Amino acid dipepetide frequency for Suttonella indologenes

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.994AlaAla: 13.994 ± 0.318
1.072AlaCys: 1.072 ± 0.047
6.041AlaAsp: 6.041 ± 0.171
7.262AlaGlu: 7.262 ± 0.175
3.708AlaPhe: 3.708 ± 0.089
7.287AlaGly: 7.287 ± 0.142
2.287AlaHis: 2.287 ± 0.07
6.012AlaIle: 6.012 ± 0.095
4.974AlaLys: 4.974 ± 0.147
12.331AlaLeu: 12.331 ± 0.21
2.615AlaMet: 2.615 ± 0.066
3.462AlaAsn: 3.462 ± 0.1
3.459AlaPro: 3.459 ± 0.088
6.852AlaGln: 6.852 ± 0.15
4.924AlaArg: 4.924 ± 0.107
4.39AlaSer: 4.39 ± 0.091
3.987AlaThr: 3.987 ± 0.123
7.226AlaVal: 7.226 ± 0.141
1.247AlaTrp: 1.247 ± 0.05
3.044AlaTyr: 3.044 ± 0.074
0.0AlaXaa: 0.0 ± 0.0
Cys
0.986CysAla: 0.986 ± 0.049
0.153CysCys: 0.153 ± 0.015
0.505CysAsp: 0.505 ± 0.026
0.505CysGlu: 0.505 ± 0.028
0.423CysPhe: 0.423 ± 0.022
0.937CysGly: 0.937 ± 0.045
0.309CysHis: 0.309 ± 0.021
0.557CysIle: 0.557 ± 0.03
0.308CysLys: 0.308 ± 0.019
1.197CysLeu: 1.197 ± 0.046
0.182CysMet: 0.182 ± 0.017
0.274CysAsn: 0.274 ± 0.02
0.438CysPro: 0.438 ± 0.028
0.488CysGln: 0.488 ± 0.026
0.614CysArg: 0.614 ± 0.033
0.598CysSer: 0.598 ± 0.03
0.394CysThr: 0.394 ± 0.028
0.589CysVal: 0.589 ± 0.028
0.092CysTrp: 0.092 ± 0.011
0.301CysTyr: 0.301 ± 0.022
0.0CysXaa: 0.0 ± 0.0
Asp
4.976AspAla: 4.976 ± 0.135
0.629AspCys: 0.629 ± 0.034
2.67AspAsp: 2.67 ± 0.122
3.417AspGlu: 3.417 ± 0.086
2.611AspPhe: 2.611 ± 0.067
3.984AspGly: 3.984 ± 0.217
0.84AspHis: 0.84 ± 0.042
3.925AspIle: 3.925 ± 0.098
3.34AspLys: 3.34 ± 0.168
4.962AspLeu: 4.962 ± 0.094
1.381AspMet: 1.381 ± 0.045
2.508AspAsn: 2.508 ± 0.083
1.786AspPro: 1.786 ± 0.054
1.318AspGln: 1.318 ± 0.047
2.238AspArg: 2.238 ± 0.068
3.388AspSer: 3.388 ± 0.102
2.563AspThr: 2.563 ± 0.108
3.278AspVal: 3.278 ± 0.074
0.956AspTrp: 0.956 ± 0.039
2.373AspTyr: 2.373 ± 0.061
0.0AspXaa: 0.0 ± 0.0
Glu
6.278GluAla: 6.278 ± 0.148
0.399GluCys: 0.399 ± 0.027
2.731GluAsp: 2.731 ± 0.07
3.717GluGlu: 3.717 ± 0.097
1.976GluPhe: 1.976 ± 0.057
3.497GluGly: 3.497 ± 0.087
1.656GluHis: 1.656 ± 0.047
4.405GluIle: 4.405 ± 0.098
3.965GluLys: 3.965 ± 0.114
5.385GluLeu: 5.385 ± 0.114
1.649GluMet: 1.649 ± 0.055
3.073GluAsn: 3.073 ± 0.088
1.773GluPro: 1.773 ± 0.062
3.95GluGln: 3.95 ± 0.096
3.665GluArg: 3.665 ± 0.086
2.89GluSer: 2.89 ± 0.077
2.782GluThr: 2.782 ± 0.065
3.373GluVal: 3.373 ± 0.089
0.625GluTrp: 0.625 ± 0.033
1.721GluTyr: 1.721 ± 0.049
0.0GluXaa: 0.0 ± 0.0
Phe
4.727PheAla: 4.727 ± 0.108
0.594PheCys: 0.594 ± 0.034
2.31PheAsp: 2.31 ± 0.059
1.971PheGlu: 1.971 ± 0.051
1.924PhePhe: 1.924 ± 0.06
3.086PheGly: 3.086 ± 0.087
0.825PheHis: 0.825 ± 0.037
2.716PheIle: 2.716 ± 0.076
1.577PheLys: 1.577 ± 0.048
3.84PheLeu: 3.84 ± 0.094
0.931PheMet: 0.931 ± 0.045
1.707PheAsn: 1.707 ± 0.048
1.413PhePro: 1.413 ± 0.05
1.191PheGln: 1.191 ± 0.044
1.48PheArg: 1.48 ± 0.055
3.121PheSer: 3.121 ± 0.07
2.067PheThr: 2.067 ± 0.06
2.47PheVal: 2.47 ± 0.069
0.529PheTrp: 0.529 ± 0.034
1.437PheTyr: 1.437 ± 0.061
0.0PheXaa: 0.0 ± 0.0
Gly
5.982GlyAla: 5.982 ± 0.114
0.674GlyCys: 0.674 ± 0.034
3.924GlyAsp: 3.924 ± 0.16
4.738GlyGlu: 4.738 ± 0.093
2.998GlyPhe: 2.998 ± 0.074
5.58GlyGly: 5.58 ± 0.179
1.442GlyHis: 1.442 ± 0.044
5.372GlyIle: 5.372 ± 0.099
5.1GlyLys: 5.1 ± 0.165
6.694GlyLeu: 6.694 ± 0.112
1.911GlyMet: 1.911 ± 0.059
3.437GlyAsn: 3.437 ± 0.166
1.039GlyPro: 1.039 ± 0.049
2.946GlyGln: 2.946 ± 0.08
3.322GlyArg: 3.322 ± 0.076
4.292GlySer: 4.292 ± 0.118
3.17GlyThr: 3.17 ± 0.14
4.423GlyVal: 4.423 ± 0.097
0.818GlyTrp: 0.818 ± 0.041
2.384GlyTyr: 2.384 ± 0.066
0.0GlyXaa: 0.0 ± 0.0
His
1.987HisAla: 1.987 ± 0.057
0.342HisCys: 0.342 ± 0.022
1.094HisAsp: 1.094 ± 0.042
1.264HisGlu: 1.264 ± 0.053
1.101HisPhe: 1.101 ± 0.043
1.654HisGly: 1.654 ± 0.059
0.819HisHis: 0.819 ± 0.041
1.926HisIle: 1.926 ± 0.059
0.944HisLys: 0.944 ± 0.041
2.622HisLeu: 2.622 ± 0.071
0.462HisMet: 0.462 ± 0.027
0.961HisAsn: 0.961 ± 0.043
1.102HisPro: 1.102 ± 0.046
1.31HisGln: 1.31 ± 0.048
1.298HisArg: 1.298 ± 0.043
1.647HisSer: 1.647 ± 0.063
0.99HisThr: 0.99 ± 0.041
1.142HisVal: 1.142 ± 0.041
0.362HisTrp: 0.362 ± 0.025
1.007HisTyr: 1.007 ± 0.044
0.0HisXaa: 0.0 ± 0.0
Ile
7.941IleAla: 7.941 ± 0.129
0.725IleCys: 0.725 ± 0.031
4.202IleAsp: 4.202 ± 0.092
4.403IleGlu: 4.403 ± 0.092
2.696IlePhe: 2.696 ± 0.079
5.14IleGly: 5.14 ± 0.102
1.398IleHis: 1.398 ± 0.052
4.098IleIle: 4.098 ± 0.098
2.761IleLys: 2.761 ± 0.072
5.791IleLeu: 5.791 ± 0.103
1.466IleMet: 1.466 ± 0.052
2.853IleAsn: 2.853 ± 0.09
2.54IlePro: 2.54 ± 0.09
2.236IleGln: 2.236 ± 0.069
3.31IleArg: 3.31 ± 0.076
4.621IleSer: 4.621 ± 0.092
3.202IleThr: 3.202 ± 0.088
4.036IleVal: 4.036 ± 0.106
0.663IleTrp: 0.663 ± 0.029
2.071IleTyr: 2.071 ± 0.062
0.0IleXaa: 0.0 ± 0.0
Lys
5.242LysAla: 5.242 ± 0.15
0.239LysCys: 0.239 ± 0.017
2.815LysAsp: 2.815 ± 0.103
2.904LysGlu: 2.904 ± 0.078
1.332LysPhe: 1.332 ± 0.049
3.121LysGly: 3.121 ± 0.091
1.178LysHis: 1.178 ± 0.052
3.388LysIle: 3.388 ± 0.082
2.566LysLys: 2.566 ± 0.075
4.256LysLeu: 4.256 ± 0.077
1.235LysMet: 1.235 ± 0.043
2.502LysAsn: 2.502 ± 0.092
2.038LysPro: 2.038 ± 0.103
2.508LysGln: 2.508 ± 0.066
2.563LysArg: 2.563 ± 0.068
2.861LysSer: 2.861 ± 0.065
3.151LysThr: 3.151 ± 0.107
2.811LysVal: 2.811 ± 0.108
0.476LysTrp: 0.476 ± 0.027
1.324LysTyr: 1.324 ± 0.05
0.0LysXaa: 0.0 ± 0.0
Leu
11.471LeuAla: 11.471 ± 0.185
1.272LeuCys: 1.272 ± 0.038
5.175LeuAsp: 5.175 ± 0.094
5.227LeuGlu: 5.227 ± 0.107
4.189LeuPhe: 4.189 ± 0.099
6.919LeuGly: 6.919 ± 0.136
2.596LeuHis: 2.596 ± 0.07
6.698LeuIle: 6.698 ± 0.129
4.626LeuLys: 4.626 ± 0.095
11.537LeuLeu: 11.537 ± 0.224
2.586LeuMet: 2.586 ± 0.071
4.456LeuAsn: 4.456 ± 0.094
5.52LeuPro: 5.52 ± 0.114
5.195LeuGln: 5.195 ± 0.113
5.67LeuArg: 5.67 ± 0.117
8.086LeuSer: 8.086 ± 0.134
4.574LeuThr: 4.574 ± 0.088
5.13LeuVal: 5.13 ± 0.112
1.364LeuTrp: 1.364 ± 0.059
2.77LeuTyr: 2.77 ± 0.072
0.0LeuXaa: 0.0 ± 0.0
Met
2.273MetAla: 2.273 ± 0.067
0.179MetCys: 0.179 ± 0.017
0.981MetAsp: 0.981 ± 0.038
1.074MetGlu: 1.074 ± 0.041
0.749MetPhe: 0.749 ± 0.04
1.592MetGly: 1.592 ± 0.054
0.466MetHis: 0.466 ± 0.027
1.525MetIle: 1.525 ± 0.051
1.34MetLys: 1.34 ± 0.049
2.685MetLeu: 2.685 ± 0.077
0.71MetMet: 0.71 ± 0.034
1.085MetAsn: 1.085 ± 0.037
1.291MetPro: 1.291 ± 0.044
1.621MetGln: 1.621 ± 0.051
1.551MetArg: 1.551 ± 0.052
1.622MetSer: 1.622 ± 0.051
1.298MetThr: 1.298 ± 0.048
1.329MetVal: 1.329 ± 0.047
0.178MetTrp: 0.178 ± 0.015
0.487MetTyr: 0.487 ± 0.028
0.0MetXaa: 0.0 ± 0.0
Asn
4.133AsnAla: 4.133 ± 0.095
0.33AsnCys: 0.33 ± 0.021
2.179AsnAsp: 2.179 ± 0.114
2.212AsnGlu: 2.212 ± 0.076
1.388AsnPhe: 1.388 ± 0.049
3.272AsnGly: 3.272 ± 0.175
1.038AsnHis: 1.038 ± 0.042
3.073AsnIle: 3.073 ± 0.083
1.849AsnLys: 1.849 ± 0.073
3.942AsnLeu: 3.942 ± 0.089
0.848AsnMet: 0.848 ± 0.037
1.905AsnAsn: 1.905 ± 0.095
2.436AsnPro: 2.436 ± 0.064
1.901AsnGln: 1.901 ± 0.062
2.184AsnArg: 2.184 ± 0.063
2.441AsnSer: 2.441 ± 0.072
2.459AsnThr: 2.459 ± 0.116
2.187AsnVal: 2.187 ± 0.065
0.502AsnTrp: 0.502 ± 0.028
1.262AsnTyr: 1.262 ± 0.044
0.0AsnXaa: 0.0 ± 0.0
Pro
3.843ProAla: 3.843 ± 0.082
0.351ProCys: 0.351 ± 0.025
2.292ProAsp: 2.292 ± 0.066
2.96ProGlu: 2.96 ± 0.064
1.632ProPhe: 1.632 ± 0.054
1.585ProGly: 1.585 ± 0.066
1.03ProHis: 1.03 ± 0.041
2.362ProIle: 2.362 ± 0.062
1.725ProLys: 1.725 ± 0.063
4.159ProLeu: 4.159 ± 0.096
0.948ProMet: 0.948 ± 0.039
1.825ProAsn: 1.825 ± 0.077
1.693ProPro: 1.693 ± 0.066
2.439ProGln: 2.439 ± 0.078
1.595ProArg: 1.595 ± 0.054
2.243ProSer: 2.243 ± 0.068
1.883ProThr: 1.883 ± 0.095
2.659ProVal: 2.659 ± 0.088
0.48ProTrp: 0.48 ± 0.028
1.362ProTyr: 1.362 ± 0.042
0.0ProXaa: 0.0 ± 0.0
Gln
6.83GlnAla: 6.83 ± 0.151
0.376GlnCys: 0.376 ± 0.025
2.528GlnAsp: 2.528 ± 0.075
3.144GlnGlu: 3.144 ± 0.099
1.773GlnPhe: 1.773 ± 0.053
3.496GlnGly: 3.496 ± 0.082
1.308GlnHis: 1.308 ± 0.049
3.136GlnIle: 3.136 ± 0.084
2.251GlnLys: 2.251 ± 0.062
4.97GlnLeu: 4.97 ± 0.105
1.23GlnMet: 1.23 ± 0.042
1.876GlnAsn: 1.876 ± 0.054
1.628GlnPro: 1.628 ± 0.068
3.076GlnGln: 3.076 ± 0.115
2.764GlnArg: 2.764 ± 0.08
3.328GlnSer: 3.328 ± 0.098
2.63GlnThr: 2.63 ± 0.083
2.61GlnVal: 2.61 ± 0.078
0.767GlnTrp: 0.767 ± 0.033
1.633GlnTyr: 1.633 ± 0.053
0.0GlnXaa: 0.0 ± 0.0
Arg
4.271ArgAla: 4.271 ± 0.096
0.432ArgCys: 0.432 ± 0.022
2.648ArgAsp: 2.648 ± 0.063
3.56ArgGlu: 3.56 ± 0.09
2.414ArgPhe: 2.414 ± 0.065
3.064ArgGly: 3.064 ± 0.073
1.716ArgHis: 1.716 ± 0.052
3.5ArgIle: 3.5 ± 0.078
2.351ArgLys: 2.351 ± 0.067
6.219ArgLeu: 6.219 ± 0.108
1.217ArgMet: 1.217 ± 0.043
1.881ArgAsn: 1.881 ± 0.063
1.924ArgPro: 1.924 ± 0.067
3.296ArgGln: 3.296 ± 0.1
3.453ArgArg: 3.453 ± 0.085
2.764ArgSer: 2.764 ± 0.061
1.807ArgThr: 1.807 ± 0.05
2.722ArgVal: 2.722 ± 0.067
0.579ArgTrp: 0.579 ± 0.03
2.056ArgTyr: 2.056 ± 0.058
0.0ArgXaa: 0.0 ± 0.0
Ser
6.341SerAla: 6.341 ± 0.097
0.525SerCys: 0.525 ± 0.026
3.198SerAsp: 3.198 ± 0.082
3.319SerGlu: 3.319 ± 0.075
2.372SerPhe: 2.372 ± 0.071
5.251SerGly: 5.251 ± 0.131
1.473SerHis: 1.473 ± 0.054
4.032SerIle: 4.032 ± 0.074
2.634SerLys: 2.634 ± 0.068
6.743SerLeu: 6.743 ± 0.135
1.342SerMet: 1.342 ± 0.045
2.422SerAsn: 2.422 ± 0.08
2.514SerPro: 2.514 ± 0.073
2.584SerGln: 2.584 ± 0.063
3.103SerArg: 3.103 ± 0.077
3.538SerSer: 3.538 ± 0.098
2.701SerThr: 2.701 ± 0.074
3.772SerVal: 3.772 ± 0.093
0.581SerTrp: 0.581 ± 0.032
1.808SerTyr: 1.808 ± 0.056
0.0SerXaa: 0.0 ± 0.0
Thr
5.268ThrAla: 5.268 ± 0.156
0.324ThrCys: 0.324 ± 0.021
2.508ThrAsp: 2.508 ± 0.172
2.391ThrGlu: 2.391 ± 0.065
1.752ThrPhe: 1.752 ± 0.046
3.806ThrGly: 3.806 ± 0.125
1.13ThrHis: 1.13 ± 0.044
2.95ThrIle: 2.95 ± 0.118
1.548ThrLys: 1.548 ± 0.071
5.593ThrLeu: 5.593 ± 0.11
0.94ThrMet: 0.94 ± 0.039
1.465ThrAsn: 1.465 ± 0.051
2.418ThrPro: 2.418 ± 0.08
2.332ThrGln: 2.332 ± 0.09
2.043ThrArg: 2.043 ± 0.064
2.224ThrSer: 2.224 ± 0.066
2.209ThrThr: 2.209 ± 0.115
3.375ThrVal: 3.375 ± 0.113
0.573ThrTrp: 0.573 ± 0.03
1.316ThrTyr: 1.316 ± 0.05
0.0ThrXaa: 0.0 ± 0.0
Val
5.696ValAla: 5.696 ± 0.129
0.659ValCys: 0.659 ± 0.031
3.144ValAsp: 3.144 ± 0.114
3.324ValGlu: 3.324 ± 0.077
2.742ValPhe: 2.742 ± 0.066
3.901ValGly: 3.901 ± 0.094
1.298ValHis: 1.298 ± 0.051
4.055ValIle: 4.055 ± 0.089
3.101ValLys: 3.101 ± 0.122
6.684ValLeu: 6.684 ± 0.126
1.595ValMet: 1.595 ± 0.048
2.493ValAsn: 2.493 ± 0.082
2.366ValPro: 2.366 ± 0.065
2.738ValGln: 2.738 ± 0.066
2.949ValArg: 2.949 ± 0.061
3.998ValSer: 3.998 ± 0.087
2.344ValThr: 2.344 ± 0.141
3.836ValVal: 3.836 ± 0.113
0.632ValTrp: 0.632 ± 0.029
1.809ValTyr: 1.809 ± 0.052
0.0ValXaa: 0.0 ± 0.0
Trp
0.899TrpAla: 0.899 ± 0.041
0.119TrpCys: 0.119 ± 0.014
0.468TrpAsp: 0.468 ± 0.027
0.46TrpGlu: 0.46 ± 0.022
0.518TrpPhe: 0.518 ± 0.027
0.689TrpGly: 0.689 ± 0.032
0.417TrpHis: 0.417 ± 0.028
0.76TrpIle: 0.76 ± 0.039
0.506TrpLys: 0.506 ± 0.03
1.945TrpLeu: 1.945 ± 0.072
0.219TrpMet: 0.219 ± 0.015
0.362TrpAsn: 0.362 ± 0.026
0.209TrpPro: 0.209 ± 0.015
1.457TrpGln: 1.457 ± 0.055
0.863TrpArg: 0.863 ± 0.037
0.505TrpSer: 0.505 ± 0.028
0.587TrpThr: 0.587 ± 0.033
0.589TrpVal: 0.589 ± 0.031
0.172TrpTrp: 0.172 ± 0.018
0.328TrpTyr: 0.328 ± 0.024
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.036TyrAla: 3.036 ± 0.076
0.451TyrCys: 0.451 ± 0.025
1.732TyrAsp: 1.732 ± 0.059
1.662TyrGlu: 1.662 ± 0.052
1.618TyrPhe: 1.618 ± 0.059
2.387TyrGly: 2.387 ± 0.079
0.81TyrHis: 0.81 ± 0.037
1.66TyrIle: 1.66 ± 0.053
1.045TyrLys: 1.045 ± 0.042
3.507TyrLeu: 3.507 ± 0.082
0.568TyrMet: 0.568 ± 0.028
0.994TyrAsn: 0.994 ± 0.039
1.478TyrPro: 1.478 ± 0.048
1.915TyrGln: 1.915 ± 0.059
2.284TyrArg: 2.284 ± 0.067
1.696TyrSer: 1.696 ± 0.048
1.368TyrThr: 1.368 ± 0.048
1.807TyrVal: 1.807 ± 0.055
0.476TyrTrp: 0.476 ± 0.028
1.187TyrTyr: 1.187 ± 0.047
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2313 proteins (731157 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski