.021
0.984MetGlu: 0.984 ± 0.024
0.87MetPhe: 0.87 ± 0.023
1.712MetGly: 1.712 ± 0.033
0.45MetHis: 0.45 ± 0.014
1.585MetIle: 1.585 ± 0.027
1.175MetLys: 1.175 ± 0.026
2.639MetLeu: 2.639 ± 0.041
0.757MetMet: 0.757 ± 0.022
0.818MetAsn: 0.818 ± 0.019
1.613MetPro: 1.613 ± 0.032
0.917MetGln: 0.917 ± 0.023
1.787MetArg: 1.787 ± 0.029
1.86MetSer: 1.86 ± 0.033
2.123MetThr: 2.123 ± 0.034
1.814MetVal: 1.814 ± 0.031
0.236MetTrp: 0.236 ± 0.012
0.38MetTyr: 0.38 ± 0.015
0.0MetXaa: 0.0 ± 0.0
Asn
3.605AsnAla: 3.605 ± 0.052
0.247AsnCys: 0.247 ± 0.014
1.718AsnAsp: 1.718 ± 0.048
1.391AsnGlu: 1.391 ± 0.028
1.104AsnPhe: 1.104 ± 0.023
2.714AsnGly: 2.714 ± 0.061
0.502AsnHis: 0.502 ± 0.02
1.683AsnIle: 1.683 ± 0.035
0.96AsnLys: 0.96 ± 0.021
2.698AsnLeu: 2.698 ± 0.049
0.688AsnMet: 0.688 ± 0.023
0.902AsnAsn: 0.902 ± 0.029
1.851AsnPro: 1.851 ± 0.031
0.806AsnGln: 0.806 ± 0.022
1.738AsnArg: 1.738 ± 0.03
1.496AsnSer: 1.496 ± 0.03
1.544AsnThr: 1.544 ± 0.032
2.417AsnVal: 2.417 ± 0.037
0.479AsnTrp: 0.479 ± 0.017
0.788AsnTyr: 0.788 ± 0.023
0.0AsnXaa: 0.0 ± 0.0
Pro
6.047ProAla: 6.047 ± 0.077
0.259ProCys: 0.259 ± 0.012
3.526ProAsp: 3.526 ± 0.05
3.066ProGlu: 3.066 ± 0.05
1.954ProPhe: 1.954 ± 0.035
4.298ProGly: 4.298 ± 0.051
0.981ProHis: 0.981 ± 0.026
2.546ProIle: 2.546 ± 0.039
2.001ProLys: 2.001 ± 0.033
4.5ProLeu: 4.5 ± 0.053
1.262ProMet: 1.262 ± 0.025
1.566ProAsn: 1.566 ± 0.033
2.542ProPro: 2.542 ± 0.064
1.699ProGln: 1.699 ± 0.031
2.794ProArg: 2.794 ± 0.053
2.951ProSer: 2.951 ± 0.043
2.768ProThr: 2.768 ± 0.04
4.143ProVal: 4.143 ± 0.049
0.647ProTrp: 0.647 ± 0.022
1.183ProTyr: 1.183 ± 0.023
0.0ProXaa: 0.0 ± 0.0
Gln
3.899GlnAla: 3.899 ± 0.054
0.205GlnCys: 0.205 ± 0.012
1.458GlnAsp: 1.458 ± 0.032
1.252GlnGlu: 1.252 ± 0.029
1.148GlnPhe: 1.148 ± 0.027
2.311GlnGly: 2.311 ± 0.04
0.624GlnHis: 0.624 ± 0.018
2.024GlnIle: 2.024 ± 0.034
1.19GlnLys: 1.19 ± 0.03
3.103GlnLeu: 3.103 ± 0.039
0.966GlnMet: 0.966 ± 0.021
1.005GlnAsn: 1.005 ± 0.023
1.787GlnPro: 1.787 ± 0.029
1.393GlnGln: 1.393 ± 0.031
2.398GlnArg: 2.398 ± 0.042
1.912GlnSer: 1.912 ± 0.036
1.827GlnThr: 1.827 ± 0.034
2.249GlnVal: 2.249 ± 0.036
0.439GlnTrp: 0.439 ± 0.014
0.66GlnTyr: 0.66 ± 0.018
0.0GlnXaa: 0.0 ± 0.0
Arg
7.22ArgAla: 7.22 ± 0.073
0.448ArgCys: 0.448 ± 0.017
3.915ArgAsp: 3.915 ± 0.049
3.492ArgGlu: 3.492 ± 0.046
2.587ArgPhe: 2.587 ± 0.04
4.549ArgGly: 4.549 ± 0.051
1.415ArgHis: 1.415 ± 0.034
3.847ArgIle: 3.847 ± 0.045
2.529ArgLys: 2.529 ± 0.043
6.629ArgLeu: 6.629 ± 0.081
1.758ArgMet: 1.758 ± 0.03
1.972ArgAsn: 1.972 ± 0.037
3.122ArgPro: 3.122 ± 0.048
2.184ArgGln: 2.184 ± 0.034
4.541ArgArg: 4.541 ± 0.067
3.598ArgSer: 3.598 ± 0.046
3.236ArgThr: 3.236 ± 0.046
4.484ArgVal: 4.484 ± 0.058
0.875ArgTrp: 0.875 ± 0.023
1.613ArgTyr: 1.613 ± 0.029
0.0ArgXaa: 0.0 ± 0.0
Ser
6.768SerAla: 6.768 ± 0.07
0.413SerCys: 0.413 ± 0.014
3.274SerAsp: 3.274 ± 0.04
2.823SerGlu: 2.823 ± 0.04
