Amino acid dipepetide frequency for Amphibalanus amphitrite (Striped barnacle) (Balanus amphitrite)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.273AlaAla: 16.273 ± 0.092	1.66AlaCys: 1.66 ± 0.028	5.953AlaAsp: 5.953 ± 0.029	6.96AlaGlu: 6.96 ± 0.039	2.347AlaPhe: 2.347 ± 0.016	8.421AlaGly: 8.421 ± 0.045	1.888AlaHis: 1.888 ± 0.016	2.613AlaIle: 2.613 ± 0.017	2.753AlaLys: 2.753 ± 0.022	8.655AlaLeu: 8.655 ± 0.046	1.71AlaMet: 1.71 ± 0.014	1.989AlaAsn: 1.989 ± 0.014	6.872AlaPro: 6.872 ± 0.048	3.418AlaGln: 3.418 ± 0.027	6.709AlaArg: 6.709 ± 0.035	6.446AlaSer: 6.446 ± 0.03	4.818AlaThr: 4.818 ± 0.027	7.369AlaVal: 7.369 ± 0.034	0.971AlaTrp: 0.971 ± 0.011	1.715AlaTyr: 1.715 ± 0.016	0.0AlaXaa: 0.0 ± 0.0
Cys	1.647CysAla: 1.647 ± 0.017	0.582CysCys: 0.582 ± 0.012	1.16CysAsp: 1.16 ± 0.013	1.032CysGlu: 1.032 ± 0.013	0.595CysPhe: 0.595 ± 0.009	1.741CysGly: 1.741 ± 0.021	0.567CysHis: 0.567 ± 0.009	0.597CysIle: 0.597 ± 0.009	0.611CysLys: 0.611 ± 0.008	1.997CysLeu: 1.997 ± 0.026	0.371CysMet: 0.371 ± 0.007	0.516CysAsn: 0.516 ± 0.009	1.403CysPro: 1.403 ± 0.022	0.933CysGln: 0.933 ± 0.012	1.918CysArg: 1.918 ± 0.021	1.679CysSer: 1.679 ± 0.02	1.027CysThr: 1.027 ± 0.015	1.44CysVal: 1.44 ± 0.018	0.303CysTrp: 0.303 ± 0.006	0.482CysTyr: 0.482 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	4.639AspAla: 4.639 ± 0.026	1.102AspCys: 1.102 ± 0.015	3.745AspAsp: 3.745 ± 0.025	3.846AspGlu: 3.846 ± 0.024	1.67AspPhe: 1.67 ± 0.015	5.053AspGly: 5.053 ± 0.03	1.193AspHis: 1.193 ± 0.015	2.058AspIle: 2.058 ± 0.016	1.892AspLys: 1.892 ± 0.018	4.718AspLeu: 4.718 ± 0.024	1.167AspMet: 1.167 ± 0.014	1.43AspAsn: 1.43 ± 0.013	3.238AspPro: 3.238 ± 0.026	2.138AspGln: 2.138 ± 0.015	3.895AspArg: 3.895 ± 0.024	4.178AspSer: 4.178 ± 0.025	2.995AspThr: 2.995 ± 0.02	3.794AspVal: 3.794 ± 0.025	0.847AspTrp: 0.847 ± 0.012	1.286AspTyr: 1.286 ± 0.014	0.0AspXaa: 0.0 ± 0.0
Glu	5.772GluAla: 5.772 ± 0.035	1.026GluCys: 1.026 ± 0.018	3.588GluAsp: 3.588 ± 0.023	5.684GluGlu: 5.684 ± 0.061	1.738GluPhe: 1.738 ± 0.013	3.504GluGly: 3.504 ± 0.027	1.449GluHis: 1.449 ± 0.013	1.848GluIle: 1.848 ± 0.018	2.717GluLys: 2.717 ± 0.026	6.525GluLeu: 6.525 ± 0.03	1.427GluMet: 1.427 ± 0.012	1.643GluAsn: 1.643 ± 0.013	4.186GluPro: 4.186 ± 0.038	2.998GluGln: 2.998 ± 0.023	5.539GluArg: 5.539 ± 0.034	3.687GluSer: 3.687 ± 0.021	3.613GluThr: 3.613 ± 0.029	3.95GluVal: 3.95 ± 0.029	0.721GluTrp: 0.721 ± 0.011	1.424GluTyr: 1.424 ± 0.016	0.0GluXaa: 0.0 ± 0.0
Phe	2.046PheAla: 2.046 ± 0.017	0.77PheCys: 0.77 ± 0.01	1.67PheAsp: 1.67 ± 0.014	1.527PheGlu: 1.527 ± 0.013	1.21PhePhe: 1.21 ± 0.011	2.274PheGly: 2.274 ± 0.018	0.764PheHis: 0.764 ± 0.009	1.225PheIle: 1.225 ± 0.013	1.112PheLys: 1.112 ± 0.012	2.687PheLeu: 2.687 ± 0.019	0.614PheMet: 0.614 ± 0.008	1.032PheAsn: 1.032 ± 0.011	1.371PhePro: 1.371 ± 0.012	1.201PheGln: 1.201 ± 0.011	2.076PheArg: 2.076 ± 0.018	2.523PheSer: 2.523 ± 0.017	1.743PheThr: 1.743 ± 0.015	2.27PheVal: 2.27 ± 0.039	0.433PheTrp: 0.433 ± 0.007	0.883PheTyr: 0.883 ± 0.008	0.0PheXaa: 0.0 ± 0.0
Gly	7.118GlyAla: 7.118 ± 0.037	1.415GlyCys: 1.415 ± 0.015	4.255GlyAsp: 4.255 ± 0.027	4.1GlyGlu: 4.1 ± 0.029	2.102GlyPhe: 2.102 ± 0.017	7.873GlyGly: 7.873 ± 0.063	1.898GlyHis: 1.898 ± 0.017	2.025GlyIle: 2.025 ± 0.016	2.399GlyLys: 2.399 ± 0.02	5.805GlyLeu: 5.805 ± 0.037	1.289GlyMet: 1.289 ± 0.016	1.72GlyAsn: 1.72 ± 0.017	4.303GlyPro: 4.303 ± 0.039	3.125GlyGln: 3.125 ± 0.025	6.349GlyArg: 6.349 ± 0.038	5.886GlySer: 5.886 ± 0.031	3.667GlyThr: 3.667 ± 0.025	4.574GlyVal: 4.574 ± 0.029	1.077GlyTrp: 1.077 ± 0.014	2.083GlyTyr: 2.083 ± 0.021	0.0GlyXaa: 0.0 ± 0.0
His	1.666HisAla: 1.666 ± 0.016	0.661HisCys: 0.661 ± 0.008	1.041HisAsp: 1.041 ± 0.011	1.17HisGlu: 1.17 ± 0.014	0.757HisPhe: 0.757 ± 0.009	1.802HisGly: 1.802 ± 0.017	0.886HisHis: 0.886 ± 0.012	0.881HisIle: 0.881 ± 0.011	0.831HisLys: 0.831 ± 0.009	2.601HisLeu: 2.601 ± 0.017	0.578HisMet: 0.578 ± 0.01	0.657HisAsn: 0.657 ± 0.01	1.511HisPro: 1.511 ± 0.015	1.288HisGln: 1.288 ± 0.017	2.08HisArg: 2.08 ± 0.017	1.707HisSer: 1.707 ± 0.019	1.21HisThr: 1.21 ± 0.011	1.709HisVal: 1.709 ± 0.014	0.378HisTrp: 0.378 ± 0.006	0.686HisTyr: 0.686 ± 0.01	0.0HisXaa: 0.0 ± 0.0
Ile	2.35IleAla: 2.35 ± 0.017	0.754IleCys: 0.754 ± 0.01	1.839IleAsp: 1.839 ± 0.014	1.836IleGlu: 1.836 ± 0.015	1.082IlePhe: 1.082 ± 0.011	2.134IleGly: 2.134 ± 0.018	0.774IleHis: 0.774 ± 0.008	1.504IleIle: 1.504 ± 0.023	1.404IleLys: 1.404 ± 0.015	2.604IleLeu: 2.604 ± 0.02	0.696IleMet: 0.696 ± 0.009	1.222IleAsn: 1.222 ± 0.013	1.625IlePro: 1.625 ± 0.014	1.355IleGln: 1.355 ± 0.013	2.233IleArg: 2.233 ± 0.015	2.437IleSer: 2.437 ± 0.017	2.064IleThr: 2.064 ± 0.019	2.211IleVal: 2.211 ± 0.017	0.411IleTrp: 0.411 ± 0.007	0.897IleTyr: 0.897 ± 0.01	0.0IleXaa: 0.0 ± 0.0
Lys	2.826LysAla: 2.826 ± 0.023	0.661LysCys: 0.661 ± 0.01	1.817LysAsp: 1.817 ± 0.019	2.58LysGlu: 2.58 ± 0.026	1.136LysPhe: 1.136 ± 0.011	1.837LysGly: 1.837 ± 0.021	0.903LysHis: 0.903 ± 0.01	1.362LysIle: 1.362 ± 0.014	2.627LysLys: 2.627 ± 0.033	3.403LysLeu: 3.403 ± 0.028	1.015LysMet: 1.015 ± 0.013	1.166LysAsn: 1.166 ± 0.013	2.106LysPro: 2.106 ± 0.024	1.608LysGln: 1.608 ± 0.015	2.762LysArg: 2.762 ± 0.023	2.17LysSer: 2.17 ± 0.017	2.115LysThr: 2.115 ± 0.017	2.421LysVal: 2.421 ± 0.024	0.447LysTrp: 0.447 ± 0.008	1.017LysTyr: 1.017 ± 0.012	0.0LysXaa: 0.0 ± 0.0
Leu	8.768LeuAla: 8.768 ± 0.043	2.079LeuCys: 2.079 ± 0.018	4.899LeuAsp: 4.899 ± 0.024	5.903LeuGlu: 5.903 ± 0.034	2.772LeuPhe: 2.772 ± 0.02	5.696LeuGly: 5.696 ± 0.028	2.433LeuHis: 2.433 ± 0.019	2.682LeuIle: 2.682 ± 0.019	3.572LeuLys: 3.572 ± 0.023	10.831LeuLeu: 10.831 ± 0.07	1.967LeuMet: 1.967 ± 0.015	2.554LeuAsn: 2.554 ± 0.018	6.145LeuPro: 6.145 ± 0.04	4.632LeuGln: 4.632 ± 0.027	7.929LeuArg: 7.929 ± 0.04	7.265LeuSer: 7.265 ± 0.03	5.684LeuThr: 5.684 ± 0.029	6.603LeuVal: 6.603 ± 0.026	1.2LeuTrp: 1.2 ± 0.014	2.203LeuTyr: 2.203 ± 0.019	0.0LeuXaa: 0.0 ± 0.0
Met	2.119MetAla: 2.119 ± 0.016	0.387MetCys: 0.387 ± 0.006	1.21MetAsp: 1.21 ± 0.012	1.462MetGlu: 1.462 ± 0.016	0.704MetPhe: 0.704 ± 0.01	1.191MetGly: 1.191 ± 0.013	0.408MetHis: 0.408 ± 0.006	0.635MetIle: 0.635 ± 0.007	1.017MetLys: 1.017 ± 0.016	1.918MetLeu: 1.918 ± 0.016	0.598MetMet: 0.598 ± 0.009	0.584MetAsn: 0.584 ± 0.007	1.053MetPro: 1.053 ± 0.012	0.751MetGln: 0.751 ± 0.009	1.309MetArg: 1.309 ± 0.01	1.499MetSer: 1.499 ± 0.013	1.248MetThr: 1.248 ± 0.012	1.467MetVal: 1.467 ± 0.014	0.246MetTrp: 0.246 ± 0.004	0.515MetTyr: 0.515 ± 0.008	0.0MetXaa: 0.0 ± 0.0
Asn	1.952AsnAla: 1.952 ± 0.015	0.563AsnCys: 0.563 ± 0.009	1.299AsnAsp: 1.299 ± 0.015	1.4AsnGlu: 1.4 ± 0.014	0.946AsnPhe: 0.946 ± 0.01	2.177AsnGly: 2.177 ± 0.021	0.616AsnHis: 0.616 ± 0.009	1.269AsnIle: 1.269 ± 0.012	1.199AsnLys: 1.199 ± 0.013	2.273AsnLeu: 2.273 ± 0.021	0.735AsnMet: 0.735 ± 0.008	1.003AsnAsn: 1.003 ± 0.017	1.374AsnPro: 1.374 ± 0.013	1.049AsnGln: 1.049 ± 0.013	1.714AsnArg: 1.714 ± 0.016	1.836AsnSer: 1.836 ± 0.016	1.434AsnThr: 1.434 ± 0.013	1.877AsnVal: 1.877 ± 0.013	0.368AsnTrp: 0.368 ± 0.006	0.779AsnTyr: 0.779 ± 0.009	0.0AsnXaa: 0.0 ± 0.0
Pro	9.361ProAla: 9.361 ± 0.069	1.017ProCys: 1.017 ± 0.021	3.639ProAsp: 3.639 ± 0.024	4.386ProGlu: 4.386 ± 0.028	1.525ProPhe: 1.525 ± 0.014	5.096ProGly: 5.096 ± 0.06	1.311ProHis: 1.311 ± 0.013	1.544ProIle: 1.544 ± 0.016	1.722ProLys: 1.722 ± 0.02	5.5ProLeu: 5.5 ± 0.03	0.942ProMet: 0.942 ± 0.01	1.274ProAsn: 1.274 ± 0.013	8.057ProPro: 8.057 ± 0.077	2.417ProGln: 2.417 ± 0.02	4.255ProArg: 4.255 ± 0.026	5.306ProSer: 5.306 ± 0.031	3.596ProThr: 3.596 ± 0.028	4.556ProVal: 4.556 ± 0.026	0.707ProTrp: 0.707 ± 0.01	1.321ProTyr: 1.321 ± 0.013	0.0ProXaa: 0.0 ± 0.0
Gln	3.409GlnAla: 3.409 ± 0.023	0.875GlnCys: 0.875 ± 0.013	1.698GlnAsp: 1.698 ± 0.013	2.715GlnGlu: 2.715 ± 0.024	1.342GlnPhe: 1.342 ± 0.012	2.063GlnGly: 2.063 ± 0.019	1.226GlnHis: 1.226 ± 0.013	1.267GlnIle: 1.267 ± 0.013	1.593GlnLys: 1.593 ± 0.014	5.725GlnLeu: 5.725 ± 0.034	1.044GlnMet: 1.044 ± 0.012	1.033GlnAsn: 1.033 ± 0.012	3.151GlnPro: 3.151 ± 0.024	3.299GlnGln: 3.299 ± 0.044	3.842GlnArg: 3.842 ± 0.026	2.638GlnSer: 2.638 ± 0.023	2.292GlnThr: 2.292 ± 0.022	2.588GlnVal: 2.588 ± 0.019	0.592GlnTrp: 0.592 ± 0.008	1.183GlnTyr: 1.183 ± 0.013	0.0GlnXaa: 0.0 ± 0.0
Arg	6.962ArgAla: 6.962 ± 0.036	1.828ArgCys: 1.828 ± 0.019	3.926ArgAsp: 3.926 ± 0.025	4.359ArgGlu: 4.359 ± 0.026	2.128ArgPhe: 2.128 ± 0.017	4.852ArgGly: 4.852 ± 0.032	2.391ArgHis: 2.391 ± 0.017	2.078ArgIle: 2.078 ± 0.014	2.537ArgLys: 2.537 ± 0.019	8.758ArgLeu: 8.758 ± 0.039	1.376ArgMet: 1.376 ± 0.011	1.696ArgAsn: 1.696 ± 0.014	5.892ArgPro: 5.892 ± 0.036	4.039ArgGln: 4.039 ± 0.021	9.183ArgArg: 9.183 ± 0.045	5.64ArgSer: 5.64 ± 0.032	3.802ArgThr: 3.802 ± 0.021	4.574ArgVal: 4.574 ± 0.028	1.197ArgTrp: 1.197 ± 0.012	1.804ArgTyr: 1.804 ± 0.016	0.0ArgXaa: 0.0 ± 0.0
Ser	7.811SerAla: 7.811 ± 0.038	1.473SerCys: 1.473 ± 0.016	4.371SerAsp: 4.371 ± 0.026	4.523SerGlu: 4.523 ± 0.028	2.106SerPhe: 2.106 ± 0.015	6.366SerGly: 6.366 ± 0.034	1.631SerHis: 1.631 ± 0.016	2.024SerIle: 2.024 ± 0.015	2.221SerLys: 2.221 ± 0.018	6.518SerLeu: 6.518 ± 0.035	1.347SerMet: 1.347 ± 0.013	1.657SerAsn: 1.657 ± 0.017	5.167SerPro: 5.167 ± 0.035	2.975SerGln: 2.975 ± 0.026	5.47SerArg: 5.47 ± 0.031	6.878SerSer: 6.878 ± 0.048	3.908SerThr: 3.908 ± 0.021	5.275SerVal: 5.275 ± 0.026	0.95SerTrp: 0.95 ± 0.009	1.683SerTyr: 1.683 ± 0.017	0.0SerXaa: 0.0 ± 0.0
Thr	6.146ThrAla: 6.146 ± 0.029	1.209ThrCys: 1.209 ± 0.017	3.16ThrAsp: 3.16 ± 0.025	3.756ThrGlu: 3.756 ± 0.037	1.724ThrPhe: 1.724 ± 0.015	4.272ThrGly: 4.272 ± 0.024	1.106ThrHis: 1.106 ± 0.013	1.951ThrIle: 1.951 ± 0.016	1.789ThrLys: 1.789 ± 0.014	5.059ThrLeu: 5.059 ± 0.027	1.107ThrMet: 1.107 ± 0.009	1.429ThrAsn: 1.429 ± 0.015	3.849ThrPro: 3.849 ± 0.028	1.859ThrGln: 1.859 ± 0.016	3.371ThrArg: 3.371 ± 0.021	4.192ThrSer: 4.192 ± 0.026	3.317ThrThr: 3.317 ± 0.03	4.551ThrVal: 4.551 ± 0.027	0.682ThrTrp: 0.682 ± 0.009	1.304ThrTyr: 1.304 ± 0.013	0.0ThrXaa: 0.0 ± 0.0
Val	6.198ValAla: 6.198 ± 0.032	1.701ValCys: 1.701 ± 0.02	3.539ValAsp: 3.539 ± 0.021	3.833ValGlu: 3.833 ± 0.022	2.289ValPhe: 2.289 ± 0.04	4.042ValGly: 4.042 ± 0.023	1.653ValHis: 1.653 ± 0.012	2.499ValIle: 2.499 ± 0.018	2.489ValLys: 2.489 ± 0.021	6.465ValLeu: 6.465 ± 0.035	1.428ValMet: 1.428 ± 0.013	2.008ValAsn: 2.008 ± 0.018	4.294ValPro: 4.294 ± 0.027	2.787ValGln: 2.787 ± 0.019	5.1ValArg: 5.1 ± 0.024	5.532ValSer: 5.532 ± 0.027	5.144ValThr: 5.144 ± 0.038	4.892ValVal: 4.892 ± 0.029	0.918ValTrp: 0.918 ± 0.01	1.717ValTyr: 1.717 ± 0.015	0.0ValXaa: 0.0 ± 0.0
Trp	0.913TrpAla: 0.913 ± 0.01	0.305TrpCys: 0.305 ± 0.006	0.687TrpAsp: 0.687 ± 0.012	0.68TrpGlu: 0.68 ± 0.011	0.418TrpPhe: 0.418 ± 0.008	0.718TrpGly: 0.718 ± 0.01	0.308TrpHis: 0.308 ± 0.006	0.444TrpIle: 0.444 ± 0.007	0.541TrpLys: 0.541 ± 0.008	1.517TrpLeu: 1.517 ± 0.015	0.342TrpMet: 0.342 ± 0.005	0.4TrpAsn: 0.4 ± 0.007	0.719TrpPro: 0.719 ± 0.009	0.545TrpGln: 0.545 ± 0.007	1.249TrpArg: 1.249 ± 0.013	1.059TrpSer: 1.059 ± 0.012	0.828TrpThr: 0.828 ± 0.011	0.76TrpVal: 0.76 ± 0.008	0.235TrpTrp: 0.235 ± 0.005	0.335TrpTyr: 0.335 ± 0.007	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.562TyrAla: 1.562 ± 0.013	0.534TyrCys: 0.534 ± 0.008	1.39TyrAsp: 1.39 ± 0.013	1.286TyrGlu: 1.286 ± 0.013	0.838TyrPhe: 0.838 ± 0.01	1.951TyrGly: 1.951 ± 0.022	0.695TyrHis: 0.695 ± 0.012	0.925TyrIle: 0.925 ± 0.011	0.954TyrLys: 0.954 ± 0.015	2.258TyrLeu: 2.258 ± 0.018	0.566TyrMet: 0.566 ± 0.007	0.849TyrAsn: 0.849 ± 0.009	1.219TyrPro: 1.219 ± 0.013	1.158TyrGln: 1.158 ± 0.012	2.042TyrArg: 2.042 ± 0.015	1.796TyrSer: 1.796 ± 0.016	1.329TyrThr: 1.329 ± 0.013	1.648TyrVal: 1.648 ± 0.013	0.32TyrTrp: 0.32 ± 0.005	0.753TyrTyr: 0.753 ± 0.011	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.002XaaXaa: 0.002 ± 0.002

Statistics based on 26159 proteins (11229583 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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