Amino acid dipepetide frequency for Beihai Nido-like virus 2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.624AlaAla: 4.624 ± 0.947
1.375AlaCys: 1.375 ± 0.362
2.624AlaAsp: 2.624 ± 0.558
3.124AlaGlu: 3.124 ± 0.756
2.499AlaPhe: 2.499 ± 0.837
3.999AlaGly: 3.999 ± 1.346
1.5AlaHis: 1.5 ± 0.45
3.624AlaIle: 3.624 ± 0.938
2.874AlaLys: 2.874 ± 0.673
7.373AlaLeu: 7.373 ± 1.545
1.125AlaMet: 1.125 ± 0.381
2.874AlaAsn: 2.874 ± 0.57
2.749AlaPro: 2.749 ± 1.107
2.499AlaGln: 2.499 ± 0.955
3.249AlaArg: 3.249 ± 0.585
4.999AlaSer: 4.999 ± 1.068
4.624AlaThr: 4.624 ± 1.316
4.374AlaVal: 4.374 ± 1.016
0.5AlaTrp: 0.5 ± 0.194
2.999AlaTyr: 2.999 ± 0.838
0.0AlaXaa: 0.0 ± 0.0
Cys
1.25CysAla: 1.25 ± 0.406
0.125CysCys: 0.125 ± 0.212
1.125CysAsp: 1.125 ± 0.304
2.124CysGlu: 2.124 ± 0.581
0.875CysPhe: 0.875 ± 0.767
2.249CysGly: 2.249 ± 0.545
0.5CysHis: 0.5 ± 0.194
1.25CysIle: 1.25 ± 0.505
1.375CysLys: 1.375 ± 0.72
1.75CysLeu: 1.75 ± 0.542
0.25CysMet: 0.25 ± 0.131
1.0CysAsn: 1.0 ± 0.389
1.125CysPro: 1.125 ± 0.614
1.875CysGln: 1.875 ± 0.5
0.75CysArg: 0.75 ± 0.333
1.375CysSer: 1.375 ± 0.69
2.124CysThr: 2.124 ± 0.688
2.499CysVal: 2.499 ± 0.678
0.25CysTrp: 0.25 ± 0.277
1.25CysTyr: 1.25 ± 0.393
0.0CysXaa: 0.0 ± 0.0
Asp
2.999AspAla: 2.999 ± 0.754
1.0AspCys: 1.0 ± 0.304
2.624AspAsp: 2.624 ± 0.435
2.374AspGlu: 2.374 ± 0.535
1.75AspPhe: 1.75 ± 0.468
3.499AspGly: 3.499 ± 0.886
2.0AspHis: 2.0 ± 0.752
4.124AspIle: 4.124 ± 0.606
2.499AspLys: 2.499 ± 0.71
5.249AspLeu: 5.249 ± 0.743
0.75AspMet: 0.75 ± 0.257
2.499AspAsn: 2.499 ± 0.451
2.499AspPro: 2.499 ± 0.37
1.75AspGln: 1.75 ± 0.391
2.499AspArg: 2.499 ± 0.795
2.499AspSer: 2.499 ± 0.49
3.749AspThr: 3.749 ± 0.765
4.249AspVal: 4.249 ± 0.668
0.75AspTrp: 0.75 ± 0.283
3.249AspTyr: 3.249 ± 0.446
0.0AspXaa: 0.0 ± 0.0
Glu
2.499GluAla: 2.499 ± 0.679
1.875GluCys: 1.875 ± 0.519
2.499GluAsp: 2.499 ± 0.391
2.624GluGlu: 2.624 ± 0.508
2.124GluPhe: 2.124 ± 0.299
2.124GluGly: 2.124 ± 0.55
1.625GluHis: 1.625 ± 0.559
2.0GluIle: 2.0 ± 0.482
1.75GluLys: 1.75 ± 0.89
3.874GluLeu: 3.874 ± 0.504
1.25GluMet: 1.25 ± 0.344
1.75GluAsn: 1.75 ± 0.434
1.75GluPro: 1.75 ± 0.675
1.0GluGln: 1.0 ± 0.384
1.375GluArg: 1.375 ± 0.596
4.499GluSer: 4.499 ± 0.827
1.375GluThr: 1.375 ± 0.387
3.374GluVal: 3.374 ± 1.017
0.375GluTrp: 0.375 ± 0.172
2.499GluTyr: 2.499 ± 0.607
0.0GluXaa: 0.0 ± 0.0
Phe
1.625PheAla: 1.625 ± 0.366
0.875PheCys: 0.875 ± 0.429
3.124PheAsp: 3.124 ± 0.406
1.5PheGlu: 1.5 ± 0.364
1.375PhePhe: 1.375 ± 0.982
2.624PheGly: 2.624 ± 0.375
0.625PheHis: 0.625 ± 0.257
2.749PheIle: 2.749 ± 0.553
2.374PheLys: 2.374 ± 0.574
3.624PheLeu: 3.624 ± 0.823
0.75PheMet: 0.75 ± 0.283
2.999PheAsn: 2.999 ± 1.084
1.25PhePro: 1.25 ± 0.448
1.125PheGln: 1.125 ± 0.349
1.5PheArg: 1.5 ± 0.332
3.124PheSer: 3.124 ± 1.348
3.499PheThr: 3.499 ± 1.024
3.999PheVal: 3.999 ± 0.775
0.25PheTrp: 0.25 ± 0.131
3.874PheTyr: 3.874 ± 0.684
0.0PheXaa: 0.0 ± 0.0
Gly
1.75GlyAla: 1.75 ± 0.416
1.375GlyCys: 1.375 ± 0.734
3.624GlyAsp: 3.624 ± 1.028
1.5GlyGlu: 1.5 ± 0.429
3.124GlyPhe: 3.124 ± 0.592
3.999GlyGly: 3.999 ± 0.994
1.5GlyHis: 1.5 ± 0.58
2.749GlyIle: 2.749 ± 1.026
3.249GlyLys: 3.249 ± 0.551
5.499GlyLeu: 5.499 ± 0.684
1.25GlyMet: 1.25 ± 0.316
2.874GlyAsn: 2.874 ± 0.842
2.124GlyPro: 2.124 ± 1.136
1.5GlyGln: 1.5 ± 0.292
2.874GlyArg: 2.874 ± 0.83
4.249GlySer: 4.249 ± 0.866
3.124GlyThr: 3.124 ± 1.409
5.874GlyVal: 5.874 ± 0.575
0.5GlyTrp: 0.5 ± 0.345
4.374GlyTyr: 4.374 ± 1.118
0.0GlyXaa: 0.0 ± 0.0
His
1.125HisAla: 1.125 ± 0.323
0.5HisCys: 0.5 ± 0.194
2.499HisAsp: 2.499 ± 0.763
1.0HisGlu: 1.0 ± 0.241
2.0HisPhe: 2.0 ± 0.487
2.249HisGly: 2.249 ± 0.725
0.875HisHis: 0.875 ± 0.333
2.374HisIle: 2.374 ± 0.434
1.375HisLys: 1.375 ± 0.58
2.374HisLeu: 2.374 ± 0.546
0.5HisMet: 0.5 ± 0.262
2.249HisAsn: 2.249 ± 0.56
1.875HisPro: 1.875 ± 0.76
1.0HisGln: 1.0 ± 0.408
0.875HisArg: 0.875 ± 0.438
2.249HisSer: 2.249 ± 0.429
2.499HisThr: 2.499 ± 0.817
2.0HisVal: 2.0 ± 0.562
0.125HisTrp: 0.125 ± 0.197
2.749HisTyr: 2.749 ± 0.532
0.0HisXaa: 0.0 ± 0.0
Ile
4.999IleAla: 4.999 ± 0.857
1.125IleCys: 1.125 ± 0.43
3.249IleAsp: 3.249 ± 1.307
2.124IleGlu: 2.124 ± 0.771
1.375IlePhe: 1.375 ± 0.562
3.249IleGly: 3.249 ± 0.811
2.0IleHis: 2.0 ± 0.626
3.374IleIle: 3.374 ± 0.442
3.249IleLys: 3.249 ± 1.413
4.874IleLeu: 4.874 ± 1.067
1.625IleMet: 1.625 ± 0.675
2.499IleAsn: 2.499 ± 0.744
3.874IlePro: 3.874 ± 0.906
2.249IleGln: 2.249 ± 0.788
2.0IleArg: 2.0 ± 0.491
4.374IleSer: 4.374 ± 0.654
4.374IleThr: 4.374 ± 0.725
5.749IleVal: 5.749 ± 1.574
0.5IleTrp: 0.5 ± 0.262
2.624IleTyr: 2.624 ± 0.447
0.0IleXaa: 0.0 ± 0.0
Lys
3.874LysAla: 3.874 ± 0.592
0.875LysCys: 0.875 ± 0.255
2.874LysAsp: 2.874 ± 0.812
2.0LysGlu: 2.0 ± 0.505
3.249LysPhe: 3.249 ± 0.514
2.624LysGly: 2.624 ± 1.134
2.0LysHis: 2.0 ± 0.702
2.374LysIle: 2.374 ± 1.034
2.874LysLys: 2.874 ± 0.412
4.624LysLeu: 4.624 ± 1.112
0.875LysMet: 0.875 ± 0.304
2.499LysAsn: 2.499 ± 0.744
2.999LysPro: 2.999 ± 1.07
1.5LysGln: 1.5 ± 0.681
2.249LysArg: 2.249 ± 0.716
3.499LysSer: 3.499 ± 0.686
2.874LysThr: 2.874 ± 0.582
2.749LysVal: 2.749 ± 0.646
0.625LysTrp: 0.625 ± 0.381
3.374LysTyr: 3.374 ± 0.939
0.0LysXaa: 0.0 ± 0.0
Leu
6.248LeuAla: 6.248 ± 1.626
1.875LeuCys: 1.875 ± 0.472
5.124LeuAsp: 5.124 ± 1.48
3.624LeuGlu: 3.624 ± 0.649
3.499LeuPhe: 3.499 ± 0.961
4.249LeuGly: 4.249 ± 1.254
2.874LeuHis: 2.874 ± 0.558
6.123LeuIle: 6.123 ± 1.303
4.999LeuLys: 4.999 ± 0.679
8.373LeuLeu: 8.373 ± 0.943
2.124LeuMet: 2.124 ± 0.851
4.374LeuAsn: 4.374 ± 0.751
4.749LeuPro: 4.749 ± 1.022
4.124LeuGln: 4.124 ± 0.42
2.999LeuArg: 2.999 ± 0.649
7.123LeuSer: 7.123 ± 1.867
6.248LeuThr: 6.248 ± 0.792
6.123LeuVal: 6.123 ± 1.399
0.75LeuTrp: 0.75 ± 0.501
5.124LeuTyr: 5.124 ± 0.789
0.0LeuXaa: 0.0 ± 0.0
Met
1.375MetAla: 1.375 ± 0.522
0.375MetCys: 0.375 ± 0.196
0.875MetAsp: 0.875 ± 0.458
1.125MetGlu: 1.125 ± 0.426
0.75MetPhe: 0.75 ± 0.345
0.25MetGly: 0.25 ± 0.131
0.75MetHis: 0.75 ± 0.344
0.875MetIle: 0.875 ± 0.458
0.375MetLys: 0.375 ± 0.196
2.624MetLeu: 2.624 ± 0.822
0.5MetMet: 0.5 ± 0.275
1.0MetAsn: 1.0 ± 0.241
1.375MetPro: 1.375 ± 0.511
0.875MetGln: 0.875 ± 0.308
1.375MetArg: 1.375 ± 0.515
2.0MetSer: 2.0 ± 0.602
1.75MetThr: 1.75 ± 0.503
1.375MetVal: 1.375 ± 0.517
0.0MetTrp: 0.0 ± 0.0
1.375MetTyr: 1.375 ± 0.396
0.0MetXaa: 0.0 ± 0.0
Asn
3.249AsnAla: 3.249 ± 0.883
1.25AsnCys: 1.25 ± 0.376
1.375AsnAsp: 1.375 ± 0.342
1.625AsnGlu: 1.625 ± 0.562
1.625AsnPhe: 1.625 ± 0.52
3.499AsnGly: 3.499 ± 1.112
0.75AsnHis: 0.75 ± 0.295
2.999AsnIle: 2.999 ± 0.818
2.624AsnLys: 2.624 ± 0.663
4.749AsnLeu: 4.749 ± 0.612
1.0AsnMet: 1.0 ± 0.267
1.75AsnAsn: 1.75 ± 1.274
3.124AsnPro: 3.124 ± 1.345
1.375AsnGln: 1.375 ± 0.581
2.499AsnArg: 2.499 ± 1.267
3.249AsnSer: 3.249 ± 1.155
3.249AsnThr: 3.249 ± 0.595
3.999AsnVal: 3.999 ± 0.856
0.125AsnTrp: 0.125 ± 0.212
2.749AsnTyr: 2.749 ± 0.654
0.0AsnXaa: 0.0 ± 0.0
Pro
3.249ProAla: 3.249 ± 0.585
1.625ProCys: 1.625 ± 0.395
3.249ProAsp: 3.249 ± 1.244
1.5ProGlu: 1.5 ± 0.712
2.249ProPhe: 2.249 ± 0.438
2.624ProGly: 2.624 ± 0.639
2.249ProHis: 2.249 ± 0.412
2.624ProIle: 2.624 ± 0.486
1.75ProLys: 1.75 ± 0.835
3.999ProLeu: 3.999 ± 0.574
1.25ProMet: 1.25 ± 0.663
1.25ProAsn: 1.25 ± 0.386
1.75ProPro: 1.75 ± 1.248
2.374ProGln: 2.374 ± 1.614
2.874ProArg: 2.874 ± 0.951
3.124ProSer: 3.124 ± 1.215
3.624ProThr: 3.624 ± 0.629
3.999ProVal: 3.999 ± 0.518
0.625ProTrp: 0.625 ± 0.435
2.0ProTyr: 2.0 ± 0.482
0.0ProXaa: 0.0 ± 0.0
Gln
2.749GlnAla: 2.749 ± 1.217
1.125GlnCys: 1.125 ± 0.398
1.5GlnAsp: 1.5 ± 0.4
0.625GlnGlu: 0.625 ± 0.234
1.375GlnPhe: 1.375 ± 1.022
2.999GlnGly: 2.999 ± 0.702
1.875GlnHis: 1.875 ± 0.792
2.0GlnIle: 2.0 ± 1.261
1.25GlnLys: 1.25 ± 0.458
4.624GlnLeu: 4.624 ± 1.056
1.0GlnMet: 1.0 ± 0.303
1.5GlnAsn: 1.5 ± 0.691
2.374GlnPro: 2.374 ± 1.26
2.0GlnGln: 2.0 ± 0.563
1.875GlnArg: 1.875 ± 0.775
2.124GlnSer: 2.124 ± 0.321
2.374GlnThr: 2.374 ± 1.108
2.499GlnVal: 2.499 ± 1.125
0.375GlnTrp: 0.375 ± 0.245
1.875GlnTyr: 1.875 ± 0.587
0.0GlnXaa: 0.0 ± 0.0
Arg
3.624ArgAla: 3.624 ± 0.869
1.375ArgCys: 1.375 ± 0.319
2.499ArgAsp: 2.499 ± 0.688
2.249ArgGlu: 2.249 ± 1.211
2.0ArgPhe: 2.0 ± 0.606
2.124ArgGly: 2.124 ± 1.567
1.25ArgHis: 1.25 ± 0.347
2.124ArgIle: 2.124 ± 0.303
2.249ArgLys: 2.249 ± 0.859
2.749ArgLeu: 2.749 ± 0.377
0.875ArgMet: 0.875 ± 0.203
1.625ArgAsn: 1.625 ± 0.842
2.124ArgPro: 2.124 ± 1.092
2.374ArgGln: 2.374 ± 0.769
2.124ArgArg: 2.124 ± 1.701
3.874ArgSer: 3.874 ± 1.802
2.374ArgThr: 2.374 ± 0.434
3.624ArgVal: 3.624 ± 0.465
0.875ArgTrp: 0.875 ± 0.314
2.374ArgTyr: 2.374 ± 0.542
0.0ArgXaa: 0.0 ± 0.0
Ser
5.124SerAla: 5.124 ± 0.866
1.625SerCys: 1.625 ± 0.345
1.625SerAsp: 1.625 ± 0.434
2.999SerGlu: 2.999 ± 0.798
2.749SerPhe: 2.749 ± 0.479
3.624SerGly: 3.624 ± 0.9
2.499SerHis: 2.499 ± 0.462
4.999SerIle: 4.999 ± 0.614
3.249SerLys: 3.249 ± 0.92
5.124SerLeu: 5.124 ± 1.291
1.5SerMet: 1.5 ± 0.643
3.624SerAsn: 3.624 ± 1.297
3.624SerPro: 3.624 ± 1.453
2.999SerGln: 2.999 ± 1.041
4.624SerArg: 4.624 ± 2.273
4.999SerSer: 4.999 ± 1.862
5.499SerThr: 5.499 ± 1.548
4.874SerVal: 4.874 ± 0.978
0.625SerTrp: 0.625 ± 0.212
4.624SerTyr: 4.624 ± 1.172
0.0SerXaa: 0.0 ± 0.0
Thr
3.874ThrAla: 3.874 ± 0.728
2.0ThrCys: 2.0 ± 0.528
2.999ThrAsp: 2.999 ± 0.881
4.124ThrGlu: 4.124 ± 1.008
3.124ThrPhe: 3.124 ± 0.766
3.499ThrGly: 3.499 ± 1.069
1.75ThrHis: 1.75 ± 0.455
4.749ThrIle: 4.749 ± 0.358
3.624ThrLys: 3.624 ± 1.059
6.748ThrLeu: 6.748 ± 1.553
2.0ThrMet: 2.0 ± 0.574
2.874ThrAsn: 2.874 ± 0.581
2.874ThrPro: 2.874 ± 0.786
1.75ThrGln: 1.75 ± 0.492
2.749ThrArg: 2.749 ± 1.898
4.624ThrSer: 4.624 ± 1.515
4.249ThrThr: 4.249 ± 0.817
4.874ThrVal: 4.874 ± 1.103
0.75ThrTrp: 0.75 ± 0.244
3.999ThrTyr: 3.999 ± 0.826
0.0ThrXaa: 0.0 ± 0.0
Val
5.499ValAla: 5.499 ± 1.17
3.124ValCys: 3.124 ± 0.764
4.999ValAsp: 4.999 ± 0.882
3.874ValGlu: 3.874 ± 1.352
3.249ValPhe: 3.249 ± 0.741
4.124ValGly: 4.124 ± 0.558
3.374ValHis: 3.374 ± 0.628
4.499ValIle: 4.499 ± 0.977
4.749ValLys: 4.749 ± 1.006
6.248ValLeu: 6.248 ± 1.168
1.125ValMet: 1.125 ± 0.456
3.624ValAsn: 3.624 ± 0.968
3.624ValPro: 3.624 ± 0.706
3.124ValGln: 3.124 ± 1.069
3.374ValArg: 3.374 ± 0.97
3.999ValSer: 3.999 ± 0.867
4.374ValThr: 4.374 ± 1.027
5.249ValVal: 5.249 ± 0.871
1.625ValTrp: 1.625 ± 0.81
3.624ValTyr: 3.624 ± 0.772
0.0ValXaa: 0.0 ± 0.0
Trp
0.75TrpAla: 0.75 ± 0.518
0.25TrpCys: 0.25 ± 0.277
0.625TrpAsp: 0.625 ± 0.423
0.5TrpGlu: 0.5 ± 0.262
1.0TrpPhe: 1.0 ± 0.286
0.75TrpGly: 0.75 ± 0.335
0.5TrpHis: 0.5 ± 0.25
0.5TrpIle: 0.5 ± 0.424
0.375TrpLys: 0.375 ± 0.172
1.375TrpLeu: 1.375 ± 0.47
0.125TrpMet: 0.125 ± 0.065
0.375TrpAsn: 0.375 ± 0.387
0.375TrpPro: 0.375 ± 0.167
0.125TrpGln: 0.125 ± 0.065
0.5TrpArg: 0.5 ± 0.406
0.5TrpSer: 0.5 ± 0.262
0.25TrpThr: 0.25 ± 0.131
0.875TrpVal: 0.875 ± 0.501
0.125TrpTrp: 0.125 ± 0.212
0.375TrpTyr: 0.375 ± 0.196
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.249TyrAla: 3.249 ± 0.63
1.375TyrCys: 1.375 ± 0.554
3.499TyrAsp: 3.499 ± 0.646
1.625TyrGlu: 1.625 ± 0.504
2.874TyrPhe: 2.874 ± 0.533
2.749TyrGly: 2.749 ± 0.699
2.0TyrHis: 2.0 ± 0.565
3.374TyrIle: 3.374 ± 1.127
3.749TyrLys: 3.749 ± 0.617
4.874TyrLeu: 4.874 ± 0.818
1.0TyrMet: 1.0 ± 0.318
3.624TyrAsn: 3.624 ± 0.881
1.75TyrPro: 1.75 ± 1.023
2.499TyrGln: 2.499 ± 0.653
2.124TyrArg: 2.124 ± 0.943
4.124TyrSer: 4.124 ± 0.729
4.999TyrThr: 4.999 ± 1.443
5.124TyrVal: 5.124 ± 1.059
0.5TyrTrp: 0.5 ± 0.262
3.999TyrTyr: 3.999 ± 1.167
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 9 proteins (8003 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski