Amino acid dipepetide frequency for Halorubrum sp. CBA1125

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.29AlaAla: 14.29 ± 0.214	0.712AlaCys: 0.712 ± 0.03	10.474AlaAsp: 10.474 ± 0.143	8.841AlaGlu: 8.841 ± 0.137	4.21AlaPhe: 4.21 ± 0.078	9.709AlaGly: 9.709 ± 0.134	1.803AlaHis: 1.803 ± 0.05	5.13AlaIle: 5.13 ± 0.078	1.76AlaLys: 1.76 ± 0.049	9.868AlaLeu: 9.868 ± 0.134	2.035AlaMet: 2.035 ± 0.057	2.484AlaAsn: 2.484 ± 0.059	3.84AlaPro: 3.84 ± 0.074	1.959AlaGln: 1.959 ± 0.058	5.943AlaArg: 5.943 ± 0.104	5.511AlaSer: 5.511 ± 0.1	7.147AlaThr: 7.147 ± 0.125	11.042AlaVal: 11.042 ± 0.165	1.169AlaTrp: 1.169 ± 0.044	2.81AlaTyr: 2.81 ± 0.074	0.0AlaXaa: 0.0 ± 0.0
Cys	0.589CysAla: 0.589 ± 0.028	0.099CysCys: 0.099 ± 0.012	0.631CysAsp: 0.631 ± 0.032	0.604CysGlu: 0.604 ± 0.032	0.243CysPhe: 0.243 ± 0.018	0.835CysGly: 0.835 ± 0.037	0.188CysHis: 0.188 ± 0.017	0.244CysIle: 0.244 ± 0.02	0.121CysLys: 0.121 ± 0.013	0.52CysLeu: 0.52 ± 0.027	0.106CysMet: 0.106 ± 0.013	0.205CysAsn: 0.205 ± 0.016	0.534CysPro: 0.534 ± 0.029	0.171CysGln: 0.171 ± 0.016	0.472CysArg: 0.472 ± 0.025	0.387CysSer: 0.387 ± 0.022	0.408CysThr: 0.408 ± 0.023	0.472CysVal: 0.472 ± 0.026	0.094CysTrp: 0.094 ± 0.011	0.172CysTyr: 0.172 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	11.106AspAla: 11.106 ± 0.167	0.596AspCys: 0.596 ± 0.029	8.391AspAsp: 8.391 ± 0.144	8.091AspGlu: 8.091 ± 0.128	1.917AspPhe: 1.917 ± 0.054	8.777AspGly: 8.777 ± 0.157	1.852AspHis: 1.852 ± 0.052	3.013AspIle: 3.013 ± 0.078	0.968AspLys: 0.968 ± 0.038	7.24AspLeu: 7.24 ± 0.121	1.125AspMet: 1.125 ± 0.045	1.361AspAsn: 1.361 ± 0.052	5.336AspPro: 5.336 ± 0.101	1.748AspGln: 1.748 ± 0.057	7.324AspArg: 7.324 ± 0.113	3.528AspSer: 3.528 ± 0.082	4.234AspThr: 4.234 ± 0.095	8.327AspVal: 8.327 ± 0.126	0.995AspTrp: 0.995 ± 0.039	1.766AspTyr: 1.766 ± 0.057	0.0AspXaa: 0.0 ± 0.0
Glu	8.943GluAla: 8.943 ± 0.128	0.533GluCys: 0.533 ± 0.032	5.433GluAsp: 5.433 ± 0.093	6.568GluGlu: 6.568 ± 0.131	2.937GluPhe: 2.937 ± 0.066	5.482GluGly: 5.482 ± 0.097	1.927GluHis: 1.927 ± 0.053	4.076GluIle: 4.076 ± 0.094	1.8GluLys: 1.8 ± 0.066	7.241GluLeu: 7.241 ± 0.118	1.781GluMet: 1.781 ± 0.05	2.233GluAsn: 2.233 ± 0.075	4.157GluPro: 4.157 ± 0.087	2.337GluGln: 2.337 ± 0.057	7.34GluArg: 7.34 ± 0.116	4.911GluSer: 4.911 ± 0.088	6.769GluThr: 6.769 ± 0.124	5.866GluVal: 5.866 ± 0.095	1.101GluTrp: 1.101 ± 0.037	2.757GluTyr: 2.757 ± 0.066	0.0GluXaa: 0.0 ± 0.0
Phe	3.774PheAla: 3.774 ± 0.081	0.306PheCys: 0.306 ± 0.02	3.312PheAsp: 3.312 ± 0.063	3.087PheGlu: 3.087 ± 0.074	0.977PhePhe: 0.977 ± 0.036	3.135PheGly: 3.135 ± 0.067	0.642PheHis: 0.642 ± 0.028	1.023PheIle: 1.023 ± 0.042	0.485PheLys: 0.485 ± 0.024	2.814PheLeu: 2.814 ± 0.073	0.513PheMet: 0.513 ± 0.025	0.701PheAsn: 0.701 ± 0.032	1.345PhePro: 1.345 ± 0.041	0.769PheGln: 0.769 ± 0.031	1.882PheArg: 1.882 ± 0.045	1.646PheSer: 1.646 ± 0.048	1.883PheThr: 1.883 ± 0.046	3.298PheVal: 3.298 ± 0.071	0.38PheTrp: 0.38 ± 0.024	0.856PheTyr: 0.856 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	7.802GlyAla: 7.802 ± 0.129	0.684GlyCys: 0.684 ± 0.034	7.574GlyAsp: 7.574 ± 0.137	7.046GlyGlu: 7.046 ± 0.123	3.129GlyPhe: 3.129 ± 0.071	7.693GlyGly: 7.693 ± 0.141	1.563GlyHis: 1.563 ± 0.049	4.361GlyIle: 4.361 ± 0.09	1.797GlyLys: 1.797 ± 0.052	6.992GlyLeu: 6.992 ± 0.11	1.593GlyMet: 1.593 ± 0.053	2.029GlyAsn: 2.029 ± 0.058	3.314GlyPro: 3.314 ± 0.072	1.832GlyGln: 1.832 ± 0.05	5.012GlyArg: 5.012 ± 0.091	5.32GlySer: 5.32 ± 0.112	5.898GlyThr: 5.898 ± 0.121	7.901GlyVal: 7.901 ± 0.122	1.074GlyTrp: 1.074 ± 0.043	2.722GlyTyr: 2.722 ± 0.061	0.0GlyXaa: 0.0 ± 0.0
His	1.988HisAla: 1.988 ± 0.06	0.172HisCys: 0.172 ± 0.015	1.742HisAsp: 1.742 ± 0.05	1.693HisGlu: 1.693 ± 0.054	0.541HisPhe: 0.541 ± 0.029	1.883HisGly: 1.883 ± 0.06	0.489HisHis: 0.489 ± 0.031	0.634HisIle: 0.634 ± 0.033	0.314HisLys: 0.314 ± 0.02	1.669HisLeu: 1.669 ± 0.047	0.3HisMet: 0.3 ± 0.019	0.477HisAsn: 0.477 ± 0.024	1.219HisPro: 1.219 ± 0.042	0.452HisGln: 0.452 ± 0.026	1.295HisArg: 1.295 ± 0.047	0.877HisSer: 0.877 ± 0.035	1.029HisThr: 1.029 ± 0.034	1.91HisVal: 1.91 ± 0.055	0.224HisTrp: 0.224 ± 0.02	0.579HisTyr: 0.579 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	5.057IleAla: 5.057 ± 0.09	0.264IleCys: 0.264 ± 0.021	4.371IleAsp: 4.371 ± 0.085	4.454IleGlu: 4.454 ± 0.084	0.909IlePhe: 0.909 ± 0.039	3.819IleGly: 3.819 ± 0.084	0.867IleHis: 0.867 ± 0.037	1.222IleIle: 1.222 ± 0.045	0.672IleLys: 0.672 ± 0.032	3.005IleLeu: 3.005 ± 0.073	0.465IleMet: 0.465 ± 0.027	1.06IleAsn: 1.06 ± 0.043	2.157IlePro: 2.157 ± 0.056	1.068IleGln: 1.068 ± 0.042	2.744IleArg: 2.744 ± 0.058	2.159IleSer: 2.159 ± 0.058	2.443IleThr: 2.443 ± 0.067	3.854IleVal: 3.854 ± 0.078	0.342IleTrp: 0.342 ± 0.025	0.879IleTyr: 0.879 ± 0.037	0.0IleXaa: 0.0 ± 0.0
Lys	1.743LysAla: 1.743 ± 0.049	0.117LysCys: 0.117 ± 0.014	1.038LysAsp: 1.038 ± 0.046	1.323LysGlu: 1.323 ± 0.044	0.513LysPhe: 0.513 ± 0.025	1.344LysGly: 1.344 ± 0.052	0.467LysHis: 0.467 ± 0.027	0.781LysIle: 0.781 ± 0.033	0.51LysLys: 0.51 ± 0.033	1.557LysLeu: 1.557 ± 0.052	0.319LysMet: 0.319 ± 0.023	0.533LysAsn: 0.533 ± 0.029	0.921LysPro: 0.921 ± 0.036	0.713LysGln: 0.713 ± 0.03	1.695LysArg: 1.695 ± 0.054	1.091LysSer: 1.091 ± 0.04	1.259LysThr: 1.259 ± 0.044	1.15LysVal: 1.15 ± 0.049	0.233LysTrp: 0.233 ± 0.017	0.565LysTyr: 0.565 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	10.749LeuAla: 10.749 ± 0.146	0.59LeuCys: 0.59 ± 0.029	7.635LeuAsp: 7.635 ± 0.116	6.173LeuGlu: 6.173 ± 0.107	2.994LeuPhe: 2.994 ± 0.074	7.164LeuGly: 7.164 ± 0.12	1.42LeuHis: 1.42 ± 0.05	3.221LeuIle: 3.221 ± 0.074	1.495LeuLys: 1.495 ± 0.052	8.133LeuLeu: 8.133 ± 0.159	1.316LeuMet: 1.316 ± 0.041	1.792LeuAsn: 1.792 ± 0.065	4.133LeuPro: 4.133 ± 0.084	1.993LeuGln: 1.993 ± 0.049	5.698LeuArg: 5.698 ± 0.105	5.316LeuSer: 5.316 ± 0.084	5.137LeuThr: 5.137 ± 0.083	8.13LeuVal: 8.13 ± 0.13	0.824LeuTrp: 0.824 ± 0.038	2.217LeuTyr: 2.217 ± 0.054	0.0LeuXaa: 0.0 ± 0.0
Met	1.69MetAla: 1.69 ± 0.052	0.121MetCys: 0.121 ± 0.014	1.169MetAsp: 1.169 ± 0.041	1.082MetGlu: 1.082 ± 0.042	0.485MetPhe: 0.485 ± 0.029	1.323MetGly: 1.323 ± 0.043	0.31MetHis: 0.31 ± 0.023	0.708MetIle: 0.708 ± 0.03	0.435MetLys: 0.435 ± 0.024	1.239MetLeu: 1.239 ± 0.043	0.305MetMet: 0.305 ± 0.022	0.581MetAsn: 0.581 ± 0.029	0.777MetPro: 0.777 ± 0.031	0.424MetGln: 0.424 ± 0.025	1.055MetArg: 1.055 ± 0.031	1.522MetSer: 1.522 ± 0.046	1.499MetThr: 1.499 ± 0.043	1.258MetVal: 1.258 ± 0.041	0.151MetTrp: 0.151 ± 0.014	0.449MetTyr: 0.449 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	2.665AsnAla: 2.665 ± 0.065	0.208AsnCys: 0.208 ± 0.016	1.785AsnAsp: 1.785 ± 0.062	1.841AsnGlu: 1.841 ± 0.063	0.661AsnPhe: 0.661 ± 0.038	2.07AsnGly: 2.07 ± 0.079	0.505AsnHis: 0.505 ± 0.027	0.854AsnIle: 0.854 ± 0.036	0.445AsnLys: 0.445 ± 0.027	1.951AsnLeu: 1.951 ± 0.043	0.358AsnMet: 0.358 ± 0.022	0.559AsnAsn: 0.559 ± 0.035	1.563AsnPro: 1.563 ± 0.045	0.728AsnGln: 0.728 ± 0.032	1.705AsnArg: 1.705 ± 0.05	1.014AsnSer: 1.014 ± 0.046	1.365AsnThr: 1.365 ± 0.058	2.441AsnVal: 2.441 ± 0.092	0.306AsnTrp: 0.306 ± 0.023	0.699AsnTyr: 0.699 ± 0.036	0.0AsnXaa: 0.0 ± 0.0
Pro	4.976ProAla: 4.976 ± 0.087	0.253ProCys: 0.253 ± 0.018	5.315ProAsp: 5.315 ± 0.096	4.464ProGlu: 4.464 ± 0.078	1.616ProPhe: 1.616 ± 0.048	3.835ProGly: 3.835 ± 0.078	0.92ProHis: 0.92 ± 0.038	2.131ProIle: 2.131 ± 0.054	0.773ProLys: 0.773 ± 0.034	3.694ProLeu: 3.694 ± 0.075	0.855ProMet: 0.855 ± 0.032	1.211ProAsn: 1.211 ± 0.044	2.282ProPro: 2.282 ± 0.061	0.962ProGln: 0.962 ± 0.037	2.265ProArg: 2.265 ± 0.059	2.711ProSer: 2.711 ± 0.069	3.075ProThr: 3.075 ± 0.069	4.329ProVal: 4.329 ± 0.085	0.498ProTrp: 0.498 ± 0.028	1.123ProTyr: 1.123 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	2.215GlnAla: 2.215 ± 0.05	0.162GlnCys: 0.162 ± 0.014	1.307GlnAsp: 1.307 ± 0.04	1.665GlnGlu: 1.665 ± 0.056	0.987GlnPhe: 0.987 ± 0.037	1.599GlnGly: 1.599 ± 0.049	0.473GlnHis: 0.473 ± 0.024	1.184GlnIle: 1.184 ± 0.036	0.571GlnLys: 0.571 ± 0.03	2.235GlnLeu: 2.235 ± 0.056	0.49GlnMet: 0.49 ± 0.024	0.716GlnAsn: 0.716 ± 0.034	1.132GlnPro: 1.132 ± 0.042	0.938GlnGln: 0.938 ± 0.047	1.865GlnArg: 1.865 ± 0.055	1.463GlnSer: 1.463 ± 0.045	1.65GlnThr: 1.65 ± 0.06	1.747GlnVal: 1.747 ± 0.05	0.321GlnTrp: 0.321 ± 0.024	0.822GlnTyr: 0.822 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	6.342ArgAla: 6.342 ± 0.09	0.468ArgCys: 0.468 ± 0.027	5.51ArgAsp: 5.51 ± 0.088	6.867ArgGlu: 6.867 ± 0.109	2.495ArgPhe: 2.495 ± 0.057	4.553ArgGly: 4.553 ± 0.078	1.315ArgHis: 1.315 ± 0.048	3.193ArgIle: 3.193 ± 0.073	1.378ArgLys: 1.378 ± 0.049	6.238ArgLeu: 6.238 ± 0.108	1.262ArgMet: 1.262 ± 0.042	1.734ArgAsn: 1.734 ± 0.053	2.713ArgPro: 2.713 ± 0.067	1.747ArgGln: 1.747 ± 0.051	5.278ArgArg: 5.278 ± 0.099	3.736ArgSer: 3.736 ± 0.074	3.984ArgThr: 3.984 ± 0.066	5.559ArgVal: 5.559 ± 0.093	0.811ArgTrp: 0.811 ± 0.037	1.979ArgTyr: 1.979 ± 0.052	0.0ArgXaa: 0.0 ± 0.0
Ser	5.311SerAla: 5.311 ± 0.107	0.342SerCys: 0.342 ± 0.024	4.546SerAsp: 4.546 ± 0.092	4.279SerGlu: 4.279 ± 0.091	1.972SerPhe: 1.972 ± 0.054	5.188SerGly: 5.188 ± 0.093	0.945SerHis: 0.945 ± 0.034	2.476SerIle: 2.476 ± 0.056	1.174SerLys: 1.174 ± 0.043	4.68SerLeu: 4.68 ± 0.084	1.002SerMet: 1.002 ± 0.04	1.398SerAsn: 1.398 ± 0.052	2.717SerPro: 2.717 ± 0.067	1.316SerGln: 1.316 ± 0.044	3.275SerArg: 3.275 ± 0.07	2.856SerSer: 2.856 ± 0.083	3.603SerThr: 3.603 ± 0.082	4.981SerVal: 4.981 ± 0.082	0.559SerTrp: 0.559 ± 0.028	1.325SerTyr: 1.325 ± 0.042	0.0SerXaa: 0.0 ± 0.0
Thr	7.09ThrAla: 7.09 ± 0.107	0.396ThrCys: 0.396 ± 0.02	5.813ThrAsp: 5.813 ± 0.112	4.725ThrGlu: 4.725 ± 0.076	2.058ThrPhe: 2.058 ± 0.049	5.855ThrGly: 5.855 ± 0.099	1.288ThrHis: 1.288 ± 0.042	2.895ThrIle: 2.895 ± 0.072	1.043ThrLys: 1.043 ± 0.033	5.562ThrLeu: 5.562 ± 0.096	0.9ThrMet: 0.9 ± 0.038	1.557ThrAsn: 1.557 ± 0.062	3.205ThrPro: 3.205 ± 0.057	1.388ThrGln: 1.388 ± 0.059	3.638ThrArg: 3.638 ± 0.074	2.966ThrSer: 2.966 ± 0.074	4.371ThrThr: 4.371 ± 0.108	7.429ThrVal: 7.429 ± 0.17	0.624ThrTrp: 0.624 ± 0.029	1.645ThrTyr: 1.645 ± 0.05	0.0ThrXaa: 0.0 ± 0.0
Val	10.601ValAla: 10.601 ± 0.144	0.701ValCys: 0.701 ± 0.029	8.346ValAsp: 8.346 ± 0.133	8.043ValGlu: 8.043 ± 0.137	2.944ValPhe: 2.944 ± 0.062	7.985ValGly: 7.985 ± 0.144	1.652ValHis: 1.652 ± 0.045	3.361ValIle: 3.361 ± 0.077	1.364ValLys: 1.364 ± 0.043	7.904ValLeu: 7.904 ± 0.129	1.264ValMet: 1.264 ± 0.04	2.066ValAsn: 2.066 ± 0.056	4.268ValPro: 4.268 ± 0.08	1.86ValGln: 1.86 ± 0.054	5.771ValArg: 5.771 ± 0.103	5.153ValSer: 5.153 ± 0.1	6.519ValThr: 6.519 ± 0.134	9.266ValVal: 9.266 ± 0.136	0.872ValTrp: 0.872 ± 0.035	2.223ValTyr: 2.223 ± 0.056	0.0ValXaa: 0.0 ± 0.0
Trp	0.94TrpAla: 0.94 ± 0.034	0.127TrpCys: 0.127 ± 0.015	0.767TrpAsp: 0.767 ± 0.03	0.869TrpGlu: 0.869 ± 0.034	0.452TrpPhe: 0.452 ± 0.029	0.797TrpGly: 0.797 ± 0.04	0.232TrpHis: 0.232 ± 0.016	0.571TrpIle: 0.571 ± 0.032	0.281TrpLys: 0.281 ± 0.018	1.08TrpLeu: 1.08 ± 0.042	0.237TrpMet: 0.237 ± 0.016	0.392TrpAsn: 0.392 ± 0.024	0.415TrpPro: 0.415 ± 0.022	0.359TrpGln: 0.359 ± 0.023	0.888TrpArg: 0.888 ± 0.035	0.611TrpSer: 0.611 ± 0.029	0.718TrpThr: 0.718 ± 0.034	0.826TrpVal: 0.826 ± 0.037	0.217TrpTrp: 0.217 ± 0.018	0.366TrpTyr: 0.366 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.866TyrAla: 2.866 ± 0.064	0.244TyrCys: 0.244 ± 0.018	2.534TyrAsp: 2.534 ± 0.06	2.48TyrGlu: 2.48 ± 0.056	0.789TyrPhe: 0.789 ± 0.032	2.292TyrGly: 2.292 ± 0.058	0.631TyrHis: 0.631 ± 0.027	0.734TyrIle: 0.734 ± 0.034	0.485TyrLys: 0.485 ± 0.027	2.512TyrLeu: 2.512 ± 0.066	0.353TyrMet: 0.353 ± 0.022	0.632TyrAsn: 0.632 ± 0.033	1.262TyrPro: 1.262 ± 0.039	0.777TyrGln: 0.777 ± 0.036	2.016TyrArg: 2.016 ± 0.053	1.166TyrSer: 1.166 ± 0.039	1.458TyrThr: 1.458 ± 0.046	2.375TyrVal: 2.375 ± 0.056	0.349TyrTrp: 0.349 ± 0.023	0.856TyrTyr: 0.856 ± 0.041	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2859 proteins (754458 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---