2.457SerPhe: 2.457 ± 0.035
5.629SerGly: 5.629 ± 0.082
1.072SerHis: 1.072 ± 0.023
3.243SerIle: 3.243 ± 0.047
2.016SerLys: 2.016 ± 0.035
5.535SerLeu: 5.535 ± 0.063
1.514SerMet: 1.514 ± 0.029
1.715SerAsn: 1.715 ± 0.035
2.88SerPro: 2.88 ± 0.042
1.751SerGln: 1.751 ± 0.032
3.479SerArg: 3.479 ± 0.045
3.61SerSer: 3.61 ± 0.063
3.071SerThr: 3.071 ± 0.043
4.403SerVal: 4.403 ± 0.053
0.744SerTrp: 0.744 ± 0.021
1.501SerTyr: 1.501 ± 0.026
0.0SerXaa: 0.0 ± 0.0
Thr
6.495ThrAla: 6.495 ± 0.077
0.419ThrCys: 0.419 ± 0.016
2.918ThrAsp: 2.918 ± 0.043
2.608ThrGlu: 2.608 ± 0.036
2.281ThrPhe: 2.281 ± 0.044
5.229ThrGly: 5.229 ± 0.081
1.02ThrHis: 1.02 ± 0.024
3.407ThrIle: 3.407 ± 0.046
1.929ThrLys: 1.929 ± 0.033
6.004ThrLeu: 6.004 ± 0.072
1.381ThrMet: 1.381 ± 0.032
1.537ThrAsn: 1.537 ± 0.036
3.429ThrPro: 3.429 ± 0.046
1.655ThrGln: 1.655 ± 0.03
3.278ThrArg: 3.278 ± 0.044
3.499ThrSer: 3.499 ± 0.055
3.409ThrThr: 3.409 ± 0.055
4.557ThrVal: 4.557 ± 0.07
0.679ThrTrp: 0.679 ± 0.019
1.315ThrTyr: 1.315 ± 0.028
0.0ThrXaa: 0.0 ± 0.0
Val
9.477ValAla: 9.477 ± 0.08
0.571ValCys: 0.571 ± 0.019
4.159ValAsp: 4.159 ± 0.046
4.025ValGlu: 4.025 ± 0.049
2.827ValPhe: 2.827 ± 0.042
5.843ValGly: 5.843 ± 0.056
1.338ValHis: 1.338 ± 0.032
4.468ValIle: 4.468 ± 0.05
2.765ValLys: 2.765 ± 0.045
7.512ValLeu: 7.512 ± 0.058
2.05ValMet: 2.05 ± 0.032
2.331ValAsn: 2.331 ± 0.042
3.794ValPro: 3.794 ± 0.052
2.238ValGln: 2.238 ± 0.039
4.486ValArg: 4.486 ± 0.056
4.646ValSer: 4.646 ± 0.056
4.841ValThr: 4.841 ± 0.067
6.324ValVal: 6.324 ± 0.068
0.878ValTrp: 0.878 ± 0.022
1.539ValTyr: 1.539 ± 0.029
0.0ValXaa: 0.0 ± 0.0
Trp
1.16TrpAla: 1.16 ± 0.023
0.126TrpCys: 0.126 ± 0.009
0.621TrpAsp: 0.621 ± 0.018
0.495TrpGlu: 0.495 ± 0.019
0.52TrpPhe: 0.52 ± 0.018
0.852TrpGly: 0.852 ± 0.024
0.32TrpHis: 0.32 ± 0.016
0.73TrpIle: 0.73 ± 0.023
0.495TrpLys: 0.495 ± 0.017
1.522TrpLeu: 1.522 ± 0.036
0.36TrpMet: 0.36 ± 0.017
0.43TrpAsn: 0.43 ± 0.016
0.665TrpPro: 0.665 ± 0.021
0.52TrpGln: 0.52 ± 0.018
1.021TrpArg: 1.021 ± 0.026
0.799TrpSer: 0.799 ± 0.021
0.79TrpThr: 0.79 ± 0.02
0.783TrpVal: 0.783 ± 0.022
0.207TrpTrp: 0.207 ± 0.01
0.276TrpTyr: 0.276 ± 0.013
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.586TyrAla: 2.586 ± 0.039
0.216TyrCys: 0.216 ± 0.011
1.444TyrAsp: 1.444 ± 0.029
1.113TyrGlu: 1.113 ± 0.026
0.974TyrPhe: 0.974 ± 0.023
2.225TyrGly: 2.225 ± 0.042
0.438TyrHis: 0.438 ± 0.016
0.98TyrIle: 0.98 ± 0.022
0.731TyrLys: 0.731 ± 0.019
2.389TyrLeu: 2.389 ± 0.037
0.466TyrMet: 0.466 ± 0.018
0.65TyrAsn: 0.65 ± 0.02
1.132TyrPro: 1.132 ± 0.026
0.76TyrGln: 0.76 ± 0.024
1.631TyrArg: 1.631 ± 0.035
1.268TyrSer: 1.268 ± 0.028
1.187TyrThr: 1.187 ± 0.033
1.712TyrVal: 1.712 ± 0.028
0.367TyrTrp: 0.367 ± 0.014
0.624TyrTyr: 0.624 ± 0.021
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5721 proteins (1807327 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski